Skip to main content
SpringerLink
Log in

Effects of Leukotrienes C4 and D4, Cyclic AMP and Methylation Reactions on Arachidonic Acid Metabolism in Rat Peritoneal Macrophages

  • Chapter
Leukotrienes and Prostacyclin

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 54))

  • 59 Accesses

Abstract

Ligand-receptor interaction in a number of biological systems, often involves release of arachidonic acid from membrane phospholipids. Understanding the physiological significance of this phenomenon should take into account the wide spectrum of biological activities which were ascribed to the various arachidonate metabolites.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. E. Dahlen, P. Hedquist, S. Hammarstrom, and B. Samuelsson, Leukotrienes are potent constrictors of human bronchi, Nature, 288: 484 (1980).

    Article  PubMed  CAS  Google Scholar 

  2. P. Sirois, S. Roy, P. Borgeat, The lung parenchymal strips as a sensitive assay for leukotriene B4, Prostaglandin and Medicine, 6: 153 (1981).

    Article  CAS  Google Scholar 

  3. S. Moncada and J. R. Vane, Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2 and prostacyclin, Pharmacol. Rev., 30: 293 (1979).

    Google Scholar 

  4. P. J. Spagnuolo, J. J. Elliner, A. Hassid, and M. Dunn, Thromboxane A2 Mediates Augmented Polymorphonuclear leukocytes adhesiveness, J. Clin. Invest., 66: 406 (1980).

    Article  PubMed  CAS  Google Scholar 

  5. E. J. Goetzl, C. Derian, and F. H. Valone, The extracellular and intracellular roles of hydroxy eicosatetraenoic acids in the modulation of polymorphonuclear leukocyte and macrophage function, J. Reticulo Soc., 28: 105s (1980).

    Google Scholar 

  6. W. F. Stenson and C. W. Parker, Monohydroxyeicosatetraenoic acids (HETEs) induce degranulation of human neutrophils, J. Immunol., 124: 2100 (1980).

    PubMed  CAS  Google Scholar 

  7. R. M. Schultz, N. A. Pavlidis, J. N. Stoychkov, and M. A. Chirigos, Prevention of macrophage tumoricidal activity by agents known to increase cellular cAMP, J. Immunol., 42: 71 (1979).

    CAS  Google Scholar 

  8. R. M. Schultz, J. N. Stoychkov, N. Pavlidis, M. A. Chirigos, and Z. L. Olkowski, Role of E-type prostaglandins in the regulation of interferon-treated macrophage cytotoxic activity, J. Reticulo Soc., 26: 93 (1979).

    CAS  Google Scholar 

  9. M. A. Bray, Prostaglandins: fine tuning the immune system? Immunology Today, Sep.: 65 (1980).

    Google Scholar 

  10. R. J. Bonney, S. Burger, P. Davies, F. A. Kuehl, and J. L. Humes, Prostaglandin E2 and prostacyclin elevate cyclic AMP in elicited populations of mouse peritoneal macrophages, Adv. Prostaglandin Thromboxane Res., 8: 1691 (1980).

    CAS  Google Scholar 

  11. R. V. Panganamela, J. S. Miller, E. T. Gwebu, H. M. Sharma, and D. G. Cornwell, Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxydase, Prostaglandins, 14: 261 (1977).

    Google Scholar 

  12. M. I. Siegel, R. T. McConnell, R. W. Bonser, and P. Cuatrecasas, The production of 5-HETE and leukotriene B in rat neutrophils from carrageenan pleural exudate, Prostaglandins, 21: 123 (1981).

    PubMed  CAS  Google Scholar 

  13. P. Borgeat and B. Samuelsson, Arachidonic acid metabolism in polymorphonuclear leukocytes: Effect of ionophore A23187, Proc. Natl. Acad. Sci. USA, 76: 2148 (1979).

    Article  PubMed  CAS  Google Scholar 

  14. A. W. Ford-Hutchinson, M. A. Bray, M. V. Doig, M. E. Shipley, and M. J. H. Smith, Leukotriene B a potent chemokinetic and aggregating substance release from polymorphonuclear leukocytes, Nature, 286: 264 (1980).

    Article  PubMed  CAS  Google Scholar 

  15. P. H. Naccache, R. I. Sha’afi, P. Borgeat, and E. J. Goetzl, Mono and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils, J. Clin. Invest., 67: 1584 (1981).

    Article  PubMed  CAS  Google Scholar 

  16. F. Hirata and J. Axelrod, Phospholipid methylation and biological signal transmission, Science, 209: 1082 (1980).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University, Washington, D.C., 20007, USA

    N. Feuerstein & P. W. Ramwell

Authors
  1. N. Feuerstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. W. Ramwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti  & G. Folco  & 

  2. University of Verona, Verona, Italy

    G. P. Velo

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Feuerstein, N., Ramwell, P.W. (1983). Effects of Leukotrienes C4 and D4, Cyclic AMP and Methylation Reactions on Arachidonic Acid Metabolism in Rat Peritoneal Macrophages. In: Berti, F., Folco, G., Velo, G.P. (eds) Leukotrienes and Prostacyclin. NATO Advanced Science Institutes Series, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4391-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4391-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4393-6

  • Online ISBN: 978-1-4684-4391-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation