MG-1, Identification of an Early Differentiation Marker for Bone Marrow Cells in a Monocytic/Granulocytic Lineage

  • B. J. Mathieson
  • F.-W. Shen
  • A. Brooks
  • W. M. Leiserson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Several reagents have been developed for use in different species that reportedly detect macrophages and subsets of bone marrow cells such as monocytes and granulocytes (1–5). At least two of these reagents are known to detect both mature macrophages and a. subset of bone marrow cells or myelocytic cells of mice (2,5). One of these reagents, 2.4G2, detects Fc receptors (FcR) on several different types of cells in mice (5). The other reagent defines another specificity known as Mac-1 that is different from FcR by molecular weight and tissue distribution. With the exception of the alloantiserum to Mph-1 (1), the other reagents (monoclonal antibodies) have been produced across xenotropic barriers and do not recognize genetic strain differences (2–5).


Bone Marrow Cell Light Scatter Unit Gravity Granulocytic Cell Forward Angle Light Scatter 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • B. J. Mathieson
    • 1
  • F.-W. Shen
    • 2
  • A. Brooks
    • 3
  • W. M. Leiserson
    • 3
  1. 1.Basel Institute for ImmunologyBaselSwitzerland
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA
  3. 3.National Institute of Allergy and Infectious DiseasesBethesdaUSA

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