Abstract
Currently, information concerning the activation requirements of B lymphocytes in different stages of differentiation is limited. It has been known for some time that resting B lymphocytes at different levels of maturation may not respond to the same stimuli in the same way. Activation of immunocompetent lymphocytes from adult animals by T-dependent (TD) antigens can lead to antibody production and memory whereas stimulation of immature lymphocytes (neonatal) may under identical conditions result in tolerance.1–4 Furthermore, it appears that primary and memory B cells do not exhibit the same requirements for activation under certain experimental conditions. Although some of these results may be explained by quantitative differences, there is evidence for qualitative differences as well.5–9
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© 1982 Plenum Press, New York
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Rennick, D.M., Morrow, P.R., Benjamini, E. (1982). Immunological Studies with Tobacco Mosaic Virus Protein: Differential Activation of B Cell Subpopulations. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides—II. Advances in Experimental Medicine and Biology, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4331-8_12
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DOI: https://doi.org/10.1007/978-1-4684-4331-8_12
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