Monocyte Production and Kinetics in Response to Listeriosis in Resistant and Susceptible Murine Hosts
Infection of mice with the facultative, intracellular, bacterial parasite, Listeria monocytogenes, has been established as a model of an acute bacterial infection in which host resistance is brought about by a cellular form of immunity (1). From our investigations (4–6) and those of others (5,6) it is evident that host resistance to this infection is controlled genetically by a single, autosomal, dominant, non-H-2- linked gene designated Lr (for Listeria resistance) (6). Mouse strains bearing the resistant (Lrr) allele (C57BL/6 and substrains; NZB, SJL) are able to control bacterial proliferation following a challenge inoculum which is lethal to strains bearing the susceptible (Lrs) allele (A, BALB/c, DBA/2, CBA) (2,4,6). This effect is seen during the early (innate) phase of the response, before the development of acquired (T-cell mediated) immunity. The Lr gene is expressed in the response of the mononuclear phagocyte system rather than that of the T-cell (7).
KeywordsListeria Monocytogenes Blood Monocyte Mononuclear Phagocyte Mononuclear Phagocyte System Bacterial Proliferation
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