Use of T Cell Hybridomas in the Analysis of Helper T Cell Functions in B Cell Responses
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The fundamental question under investigation is to determine the role of helper T cells in the induction of B cell antibody synthesis. Based on our previous work we have proposed that helper T cells mediate two types of helper functions; the production of antigen non-specific factors i.e. lymphokines and antigen specific help 1,2.
KeywordsSpleen Cell Keyhole Limpet Hemocyanin Soluble Antigen Helper Activity Primed Lymph Node
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- 1.J. E. Swierkosz, P. Marrack and J. W. Kappler, Functional analysis of T cells expressing I A antigens. I. Demonstration of helper T cell heterogeneity, J. Exp. Med. 150: 1293 (1979)Google Scholar
- 9.E. Walker, N. Warner, R. Chesnut, H. M. Grey, P. Marrack and J. W. Kappler, manuscript in preparation.Google Scholar
- 10.D. McKean, A. J. Infante, A. Nilson, M. Kimoto, C. G. Fathman, E. Walker and N. Warner, MHC restricted antigen presentation to antigen reactive T cells by B lymphocyte tumor cells, J. Exp. Med. in press (1981)Google Scholar