Myoglobin-Reactive T Cell Clones
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Myoglobin has been used for a considerable period of time as a “model” antigen for immunological studies. Since the sequence and crystal structure of myoglobin from sperm whale skeletal muscle are well known, myoglobin can be studied in great detail as an antigen. The immunological studies that have been done with Mb to date have provided useful information bearing on a number of important questions. We have used myoglobin as a model antigen to study via the new and powerful techniques made possible by T cell cloning. Since the T cell clones which we utilize are of the helper/inducer subset (TH, see below) and therefore occupy a central role in vivo in controlling immune responsiveness, these techniques should provide both specific and generalized information relating to the immune responses to complex protein antigens.
KeywordsAntigen Present Cell Cell Clone Sperm Whale Cyanogen Bromide Immune Response Gene
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- 4.Kimoto, M. and C.G. Fathman.: Antigen reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. J. Exp. Med., 152: 759, (1980).Google Scholar
- 9.Infante, A.J. and C.G. Fathman.: A T cell clone responds to quantitative differences in antigen and la on antigen presenting cells. (submitted for publication).Google Scholar
- 12.Atassi, M.Z., S. Yokota, S.S. Twining, H. Lehmann and C.S. David.: Genetic control of the immune response to myoglobin VI. Inter-site influences in T-lymphocyte proliferative response from analysis of cross-reactions of ten myoglobins in terms of substitutions in the antigenic sites and in environmental residues of the sites. Molecular Immunol. (in press).Google Scholar
- 15.McNicholas, J.M., D.B. Murphy, L.A. Matis, R.H. Schwartz, E.A. Lerner, C.A. Janeway, Jr., and P.P. Jones.: Immune response gene function correlates with the expression of an la antigen. I. Preferential association of certain Ae and Ea chains results in a quantitative deficiency in expression of an Ae:Ea complex. J. Exp. Med. (in press).Google Scholar
- 16.Singer, A., Y. Asano, M. Shigeta, K.S. Hathcock, A. Ahmed, C.G. Fathman and R.J. Hodes.: Distinct B cell subpopulations differ in their genetic requirements for activation by T Helper cells. Immunol. Rev. (in press).Google Scholar