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Phospholipases: Link Between Membrane Phospholipids and Arachidonate Metabolites

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Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 54))

Abstract

This paper deals with the relationship between phospholipid arachidonate and free arachidonate which constitutes the substrate for cyclo-oxygenase and lipoxygenase. The available evidence for the role of phospholipases in the release of arachidonate will be discussed with some emphasis on the possible regulation of this phospholipase activity.

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References

  1. H. van den Bosch, Phosphoglyceride metabolism, Annu. Rev. Biochem. 43: 243 (1974).

    Article  Google Scholar 

  2. G.P.H. van Heusden and H. van den Bosch, The Influence of exogenous and membrane-bound phosphatidate concentration on the activity of CTP:phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase, Eur. J. Biochem. 84:405 (1978).

    Article  PubMed  Google Scholar 

  3. J.H.E. Moonen, P. Trienekens and H. van den Bosch, The action of purified lysophospholipases on microsomal membrane-bound lysophosphatidylcholine, Biochim. Biophys. Acta 489:423 (1977).

    CAS  Google Scholar 

  4. A.J. Marcus, H.L. Ullman and L.B. Safier, Lipid composition of subcellular particles of human blood platelets, J. Lipid Res. 10:108 (1969).

    PubMed  CAS  Google Scholar 

  5. F. Possmayer, G.L. Scherphof, T.M.A.R. Dubbelman, L.M.G. van Golde and L.L.M. van Deenen, Positional specificity of saturated fatty acids in phosphatidic acid from rat liver, Biochim. Biophys. Acta 176:95 (1969).

    CAS  Google Scholar 

  6. S. Yamashita and S. Numa, Partial Purification and properties of glycerophosphate acyltransferase from rat liver, Eur. J. Biochem. 31:565 (1972).

    Article  PubMed  CAS  Google Scholar 

  7. S. Yamashita, K. Hosaka and S. Numa, Resolution and reconstitution of the phosphatidate-synthesizing system of rat liver microsomes, Proc; Natl. Acad. Sci. USA 69:3490 (1972).

    Article  CAS  Google Scholar 

  8. S. Yamashita, N. Nakaya, Y. Míki and S. Numa, Separation of 1-acylglycerolphosphate acyltransferase and 1-acylglycerolphosphorylcholine acyltransferase of rat liver microsomes, Proc. Natl. Acad. Sci. USA 72:600 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. A. Derksen and P. Cohen, Patterns of fatty acid release from endogenous substrates by human platelets homogenates and membranes, J. Biol. Chem. 250:9342 (1975).

    PubMed  CAS  Google Scholar 

  10. D.A. van Dorp, R.K. Beerthuis, D.H. Nugteren and H. Vonkeman, The biosynthesis of prostaglandins, Biochim. Biophys. Acta 90:204 (1964).

    CAS  Google Scholar 

  11. S. Bergström, H. Danielsson and B. Samuelsson, The enzymatic formation of prostaglandin E2 from arachidonic acid, Biochim. Biophys. Acta 90:207 (1964).

    Google Scholar 

  12. W. Vogt, Role of phospholipase A2 in prostaglandin formation, in: “Advances in prostaglandin and thromboxane research”, C. Galli et al., ed., Raven Press, New York, p. 89 (1978).

    Google Scholar 

  13. W.E.M. Lands and B. Samuelsson, Phospholipid precursors of prostaglandins, Biochim. Biophys. Acta 164:426 (1968).

    CAS  Google Scholar 

  14. H. Vonkeman and D.A. van Dorp, The action of prostaglandin synthetase on 2-arachidonoyl-lecithin, Biochim. Biophys. Acta 164:430 (1968).

    CAS  Google Scholar 

  15. W. Vogt, U. Meyer, H. Kunze, E. Lufft and S. Babilli, Entstehung von SRSC in der durchstromten Meerschweichenlunge durch phospholipase A. Identifizierung mit prostaglandin, NaunynSchmiedebergs Arch. Exp. Path. Pharmak. 262:124 (1969).

    CAS  Google Scholar 

  16. J. Bartels, H. Kunze, W. Vogt and G. Willis, Prostaglandin: liberation from and formation in perfused frog intestineNaunyn-Schmiedebergs Arch. Pharmacol. 266:207 (1970).

    Google Scholar 

  17. B. Haye, S. Champion and C. Jacquemin, Control of TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid, FEBS Lett. 30: 253 (1973).

    Article  PubMed  CAS  Google Scholar 

  18. R.J. Flower and G.J. Blackwell, The importance of phospholipase A2 in prostaglandin biosynthesis, Biochem. Pharmacol. 25: 285 (1976).

    CAS  Google Scholar 

  19. P.C. Isakson, A. Raz, W. Hsueh and P. Needleman, Lipases and prostaglandin biosynthesis, in: “Advances in prostaglandin and thromboxane research”, C. Galli et al., ed., Raven Press, New York, p. 113 (1978).

    Google Scholar 

  20. T.K. Bills, J.B. Smith and N.J. Silver, Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin, J. Clin. Invest. 60:1 (1977).

    Article  PubMed  CAS  Google Scholar 

  21. G.J. Blackwell, W.G. Duncombe, R.J. Flower, M.F. Parsons and J.R. Vane, The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs, Br. J. Pharmacol. 59:353 (1977).

    PubMed  CAS  Google Scholar 

  22. E.G. Lapetina, K.A. Chandrabose and P. Cuatrecasas, Ionophore A 23187- and thrombin-induced platelet aggregation: independence from cyclo-oxygenase products, Proc. Natl. Acad. Sci. USA 75:818 (1978).

    Article  PubMed  CAS  Google Scholar 

  23. S.L. Hong and L. Levine, Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory cortico-steroids, Proc. Natl. Acad. Sci. USA 73:1730 (1976).

    Article  PubMed  CAS  Google Scholar 

  24. H. van den Bosch, Intracellular phospholipases A, Biochim. Biophys. Acta 604:191 (1980).

    Google Scholar 

  25. P. Eisbach, J. Weiss, R.C. Franson, S. Beckerdite-Quagliata, A. Schneider and L. Harris, Separation and purification of a potent bactericidal/permeability increasing protein and a closely associated phospholipase A9 from rabbit polymorphonuclear leucocytes, J. Biol. Chem. 254:11000 (1979).

    Google Scholar 

  26. R.M. Kramer, C. Wüthrich, C. Bollier, P.R. Allegrini and P. Zahler, Isolation of phospholipase A2 from sheep erythrocyte membranes in the presence of detergents, Biochim. Biophys. Acta 507:381 (1978).

    CAS  Google Scholar 

  27. R. Kannagi and K. Koizumi, Effect of different physical states of phospholipid substrates on partially purified phospholipase A2 activity, Biochim. Biophys. Acta 556:423 (1979).

    CAS  Google Scholar 

  28. R.J. Apitz-Castro, M.A. Mas, M.R. Cruz and M.K. Jain, Isolation of homogeneous phospholipase A2 from human platelets, Biochem. Biophys. Res. Commun. 91:63 (1979).

    CAS  Google Scholar 

  29. Y. Natori, M. Nishijima, S. Nojima and H. Satoh, Purification and properties of a membrane-bound phospholipase A2 from rat ascites hepatoma 108A cells, J. Biochem. 87:959 (1980).

    PubMed  CAS  Google Scholar 

  30. H. van den Bosch and A.J. Aarsman, A review on methods of phospholipase A determination, Agents and Actions 9:382 (1979).

    Article  PubMed  Google Scholar 

  31. A.J. Aarsman, L.L.M. van Deenen and H. van den Bosch, Synthesis of acylthioester analogs of lysolecithin and their use in a continuous spectrophotometric assay for lysophospholipases, a method with potential applicability to other lipolytic enzymes, Bioorganic Chemistry 5:241 (1976).

    Article  CAS  Google Scholar 

  32. C.O. Rock and F. Snyder, Rapid purification of phospholipase A2 from Crotalus adamanteus venom by affinity chromatography, J. Biol. Chem. 250:6564 (1975).

    PubMed  CAS  Google Scholar 

  33. R.E. Barden, P.L. Darke, R.A. Deems and E.A. Dennis, Interaction of phospholipase A2 from cobra venom with cibacron blue F3GA, Biochemistry 19:1621 (1980).

    Article  PubMed  CAS  Google Scholar 

  34. R.J. Flower, Phospholipases and their relevance to prostaglandin biosynthesis, in: “The prostaglandin system”, F. Berti and G.P. Velo, eds., Plenum Press, New York, p. 27 (1981).

    Google Scholar 

  35. G.H. de Haas, N.M. Postema, W. Nieuwenhuizen and L.L.M. van Deenen, Purification and properties of an anionic zymogen of phospholipase A from porcine pancreas, Biochim. Biophys. Acta 159:118 (1969).

    Google Scholar 

  36. W.C. Pickett, R.L. Jesse and P. Cohen, Trypsin-induced phospholipase activity in human platelets, Biochem. J. 160:405 (1976).

    PubMed  CAS  Google Scholar 

  37. S.L. Hong, R. Polsky-Cynkin and L. Levine, Stimulation of prostaglandin biosynthesis by vasoactive substances in methylcholanthrene-transformed mouse BALB/3T3 cells, J. Biol. Chem. 251:776 (1976).

    PubMed  CAS  Google Scholar 

  38. M.B. Feinstein, E.L. Becher and C. Fraser, Thrombin, collagen and A 23187 stimulated endogenous platelet arachidonate metabolism: differential inhibition by PGE1, local anaesthetics and a serine-protease inhibitor, Prostaglandins 14: 1075 (1977).

    PubMed  CAS  Google Scholar 

  39. R. Walenga, J.Y. Vanderhoek and M.B. Feinstein, Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositol-specific phospholipase C activity in platelets, J. Biol. Chem. 255:6024 (1980).

    PubMed  CAS  Google Scholar 

  40. R.J. Gryglewski, B. Panczenko, R. Korbut, L. Grodszinska and A. Ocetkiewicz, Cortico-steroids inhibit prostaglandin release from perfused lungs of sensitized guinea pigs, Prosta glandins 10:343 (1975).

    PubMed  CAS  Google Scholar 

  41. R.J. Flower and G.J. Blackwell, Anti-inflammatory steroids induce the biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation, Nature 278:456 (1979).

    Article  PubMed  CAS  Google Scholar 

  42. F. Hirata, E. Schiffmann, K. Venkatasubramanian, D. Salomon and J. Axelrod, A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids, Proc. Natl. Acad. Sci. USA 77:2533 (1980).

    Article  PubMed  CAS  Google Scholar 

  43. G.J. Blackwell, R. Carnuceio, M. DiRosa, R.J. Flower, L. Parente and P. Persico, Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids, Nature 287:147 (1980).

    Article  PubMed  CAS  Google Scholar 

  44. F.P. Nijkamp, R.J. Flower, S. Moncada and J.R. Vane, Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids, Nature 263:479 (1976).

    Article  PubMed  CAS  Google Scholar 

  45. F. Hirata, B.A. Corcoran, K. Venkatasubramanian, E. Schiffmann and J. Axelrod, Chemoattractants stimulate degradation of methylated phospholipids and release of arachidonic acid in rabbit leucocytes, Proc. Natl. Acad. Sci. USA 76:2640 (1979).

    Article  PubMed  CAS  Google Scholar 

  46. W.C. Pickett, R.L. Jesse and P. Cohen, Initiation of phospholipase A2 activity in human platelets by the calcium ion ionophore A 23187, Biochim. Biophys. Acta 486:209 (1977)

    CAS  Google Scholar 

  47. S. Rittenhouse-Simmons and D. Deykin, The activation by Cat+ of platelet phospholipase A2. Biochim. Biophys. Acta 543:409 (1978).

    CAS  Google Scholar 

  48. M. Minkes, N. Stanford, M.M.Y. Chi, G.J. Roth, A. Raz, P. Needleman and P.W. Majerus, Cyclic adenosine 3’,5’-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions, J. Clin. Invest. 59:449 (1977).

    Article  PubMed  CAS  Google Scholar 

  49. E.G. Lapetina, C.J. Schmitges, K. Chandrabose and P. Cuatrecasas, Cyclic adenosine 3’,5’-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets, Biochem. Biophys. Res. Commun. 76:828 (1977).

    CAS  Google Scholar 

  50. E. Frei and P. Zahler, Phospholipase A22 from sheep erythrocyte membranes. Ca2+ dependence and lozalization, Biochim. Biophys. Acta 550:450 (1979).

    CAS  Google Scholar 

  51. S. Rittenhouse-Simmons, Production of diglyceride from phosphatidylinositol in activated human platelets, J. Clin. Invest. 63:580 (1979).

    Article  PubMed  CAS  Google Scholar 

  52. R.L. Bell and P.W. Majerus, Thrombin-induced hydrolysis of phosphatidylinositol in human platelets, J. Biol. Chem. 255: 1790 (1980).

    PubMed  CAS  Google Scholar 

  53. R.L. Bell, D.A. Kennerly, N. Stanford and P.W. Majerus, Diglyceride lipase: a pathway for arachidonate release from human platelets, Proc. Natl. Acad. Sci. USA 76:3238 (1979).

    Article  PubMed  CAS  Google Scholar 

  54. M.J. Broekman, J.W. Ward and A.J. Marcus, Phospholipid metabolism in stimulated human platelets. Changes in phosphatidylinositol, phosphatidic acid and lysophospholipids, J. Clin. Invest. 66:275 (1980).

    Article  PubMed  CAS  Google Scholar 

  55. M.L. McKean, J.B. Smith and M.J. Silver, Formation of lysophosphatidylcholine by human platelets in response to thrombin, J. Biol. Chem. 256:1522 (1981).

    PubMed  CAS  Google Scholar 

  56. E.G. Lapetina, M.M. Billah and P. Cuatrecasas, The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid, J. Biol. Chem. 256:5037 (1981).

    PubMed  CAS  Google Scholar 

  57. M.M. Billah, E.G. Lapetina and P. Cuatracasas, Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets, J. Biol. Chem. 256:5399 (1981).

    PubMed  CAS  Google Scholar 

  58. S.L. Hong and D. Deykin, The activation of phosphatidylinositol-hydrolyzing phospholipase A2 during prostaglandin synthesis in transformed mouse BALB/3T3 cells, J. Biol. Chem. 256:5215 (1987).

    Google Scholar 

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© 1983 Plenum Press, New York

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van den Bosch, H. (1983). Phospholipases: Link Between Membrane Phospholipids and Arachidonate Metabolites. In: Berti, F., Folco, G., Velo, G.P. (eds) Leukotrienes and Prostacyclin. NATO Advanced Science Institutes Series, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4391-2_1

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  • DOI: https://doi.org/10.1007/978-1-4684-4391-2_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4393-6

  • Online ISBN: 978-1-4684-4391-2

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