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In Search of the Active Sites in Endotoxins

  • Chapter
Beneficial Effects of Endotoxins

Abstract

The history of fever, studies of its effects and search for its origin, go back as far as the history of medicine. The beneficial effects of fever were praised by famous healers in Egypt, Greece, and in the Roman and Persian empires several millenia ago. This appreciation continued through the Middle Ages into our modern times, when “fever therapy” was applied to diseases as diverse as rheumatoid arthritis (Barsi, 1947), manic depression (Terry, 1939), headaches (Sutherland and Wolf, 1940), neurosyphilis (Favorite and Morgan, 1946), herpes zoster (Bernstein and Klotz, 1947), various eye and skin diseases (Tucker, 1946), and many others.

The most acute, strongest, most dangerous, and fatal diseases, occur in the continual fever. The least dangerous of all, and the mildest and most protracted is the quartan, for it is not only such from itself, but it also carries off other great diseases.

— Hippocrates, Of the Epidemics

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  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    A. Nowotny

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  1. Center for Oral Health Research, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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Nowotny, A. (1983). In Search of the Active Sites in Endotoxins. In: Nowotny, A. (eds) Beneficial Effects of Endotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4364-6_1

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