Immunological Studies with Tobacco Mosaic Virus Protein: Differential Activation of B Cell Subpopulations

  • Donna M. Rennick
  • Philip R. Morrow
  • Eli Benjamini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 150)


Currently, information concerning the activation requirements of B lymphocytes in different stages of differentiation is limited. It has been known for some time that resting B lymphocytes at different levels of maturation may not respond to the same stimuli in the same way. Activation of immunocompetent lymphocytes from adult animals by T-dependent (TD) antigens can lead to antibody production and memory whereas stimulation of immature lymphocytes (neonatal) may under identical conditions result in tolerance.1–4 Furthermore, it appears that primary and memory B cells do not exhibit the same requirements for activation under certain experimental conditions. Although some of these results may be explained by quantitative differences, there is evidence for qualitative differences as well.5–9


Antibody Response Memory Regeneration Brucella Abortus Immunoglobulin Isotype Composite Binding 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Donna M. Rennick
    • 1
  • Philip R. Morrow
    • 1
  • Eli Benjamini
    • 1
  1. 1.Department of Medical Microbiology, School of MedicineUniversity of CaliforniaDavisUSA

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