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The Radioprotective Effect of Bacterial Endotoxin

  • Chapter
Beneficial Effects of Endotoxins

Abstract

The exposure of a mammal to a single whole-body dose of rapidly delivered ionizing radiation of approximately 100 R or more results in the development of a complex set of clinical signs and symptoms that are collectively termed the acute radiation syndrome (Cronkite, 1964; Wald et al., 1962). The time of onset, nature, and severity of this syndrome are a function of the total exposure dose, quality of radiation, and many variables related to the irradiated host. In most of the experimental work described here, X- or γ-radiation was delivered uniformly to the entire body in a single exposure lasting on the order of minutes. The dosage of radiation in these experiments fell within the range of threshold lethal, for this represents the minimum amount of radiation causing death within 30 days of exposure. Peak incidence of mortality for the midlethal dose (LD50/30) generally occurs between 10 and 14 days following irradiation. Whole-body irradiation in this dose range produces a complex series of physiological disturbances and morphological changes that are the cumulative results of radiation-induced damage or death of individual cells.

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Authors and Affiliations

  1. Oyster Creek Nuclear Cenerating Station, Forked River, New Jersey, 08731, USA

    Ulrich H. Behling

  2. School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Ulrich H. Behling

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  1. Ulrich H. Behling
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  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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Behling, U.H. (1983). The Radioprotective Effect of Bacterial Endotoxin. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_6

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