Immune Response Gene Control of T Dependent Reactivity to Collagen in Man
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T dependent reactivity controlled by immune response (Ir) genes in rodents exhibits the following three characteristics. (1–3) First, it is dependent on interactions between T cells and antigen presenting accessory cells (conveniently referred to here as MØ). Second, the reactivity is directed against determinants inherent in either synthetic polypeptides or limited regions of globular proteins. Third, the reactivity is controlled by genes present in the immune response (Ir) locus of the major histocompatibility complex.
KeywordsRheumatoid Arthritis Peripheral Blood Mononuclear Cell Collagen Reactivity Dependent Reactivity Synthetic Polypeptide
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