Phagocytic Enhancement of Granulocytes and Monocytes by Cationic Proteins from Human Polymorphonuclear Leukocytes
Defense against infection includes both humoral and phagocyte-mediated mechanisms. Close cooperation between these two mechanisms has been well documented. Certain substances that belong to the humoral compartment also serve as opsonins and chemotactic attractants. On the other hand, phagocytes produce and secrete several proteins which participate in bactericidal and bacteriolytic activities including complement and lysozyme. We described a few years ago another complex composed of nuclear and cytoplasmic cationic proteins which directly affects microorganisms and also enhances phagocytosis (1). In this paper we provide evidence that cationic proteins enhance phagocytosis in man.
KeywordsPhagocytic Activity Cationic Protein Neutral Protease Phagocytic Index Human Polymorphonuclear Leukocyte
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