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Induction of Interferon by Endotoxin

  • Chapter
Beneficial Effects of Endotoxins

Abstract

The ability of bacterial endotoxin to modify virus infections was well documented before it was found it could induce interferon. Endotoxin decreased both the toxicity and the replication of some viruses. Hook and Wagner (1959) found that as little as 0.008 μg of purified E. coli lipopolysaccharide (LPS) inoculated intracerebrally in mice 75 min to 31/2 hr before an intracerebral challenge of 3–8 LD50 of WS influenza virus decreased the direct neurotoxic effects of this virus. Typhoid vaccine was similarly effective. This protective effect lasted for about 7 days. No effect on viral multiplication in the brain was found.

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Authors and Affiliations

  1. Department of Microbiology, Graduate School of Public Health, Pittsburgh, Pennsylvania, 15261, USA

    Monto Ho

  2. Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261, USA

    Monto Ho

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  1. Monto Ho
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Editors and Affiliations

  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1983 Plenum Press, New York

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Ho, M. (1983). Induction of Interferon by Endotoxin. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_19

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  • DOI: https://doi.org/10.1007/978-1-4684-4364-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4366-0

  • Online ISBN: 978-1-4684-4364-6

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