Changes in Surface Markers of Human Monocytes Following Their In Vitro Maturation to Macrophages

  • Abraham J. Treves
  • Adriana Haimovitz
  • Zvi Fuks
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Peripheral blood monocytes are a transitory population between bone marrow promonocytes and tissue macrophages (1,2). Blood monocytes have several characteristics which assign them to the macrophage lineage. However, each of the macrophage markers is not always expressed on the entire monocyte population (3,4) and some markers and functions are altered during monocyte maturation or activation (5,6,7). In vitro cultivation of human monocytes is accompanied by a series of changes which results in their transition to macrophages (8). In the present study, we analyzed membrane markers on freshly obtained monocytes and on mature macrophages. These were the receptor for peanut agglutinin (PNA), which is associated with cell maturation in T lymphocytes (9) and the HLA-DR which is associated with some immune functions (10–12).


Peanut Agglutinin Mature Macrophage Monocyte Macrophage Fluorescent Positive Cell Transitory Population 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Abraham J. Treves
    • 1
  • Adriana Haimovitz
    • 1
  • Zvi Fuks
    • 1
  1. 1.Department of Radiation and Clinical OncologyHadassah University Medical CenterJerusalemIsrael

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