Abstract
The method of aggregometry introduced by Born [1] in 1962 has been used extensively to study platelet aggregation and disaggregation in vitro and ex vivo. Although it is generally accepted that in vitro data does not always reflect in vivo data [2], fewer studies have been undertaken on platelets in vivo. Such, in vivo studies are limited by the cumbersome and invasive nature of existing techniques [3] which has prompted development of a simple, minimally invasive technique for the continuous monitoring of radiolabeled platelets in vivo [4].
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References
G. V. R. Born, Quantitative investigations into the aggregation of blood platelets, J. Physiol., 162: 67 (1962).
P. Didisheim and V. Fuster, Actions and clinical status of platelet suppressive agents, sem hem., 15: 55–72 (1978).
G. M. Smith, A study of intravascular platelet aggregation by continuous platelet counting, TIPS, 2: 105–107 (1981).
O. J. Davies, J. Morley, C. Page, and W. Paul, In vivo aggregation of guinea-pig platelets, J. Physiol. (1981).
W. A. Heaton, H. H. Davis, M. J. Welch, C. J. Mathias, J. H. Joist, L. A. Sherman, and B. A. Siegal, Indium-111: a new radionuclide label for studying human platelet kinetics, Brit. J. Haemat., 42: 613–622 (1978).
D. C. MacMillan, Secondary clumping effect in human citrated platelet rich plasma produced by adenosine diphosphate and adrenaline, Nature, 211: 140–144 (1966).
B. B. Vargaftig, J. Lefort, D. Joseph, and F. Fouque, Mechanisms of bronchoconstriction and thrombocytopenia induced by collagen in the guinea-pig, Eur. J. Pharmacol., 58: 273–284 (1978).
B. B. Vargaftig, J. Lefort, M. Chignard, and J. Beneveniste, Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives, Eur. J. Pharmacol., 65: 185–192 (1980).
S. Bunting, R. Gryglewski, S. Moncada, and J. R. Vane, Arterial walls generated from prostaglandin endoperoxides, a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation, Prostaglandins, 12: 897–973 (1976).
R. J. Gryglewski, R. Korbut, A. Ocetkiewicz, J. Splawinski, B. Wojtaszek, and J. Swies, Lungs as a generator of prostacylinHypothesis on physiological significance, Naunyn-Schmiedeberg’s Arch. Pharmacol., 304: 45–50 (1978).
J. Morley, C. P. Page, W. Paul, N. Monjelli, R. Cesarini, and C. Gandolfi, A comparative study of prostacyclin and two analogues (FCE 21258, FCE 21292) in various in vitro and in vivo systems, Prostaglandins and Med. (1981).
J. Morley, C. P. Page, and W. Paul, The effect of heparin on platelet aggregation in vivo, Brit. J. Pharm. (1981).
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© 1983 Plenum Press, New York
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Page, C.P., Paul, W. (1983). An in Vivo Aggregometer. In: Berti, F., Folco, G., Velo, G.P. (eds) Leukotrienes and Prostacyclin. NATO Advanced Science Institutes Series, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4391-2_14
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DOI: https://doi.org/10.1007/978-1-4684-4391-2_14
Publisher Name: Springer, Boston, MA
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