Abstract
The first systematic studies of bacterial vaccines in the treatment of human cancer were performed by W. B. Coley (1891, 1893, 1898, 1906). Additional reports of cancer treatment with such vaccines appeared although not all were of a positive nature (reviewed by Nauts et al., 1946). The use of Coley’s toxins (mixtures of Streptococcus pyogenes and Serratia marcescens) fell into disfavor because of a lack of consistency, which was due, in part, to a lack of potency and a lack of knowledge regarding dosage, site of administration, and frequency of injections. However, a case study by Nauts et al. (1953) revealed the effectiveness of Coley’s toxins when these parameters were taken into consideration. Interest in bacterial products was revived by the experiments of Shwartzman and Michailovsky (1932) and of Duran-Reynals (1935) wherein they showed that bacterial filtrates of gram-negative organisms were effective in producing hemorrhagic necrosis of murine tumors.
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References
Alexander, P., and Evans, R., 1971, Endotoxin and double stranded RNA render macrophages cytotoxic, Nature New Biol. 232:76.
Andervont, H. B., 1936, The reaction of mice and of various mouse tumors to the injection of bacterial products, Am. J. Cancer 27:77.
Berendt, M. J., and Saluk, P. H., 1976, Tumor inhibition in mice by lipopolysaccharide-induced peritoneal cells and an induced soluble factor, Inject. Immun. 14:965.
Berendt, M. J., Mezrow, G. F., and Saluk, P. H., 1978a, Requirement for a radiosensitive lymphoid cell in the generation of lipopolysaccharide-induced rejection of a murine tumor allograft, Infect. Immun. 21:1033.
Berendt, M. J., North, R. J., and Kirstein, D. P., 1978b, Ehe immunological basis of en-dotoxin-induced tumor regression: Requirement for T-cell-mediated immunity, J. Exp. Med. 148:1550.
Berendt, M. J., North, R. J., and Kirstein, D. P., 1978c, The immunological basis of en-dotoxin-induced tumor regression: Requirement for a pre-existing state of concomitant anti-tumor immunity,JExp. Med. 148:1560.
Berendt, M. J., Newborg, M. F., and North, R. J., 1980, Increased toxicity of endotoxin for tumor-bearing mice and mice responding to bacterial pathogens: Macrophage activation as a common denominator, Infect. Immun. 28:645.
Bianco, C., Griffin, E. M., and Silverstein, S. C., 1975, Studies of the macrophage complement receptor: Alteration of receptor function upon macrophage activation, J. Exp. Med. 141:1278.
Blarney, R. W., Crosby, D. L., and Baker, J. M., 1969, Reticuloendothelial activity during the growth of rat sarcomas, Cancer Res. 29:335.
Bober, E. A., Kranepool, M. J., and Hollander, V. P., 1976, Inhibitory effect of endotoxin on the growth of plasma cell tumor, Cancer Res. 36:927.
Butler, R. C., Abdclnoor, A., and Nowotny, A., 1978, Bone marrow colony-stimulating factor and tumor resistance-enhancing activity of postendotoxin mouse sera, Proc. Natl. Acad. Sci USA 75:2893.
Carswell, E. A., Old, E. J., Kassel, R. E., Green, S., Fiore, N., and Williamson, B., 1975, An endotoxin-induced serum factor that causes necrosis of tumors, Proc. Natl. Acad. Sci. USA 72:3666.
Coley, W. B., 1891, Contribution to the knowledge of sarcoma, Ann. Surg. 14:199.
Coley, W. B., 1893, Ehe treatment of malignant tumors by repeated inoculations of erysipelas, with a report of original cases, Am. J. Med. Sci. 105:487.
Coley, W. B., 1898, Ehe treatment of inoperable sarcoma with the mixed toxins of erysipelas and Bacillus prodigiosus: Immediate and final results in one hundred and forty cases,J. Am. Med. Assoc. 31:389.
Coley, W. B., 1906, Eate results of the treatment of inoperable sarcoma by the mixed toxins of erysipelas and Bacillus prodigiosus, Am. J. Med. Sci. 131:376.
Doe, W. F., and Henson, P. M., 1978, Macrophage stimulation by bacterial lipopolysac-charides. I. Cytolytic effect on tumor target cells, J. Exp. Med. 148:544.
Duran-Reynals, F., 1935, Reaction of spontaneous mouse carcinomas to blood-carried bacterial toxins, Proc. Soc. Exp. Biol. Med. 32:1517.
Fidler, I. J., Darnell, J. H., and Budman, M. B., 1976, In vitro activation of mouse macrophages by rat lymphocyte mediators,J. Immunol. 117:666.
Grant, C. K., and Alexander, P., 1974, Nonspecific cytotoxicity of spleen cells and the specific cytotoxic action of thymus-derived lymphocytes in vitro, Cell. Immunol. 14:46.
Green, S., Dobrjansky, A., Carswell, E., Kassel, R., Old, L., Fiore, N., and Schwartz, M., 1976, Partial purification of a serum factor that causes necrosis of tumors, Proc. Natl. Acad. Sci. USA 73:381.
Grohsman, J., and Nowotny, A., 1972, The immune recognition of TA3 tumors, its facilitation by endotoxin, and abrogation by ascites fluid,J. Immunol. 109:1090.
Hibbs, J. B., Jr., Taintor, R. R., Chapman, H. A., Jr., and Weinberg, J. B., 1977, Macrophage tumor killing: Influence of the local environment, Science 197:279.
Hoffman, M., Oettgen, H., Old, L., Mittler, R., and Hämmerling, U., 1978, Induction and immunological properties of tumor necrosis factor, J. Reticuloendothelial Soc. 23:307.
Ikawa, M., Koepfli, J. B., Mudd, S. G., and Niemann, C., 1952, An agent from E. coli causing hemorrhage and regression of an experimental mouse tumor. I. Isolation and properties,J. Natl. Cancer Inst. 13:157.
Kassel, R., Old, L., Carswell, E., Fiore, N., and Hardy, W., 1973, Serum-mediated leukemia cell destruction in AKR mice: Role of complement in the phenomenon, J. Exp. Med. 138:925.
Levy, G. A., and Edgington, T. S., 1980, Lymphocyte cooperation is required for amplification of macrophage procoagulant activity, J Exp. Med. 151:1232.
Männel, D. N., Rosenstreich, D. L., and Mergenhagen, S. E., 1979, Mechanism of lipo-polysaccharide-induced tumor necrosis: Requirement for lipopolysaccharide-sensitive lymphoreticular cells, Infect. Immun. 24:573.
Männel, D. N., Moore, R. N., and Mergenhagen, S. E., 1980, Macrophages as a source of tumoricidal activity (tumor necrosis factor), Infect. Immun. 30:523.
Mizuno, D., Yoshioka, O., Akamatu, M., and Kataoka, T., 1968, Antitumor effect of intracutaneous injection of bacterial lipopolysaccharide, Cancer Res. 28:1531.
Nauts, H. C., Swift, W. E., and Coley, B. L., 1946, The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M. D., reviewed in the light of modern research, Cancer Res. 6:205.
Nauts, H. C., Fowler, G. A., and Bogatko, F. H., 1953, A review of the influence of bacterial infection and of bacterial products (Coley’s toxins) on malignant tumors in man, Acta Med. Scand. 145(Suppl. 276): 103.
Nelson, D. S., and Kearney, R., 1976, Macrophages and lymphoid tissues in mice with concomitant tumour immunity, Br. J. Cancer 34:221.
North, R. J., and Kirstein, D. P., 1977, T-Cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites, J Exp. Med. 145:275.
Nowakowski, M., Edelson, P. J., and Bianco, C., 1980, Activation of C3H JHeJ macrophages by endotoxin,J. Immunol. 125:2189.
Nowotny, A., Golub, S., and Key, B., 1971, Fate and effect of endotoxin derivatives in tumor-bearing mice, Proc. Soc. Exp. Biol. Med. 136:66.
Parr, I., Wheeler, E., and Alexander, P., 1973, Similarities of the anti-tumour actions of endotoxin, lipid A and double-stranded RNA, Br. J. Cancer 27:370.
Roubin, R., Kennard, J., Foley, D., and Zola-Pazner, S., 1981, Markers of macrophage heterogeneity: Altered frequency of macrophage subpopulations after various pathologic stimuli,J. Reticuloendothelial Soc. 29:423.
Ruco, L. P., and Meltzer, M. S., 1978, Macrophage activation for tumor cytotoxicity: Development of macrophage cytotoxic activity requires completion of a sequence of short-lived intermediary reactions,J. Immunol. 121:2035.
Russell, S. W., Doe, W. F., and Mcintosh, A. T., 1977, Functional characterization of a stable, noncytolytic stage of macrophage activation in tumors,JExp. Med. 146:1511.
Ryan, J. L., Glode, L. M., and Rosenstreich, D. L., 1979, Lack of responsiveness of C3H JHeJ macrophages to lipopolysaccharide: The cellular basis of LPS-stimulated metabolism,J. Immunol. 122:932.
Saluk, P. H., Edmundowicz, S., Wrigley, D. M., and Tabor, D. R., 1981, Co-expression of enhanced spreading, ingestion, and inhibition of tumor cell proliferation by macrophages from lipopolysaccharide-injected mice, Cancer Immunol. Immunother. 11:159.
Shear, M. J., 1941, Effects of a concentrate from B. prodigiosus filtrate on subcutaneous primary induced mouse tumors, Cancer Res. 1:731.
Shear, M. J., 1943, Chemical treatment of tumors. IX. Reactions of mice with primary subcutaneous tumors to injection of a hemorrhagic-producing bacterial polysaccharide, J. Natl. Cancer Inst. 4:461.
Shear, M. J., and Turner, F. C., 1943, Chemical treatment of tumors. V. Isolation of the hemorrhage-producing fraction from Serratia marcescens Bacillus prodigiosus) culture filtrate, J. Natl. Cancer Inst. 4:81.
Shear, M. J., Perrault, A., and Adams, J. R., 1943, Chemical treatment of tumors. VI. Method employed in determining the potency of hemorrhage-producing bacterial preparations,J. Natl. Cancer Inst. 4:105.
Shwartzman, C., and Michailovsky, N., 1932, Phenomenon of local skin reactivity to bacterial filtrates in the treatment of mouse sarcoma 180, Proc. Soc. Exp. Biol. Med. 29: 737.
Tabor, D. R., and Saluk, P. H., 1981, The functional heterogeneity of murine resident macrophages to a chemotactic stimulus and induction of C3b-receptor-mediated ingestion, Immunol. Lett. 3:371.
Tripodi, D., Hollenbeck, L., and Pollack, W., 1970, The effect of endotoxin on the implantation of a mouse sarcoma, Int. Arch. Allergy Appl. Immunol. 37:575.
Weinberg, J. B., Chapman, H. A., Jr., and Hibbs, J. B., Jr., 1978, Characterization of the effects of endotoxin on macrophage tumor cell killing,J. Immunol. 121:72.
Wilton, J. M., Rosenstreich, D. L., and Oppenheim, J. J., 1975, Activation of guinea pig macrophages by bacterial lipopolysaccharide requires bone-marrow-derived lymphocytes,J. Immunol. 114:388.
Wrigley, D. M., and Saluk, P. H., 1981, Induction of C3b-mediated phagocytosis in macrophages by distinct populations of lipopolysaccharide-stimulated lymphocytes, Infect. Immun. 34:780.
Yang, C., and Nowotny, A., 1974, Effect of endotoxin on tumor resistance in mice, Infect, Immun. 9:95.
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© 1983 Plenum Press, New York
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Saluk, P.H. (1983). Induced Enhanced Resistance to Transplantable Tumors in Mice. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_26
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DOI: https://doi.org/10.1007/978-1-4684-4364-6_26
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