Skip to main content
SpringerLink
Log in

Progestins in Prostatic Cancer

  • Chapter
Cancer of the Prostate and Kidney

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 53))

Abstract

Progestins are synthetic compounds with progestational activity. One group of these compounds related to 17-alpha-hydroxyprogesterone has mainly progestational effects while another group exerts more anti-androgenic activity. This paper reviews the effect of treatment of the first group of compounds in patients with advanced prostatic cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R. Gutierrez, New horizons in surgical management of carcinoma of the prostate gland, Amer. J. Surg. 78: 147 (1949).

    Article  PubMed  CAS  Google Scholar 

  2. J. Trunnel and B. Dubby, Influence of certain steroids on behaviour of human prostatic cancer, Trans. N.Y. Acad. Sci. 12: 238 (1950).

    Article  Google Scholar 

  3. J. Geller, B. Fruchtman, H. Newman, J. Roberts, and R. Silva, Effect of progestational agents on carcinoma of the prostate, Cancer Chemother. Rep. 51: 41 (1967).

    PubMed  CAS  Google Scholar 

  4. G. Popelier, Behandlung des Prostatakarcinoms mit Gestagenen, Urologe A 12: 134 (1973).

    PubMed  CAS  Google Scholar 

  5. D. Johnson, K. Keasler, and A. Ayala, Megestrol acetate for treatment of advanced carcinoma of the prostate, J. Surg. Oncol. 7: 9 (1975).

    Article  PubMed  CAS  Google Scholar 

  6. G. Sala, B. Camerino, and C. Cavallero, Progestational activity of 6 alpha-methyl-17-alpha-hydroxyprogesterone acetate, Acta Endocrinol. 29: 508 (1958).

    PubMed  CAS  Google Scholar 

  7. Y.C. Babcock, E.S. Gutsell, N.H. Heve, Y.A. Hogg, Y.C. Stucky, W.E. Barnes, and W.E. Dublin, 6 alpha-methyl-17 alpha-hydroxy-progesterone-17-acylates: A new class of potent progestins, J. Am. Chem. Soc. 80: 2904 (1958).

    Article  CAS  Google Scholar 

  8. S. Iacobelli and A.D. Marco, “Role of Medroxyprogesterone in Endocrine Related Tumors,” Raven Press, New York (1980), p.29.

    Google Scholar 

  9. O. Ferulano, F. Petrarola, and A. Castaldo, Trattamento del cancro della prostata con il controllo dell’arco dienfalo-ipofisario, Minerva Urologica 24: 274 (1972).

    PubMed  CAS  Google Scholar 

  10. A. Kondo and Y. Saito, Gestagen Therapy of Benign Prostatic Hyperplasia and Prostatic Carcinoma, Jap. J. Urol. 36: 730 (1974).

    Google Scholar 

  11. D.P. Byar, VACURG Studies on Prostatic Cancer and its Treatment, in: “Urologic Pathology: The Prostate,” M. Tannenbaum, ed., Lea & Febiger, Philadelphia (1977), p. 241.

    Google Scholar 

  12. S. Rafla and R. Johnson, The treatment of advanced prostatic carcinoma with medroxyprogesterone, Current Therapy Research, 16: 261 (1974).

    CAS  Google Scholar 

  13. C. Bouffioux, Le Cancer de la Prostate, Acta Urol. Belg, 47: 189 (1979).

    PubMed  CAS  Google Scholar 

  14. G. Prout Jr. and L. Denis, Unpublished Data on Pilot Trial, Prostate StudyGroup, 1962 Grant GYP 5631.

    Google Scholar 

  15. L. Denis and G. Declercq, Progestagens in Prostatic Cancer, Eur. Urol. 4: 162 (1978).

    PubMed  CAS  Google Scholar 

  16. C. Bouffioux, Treatment of Prostatic Cancer with Medroxyprogesterone Acetate (MAP), in: “Bladder Tumors and Other Topics in Urological Oncology,” M. Pavone-Macaluso, P.H. Smith, and F. Edsmyr, eds., Plenum Press, London and New York (1980), p.463.

    Chapter  Google Scholar 

  17. A. Rifkind, H. Kulin, C. Cargille, P. Rayford, and G. Ross, Suppression of urinary excretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH) by medroxyprogesterone acetate, J. Clin. Endocr. 29: 506 (1969).

    Article  PubMed  CAS  Google Scholar 

  18. C.W. Bardin and J.F. Catterall, Testosterone: A Major Determinant of extragenital Sexual Dimorphism, Science 211: 1285 (1981).

    Article  PubMed  CAS  Google Scholar 

  19. W.W. Scott, Rationale and results of primary endocrine therapy in patients with prostatic cancer, Cancer, 32: 1119 (1973).

    Article  PubMed  CAS  Google Scholar 

  20. D.S. Coffey and J.T. Isaacs, Prostate Tumor Biology and Cell Kinetics Theory, Urology Suppl. 17: 40 (1981).

    CAS  Google Scholar 

  21. J.F. Altwein and G.H. Jacobi, Hormontherapie des Prostatakarzinoms, Der Urologe A: 19: 350 (1980).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. A.Z. Middelheim, Antwerp, Belgium

    L. Denis

  2. Hôpital de Bavière, University of Liège, Belgium

    C. Bouffioux

Authors
  1. L. Denis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Bouffioux
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Palermo, Palermo, Italy

    M. Pavone-Macaluso

  2. St. James’s University Hospital, Leeds, England

    P. H. Smith

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer Science+Business Media New York

About this chapter

Cite this chapter

Denis, L., Bouffioux, C. (1983). Progestins in Prostatic Cancer. In: Pavone-Macaluso, M., Smith, P.H. (eds) Cancer of the Prostate and Kidney. NATO Advanced Science Institutes Series, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4349-3_41

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4349-3_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4351-6

  • Online ISBN: 978-1-4684-4349-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation