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Phagocytic Enhancement of Granulocytes and Monocytes by Cationic Proteins from Human Polymorphonuclear Leukocytes

  • W. Pruzanski
  • N. S. Ranadive
  • S. Saito
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Defense against infection includes both humoral and phagocyte-mediated mechanisms. Close cooperation between these two mechanisms has been well documented. Certain substances that belong to the humoral compartment also serve as opsonins and chemotactic attractants. On the other hand, phagocytes produce and secrete several proteins which participate in bactericidal and bacteriolytic activities including complement and lysozyme. We described a few years ago another complex composed of nuclear and cytoplasmic cationic proteins which directly affects microorganisms and also enhances phagocytosis (1). In this paper we provide evidence that cationic proteins enhance phagocytosis in man.

Keywords

Phagocytic Activity Cationic Protein Neutral Protease Phagocytic Index Human Polymorphonuclear Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

  1. 1.
    Pruzanski, W., and Saito, S., Exper. Cell Research 177:1, 1978.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. Pruzanski
    • 1
  • N. S. Ranadive
    • 1
  • S. Saito
    • 1
  1. 1.Department of Medicine and PathologyUniversity of TorontoTorontoCanada

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