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Viruses as Environmental Carcinogens: An Agricultural Perspective

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Genetic Toxicology

Part of the book series: Basic Life Sciences ((BLSC,volume 6))

Abstract

Under natural circumstances tumor viruses can be considered as risk factors which in themselves are neither necessary nor sufficient to produce cancer; they may do so, however, if provided with suitable genetic and environmental conditions. It follows that a reduction in amount of virus or other environmental cofactors may prevent the associated tumors. In this paper we will consider four major families of viruses associated with cancer in animals and man, and will highlight the exogenous cofactors and related preventive measures. We will mention those agricultural practices that have resulted in significant economic loss from virus Induced cancer in farm and domestic animals and will summarize some of the occupational hazards from environmental agents other than tumor viruses.

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References

  1. Alexander, J., G. Macrab, R. Saunders. Studies on In Vitro Production of Hepatitis B Surface Antigen by a Human Cell Line. Perspect. Virol. 10: 103, 1978.

    Google Scholar 

  2. Barbacid, M., D. Bolognesi, S. A. Aaronson. Humans Have Antibodies Capable of Recognizing Oncoviral Glycoproteins: Demonstration That These Antibodies are Found in Response to Cellular Demonstration of Glycoproteins Rather than as Consequences of Exposure to Virus. PNAS 77: 1617, 1980.

    Article  PubMed  CAS  Google Scholar 

  3. Bishop, J. M. The Molecular Biology of RNA Tumor Viruses: A Physician’s Guide. NEJM 303: 675, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Blumberg, B. S., B. Larouze, W. T. London, B. Werner, J. E. Hesser, I. Millman, G. Saimot, M. Paget. The Relation of Infection with the Hepatitis B Agent to Primary Hepatic Carcinoma. Am. J. Path. 81: 669, 1975.

    PubMed  CAS  Google Scholar 

  5. Brechot, C., M. Hadchonel, J. Scotto, F. Degos, P. Charnoy, C. Trepo, P. Tilollos, Detection of Hepatitis B Virus DNA in Liver and Serum: A Direct Appraisal of the Chronic Carrier State. The Lancet II, 765, 1981.

    Google Scholar 

  6. Campo, M. S., M. W. Moar, W. F. H. Jarrett, H. M. Laird. A New Papillomavirus Associated with Alimentary Cancer in Cattle. Nature 286: 180, 1980.

    Article  CAS  Google Scholar 

  7. Coffin, J. M., H. E. Varmus, J. M. Bishop, et al. A Proposal for Naming Host Cell-Derived Inserts in Retrovirus Genomes. J. Virol. 40: 953, 1981

    PubMed  CAS  Google Scholar 

  8. Essex, J., A. Sllski, S. M. Cotter, R. M. Jakowskl, W. D. Hardy. Immunosurveillance of Naturally-Occurring Feline Leukemia. Science 190: 790, 1975.

    Article  PubMed  CAS  Google Scholar 

  9. Ferrer, J. F., S. F. Kenyon, P. Gupta. Milk of Dairy Cows Frequently Contains a Leukemogenie Virus. Science 213: 1014, 1981.

    Article  PubMed  CAS  Google Scholar 

  10. Gardner, M. B. Current Information on Feline and Canine Cancers and Relationship or Lack of Relationship to Human Cancer. JNCI 46: 281, 1971.

    PubMed  CAS  Google Scholar 

  11. Gardner, M. B. Feline Oncogenic Viruses: A Brief Overview. Mod. Vet. Prac. Feb. 1980, 127.

    Google Scholar 

  12. Gardner, M. B. Historical Background (Chapter 1) In: Molecular Biology of RNA Tumor Viruses J. R. Stephenson (ed). Acad. Press, N.T., P. 1, 1980.

    Google Scholar 

  13. Gardner, M. B. Avian and Murine RNA Tumor Viruses: Modes of Transmission. In: Biohazards in Biological Research Eds. A. Hellman, M. N. Oxman, R. Pollack. Cold Spring Harbor Laboratory, p. 143, 1973.

    Google Scholar 

  14. Gardner, M. B., J. C. Brown, H. P. Charman, et al. FeLV Epidemiology in Los Angeles Cats: Appraisal of Detection Methods. Int. J. Cancer 19: 581, 1977.

    Article  PubMed  CAS  Google Scholar 

  15. Gardner, M. B., A. Chiri, M. F. Dougherty, J. Casagrande, J. D. Estes. Congenital Transmission of Murine Leukemia Virus from Wild Mice Prone to Development of Lymphoma and Paralysis. JNCI 62: 63, 1979.

    PubMed  CAS  Google Scholar 

  16. Gardner, M. B., J. D. Estes, J. Casagrande, S. Rasheed. Prevention of Paralysis and Supresslon of Lymphoma in Wild Mice by Passive Immunization to Congenltally Transmitted Murine Leukemia Virus. JNCI 64: 359, 1980.

    PubMed  CAS  Google Scholar 

  17. Gardner, M. B., B. E Henderson, H. Menck, J. Parker, J. D. Estes, R. J. Huebner. Spontaneous Tumor Occurrence and C-Type Virus Expression in Polyoma Infected Aging Wild Mice. JNCI 52: 979, 1974.

    PubMed  CAS  Google Scholar 

  18. Gardner, M. B., V. Klement, B. E. Henderson, H. Meier, J D. Estes, R. J. Huebner Genetic Control of Type C Virus of Wild Mice. Nature 259: 143, 1976.

    Article  PubMed  CAS  Google Scholar 

  19. Gardner, M. B., S. Rasheed. Retroviruses in Feral Mice. Inter. Rev. Exp. Pathol., 23: 209–267, 1982.

    CAS  Google Scholar 

  20. Gardner, M. B., S. Rasheed, B. A. Pal, J. D. Estes, S. T. O’Brien, Alvr-1, A Dominant Murine Leukemia Virus Restriction Gene, is Polymorphic in Leukemia-Prone Wild Mice. PNAS 77: 531, 1980.

    Article  PubMed  CAS  Google Scholar 

  21. Gardner, M. B., S. Rasheed, S. Shimizu, R. W. Rongey, B. E. Henderson, R. M. McAllister, V. Klement, H. P. Charman, R. V. Gilden, R. L. Heberling, R. J. Huebner. Search for RNA Tumor Virus in Humans. In: Origins of Human Cancer. Eds. H. H. Hiatt, J. D. Watson, J. A. Winster. Gold Spring Harbor Laboratory p. 1235, 1977.

    Google Scholar 

  22. Gardner, M. B., R. W. Rongey, P. Sarma, P. Arnstein. Electron Microscopic Search for Retrovirus Particles in Spontaneous Tumors of the Parakeet. Vet. Pathol. 18: 700, 1981.

    PubMed  CAS  Google Scholar 

  23. Gavora, J. S., J. L. Spencer. Marek’s Disease in Chickens: Genetic Resistance to a Viral Neoplastic Disease. A Review. In: Genetic Control of Natural Resistance to Infection and Malignancy Eds: E. Skamene, P. A. L. Kongshavn, M. Landy. Acad. Press, p. 361, 1980.

    Google Scholar 

  24. Grant, C. V., G. deNoronha, E. Tusch, M. T. Michalek, M. F. McLane. Protection of Cats Against Progressive Fibrosarcomas and Persistent Leukemia Virus Infection by Vaccination with Feline Leukemia Virus. JNCI 65: 1285, 1980.

    PubMed  CAS  Google Scholar 

  25. Green, M., W. S. M. Wold, J. K. Mackey, P. Rigden. Analysis of Human Tonsil and Cancer DNAs and RNAs for DNA Sequence of Group C (Serotypes 1.2.5.6.) Human Adenoviruses. PNAS 76: 6606, 1979.

    Article  PubMed  CAS  Google Scholar 

  26. Gribble, D. H., C. C. Haden, L. W. Schwartz, R. V. Henrickson. Spontaneous Progressive Multifocal Leukoen-cephalopathy (PML) in Macaques. Nature 254: 602, 1975.

    Article  PubMed  CAS  Google Scholar 

  27. Henderson, B. E., M. B. Gardner, H. P. Charman, E. Y. Johnson, T. Rucio, P. Sarma, B. Alena, R. J. Huebner. Investigation of an Increase of Solid Tumors in Chickens Vaccinated Against Marek’s Disease. Avian Diseases 18: 58, 1974.

    Article  PubMed  CAS  Google Scholar 

  28. Henderson, B. E, E. Louie, J. Jing, P. Buell, M. B. Gardner. Risk Factors Associated with Nasopharyngeal Carcinoma. NEJM 295: 1101, 1976.

    Article  PubMed  CAS  Google Scholar 

  29. Hinuma, Y., K. Nagata, M. Hanoka, M. Nakai, T. Matsumoto, K. Kinoshita, S. Shirakawa, I. Miyoshi. Antigen in an Adult T-Cell Leukemia Cell Line and Detection of Antibodies to the Antigen in Human Sera. PNAS 78: 6476, 1981.

    Article  PubMed  CAS  Google Scholar 

  30. Howley, P. M., M. F. Low, C. Hellman, L. Engel, M. C. Alonso, M. A. Israel, D. R. Lowy. Molecular Characterization of Papilloma Virus Genomes. In: Viruses in Naturally-Occurring Cancer. Eds: M. Essex, G. J. Todaro, H. Zur Hausen. Cold Spring Harbor Laboratory, p. 233, 1980.

    Google Scholar 

  31. Huebner, R. J., R. V. Gilden, R. Toni, R. W. Hill, R. W. Trimmer, D. C. Fish, B. Sass. Prevention of Spontaneous Leukemia in AKR Mice by Type-Specific Immunosuppression of Endogenous Ecotropic Virogenes. PNAS 73: 4633, 1976.

    Article  PubMed  CAS  Google Scholar 

  32. Huebner, R. J., G. J. Todaro. Oncogenes of RNA Tumor Viruses as Determinants of Cancer. PNAS 64: 1087, 1969.

    Article  PubMed  CAS  Google Scholar 

  33. Hymes, H. B., J. B. Greene, A. Marcus, D. C. William, T. Cheung, N. S. Prose, H. Ballard, L. F. Laubenstein. Kaposi’s Sarcoma in Homosexual Men — A Report of Eight Cases. Lancet II 598, 1981.

    Google Scholar 

  34. Jarrett, W. F. H., P. E. McNeil, W. T. R. Grimshaw, I. E. Selman, W. I. M. Mclntyre. High Incidence Area of Cattle Cancer with a Possible Interaction Between an Environmental Carcinogen and a Papilloma Virus. Nature 274: 215, 1978.

    Article  PubMed  CAS  Google Scholar 

  35. Jarrett, W. O., J. Jarrett, H. Mackey, H. Laird, C. Hood, D. Hay. Vaccination Against Feline Leukemia Virus Using a Cell Membrane Antigen System. Int. J, Cancer 16: 134, 1975.

    Article  CAS  Google Scholar 

  36. Kelloff, G. J., R. L. Peters, R. M. Donahoe, I. Ghazzouli, B. Sass, R. M. Nims, R. J. Huebner. An Approach to C-Type Virus Immunoprevention of Spontaneously Occurring Tumors in Laboratory Mice. Cancer Res. 36: 622, 1976.

    PubMed  CAS  Google Scholar 

  37. Kleckner, N. Translocatable Elements in Procaryotes. Cell 11: 11, 1977.

    Article  PubMed  CAS  Google Scholar 

  38. Lancaster, W. D., G. H. Theilen, C. Olson. Hybridization of Bovine Papilloma Virus Type 1 and Type 2 DNA to DNA from Virus-Induced Hamster Tumors and Naturally-Occurring Equine Tumors. Intervirology 11: 227, 1979.

    Article  PubMed  CAS  Google Scholar 

  39. Lane, M. A., A. Sainten, G. M. Cooper. Activation of Related Transforming Genes in Mouse and Human Mammary Carcinomas. PNAS 78: 5185, 1981.

    Article  PubMed  CAS  Google Scholar 

  40. Lapin, B. A., V. A. Agrba, A. F. Voevodin, A. G. Dyachenko, L. A. Yakovleva, L. V. Kokosha, G. N. Chuvirov, H. Rabin, F. Deinhardt, L. Folk. Characterization of the Baboon Herpesvirus (HVP) Associated with Malignant Lymphoma in the Sukhumi Hamadryas Baboon Colony. Adv. in Comparative Cancer Research, Eds: D. S. Yohn, B. A. Lapin, J. R. Blakeslee. Elsevier/North-Holland 1979, pg 413.

    Google Scholar 

  41. Laufs, R., H. Steinke. Vaccination of Non-Human Primates Against Malignant Lymphoma. Nature 253: 71, 1975.

    Article  PubMed  CAS  Google Scholar 

  42. Lewis, M. G., L. E. Mathes, R. G. Olsen. Protection Against Feline Leukemia by Vaccination with a Subunit Vaccine. In Press.

    Google Scholar 

  43. Lilly, F., T. Pincus. Genetic Control of Viral Leukemogenesis. Adv. Cancer Res. 17: 231, 1973.

    Article  Google Scholar 

  44. Marlon, P. L., W. S. Robinson. Hepatitis B Virus and Hepatocellular Carcinoma. In: Viruses in Naturally-Occurring Cancers Eds: M. Essex, G. J. Todara, H. Zur Hausen. Cold Spring Harbor Laboratory p. 423, 1980.

    Google Scholar 

  45. Maupas, P. A. Goudeau, P. Coursaget, J. Drucker, P. Bagros. Hepatitis B Vaccine: Efficacy in High Risk Settings, A Two-Year Study. Intervirology 10: 196, 1978.

    Article  PubMed  CAS  Google Scholar 

  46. Murray, M. J., B-Z Shilo, C. Shlh, D. Cowing, H. W. Hsu, R. A. Weinberg. Three Different Human Tumor Cell Lines Contain Different Oncogenes. Cell 25: 355, 1981.

    Article  PubMed  CAS  Google Scholar 

  47. Olson, C., D. E. Gordon, M. G. Robl, K. P. Lee. Oncogenicity of Bovine Papilloma Virus. Arch. Environ. Health 19: 827, 1969.

    PubMed  CAS  Google Scholar 

  48. Orth, G. S., S. Jablonska, F. Breltburd, M. Favre, O. Croissant. The Human Papillomaviruses. Bull. Cancer 65: 151, 1978.

    PubMed  CAS  Google Scholar 

  49. Palmer, S. R. A Common-Source Outbreak of Ornithosis in Veterinary Surgeons. The Lancet II p. 798, 1981.

    Google Scholar 

  50. Pedersen, N. C., G. H. Thellen, L. L. Warner. Safety and Efficacy Studies of Live and Killed Feline Leukemia Virus Vaccines. Amer. J. Vet. Res. 40: 1120, 1978.

    Google Scholar 

  51. Poisez, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, R. C. Gallo. Detection and Isolation of Type C Retro-virus Particles from Fresh and Cultured Lymphocytes of a Patient with Cutaneous T-Cell Lymphoma. PNAS 77: 7415, 1980.

    Article  Google Scholar 

  52. Prineas, J. W., R. G. Wright. The Fine Structure of Peripheral Nerve Lesions in a Virus-Induced Demyellnation Disease in Fowl (Marek’s Disease). Lab. Invest. 26: 548, 1972.

    PubMed  CAS  Google Scholar 

  53. Purchase, H. G., Prevention of Marekfs Disease: A Review. Cancer Research 36: 396, 1976.

    Google Scholar 

  54. Purtilo, D. T., L. Paguin, T. Gindhart. Genetics of Neoplasia — Impact of Ecogenetics on Oncogenesis. Amer. J. Path. 91: 609, 1978.

    PubMed  CAS  Google Scholar 

  55. Rasheed, S., M. B. Gardner. Growth Properties and Susceptibility to Viral Transformation of Skin Fibroblasts from Individuals at High Genetic Risk to Colorectal Cancer. JNCI 66: 43, 1981.

    PubMed  CAS  Google Scholar 

  56. Rasheed, S., M. B. Gardner. Isolation of Feline Leukemia Virus from a Leopard Cat. Cell Line and Search for Retrovirus in Wild Felidae. JNCI 67: 929, 1981.

    PubMed  CAS  Google Scholar 

  57. Rasheed, S., M. B. Gardner. In Vitro Isolation of Stable Rat Sarcoma Viruses PNAS 75: 2972, 1978.

    CAS  Google Scholar 

  58. Rolzman, B., N. Frenkel, E. D. Kieff, P. G. Spear. The Structure and Expression of Human Herpesvirus DNA in Productive Infection and in Transformed Cells. In: Origins of Human Cancer Cold Spring Harbor Laboratory p. 1069, 1977.

    Google Scholar 

  59. Skafritz, D. A., D. Skouval, H. J. Sherman, S. J. Hadziyarmis, M. C. Kew. Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma. NEJM 305: 1067, 1981.

    Article  Google Scholar 

  60. Stowell, R. E., E. K. Smith, C. Espana, V. G. Nelson. Outbreak of Malignant Lymphoma In Rhesus Monkeys. Lab. Invest 25: 476, 1971.

    PubMed  CAS  Google Scholar 

  61. Summers, J., J. M. Smolec, R. L. Synder. A Virus Similar to Human Hepatitis B Virus Associated with Hepatitis and Hepatoma in Woodchucks. PNAS 75: 4533, 1978.

    Article  PubMed  CAS  Google Scholar 

  62. K. K. Takemoto. Human Polyoma Viruses: Evaluation of Their Possible Involvement in Human Cancer. In: Viruses in Naturally-Occurring Cancers. Eds: M. Essex, G. J. Todaro, H. Hausen. Cold Spring Laboratory p. 311, 1980.

    Google Scholar 

  63. Todaro, G. T. Evolution and Modes of Transmission of RNA Tumor Viruses. Park-Davis Award Lecture. Am. J. Pathol. 81: 590: 1975.

    CAS  Google Scholar 

  64. Veterinary Cancer Medicine. Eds: G. H. Theilen, B. R. Madewell. Lea & Fieberger, p. 204, 1979.

    Google Scholar 

  65. Welsh, R. M., F. C. Jensen, N. R. Cooper, M. B. A. Oldstone. Inactivatlon and Lysis of Oncornaviruses by Human Serum. Virology 74: 432, 1976.

    Article  PubMed  Google Scholar 

  66. Wong-Staal, F., R. Dalla-Favera, G. Franchini, E. P. Gelman, R. C. Gallo. Three Distinct Genes in Human DNA Related to the Transforming Genes of Mammalian Sarcoma Retroviruses. Science 213: 226, 1981.

    Article  PubMed  CAS  Google Scholar 

  67. Zur Hausen, H., W. Scheiber, G. W. Bornkama. Attempts to Detect Virus Specific DNA in Human Tumors: I: Nucleic Acid Hybridization with Complimentary RNA of Human Wart Virus. Int. J. Cancer 13: 650, 1974.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology School of Medicine, University of California, Davis, California, 95616, USA

    Murray B. Gardner

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Editors and Affiliations

  1. University of California, Davis, Davis, California, USA

    Raymond A. Fleck

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

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© 1982 Plenum Press, New York

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Gardner, M.B. (1982). Viruses as Environmental Carcinogens: An Agricultural Perspective. In: Fleck, R.A., Hollaender, A. (eds) Genetic Toxicology. Basic Life Sciences, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4352-3_16

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  • DOI: https://doi.org/10.1007/978-1-4684-4352-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4354-7

  • Online ISBN: 978-1-4684-4352-3

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