Abstract
Interest in the use of heat for cancer treatment has increased markedly in recent years (1–4). Information has accumulated that such hyperthermia causes a selective and irreversible inhibition of metabolism in certain animal and human tumors correlated to cell killing (5–8). It remains uncertain, however, whether and under which conditions heat exerts a specific influence on tumor tissue since much of the information available is based on cells cultured in vitro. Nevertheless, the potential application of hyperthermia in the treatment of cancer is extremely attractive since, with the exception of systemic chemotherapy, which is a notoriously blunt weapon, regional and whole body hyperthermia are the only treatment modalities presently available which could address the major problem of human cancer: the metastatic lesion. It is not known, however, whether metastasizing tumors are more susceptible to hyperthermic treatment than non-metastasizing ones, although in vitro studies are consistent with this possibility (9). The metastatic capacities of a tumor cell are related to its surface (10, 11) and one of the major mechanisms of action of hyperthermia is thought to act via the membrane (12, 13). It, therefore, was of interest to compare the membrane properties and heat sensitivity in two closely related tumor strains of which one metastasizes whereas the other does not.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cavaliere, R., Ciocatto, E. C., Giovanella, B. C., Heidelberger, C., Johnson, R. O., Margottini, M., Mondovi, B., Moricca, G., and Rossi-fanelli, A. Selective Heat Sensitivity of Cancer Cells. Cancer 20:1351–1381, 1967.
Stehlin, J. S. Hyperthermic Profusion with Chemotherapy for Cancer of the Extremities. Surgical Gynecology Obstetrics 128:305–318, 1969.
Pettigrew, R. T., Galt, J. N., Ludgate, C. M., Smith, A. N. Clinical Affects of Whole Body Hyperthermia in Advanced Malignancy. British Journal of Medicine 4:679–682, 1974.
Streffer, C. Cancer Therapy by Hyperthermia and Radiation, Urban and Schwarzenberg, Munich, Baltimore, pgs. 3–341, 1978.
Dickson, J. A. The Effects of Hyperthermia on Animal Tumor Systems, In: Selective Heat Sensitivity of Cancer Cells, eds., Rossi-fanelli, A., Cavaliere, R., Mondovi, B., Moricca, G., Recent Results in Cancer Research 59:43–111, 1977.
Giovanella, B. C., Stehlin, J. S., Morgan, A. C. Selective Lethal Effect of Supra-normal Temperature in Human Neoplastic Cells, Cancer Research 36:3944–3950, 1976.
Overgaard, K., Overgaard, J. Investigations on a Possibility of a Thermic Tumor Therapy. I. Short-wave Treatment of a Transplanted Isologous Mouse Mammary Carcinoma, European Journal of Cancer 8:65–78, 1972.
Crile, G. The Effects of Heat and Radiation on Cancers Implanted in the Feet of Mice, Cancer Research 23:372–380, 1963.
Tomasovic, S. P., and Nicolson, G. L. Heterogeneity in Hyperthermic Killing of Mammary Tumor Cell Clones of Differing Metastatic Potential, Abs. DG-14, 29th Annual Meeting of the Radiation Research Society, June 1981.
Kim, U. Factors Influencing Metastasis of Breast Cancer, McGuire, W. L., ed., Breast Cancer, Vol. 3, Plenum Publishing Corp., 1979, pgs. 1–49.
Martines-Polomo, A. The Nature of Neoplastic Cell Membranes, Experimental and Molecular Pathology 31:219–235, 1979.
Yatvin, M. B. The Influence of Membrane Lipid Composition and Procaine on Hyperthermic Death of Cells, Int. J. of Rad. Biol. 32:513–521, 1977.
Mulcahy, R. T., Gould, M. N., Hidvegi, E. G., Elson, C. E., and Yatvin, M. B. Hyperthermia and Surface Morphology of P388 Ascites Tumor Cells: Effects of Membrane Modificaions, Int. J. of Radiat. Biol. 39:95–106, 1981.
Bligh, E. G., and Dyer, W. J. A Rapid Method of Total Lipid Extraction and Purification. Can. J. Biochem. Physiol. 37:911–917, 1959.
Sinensky, C. Homeoviscous Adaptation: A Homeostatic Process that Regulates the Viscosity of Membrane Lipids in Escherichia coli. Proc. Natl. Acad. Sci. 71:522–525, 1974.
Helmkamp, G. M. Effects of Phospholipid Fatty Acid Composition and Membrane Fluidity on the Activity of Bovine Brain Phospholipid Exchange Position. Biochemistry 19:2050–2051, 1980.
Lepock, J. R., Mossicotte-Nolan, P., Rule, G. S., and Kruuv, J. Lack of a Correlation between Hyperthermic Cell Killing, Thermotolerance, and Membrane Lipid Fluidity, Radiation Research 87:300–313, 1981.
Harms-Ringdahl, M. Effects of the Fatty Acid Composition of Membranes on Radiosensitivity and Hyperthermia in Mice and E. Ascites Cells. Abs. #24, 2nd WCCC International Workshop on Experimental Oncology, Madison, WI, May, 1981.
Hidvegi, E. G., Yatvin, M. B., Dennis, W. H., and Hidveg, Eva. Effect of Altered Membrane Lipid Composition and Procaine on Hyperthermic Killing of Ascites Tumor Cells, Oncology 37:360–363, 1980.
Jirtle, R. L. Blood Flow to Lymphatic Metastases in Conscious Rats. European J. of Cancer 17(1):53–60, 1981.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Yatvin, M.B., Vorpahl, J., Kim, U. (1982). Differential Response to Heat of Metastatic and Non-Metastatic Rat Mammary Tumors. In: Bicher, H.I., Bruley, D.F. (eds) Hyperthermia. Advances in Experimental Medicine and Biology, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4388-2_15
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4388-2_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4390-5
Online ISBN: 978-1-4684-4388-2
eBook Packages: Springer Book Archive