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Adaptability of Microbial Mutagenicity Assays to the Study of Problem of Environmental Concern

  • Chapter
Induced Mutagenesis

Part of the book series: Basic Life Sciences ((BLSC,volume 15))

Abstract

It is now well recognized that short-term microbial assays, when run under carefully controlled conditions, have predictive value for the detection of the potential cancer-causing properties of most classes of chemicals. Indeed, our Laboratory has participated both in the development and validation of such assays. However, in an eagerness to obtain reliable data relating to the potential genotoxic and/or carcinogenic potentials, too much emphasis has been placed on procedural details such that sight is lost of the fact that these assays lend themselves — when suitably modified — to the elucidation of some basic biological problems. There is an increasing number of these which can be used to illustrate this point. The present report, however, deals primarily with data obtained in our own Laboratories.

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Author information

Author notes

  1. Herbert S. Rosenkranz, Monika Anders, E. Joshua Rosenkranz & Elena C. McCoy

    Present address: Center for the Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA

Authors and Affiliations

  1. Department of Microbiology, New York Medical College, Valhalla, New York, 10595, USA

    Herbert S. Rosenkranz, George E. Karpinsky, Monika Anders, George DeMarco, E. Joshua Rosenkranz, Lynn A. Petrullo & Elena C. McCoy

  2. Joseph C. Wilson Center for Technology, Xerox Corporation, Rochester, N.Y., 14644, USA

    Robert Mermelstein

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  1. Herbert S. Rosenkranz
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Editors and Affiliations

  1. School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA

    Christopher W. Lawrence (Chairman) (Chairman)

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© 1983 Plenum Press, New York

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Rosenkranz, H.S. et al. (1983). Adaptability of Microbial Mutagenicity Assays to the Study of Problem of Environmental Concern. In: Lawrence, C.W. (eds) Induced Mutagenesis. Basic Life Sciences, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4382-0_15

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  • DOI: https://doi.org/10.1007/978-1-4684-4382-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4384-4

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