Skip to main content
SpringerLink
Log in
Book cover

Cancer of the Prostate and Kidney pp 167–177Cite as

The Clinical Value of the Serum Acid Phosphatase in Carcinoma of the Prostate

  • Chapter

Part of the book series: NATO Advanced Science Institutes Series ((NSSA,volume 53))

Abstract

A phosphatase which was particularly active at an acid pH was shown to be present in red blood cells in 1924 (1). Acid phosphatases are also present in leucocytes, platelets, osteoclasts, reticuloendothelial cells, and in liver, kidney, spleen and other organs. Their clinical importance derives from the fact that the concentration of the enzyme is far greater in the prostate than in any other human tissue (2).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Martland, F.S. Hansman and R. Robison, The phosphoric esterase of blood, Biochem. J. 18:115 (1924).

    Google Scholar 

  2. L.T. Yam, Clinical significance of the human acid phosphatase: a review, Am. J. Med. 56:604 (1974).

    Article  PubMed  CAS  Google Scholar 

  3. E.B. Gutman, E.E. Sproul and A.B. Gutman, Significance of increased phosphatase activity of bone at the site of osteoblastic metastases secondary to carcinoma of the prostate gland, Am. J. Cancer 28:485 (1936).

    CAS  Google Scholar 

  4. A.E. Reif, R.M. Schlesinger, C.A. Fish and C.M. Robinson, Acid phosphatase iso-enzymes in cancer of the prostate, Cancer 31:689 (1973).

    Article  PubMed  CAS  Google Scholar 

  5. A.B. Gutman and E.B. Gutman, An “acid” phosphatase occurring in the serum of patients with metastasising adenocarcinoma of the prostate gland, J. Clin. Invest. 17:473 (1938).

    Article  PubMed  CAS  Google Scholar 

  6. M.A. Abul-Fadl and E.J. King, Properties of the acid phosphatase of erythrocytes and of the human prostate gland, Biochem. J. 45:51 (1949).

    CAS  Google Scholar 

  7. T. M. Sodeman and J.G. Batsakis, Acid phosphatase, in: “Urologic Pathology: The Prostate,” M. Tannenbaum, ed, Lea and Febiger, Philadelphia (1979) p 129.

    Google Scholar 

  8. D.T. Chua, R.J. Veenema, F. Muggia and A. Graff, Acid phosphatase levels in bone marrow: value in detecting early bone metastases from carcinoma of the prostate, J. Urol. 103:462 (1970).

    PubMed  CAS  Google Scholar 

  9. E.O. Gursel, M. Rezvan, F.A. Sy and R.J. Veenema, Comparative evaluation of bone marrow acid phosphatase v. bone scanning in staging of prostatic cancer, J. Urol. 111:53 (1974).

    PubMed  CAS  Google Scholar 

  10. J.E. Pontes, S.W. Alcorn, A.J. Thomas and J.M. Piercy, Bone marrow acid phosphatase in staging prostatic carcinoma, J. Urol. 114:422 (1975).

    PubMed  CAS  Google Scholar 

  11. A.W. Bruce, F. O’Cleireachan, A. Morales and S.A. Owad, Carcinoma of the prostate: A critical look at staging, J. Urol. 117:319 (1977).

    PubMed  CAS  Google Scholar 

  12. R.J. Veenema, E.O. Gursel, N. Romas, M. Wechsler and J.K. Lattimer, Bone marrow acid phosphatase: Prognostic value in patients undergoing radical prostatectomy, J. Urol. 117:81 (1977).

    PubMed  CAS  Google Scholar 

  13. R. Kahn, B. Turner, M. Edson and M. Dolan, Bone marrow acid phosphatase: Another look, J. Urol. 117:79 (1977).

    Google Scholar 

  14. J.E. Pontes, B.K. Choe, N.R. Rose and J.M. Pierce, Bone marrow staging of prostatic cancer: How reliable is it? J. Urol. 119:772 (1978).

    PubMed  CAS  Google Scholar 

  15. A. W. Bruce, D.E. Mahan, A. Morales, A.F. Clark and W.D. Belville, An objective look at acid phosphatase determinations, Brit. J. Urol. 51:213 (1979).

    Article  PubMed  CAS  Google Scholar 

  16. S.D. Fosså, J. Sokolowsi and L. Theodorsen, The significance of bone marrow acid phosphatase in patients with prostatic carcinoma, Br. J. Urol. 50:185 (1978).

    Article  PubMed  Google Scholar 

  17. W.M. Boehme, R.R. Augsburger, S.F. Wallner and R.E. Donohue, Lack of usefulness of bone marrow enzymes and calcium in staging patients with prostatic cancer, Cancer 41:1433 (1978).

    Article  PubMed  CAS  Google Scholar 

  18. A.N. Romas, R.J. Veenema, K.C. Shu, P. Tomashefszy, J.K. Lattimer and M. Tannenbaum, Bone marrow acid phosphatase in prostatic cancer. An assessment by immuno assay and biochemical methods, J. Urol. 123:392 (1980).

    PubMed  CAS  Google Scholar 

  19. S.D. Fosså, A. Skinningsrud, O. Kaalhus and A. Engeseth, Is determination of prostatic acid phosphatase in bone marrow by radioimmunoassay (BM-PAP) useful in patients with prostatic cancer, in: “Cancer of the Prostate and Kidney,” P.H. Smith and M. Pavone-Macaluso, eds., Plenum Press, London and New York (1982).

    Google Scholar 

  20. S. Shulman, L. Mamrod, M.J. Gonda and W.A. Soanes, The detection of prostatic acid phosphatase by antibody reactions in gel diffusion, J. Immunol. 93:474 (1964).

    PubMed  CAS  Google Scholar 

  21. A.G Foti, H. Herschman and J.F. Cooper, Iso-enzymes of acid phosphatase in normal and cancerous human prostatic tissue, Cancer Res. 37:4120 (1977).

    PubMed  CAS  Google Scholar 

  22. A.G. Foti, J.F. Cooper, H. Herschman and R.R. Malvaex, Detection of prostatic cancer by solid phase R.I.A. of serum prostatic acid phosphatase, N. Engl. J. Med. 297:1357 (1977)

    Article  PubMed  CAS  Google Scholar 

  23. T.M. Chu, M.C. Want, W.W. Scott, R.P. Gibbons, D.E. Johnson, J.D. Schmidt, S.A. Loening, G.R. Prout and G.P. Murphy, Immunochemical detection of serum prostatic acid phosphatase, Invest. Urol. 15:319 (1978).

    PubMed  CAS  Google Scholar 

  24. B.K. Choe, E.J. Pontes, M.K. Morrison and N.R. Rose, Human prostatic acid phosphatases, 2: a double antibody radioimmuno assay, Arch. Androl. 1:227 (1978).

    Article  PubMed  CAS  Google Scholar 

  25. D.E. Mahan and B.P. Doctor, A radio-immune assay for human prostatic acid phosphatase levels in prostatic disease, Clin. Biochem. 12:10 (1979).

    Article  PubMed  CAS  Google Scholar 

  26. A.W. Bruce, D. Mahan and W.D. Melville, The role of radioimmuno assay for prostatic acid phosphatase in prostatic carcinoma, Urol. Clin. North Am. 12:226 (1979).

    Google Scholar 

  27. G.P. Murphy, T.M. Chu and J.P. Karr, Prostatic acid phosphatase: The developing experience, Clin. Biochem. 12:226 (1979).

    Article  PubMed  CAS  Google Scholar 

  28. J.C. Griffiths, Prostatic specific acid phosphatase, Re-evaluation of radio-immuno assay in diagnosing prostatic disease, Clin. Chem. 26:433 (1980).

    PubMed  CAS  Google Scholar 

  29. K.Q. Woodward, Factors leading to elevation in serum and glycerophosphate, Cancer 5:236 (1952).

    Article  PubMed  CAS  Google Scholar 

  30. G.P. Murphy, J. Karr and T.M. Chu, Prostatic acid phosphatase: Where are we? Cancer 28:258 (1978).

    CAS  Google Scholar 

  31. Anonymous, New tests for prostatic cancer: Advisers routine, Med. World News 19:13 (1978).

    Google Scholar 

  32. R. Gittes, Acid phosphatase reappraised, New Engl. J. Med. 297:1398 (1977).

    Article  PubMed  CAS  Google Scholar 

  33. R.A. Watson and D.B. Tang, The predictive value of prostatic acid phosphatase as a screening test for prostatic cancer, New Engl. J. Med. 303:497 (1980).

    Article  PubMed  CAS  Google Scholar 

  34. G.R. Lindholm, M.S. Stirton, R.J. Liedtke and J.D. Batjer, Prostatic acid phosphatase by radio-immuno assay, J.A.M.A. 244:2071 (1980).

    Article  PubMed  CAS  Google Scholar 

  35. L.A. Klein, Prostatic carcinoma, New Engl. J. Med. 300:824 (1979).

    Article  PubMed  CAS  Google Scholar 

  36. D.E. Johnson, W.W. Scott and R.P. Gibbons, Clinical significance of serum acid phosphatase levels in advanced prostatic carcinoma, Urology 8:123 (1976).

    Article  PubMed  CAS  Google Scholar 

  37. W.R. Berry, J. Laslo, E. Cox, A. Walker and D. Paulson, Prognostic factors in metastatic v. hormonally unresponsive carcinoma of the prostate, Cancer 44:763 (1979).

    Article  PubMed  CAS  Google Scholar 

  38. R.M. Nesbit and W.C. Baum, Serum phosphatase determination in diagnosis of prostatic cancer: A review of 1150 cases, J.A.M.A. 145:1321 (1951).

    Article  CAS  Google Scholar 

  39. V.A.C.U.R.G., Factors in the prognosis of carcinoma of the prostate: A cooperative study, J. Urol. 100:59 (1968).

    Google Scholar 

  40. M. de Pauw, S. Suciu, R. Sylvester, P.H. Smith, M. Pavone-Macaluso and the E0RTC Urological Group, Preliminary results of two EORTC randomized trials in previously untreated patients with advanced T3 – T4 prostatic cancer, in: “Cancer of the Prostate and Kidney,” P.H. Smith and M. Pavone-Macaluso, eds., Plenum Press, London and New York (1982).

    Google Scholar 

  41. C. Huggins and C.V. Hodges, Studies on prostatic cancer: 1. The effect of castration, of oestrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate, Cancer Res. 1:293 (1941).

    CAS  Google Scholar 

  42. C.R. Franks, Melphalan in metastatic cancer of the prostate, Cancer Treat. Reviews 6 (Suppl.):121 (1979).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. York District Hospital, York, UK

    B. Richards

  2. EORTC Data Centre, Brussels, Belgium

    R. Sylvester & M. de Pauw

Authors
  1. B. Richards
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Sylvester
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. de Pauw
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

the EORTC Urological Group

Editor information

Editors and Affiliations

  1. University of Palermo, Palermo, Italy

    M. Pavone-Macaluso

  2. St. James’s University Hospital, Leeds, England

    P. H. Smith

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Springer Science+Business Media New York

About this chapter

Cite this chapter

Richards, B., Sylvester, R., de Pauw, M., the EORTC Urological Group. (1983). The Clinical Value of the Serum Acid Phosphatase in Carcinoma of the Prostate. In: Pavone-Macaluso, M., Smith, P.H. (eds) Cancer of the Prostate and Kidney. NATO Advanced Science Institutes Series, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4349-3_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4349-3_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4351-6

  • Online ISBN: 978-1-4684-4349-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation