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Isolation and Characterization of Human Monocyte Subsets

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Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

Human peripheral blood monocytes manifest several functions in vitro that are thought to be important to host defenses. Monocytes and/or their more differentiated forms exhibit chemotaxis, phagocytosis, bacterial killing, tumor cytotoxicity, and modulation of immunity and hematopoiesis. Peripheral blood monocytes, for all their demonstrable functions, are thought to be cells in transit, i.e., merely passengers in the blood stream traveling from their origin in the bone marrow to their destiny in tissues where they function as macrophages (1–3). Tissue macrophages in animals demonstrate a staggering heterogeneity wherein function differs depending upon the site from which they are obtained, the stimulus which induced their accummulation, and the interval between that stimulus and their collection and testing (4–9).

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Authors and Affiliations

  1. Division of Medical Oncology, University of Florida, Gainesville, Florida, 32610, USA

    Roy S. Weiner

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  1. Roy S. Weiner
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Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

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© 1982 Plenum Press, New York

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Weiner, R.S. (1982). Isolation and Characterization of Human Monocyte Subsets. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_20

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  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4396-7

  • Online ISBN: 978-1-4684-4394-3

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