Skip to main content
SpringerLink
Log in

Analysis of Hydroxy Acids

  • Chapter
Leukotrienes and Prostacyclin

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 54))

  • 62 Accesses

Abstract

The variety of hydroxy acids derived from arachidonic acid and other polyunsaturated fatty acids that have been isolated from mammalian tissues is increasing rapidly. These hydroxy acids are products of metabolism initiated by several different enzymes. These include fatty acid cyclooxygenase [1–3], 5-lipoxygenase [4–24], 12lipoxygenase [25–31], 15-lipoxygenase [32–36], and thyroid iodide peroxidase [37–39]. In addition, hydroxy acids derived from arachidonic acid and other polyunsaturated fatty acids have been isolated from mammalian tissues which may be products of enzymes that have not been classified [40–45]. In some instances, hydroxy acids isolated from mammalian tissues may be nonenzymatically formed oxygenation products of arachidonic acid and other polyunsaturated fatty acids.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Hamberg and B. Samuelsson, J. Biol. Chem., 242: 5344–5354 (1967).

    PubMed  CAS  Google Scholar 

  2. M. E. Hemler, C. G. Crawford, and W. E. M. Lands, Biochemistry, 11:1772–1779 (1978).

    Article  Google Scholar 

  3. W. C. Hubbard, A. J. Hough, A. R. Brash, J. T. Watson, and J. A. Oates, Prostaglandins, 20:431–447 (1980).

    Article  PubMed  CAS  Google Scholar 

  4. P. Borgeat, M. Hamberg, and B. Samuelsson, J. Biol. Chem., 251: 7816–7820 (1976).

    PubMed  CAS  Google Scholar 

  5. P. Borgeat, M. Hamberg, and B. Samuelsson, J. Biol. Chem., 252: 8772 (1977).

    Google Scholar 

  6. P. Borgeat and B. Samuelsson, J. Biol. Chem., 254:2643–2646 (1979).

    PubMed  CAS  Google Scholar 

  7. P. Borgeat and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 76: 2148–2152 (1979).

    Article  CAS  Google Scholar 

  8. P. Borgeat and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 76: 7865–7869 (1979).

    Google Scholar 

  9. B. Samuelsson, P. Borgeat, S. Hammarstrom, and R. C. Murphy, in: “Advances in Prostaglandin and Thromboxane Research” (B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), Vol. 6, Raven Press, New York, pp. 1–18 (1980).

    Google Scholar 

  10. M. K. Bach, J. R. Brashler, S. Hammarstrom, and B. Samuelsson, Biochem. Biophys. Res. Comm., 93:1121–1126 (1980).

    CAS  Google Scholar 

  11. B. Samuelsson and S. Hammarstrom, Prostaglandins, 19:645–648 (1980).

    Article  PubMed  CAS  Google Scholar 

  12. R. C. Murphy, S. Hammarstrom, and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 76:4275–4279 (1979).

    Article  CAS  Google Scholar 

  13. S. Hammarstrom, R. C. Murphy, D. A. Clark, C. Mioskowski, and E. J. Corey, Biochem. Biophys. Res. Commun., 91:1266–1272 (1979).

    CAS  Google Scholar 

  14. O. Radmark, C. Malmsten, B. Samuelsson, D. A. Clark, G. Goto, A. Marfat, and E. J. Corey, Biochem. Biophys. Res. Commun., 92:954–961 (1980).

    CAS  Google Scholar 

  15. C. W. Parker, B. A. Jakschik, M. M. Huber, and S. F. Falkenhein, Biochem. Biophys. Res. Commun., 89:1186–1192 (1979).

    CAS  Google Scholar 

  16. C. W. Parker, M. M. Huber, and S. F. Falkenhein, Prostaglandins, 18:673–686 (1979).

    Article  PubMed  CAS  Google Scholar 

  17. H. R. Morris, G. W. Taylor, P. J. Piper, M. N. Samhoun, and J. R. Tippins, Prostaglandins, 19:185–201 (1980).

    Article  PubMed  CAS  Google Scholar 

  18. H. R. Morris, P. J. Piper, G. W. Taylor, and J. R. Tippins, Prostaglandins, 19:371–383 (1980).

    Article  PubMed  CAS  Google Scholar 

  19. R. A. Lewis, K. F. Austen, J. M. Drazen, D. A. Clark, A. Marfat, and E. J. Corey, Proc. Natl. Acad. Sci. USA, 77:3710–3714 (1980)

    Article  CAS  Google Scholar 

  20. S. Hammarstrom, B. Samuelsson, D. A. Clark, G. Goto, A. Marfat, C. Mioskowski, and E. J. Corey, Biochem. Biophys. Res. Commun., 92:946–953 (1980).

    CAS  Google Scholar 

  21. D. A. Clark, G. Goto, A. Marfat, E. J. Corey, S. Hammarstrom, and B. Samuelsson, Biochem. Biophys. Res. Commun., 94:1133–1139 (1980).

    CAS  Google Scholar 

  22. B. Samuelsson, Trends in Pharmacol. Sci., 1:227–230 (1980).

    CAS  Google Scholar 

  23. L. Orning, D. Widegran, S. Hammarstrom, and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 77:2014–2017 (1980).

    Article  CAS  Google Scholar 

  24. R. A. Lewis, J. M. Drazen, K. F. Austen, D. A. Clark, and E. J. Corey, Biochem. Biophys. Res. Commun., 96:271–277 (1980).

    CAS  Google Scholar 

  25. M. Hamberg and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 71: 3400–3417 (1974).

    Article  CAS  Google Scholar 

  26. D. H. Nugteren, Biochem. Biophys. Acta, 380:299–307 (1975).

    CAS  Google Scholar 

  27. M. Hamberg, J. Svensson, and B. Samuelsson, Proc. Natl. Acad. Sci. USA, 71:3824–3828 (1974).

    Article  CAS  Google Scholar 

  28. R. W. Bryant and J. M. Bailey, Prostaglandins, 17:9–18 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. I. C. Walker, R. L. Jones, and N. H. Wilson, Prostaglandins, 18:173–178 (1979).

    Article  PubMed  CAS  Google Scholar 

  30. R. W. Bryant and J. M. Bailey, Biochem. Biophys. Res. Commun., 92:268–275 (1980).

    CAS  Google Scholar 

  31. U. Lundberg, O. Radmark, C. Malmsten, and B. Samuelsson, FEBS Lett., 126:127–132 (1980).

    Article  Google Scholar 

  32. W. Jubiz, O. Radmark, J. A. Lindgren, C. Malmsten, and B. Samuelsson, Biochem. Biophys. Res. Commun., 99:976–986 (1981).

    CAS  Google Scholar 

  33. R. L. Maas, A. R. Brash, and J. A. Oates, in: “SRS-A and Leukotrienes” (P. J. Piper, ed.), John Wiley & Sons, Ltd., London, pp. 151–159 (1981).

    Google Scholar 

  34. R. L. Maas, A. R. Brash, and J. A. Oates, in: “Advances in Prostaglandin, Thromboxane and Leukotriene Research” (B. Samuelsson and R. Paoletti, eds.), Vol. 9, Raven Press, New York (in press).

    Google Scholar 

  35. R. L. Maas, A. R. Brash, and J. A. Oates, Proc. Natl. Acad. Sci. USA (in press).

    Google Scholar 

  36. J. M. Boeynaems and W. C. Hubbard, J. Biol. Chem., 255:90019004 (1980).

    Google Scholar 

  37. J. M. Boeynaems, D. Reagan, and W. C. Hubbard, Lipids, 16:246249 (1981).

    Google Scholar 

  38. J. M. Boeynaems, J. T. Watson, J. A. Oates, and W. C. Hubbard, Lipids, 16:323–327 (1981).

    Article  PubMed  CAS  Google Scholar 

  39. M. Hamberg, Biochem. Biophys. Acta, 431:651–654 (1976).

    CAS  Google Scholar 

  40. L. J. Roberts, R. A. Lewis, J. A. Lawson, B. J. Sweetman, K. F. Austen, and J. A. Oates, Prostaglandins, 15:717 (1978).

    Article  Google Scholar 

  41. L. J. Roberts, R. A. Lewis, J. A. Oates, and K. F. Austen, Biochem. Biophys. Acta, 575:185–192 (1979).

    CAS  Google Scholar 

  42. F. H. Valone, M. Franklin, F. F. Sun, and E. J. Goetzl, Cell. Immunol., 54:390–401 (1980).

    Article  PubMed  CAS  Google Scholar 

  43. M. Hamberg and B. Samuelsson, Biochem. Biophys. Res. Commun., 61:942–949 (1974).

    CAS  Google Scholar 

  44. A. G. Herman, M. Claeys, S. Moncada, and J. R. Vane, Prostaglandins, 18:439–452 (1979).

    Article  PubMed  CAS  Google Scholar 

  45. S. Hammarstrom and P. Falardeau, Proc. Natl. Acad. Sci. USA, 74:3691–3695 (1977).

    Article  CAS  Google Scholar 

  46. E. J. Corey, J. 0. Albright, Barton, and S. Hashimoto, J. Am. Chem. Soc., 102:1435–1436 (1980).

    Article  CAS  Google Scholar 

  47. C. P. A. Van Os, G. P. M. Rijke-Schilder, H. Van Halbeek, J Verhagen, and J. F. G. Vligenthart, Biochem. Biophys. Acta, 663:177–193 (1981)

    Google Scholar 

  48. E. J. Corey and S. Hashimoto, Tetrahedron Lett., 22:299–302 (1981).

    Article  CAS  Google Scholar 

  49. E. J. Corey, A. Marfat, J. K. Falck, and J. 0. Albright, J. Am. Chem. Soc., 102:1433–1435 (1980).

    Article  CAS  Google Scholar 

  50. E. J. Corey, A. Marfat, G. Goto, and F. Brion, J. Am. Chem. Soc., 102:7984–7985 (1980).

    Article  CAS  Google Scholar 

  51. J. M. Boeynaems, A. R. Brash, J. A. Oates, and W. C. Hubbard, Analyt. Biochem., 104:259–267 (1980).

    Article  PubMed  CAS  Google Scholar 

  52. N. Porter, R. A. Wolf, E. M. Yarbro, and H. Weenen, Biochem. Biophys. Res. Commun., 89:1058–1064 (1979).

    CAS  Google Scholar 

  53. H. W. S. Chan and G. Levett, Lipids, 12:99–104 (1977).

    Article  PubMed  CAS  Google Scholar 

  54. M. L. Ogletree, K. Schlesinger, M. Nettleman, and W. C. Hubbard, in: “Prostaglandins and Arachidonate Metabolites: Methods in Enzymology” (W. E. M. Lands and W. S. Smith, eds.), Academic Press, New York (in press).

    Google Scholar 

  55. W. C. Hubbard, unpublished observations.

    Google Scholar 

Download references

Author information

Author notes

  1. Dr. Douglass F. Taber

    Present address: Department of Chemistry, University of Delaware, Newark, Delaware, USA

Authors and Affiliations

  1. Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, 37232, USA

    Walter C. Hubbard & Dr. Douglass F. Taber

Authors
  1. Walter C. Hubbard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. Douglass F. Taber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Milan, Milan, Italy

    F. Berti  & G. Folco  & 

  2. University of Verona, Verona, Italy

    G. P. Velo

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Hubbard, W.C., Taber, D.F. (1983). Analysis of Hydroxy Acids. In: Berti, F., Folco, G., Velo, G.P. (eds) Leukotrienes and Prostacyclin. NATO Advanced Science Institutes Series, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4391-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4391-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4393-6

  • Online ISBN: 978-1-4684-4391-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation