Abstract
Considerable insight into the mechanisms of heat induced cell death in vitro has been gained during recent years (for reviews see 1–3). Besides the direct cell killing effect of heat, many microenvironmental or milieu factors seem to play an important role during heat treatment of solid tumors in vivo, such that a preferential effect of hyperthermia on tumors has been postulated for the in situ conditions. Environmental factors affecting the tumor milieu, such as tissue oxygen partial pressures, pH values, glucose (?) and lactate levels, nutrient supply and drainage of wastes, have thus become a subject of topical interest.
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© 1982 Plenum Press, New York
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Otte, J., Manz, R., Thews, G., Vaupel, P. (1982). Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors. In: Bicher, H.I., Bruley, D.F. (eds) Hyperthermia. Advances in Experimental Medicine and Biology, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4388-2_6
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DOI: https://doi.org/10.1007/978-1-4684-4388-2_6
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