Immune Response Gene Control of T Dependent Reactivity to Collagen in Man

  • Alan M. Solinger
  • John D. Stobo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 150)


T dependent reactivity controlled by immune response (Ir) genes in rodents exhibits the following three characteristics. (1–3) First, it is dependent on interactions between T cells and antigen presenting accessory cells (conveniently referred to here as MØ). Second, the reactivity is directed against determinants inherent in either synthetic polypeptides or limited regions of globular proteins. Third, the reactivity is controlled by genes present in the immune response (Ir) locus of the major histocompatibility complex.


Rheumatoid Arthritis Peripheral Blood Mononuclear Cell Collagen Reactivity Dependent Reactivity Synthetic Polypeptide 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Alan M. Solinger
    • 1
  • John D. Stobo
    • 1
  1. 1.Section of Rheumatology/Clinical Immunology Dept. of Medicine and The Howard Hughes Medical InstituteUniversity of California, San FranciscoSan FranciscoUSA

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