Isolation and Characterization of Human Monocyte Subsets

  • Roy S. Weiner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Human peripheral blood monocytes manifest several functions in vitro that are thought to be important to host defenses. Monocytes and/or their more differentiated forms exhibit chemotaxis, phagocytosis, bacterial killing, tumor cytotoxicity, and modulation of immunity and hematopoiesis. Peripheral blood monocytes, for all their demonstrable functions, are thought to be cells in transit, i.e., merely passengers in the blood stream traveling from their origin in the bone marrow to their destiny in tissues where they function as macrophages (1–3). Tissue macrophages in animals demonstrate a staggering heterogeneity wherein function differs depending upon the site from which they are obtained, the stimulus which induced their accummulation, and the interval between that stimulus and their collection and testing (4–9).


Peripheral Blood Monocyte Antibody Dependent Cellular Cytotoxicity Native Cytotoxicity Human Peripheral Blood Monocyte Hexose Monophosphate 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Roy S. Weiner
    • 1
  1. 1.Division of Medical OncologyUniversity of FloridaGainesvilleUSA

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