Skip to main content
SpringerLink
Log in

Mutagens in Cooked Food

  • Chapter
Genetic Toxicology

Part of the book series: Basic Life Sciences ((BLSC,volume 6))

Abstract

The incidences of cancers in various organs of the body differ in different countries (14,100). For instance, in Japan stomach cancer is the predominant cancer of the digestive tract, but in most Western countries intestinal cancer is predominant. Japanese immigrants to the United States show a decrease in the incidence of stomach cancer with an increase in that of intestinal cancer, presumably because of change in their life style (34).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H.U. Aeschbacher, C. Chappuis, and H.P. Würzner, Mutagenicity testing of coffee: A study of problems encountered with the Ames Salmonella test system, Fd. Cosmet. Toxicol. 18: 605 (1980).

    Article  CAS  Google Scholar 

  2. D.E. Amacher, S.C. Paillet, G.N. Turner, V.A. Ray, and D.S. Salsburg, Point mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells, Mutation Res. 72: 447 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. B.N. Ames, J. McCann, and E. Yamasaki, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test, Mutation Res. 31: 347 (1975).

    PubMed  CAS  Google Scholar 

  4. B. Armstrong and R. Doll, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices,Int. J. Cancer15: 617 (1975).

    Article  PubMed  CAS  Google Scholar 

  5. I. Berenblum, The mechanism of cocarcinogenesis: A study of the significance of cocarclnogenlc action and related phenomena, Cancer Res. 1: 807 (1941).

    CAS  Google Scholar 

  6. L.F. Bjeldanes and H. Chew, Mutagenicity of 1, 2-dicarbonyl compounds: Maltol, kojic acid, diacetyl and related substances, Mutation Res. 67: 367 (1979).

    Article  PubMed  CAS  Google Scholar 

  7. W. Bollag, Therapy of chemically Induced skin tumors of mice with vitamin A palmltate and vitamin A acid, Experientia 27: 90 (1971).

    Article  PubMed  CAS  Google Scholar 

  8. J.P. Brown, P.S. Dietrich, and R.T. Brown, Frameshlft mutagenicity of certain naturally occurring phenolic compounds In the “Salmonella/mlcrosome” test: Activation of anthraqulnone and flavonol glycosides by gut bacterial enzymes, Biochem. Soc. Trans. 5: 1489 (1977).

    PubMed  CAS  Google Scholar 

  9. M.K. Buenlng, R.L. Chang, M.T. Huang, J.6. Fortner, A.W. Wood, and A.H. Conney, Activation and Inhibition of benzo(a)pyrene and aflatoxln B, metabolism In human liver microsomes by naturally occurring flavonolds, Cancer Res. 41: 67 (1981).

    Google Scholar 

  10. K.K. Carrol, Experimental evidence of dietary factors and hormone-dependent cancers, Cancer Res. 35: 3374 (1975).

    Google Scholar 

  11. S.M. Cohen, M. Aral, J.B. Jacobs, and 6.H. Frledell, Promotion effect of saccharin and DL-tryptophan In urinary bladder carcinogenesis, Cancer Res. 39: 1207 (1979).

    PubMed  CAS  Google Scholar 

  12. R.J. Collier, Diphtheria toxin: Mode of action and structure, Bacteriol. Rev. 39: 54 (1975).

    PubMed  CAS  Google Scholar 

  13. C.C.J. Culvenor, J.A. Edgar, L.W. Smith, and I. Hirono, The occurrence of senkirkine in Tussilago farfara, Aust. J. Chem. 29: 229 (1976).

    Article  CAS  Google Scholar 

  14. R. Doll, Strategy for detection of cancer hazards to man, Nature 265: 589 (1977).

    Article  PubMed  CAS  Google Scholar 

  15. H. Esumi, M. Okui, S. Sato, T. Sugimura, and S. Nagase, Absence of albumin mRNA in the liver of analbuminemic rats, Proc. Natl. Acad. Sci. USA 77: 3215 (1980).

    Article  PubMed  CAS  Google Scholar 

  16. H. Esumi, S. Sato, M. Okui, T. Sugimura, and S. Nagase, Turnover of serum proteins in rats with analbuminemia, Biochem. Biophys. Res. Commun. 87: 1191 (1979).

    Article  PubMed  CAS  Google Scholar 

  17. H. Esumi, S. Sato, Y. Takahashi, S. Nagase, and T. Sugimura, A seven base pair deletion in an intron blocks albumin mRNA processing, in: “Primary and Tertiary Structure of Nucleic Acids and Cancer Research”, H. Miwa, S. Nishimura, A. Rich, D. Söll, and T. Sugimura, Japan Sel. Soc. Press, Tokyo, In press.

    Google Scholar 

  18. H. Esumi, Y. Takahashi, T. Sekiya, S. Sato, S. Nagase, and T. Sugimura, Presence of nuclear albumin mRNA precursors In analbuminemic rat liver lacking cytoplasmic albumin mRNA, Proc. Natl. Acad. Sci. USA, 79: 734 (1982).

    Article  PubMed  CAS  Google Scholar 

  19. I.A. Evans and J. Mason, Carcinogenic activity of bracken, Nature(London) 208: 913 (1965).

    Article  CAS  Google Scholar 

  20. H. Fujikl, M. Mori, M. Nakayasu, M. Terada, T. Sugimura, and R.E. Moore, Indole alkaloids: Dihydroteleocidin B, teleocldin, and lygnbyatoxln A as, members of a new class of tumor promoters, Proc. Natl. Acad. Sci. USA 78: 3872 (1981).

    Article  Google Scholar 

  21. H. Fujiki, T. Sugimura, and R.E. Moore, New classes of environmental tumor promoters: Indole alkaloids and polyacetate, in: “Abstract of International Symposium on Health Effects of Tumor Promotion” (1981) p. 14.

    Google Scholar 

  22. M. Fukuoka, M. Ruroyanagi, K. Yoshihira, S. Natori, M. Nagao, Y. Takahashi, and T. Sugimura, Chemical and toxlcologlcal studies on bracken fern, Pterldium aqulllnum var. Latiusculum. IV, Surveys on bracken constituents by mutagenicity test, J. Pharm. Dyn. 1: 324 (1978).

    Article  CAS  Google Scholar 

  23. M. Fukuoka, K. Yoshihira, S. Natori, K. Sakamoto, S. Iwahara, S. Hosaka, and I. Hlrono, Characterization of mutagenic principles and carcinogenicity of dill weed and seeds, J. Pharm. Dyn. 3: 236 (1980).

    Article  CAS  Google Scholar 

  24. M.A. Glanturco, A.S. Glammarlno, and P. Frledel, Volatile constituents of coffee-V, Nature 210: 1358 (1966).

    Article  Google Scholar 

  25. T.W. Glover, C.-C. Chang, J.E. Trosko, and S.S.-L. Li, Ultraviolet light induction of diphtheria toxin-resistant mutants in normal and xeroderma pigmentosum human fibroblasts, Proc. Natl. Acad. Scl. USA 76: 3982 (1979).

    Article  CAS  Google Scholar 

  26. R.S. Gupta and S. Goldstein, Diphtheria toxin resistance in human fibroblast cell strains from normal and cancer-prone individuals, Mutation Res. 73: 331 (1980).

    Article  PubMed  CAS  Google Scholar 

  27. R.S. Gupta and L. Siminovitch, Genetic markers for quantitative mutagenesis studies in Chinese hamster ovary cells, Mutation Res. 69: 113 (1980).

    Article  PubMed  CAS  Google Scholar 

  28. Y. Hashimoto, K. Shudo, and T. Okamoto, Structural identification of a modified base in DNA covalently bound with mutagenic 3-amino-l-methyl-5Bh-pyrido[4,3-b] indole. Chem. Pharm. Bull. 27: 1058 (1979).

    Article  PubMed  CAS  Google Scholar 

  29. Y. Hashimoto, K. Shudo, and T. Okamoto, Metabolic activation of a mutagen, 2-amino-6-methyldipyrido[1,2-a:3;,2;-d]- imidazole and its reaction with DNA, Biochem. Biophys. Res. Commun. 92: 971 (1980).

    Article  PubMed  CAS  Google Scholar 

  30. Y. Haslmoto, К. Shudo, and T. Okamoto, Activation of a mutagen, 3-amino-l-methyl-5H-pyrido[4,3-b] indole. Identification of 3-hydroxyamino-l-methyl-5H-pyrido[4,3-b]indole and its reaction with DNA, Biochem. Biophys. Res. Commun. 96: 355 (1980).

    Article  Google Scholar 

  31. E. Heeker, Phorbol esters from croton oil, chemical nature and biological activities, Naturwissenschaften 54: 282 (1967).

    Article  Google Scholar 

  32. E. Heeker, Cocarcinogenesis and tumor promoters of the diterpene ester type as possible carcinogenic risk factors, J. Cancer Res. Clin. Oncol. 99: 103 (1981).

    Article  Google Scholar 

  33. R.M. Hicks, J. St. J. Wakefield, and J. Chowaniec, Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide, Chem.-biol. Interact. 11: 225 (1975).

    Article  PubMed  CAS  Google Scholar 

  34. T. Hlrohata, Shift in cancer mortality from 1920 to 1970 among various ethnic groups in Hawaii, in: “Genetic and Environmental Factors in Experimental and Human Cancer”, H.V. Gelboln, B. MacMahon, T. Matsushima, T. Sugimura, S. Takayama, and H. Takebe, eds. Japan Scl. Soc. Press, Tokyo (1979) pp. 341–350.

    Google Scholar 

  35. I. Hlrono, H. Mori, M. Haga, M. Fujii, K. Yamada, Y. Hirata, H. Takanashi, E. Uchida, S. Hosaka, I. Ueno, T. Matsushima, K. Umezawa, and A. Shirai, Edible plants containing carcinogenic pyrrolizidine alkaloids in Japan, in; “Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogenesis”, E.C. Miller, J.A. Miller, T. Hirono, T. Sugimura, and S. Takayama, eds., Japan Sci. Soc. Press, Tokyo (1979) pp. 79–87.

    Google Scholar 

  36. I. Hirono, I. Sasaoka, C. Shibuya, M. Shimizu, K. Fushimi, H. Mori, K. Kato, and M. Haga, Natural carcinogenic products of plant origin, Gann Mbnogr. Cancer Res. 17: 205 (1975).

    CAS  Google Scholar 

  37. I. Hirono, I. Ueno, S. Hosaka, H. Takanashi, T. Matsushima, T. Sugimura, and S. Natori, Carcinogenicity examination of quercetin and rutin in ACI rats, Cancer Lett. 13: 15 (1981).

    Article  PubMed  CAS  Google Scholar 

  38. D.P. Hsieh, Z.A. Wong, J.J. Wong, C. Michans, and B.H. Ruebner, Comparative metabolism of aflatoxin, in: Mycotoxins in Human and Animal Health, J.V. Rodricks, C.W. Hesseltlne, and M.A. Mehlman, eds., Pathodox, Park Forest South (1977) pp. 37–50.

    Google Scholar 

  39. K. Ishii, Y. Yamazoe, T. Kamataki, and R. Kato, Metabolic activation of glutamic acid pyrolysie products, 2-amino-6- methyldipyrido[1,2-a:3′,2′-d] imidazole and 2-aminodipyrido- [1,2-2′-jd] imidazole, by purified cytochrome P-450, Chem.-biol. Interact. 38: 1 (1981).

    Article  PubMed  CAS  Google Scholar 

  40. H. Kasai, Z. Yamaizumi, S. Nishimura, K. Wakabayashi, M. Nagao, T. Sugimura, N.E. Splngarn, J.H. Weisburger, S. Yokoyama, and T. Mlyazawa, A potent mutagen in broiled fish. Part 1. 2-Amino-3-methyl-3H-imidazo [4,5-f] quinoline, J. Chem. Soc. Perkin 1: 2290 (1981).

    Article  Google Scholar 

  41. H. Kasai, Z. Yamaizumi, T. Shiomi, S. Yokoyama, T. Mlyazawa, K. Wakabayashi, M. Nagao, T. Sugimura, and S. Nishimura, Structure of a potent mutagen isolated from fried beef, Chem. Lett. 485 (1981).

    Google Scholar 

  42. H. Kasai, Z. Yamaizumi, K. Wakabayashi, M. Nagao, T. Sugimura, S. Yokoyama, T. Mlyazawa, and S. Nishimura, Structure and chemical synthesis of Me-IQ, a potent mutagen Isolated from broiled fish. Chem. Lett. 1391 (1980).

    Google Scholar 

  43. T. Kawachi, M. Nagao, T. Yahagi, Y. Takahashi, T. Sugimura, T. Matsushima, T. Kawakami, and M. Ishidate, Our view on the relation between mutagens and carcinogens in: “Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogenesis”, E.C. Miller, J.A. Miller, I. Hirono, T. Sugimura, and S. Takayama, eds., Japan Sci. Soc. Press, Tokyo (1979) pp. 337–344.

    Google Scholar 

  44. W. Lijinsky and P. Shubik, Benzo[a] pyrene and other polynuclear hydrocarbons in charcoal-broiled meat, Science 145: 53 (1964).

    Article  PubMed  CAS  Google Scholar 

  45. B. MacMahon, S. Yen, D. Trichopoulos, K. Warren, and G. Nardi, Coffee and cancer of the pancreas, N. Engl. J. Med. 304: 630 (1981).

    Article  PubMed  CAS  Google Scholar 

  46. N. Matsukura, T. Kawachi, K. Morino, H. Ohgaki, T. Sugimura, and S. Takayama, Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate, Science 213: 346

    Google Scholar 

  47. T. Matsumoto, D. Yoshida, and H. Tomlta, Determination of mutagens, amino-a-carbolines in grilled foods and cigarette smoke condensate, Cancer Lett. 12: 105 (1981).

    Article  PubMed  CAS  Google Scholar 

  48. M. Mazaki, T. Ishii, and M. Uyeta, Mutagenicity of hydrolysates of citrus fruit juices, Mutation Res., in press.

    Google Scholar 

  49. J. McCann and B.N. Ames, Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals: Discussion, Proc. Natl. Acad. Sci. USA 73: 950 (1976).

    Article  PubMed  CAS  Google Scholar 

  50. J. McCann, N.E. Spingarn, J. Kobori, and B.N. Ames, Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids, Proc. Natl. Acad. Sci. USA 72: 979 (1975).

    Article  PubMed  CAS  Google Scholar 

  51. M.L. Meltz and J.T. MacGregor, Activity of the plant flavanol quercetin in the mouse lymphoma 15178Y TK+/- mutation, DNA single-strand break, and Balb/c 3T3 chemical transformation assays. Mutation Res. 88: 317 (1981).

    Article  PubMed  CAS  Google Scholar 

  52. R.W. Miller, Epidemiology, in: “Cancer in China, Section 3, Etiology”, H.S. Kaplan and P.J. Tsuchitani, eds., Liss, New York (1978) pp. 39–57.

    Google Scholar 

  53. S.S. Mirvish, L. Wallcave, M. Eagan, and P. Shubik, Ascorbate nitrite reaction: Possible means of blocking the formation of carcinogenic N-nitroso compounds, Science 177: 65 (1972).

    Article  PubMed  CAS  Google Scholar 

  54. J.A. Moehring, T.J. Moehring, and D.E. Danley, Postradiational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-Kl cells, Proc. Natl. Acad. Sci. USA 77: 1010 (1980).

    Article  PubMed  CAS  Google Scholar 

  55. K. Morlno, N. Matsukura, H. Ohgaki, T. Kawachi, T. Sugimura, and I. Hirono, Carcinogenicity test of quercetin and rutin in golden hamsters by oral administration, Carcinogenesis, 3: 93

    Google Scholar 

  56. M. Nagao, M. Honda, Y. Seino, T. Yahagi, T. Kawachi, and T. Sugimura, Mutagenicities of protein pyrolysates, Cancer Lett. 2: 335 (1977).

    Article  PubMed  CAS  Google Scholar 

  57. M. Nagao, M. Honda, Y. Seino, T. Yahagi, and T. Sugimura, Mutagenicities of smoke condensates and the charred surface of fish and meat, Cancer Lett. 2: 221 (1977).

    Article  PubMed  CAS  Google Scholar 

  58. M. Nagao, N. Morita, T. Yahagi, M. Shlmizu, M. Kuroyanagi, M. Fukuoka, K. Yoshihlra, S. Natori, T. Fujino, and T. Sugimura, Mutagenicities of 61 flavonolds and 11 related compounds, Env. Mutagen 3: 401 (1981).

    Article  CAS  Google Scholar 

  59. M. Nagao, Y. Takahashl, K. Wakabayashi, and T. Sugimura, Mutagenicity of alcoholic beverages, Mutation Res. 88: 147 (1981).

    Article  PubMed  CAS  Google Scholar 

  60. M. Nagao, Y. Takahashl, H. Yamanaka, and T. Sugimura, Mutagens in coffee and tea, Mutation Res. 68: 101 (1979).

    Article  PubMed  CAS  Google Scholar 

  61. S. Nagase, C. Fujimakl, and H. Isaka, Effect of administration of quercetin on the production of experimental liver cancers in rats fed p-dimethylaminoazobenzene, Proc. Japan Cancer Assoc. 23rd Meeting (1964) pp. 26–27.

    Google Scholar 

  62. S. Nagase, K. Shimamune, and S. Shumlya, Albumin-deficient rat mutant, Science 205; 590 (1979).

    Article  PubMed  CAS  Google Scholar 

  63. P.M. Newberne and M. Connor, Effects of sequential exposure to aflatoxin B1 and dlethylnitrosamine on vascular and stomach tissue and additional target organs in rats, Cancer Res. 40: 4037 (1980).

    PubMed  CAS  Google Scholar 

  64. A. Nomura, G.N. Stemmermann and L.K. Heilbrum, Coffee and pancreatic cancer, Lancet 474 (1981).

    Google Scholar 

  65. A.M. Pamukcu, S. Yalciner, J.F. Hatcher, and G.T. Bryan, Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum), Cancer Res. 40: 3468 (1980).

    PubMed  CAS  Google Scholar 

  66. B.G. Piacek-Llanes, D.E.G. Shuker, and S.R. Tannenbaum, N-Nitrosamides of natural origin, in: “Proceeding of 7th International Meeting on Analysis and Formation of N-Nitroeo Compounds”, Int. Agency Res. Cancer, Lyon, in press.

    Google Scholar 

  67. L.F.H. Purchase, E. Longstaff, J. Ashby, J.A. Styles, D. Anderson, P.A. Lefevre, and F.R. Westwood, Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use, Nature 264: 624 (1976).

    Article  PubMed  CAS  Google Scholar 

  68. R.K. Sahu, R. Basu, and A. Sharma, Genetic toxlcological testing of some plant flavonoids by the mlcronuleus test, Mutation Res. 89: 69 (1981).

    Article  PubMed  CAS  Google Scholar 

  69. D. Sait о, A. Shirai, T. Matsushlma, T. Sugimura, and I. Hirono, Test of carcinogenicity of quercetin, a widely distributed mutagen in food, Teratogen. Carcinogen. Mutagen. 1: 213 (1980).

    Article  Google Scholar 

  70. Y. Seino, M. Nagao, T. Yahagi, T. Sugimura, T. Yashuda, and S. Nishimura, Identification of a mutagenic substance in a spice, sumac, as quercetin, Mutation Res. 58: 225 (1978).

    Article  PubMed  CAS  Google Scholar 

  71. J.K. Sims and R.D.Z. Van Rilland, Escharotic stomatitis caused by the “Stinging seaweed” Microсоlens lyngbyaceus (formerly Lyngbya majuscule), Hawaii Med. J. 40: 243 (1981).

    PubMed  CAS  Google Scholar 

  72. M.B. Sporn, N.M. Dunlop, D.L. Newton, and J.M. Smith, Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids), Fed. Proc. 35: 1332 (1976).

    PubMed  CAS  Google Scholar 

  73. H.F. Stich, W. Stich, and M.P. Rosin, and W.D. Powrie, Clastogenic activity of caramel and caramelized sugars, Mutation Res. 91: 129 (1981).

    Article  PubMed  CAS  Google Scholar 

  74. T. Sugimura, Let’s be scientific about the problem of mutagens in cooked food, Mutation Res. 55: 149 (1978).

    PubMed  CAS  Google Scholar 

  75. T. Sugimura, The Ernst W. Bertner Memorial Award Lecture: Tumor initiators and promoters associated with ordinary foods, in: “Molecular Interrelations of Nutrition and Cancer”, M.S. Arnott, J. van Eys, and Y.-M. Wang eds., Raven Press, New York, (1982) pp. 3–24.

    Google Scholar 

  76. T. Sugimura, H. Fujlki, M. Mori, M. Nakayasu, M. Terada, R. Umezawa, and R.E. Moore, Teleocldin: New naturally occurring tumor promoter, In; “Carcinogenesis, vol. 7”, E. Becker, N. Fuselng, F. Marks, and W. Kunz, eds., Raven Press, New York (1982) pp. 69–73.

    Google Scholar 

  77. T. Sugimura, T. Kawachi, M. Nagao, T. Yahagi, Y. Seino, T. Okamoto, K. Shudo, T. Kosuge, K. Tsuji, K. Wakabayashi, T. lltaka, and A. Itai, Mutagenic principle(s) in tryptophan and phenylalanine pyrolysis products, Proc. Jpn Acad. 53: 58 (1977).

    Article  CAS  Google Scholar 

  78. T. Sugimura and M. Nagao, Mutagenic factors in cooked foods, CRC Critical Rev. Toxicol. 6: 189 (1979).

    Article  CAS  Google Scholar 

  79. T. Sugimura, M. Nagao, T. Kawachi, M. Honda, T. Yahagi, Y. Seino, S. Sato, N. Matsukura, T. Matsushima, A. Shirai, M. Sawamura, and H. Matsumoto, Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled food, in: “Origins of Human Cancer, Book С”, H.H. Hiatt, J.D. Watson, and J.A. Winsten, eds., Cold Spring Harbor Laboratory, New York (1977) pp. 1561–1576.

    Google Scholar 

  80. T. Sugimura, M. Nagao, and R. Wakabayashi, Mutagenic heterocyclic amines in cooked foods, in: “Environmental Carcinogens-Selected Methods of Analysis, vol. 4. Some Aromatic Amines and Azo Dyes in the General and Industrial Environment,” IARC Scientific Publications No. 40, H. Egan, L. Fishbein, M. Castegnaro, I.K. O’Neill, H. Bartsch, and W. Davie, eds., International Agency for Research on Cancer, Lyon (1981) pp. 251–267.

    Google Scholar 

  81. T. Sugimura, S. Sato, M. Nagao, T. Yahagi, T. Matsushima, Y. Seino, M. Takeuchi, and T. Kawachi, Overlapping of carcinogens and mutagens, in: “Fundamentals in Cancer Prevention”, P.N. Magee, S. Takayama, T. Sugimura, and T. Matsushima, eds., Japan Scientific Societies Press, Tokyo/University Park Press, Baltimore (1976) pp. 191–215.

    Google Scholar 

  82. Y. Suwa, M. Nagao, K. Wakabayshi, A. Kosugi, and T. Sugimura, Inactivatlon of mutagens in coffee by sulfite, in: “Abstacts of Third International Conference on Environmental Mutagens (Tokyo)” (1981) p. 83.

    Google Scholar 

  83. M. Tada, Metabolism fo 4-nitroqulnollne 1-oxide and related compounds, in: “Carcinogenesis, vol. 6”, T. Sugimura, ed., Raven Press, Nèw York (1981) pp. 25–45.

    Google Scholar 

  84. Y. Takahashi, M. Nagao, T. Fujino, Z. Yamaizumi, and T. Sugimura, Mutagens in Japanese pickle identified as flavonolds, Mutation Res. 68: 117 (1979).

    Article  PubMed  CAS  Google Scholar 

  85. G. Tamura, C. Cold, A. Ferro-Luzzi, and B.N. Ames, Fecalase: A model for activation of dietary glycosides to mutagens by intestinal flora, Proc. Natl. Acad. Sci. USA 77: 4961 (1980).

    Article  PubMed  CAS  Google Scholar 

  86. A. Tannenbaum and H. Silverstone, Nutrition in relation to cancer, Advances in Cancer Res. 1: 451 (1953).

    Article  CAS  Google Scholar 

  87. M. Terada, M. Nakayasu, H. Sakamoto, K. Wakabayashi, M. Nagao, H.S. Rosenkranz, and T. Sugimura, Mutagenic activity of nitropyrenes and heterocyclic amines on Chinese hamster cells with diphtheria toxin resistance as a marker. In: “Abstracts of Third International Conference on Environmental Mutagens (Tokyo)” (1981) p. 128.

    Google Scholar 

  88. M. Tsuda, M. Nagao, T. Hirayama, and T. Sugimura, Nitrite converts 2-amino-a-carboline, an Indirect mutagen, into 2- hydroxy-a-carboline, a non-mutagen and 2-hydroxy-3-nitroso-a- carbollne, a direct mutagen, Mutation Res. 83:61 (1981),

    Google Scholar 

  89. M. Tsuda, Y. Takahashl, M. Nagao, T. Hirayama, and T. Sugimura, Inactivatlon of mutagens from pyrolysates of tryptophan and glutamic acid by nitrite In acidic solution, Mutation Res. 78: 331 (1980).

    Article  PubMed  CAS  Google Scholar 

  90. M. Tsuda, K. Wakabayashi, T. Hirayama, T. Kawachi, and T. Sugimura, Inactlvatlon of the pyrolysate mutagens Trp-P-2, Glu-P-1 and IQ by treatment with chlorinated tap water, in: “Abstract of Third International Conference on Environmental Mutagens (Tokyo)” (1981) p. 121.

    Google Scholar 

  91. R.R. Upadhyay, S. Islampanah, and A. Davoodi, Presence of a tumor-promoting factor in honey, Gann 71: 557 (1980).

    PubMed  CAS  Google Scholar 

  92. M. Uyeta, S. Taue, and M. Mazaki, Mutagenicity of hydrolysates of tea infusions, Mutation Res. 88: 233 (1981).

    Article  PubMed  CAS  Google Scholar 

  93. B.L. Van Duuren, Tumor-promoting agents in two-stage carcinogenesis, Prog. Exp. Tumor Res. 11: 31 (1969).

    PubMed  Google Scholar 

  94. B.G. Van Ness, J.B. Howard, and J.W. Bodley, ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products, J. Biol. Chem. 255: 10710 (1980).

    PubMed  Google Scholar 

  95. K. Wakabayashi, K. Tsuji, T. Kosuge, K. Takeda, K. Yamaguchi, K. Shudo, T. Iitaka, T. Okamoto, T. Yahagi, M. Nagao, and T. Sugimura, Isolation and structure determination of a mutagenic substance in L-lysine pyrolysate, Proc. Jpn Acad. 54B: 569 (1978).

    Article  CAS  Google Scholar 

  96. E.A. Walker, L. Grlciute, M. Castegnaro, M. Börzsönyi, and W. Davis, , “N-Nitroso Compounds: Analysis, Formation and Occurrence”, IARC Scientific Publications No. 31, International Agency for Research on Cancer, Lyon (1980).

    Google Scholar 

  97. J. Weber and E. Heeker, Cocarclnogens of the diterpene ester type from Croton flavens L. and esophageal cancer in Curacao, Experientia 34: 679 (1978).

    Article  PubMed  CAS  Google Scholar 

  98. F.J. Wiebel, H.V. Gelboin, N.P. Buu-Hoi, M.G. Stout, and W.S. Burnham, Flavones and polycyclic hydrocarbons as modulators of aryl hydrocarbon [benzo(a)pyrene] hydrolase, in: “The Biochemistry of Disease, vol. 4, Chemical Carcinogenesis, Part A”, P.O.P. Ts’o and J.A. DiPaolo, eds., Marcel Dekker, Inc., New York (1974) pp. 249–270.

    Google Scholar 

  99. H.P. Würzmer, E. Lindström, and L. Vuataz, A 2-year feeding of instant coffees in rats. II. Incidence and types of neoplasms, Fd Cosmet. Toxicol. 15: 289 (1977).

    Article  Google Scholar 

  100. E.L. Wynder and G.B. Gori, The contribution of the environment to cancer incidence: An epidemiologic exercise, J. Natl. Cancer Inst. 58: 825 (1977).

    PubMed  CAS  Google Scholar 

  101. K. Yamaguchi, K. Shudo, T. Okamoto, T. Sugimura, and T. Kosuge, Presence of 2-amiodipyrido[1,2-a:3′,2′-d]imidazole in broiled cuttlefish, Gann 71: 743 (1980).

    PubMed  CAS  Google Scholar 

  102. K. Yamaguchi, K. Shudo, T. Okamoto, T. Sugimura, and T. Rosuge, Presence of 3-amino-l,4-dimethyl-5H-pyrido[4,3-b]indole in broiled beef, Gann 71: 745 (1980).

    PubMed  CAS  Google Scholar 

  103. Z. Yamaizumi, T. Shiomi, H. Kasai, S. Nishimura, Y. Takahashi, M. Nagao, and T. Sugimura, Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish, Cancer Lett. 9: 75 (1980).

    Article  PubMed  CAS  Google Scholar 

  104. T. Yamamoto, K. Tsuji, T. Kosuge, T. Okamoto, K. Shudo, K. Takeda, Y. Iitaka, K. Yamaguchi, Y. Seino, T. Yahagi, M. Nagao, and T. Sugimura, Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate, Proc. Jpn Acad. 54B: 248 (1978).

    Article  CAS  Google Scholar 

  105. H. Yamanaka, M. Nagao, T. Sugimura, T. Furuya, A. Shirai, and T. Matsushima, Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test, Mutation Res. 68: 211 (1979).

    Article  PubMed  CAS  Google Scholar 

  106. Y. Yamazoe, K. Ishii, T. Kamataki, R. Kato, and T. Sugimura, Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, Trp-P-2, formed by rat liver microsomes, Chem.-biol. Interact. 30: 125 (1980).

    Article  PubMed  CAS  Google Scholar 

  107. Y. Yamazoe, M. Tada, T. Kamataki, and R. Kato, Enhancement of binding of Nrbydroxy-Trp-P-2 to DNA by seryl-tRNA synthetase, Biochem. Biophys. Res. Commun. 102: 432 (1981).

    Article  PubMed  CAS  Google Scholar 

  108. M. Yokota, K. Narita, T. Kosuge, K. Wakabayashi, M. Nagao, T. Sugimura, K. Yamaguchi, K. Shudo, Y. Iitaka, and T. Okamoto, A potent mutagen isolated from a pyrolysate of L-ornithine, Chem. Pharm. Bull. 29: 1473 (1981).

    Article  PubMed  CAS  Google Scholar 

  109. D. Yoehida, T. Matsumoto, R. Yoshimura, and T. Matsuzaki, Mutagenicity of amino-a-carbolines in pyrolysis products of soybean globulin, Biochem. Biophys. Res. Commun. 83: 915 (1978).

    Article  Google Scholar 

  110. M. Yoshlda, M. Sasaki, K. Sugimura, and T. Kawachi, Cytogenetic effects of quercetln on cultured mammalian cells, Proc. Jpn Acad. 56: 443 (1980).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Cancer Center Research Institute, Tokyo, Japan

    Takashi Sugimura

Authors
  1. Takashi Sugimura
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of California, Davis, Davis, California, USA

    Raymond A. Fleck

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Sugimura, T. (1982). Mutagens in Cooked Food. In: Fleck, R.A., Hollaender, A. (eds) Genetic Toxicology. Basic Life Sciences, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4352-3_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4352-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4354-7

  • Online ISBN: 978-1-4684-4352-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation