Skip to main content
SpringerLink
Log in

Membrane Receptors and the Regulation of Mononuclear Phagocyte Effector Functions

  • Chapter
Book cover Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

Mononuclear phagocytes form a body-wide system of cells (1) that originate from precursors in the bone marrow, circulate in the blood, and emigrate from the vascular compartment into the tissues where they spend the major portion of their life span. At the time of their emigration from the blood into the tissues mononuclear phagocytes are extremely immature cells. In the tissues they differentiate into their adult form, the macrophage. Macrophages in different tissues develop characteristic metabolic and structural properties. Thus alveolar macrophages develop a high capacity for oxidative metabolites (2), while splenic and peritoneal macrophages derive the major proportion of their metabolic energy from anerobic glycolysis (3). Inflammatory macrophages may develop into sheets of interlocking epithelioid cells, or fuse to form multinucleate giant cells (4). In the bones they fuse to produce osteoclasts (5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. van Furth, R., In “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 1–30, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  2. Axline, S. G., Simon, L. M., Robin, E. D., and Pesanti, E. L., in “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 1247–1260., Martinus Nijhoff Publishers, Inc., the Hague, 1980.

    Google Scholar 

  3. Loike, J. D., Silverstein, S. C., and Sturtevant, J. M., Proc. Natl. Acad. Sci. U.S.A. 78:5958, 1981.

    Article  PubMed  CAS  Google Scholar 

  4. Adams, D. O., In “Basic and Clinical Aspects of Granulomatous Diseases” (D. Boros and T. Yoshida, eds.), pp. 153–169, Elsevier/North Holland, Inc., New York, New York, 1980.

    Google Scholar 

  5. Erickson, J. L. E., In “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 203–230, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  6. Dinarello, C. A., Fed. Proc. 38:52, 1979.

    PubMed  CAS  Google Scholar 

  7. Wright, A. E., and Douglas, S. R., Proc. Roy. Soc. Lond. B. Biol. Sci. 72:357, 1904.

    Google Scholar 

  8. Silverstein, S. C., Steinman, R. M., and Cohn, Z. A., Ann. Rev. of Biochem. 46:669, 1977.

    Article  CAS  Google Scholar 

  9. Silverstein, S. C., Michl, J., and Loike, J., In “International Cell Biology” (Schweiger, H. G., ed.), pp. 604–612, Springer-Verlag, Berlin, 1981.

    Google Scholar 

  10. Shaw, D. R and Griffin, F. M. Jr., Nature 289:409, 1981.

    Article  PubMed  CAS  Google Scholar 

  11. Michl, J., Pieczonka, M. M., Unkeless, J. C., and Silverstein, S. C., J. Exp. Med., 150:607, 1979.

    Article  PubMed  CAS  Google Scholar 

  12. Hartwig, J. H., Yin, H. L., and Stossel, T. P., In: “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 971–996, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  13. Tilney, L. G., Kiehart, D. P., Sardet, C., and Tilney, M., J. Cell Biol. 77:536, 1978.

    Article  CAS  Google Scholar 

  14. Hoffstein, S., J. Immunol. 123:1395, 1979.

    PubMed  CAS  Google Scholar 

  15. Korchak, H. M., and Weissmann, G., Proc. Natl. Acad. Sci., U.S.A. 75:3818, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Gallin, E. K., and Livengood, D. R., Am. J. Physiol. 241:C9, 1981.

    PubMed  CAS  Google Scholar 

  17. Yin, H. L., Hartwig, T. H., Maruyama, K., and Stossel, T. P., J. Biol. Chem. 256:9693, 1981.

    PubMed  CAS  Google Scholar 

  18. Gordon, S., in: “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 1273–1294, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  19. Gordon, S., Todd, J., and Cohn, Z. A., J. Exp. Med. 137:1228, 1974.

    Article  Google Scholar 

  20. Werb, Z., and Gordon, S., J. Exp. Med. 142:346, 1975.

    Article  PubMed  CAS  Google Scholar 

  21. Stadecker, M. J., Calderon, J., Karnovsky, M. L., and Unanue, E. R., J. Immunol. 119:1738, 1977.

    PubMed  CAS  Google Scholar 

  22. Danes, P., Bonney, R. J., Humes, J. L., and Kuehl, F. F. Jr., in: “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 1317–1345, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  23. Johnston, R. B. Jr., Lehmeyer, J. E., and Guthrie, L. A., J. Exp. Med. 143:1551, 1976.

    Article  PubMed  CAS  Google Scholar 

  24. Nathan, C. F., and Root, R. K., J. Exp. Med. 148:1648, 1977.

    Article  Google Scholar 

  25. Whaley, K., J. Exp. Med. 151:501, 1980.

    Article  PubMed  CAS  Google Scholar 

  26. van Ginkel, R. J. W., and van Aken, W. G., in: “The Mononuclear Phagocyte” (R. van Furth, ed.), pp. 1351–1365, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  27. Alitalo, K., Honi, T., and Vaheri, A., J. Exp. Med. 151:602, 1980.

    Article  PubMed  CAS  Google Scholar 

  28. Johansson, S., Rubin, K., Hook, M., Allgran, T., and Seljelid, R., FEBS Lett. 105:313, 1979.

    Article  PubMed  CAS  Google Scholar 

  29. Mizel, S. B., and Farrar, J. F., Cell. Immunol. 48:433, 1979.

    Article  PubMed  CAS  Google Scholar 

  30. Smith, T. J., and Wagner, R. M., J. Exp. Med. 125:559, 1967.

    Article  PubMed  CAS  Google Scholar 

  31. Nathan, C. F., Brukner, L. H., Silverstein, S. C., and Cohn, Z. A., J. Exp. Med. 149:84, 1979.

    Article  PubMed  CAS  Google Scholar 

  32. Scott, W. A., Pawlowski, N. A., Murray, H. W., Andreach, M., Zrike, J., and Cohn, Z. A., J. Exp. Med. 155:535, 1982.

    Article  PubMed  CAS  Google Scholar 

  33. Unkeless, J. C., and Eisen, H. N., J. Exp. Med. 142:1520, 1975.

    Article  PubMed  CAS  Google Scholar 

  34. Unkeless, J. C., Fleit, H., and Mellman, I. S., Advances Immunol. 31:247, 1981.

    Article  CAS  Google Scholar 

  35. Diamond, B., and Yelton, D. E., J. Exp. Med. 153:514, 1981.

    Article  PubMed  CAS  Google Scholar 

  36. Ross, G. D., and Lambris, J. D., J. Exp. Med. 155:96, 1982.

    Article  PubMed  CAS  Google Scholar 

  37. Griffin, F. M. Jr., Bianco, C., and Silverstein, S. C., J. Exp. Med. 141:1269, 1975.

    Article  PubMed  Google Scholar 

  38. Ehlenberger, A. G., and Nussenzweig, V., J. Exp. Med. 145:357, 1977.

    Article  PubMed  CAS  Google Scholar 

  39. Wright, S. D., and Silverstein, S. C., J. Cell Biol. 91:255a, 1981.

    Article  Google Scholar 

  40. Bianco, C., Griffin, F. M. Jr., and Silverstein, S. C., J. Exp. Med. 141:1278, 1975.

    Article  PubMed  CAS  Google Scholar 

  41. Griffin, F. M. Jr., and Mullinax, P. J., J. Exp. Med. 154:291, 1981.

    Article  PubMed  CAS  Google Scholar 

  42. Nichols, B. A., J. Exp. Med. 144:906, 1976.

    Article  PubMed  CAS  Google Scholar 

  43. Murphy, P. A., Simon, P. L., and Willoughby, W. F., J. Immunol. 124:2498, 1980.

    PubMed  CAS  Google Scholar 

  44. Fuller, G. M., and Ritchie, D. G., Annals of the New York Academy of Sciences, 1981, in press.

    Google Scholar 

  45. Sanders, K. D., and Fuller, G. M., J. Cell Biol. 91:401a, 1981.

    Article  Google Scholar 

  46. Sluitter, W., van Waarde, D., Hulsing-Hesselink, E., Elzenga-Claasen, I. L., and van Furth, R., in: “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 325–339, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  47. Ash, P., Loutit, J. F., and Townsend, K. M. S., Nature 283:669, 1980.

    Article  PubMed  CAS  Google Scholar 

  48. Coccia, P. F., Krivit, W., Cervenka, J., Clauson, C. Kersey, J. H., Kim, J. H., Nesbit, M. E., Ramsay, N. K. C., Warkentin, P. I., Teitelbaum, S. L., Kah, A. J., and Brown, D. M., New Eng. J. Med. 302:701, 1980.

    Article  PubMed  CAS  Google Scholar 

  49. Fowler, S., Shio, H., and Haley, N. J., Lab. Invest. 41:372, 1979.

    PubMed  CAS  Google Scholar 

  50. Mackaness, G. B., in: “Mononuclear Phagocytes” (R. van Furth, ed.), Blackwell Scientific Publications, Oxford, 1970.

    Google Scholar 

  51. North, R. J., in: “Mechanisms of Cell-mediated Immunity” (McClusky, R. T., and Cohen, S., eds.), p. 185, John Wiley and Sons, Inc., New York, 1974.

    Google Scholar 

  52. David, J. R., Proc. Natl. Acad. Sci. U.S.A. 56:72, 1966.

    Article  PubMed  CAS  Google Scholar 

  53. Bloom, B. R., and Bennett, B., Science 153:80, 1966.

    Article  PubMed  CAS  Google Scholar 

  54. Sheagren, J. N., Simon, H. B., Tuazon, C. U., and Mehrotra, P. O., in: “Mononuclear Phagocytes” (R. van Furth, ed.), Blackwell Scientific Publications, Oxford, 1970.

    Google Scholar 

  55. Nogueira, N., Kaplan, G., and Cohn, Z. A., in: “The Mononuclear Phagocytes” (R. van Furth, ed.), pp. 1587–1606, Martinus Nijhoff Publishers, Inc., The Hague, 1980.

    Google Scholar 

  56. Fidler, I. J., J. Natl. Canc. Inst. 55:1159, 1975.

    CAS  Google Scholar 

  57. Piessens, W. F., Churchill, W. A., and David, J. R., J. Immunol. 114:293, 1975.

    PubMed  CAS  Google Scholar 

  58. Nathan, C. F., Nogueira, N., Juangbhanich, C. W., Ellis, J., and Cohn, Z. A., J. Exp. Med. 149:1056, 1979.

    Article  PubMed  CAS  Google Scholar 

  59. Murray, H. W., Juangbhanich, C. W., Nathan, C. F., and Cohn, Z. A., J. Exp. Med. 150:950, 1979.

    Article  PubMed  CAS  Google Scholar 

  60. Nathan, C. F., Silverstein, S. C., Brukner, L. H., and Cohn, Z. A., J. Exp. Med. 149:100, 1979.

    Article  PubMed  CAS  Google Scholar 

  61. Horwitz, M. A., and Silverstein, S. C., J. Clin. Invest. 66:441, 1980.

    Article  PubMed  CAS  Google Scholar 

  62. Horwitz, M. A., and Silverstein, S. C., J. Exp. Med. 153:398, 1981.

    Article  PubMed  CAS  Google Scholar 

  63. Horwitz, M. A., and Silverstein, S. C., J. Exp. Med. 154:1618, 1982.

    Article  Google Scholar 

  64. Poste, G., and Kirsch, R., Cancer Res. 39:2582, 1979.

    PubMed  CAS  Google Scholar 

  65. Metchnikoff, E., Lectures on the Comparative Pathology of Inflammation, Dover Publications, Inc., New York, 1968.

    Google Scholar 

  66. Rowbotham, T. J., J. Clin. Pathol. 33:1179, 1980.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York, 10021, USA

    Samuel C. Silverstein

Authors
  1. Samuel C. Silverstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Silverstein, S.C. (1982). Membrane Receptors and the Regulation of Mononuclear Phagocyte Effector Functions. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4396-7

  • Online ISBN: 978-1-4684-4394-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation