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The Induction of Resistance to Alkylation Damage in Mammalian Cells

  • Chapter
Induced Mutagenesis

Part of the book series: Basic Life Sciences ((BLSC,volume 15))

Abstract

We are continuously exposed to non-toxic levels of carcinogens both from our environment and from our diet. It would therefore seem important to determine how cells respond to this particular kind of treatment. Some years ago, an attempt to simulate this chronic environmental exposure to mutagens revealed the existence of an inducible antimutagenic DNA repair pathway in E. coli — the adaptive DNA repair pathway (1). The obvious progression from finding a new type of DNA repair in E. coli was to ask whether an equivalent pathway exists in mammalian cells, and ultimately whether it exists in human cells. We now have good biological evidence for the existence of an adaptive DNA repair pathway in cultured rodent and human cell lines (2). In order to set the scene for our recent findings in mammalian cells, we should first consider what is presently known about E. coli adaptation.

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Author information

Authors and Affiliations

  1. Biochemistry Department, University of California, Berkeley, California, USA

    Leona Samson

  2. Lab of Radiobiology, University of California, San Francisco, California, USA

    Jeffrey L. Schwartz

Authors
  1. Leona Samson
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  2. Jeffrey L. Schwartz
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Editor information

Editors and Affiliations

  1. School of Medicine and Dentistry, The University of Rochester, Rochester, New York, USA

    Christopher W. Lawrence (Chairman) (Chairman)

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© 1983 Plenum Press, New York

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Samson, L., Schwartz, J.L. (1983). The Induction of Resistance to Alkylation Damage in Mammalian Cells. In: Lawrence, C.W. (eds) Induced Mutagenesis. Basic Life Sciences, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4382-0_12

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  • DOI: https://doi.org/10.1007/978-1-4684-4382-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4384-4

  • Online ISBN: 978-1-4684-4382-0

  • eBook Packages: Springer Book Archive

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