Use of T Cell Hybridomas in the Analysis of Helper T Cell Functions in B Cell Responses

  • Neal Roehm
  • John Kappler
  • Philippa Marrack
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 150)


The fundamental question under investigation is to determine the role of helper T cells in the induction of B cell antibody synthesis. Based on our previous work we have proposed that helper T cells mediate two types of helper functions; the production of antigen non-specific factors i.e. lymphokines and antigen specific help 1,2.


Spleen Cell Keyhole Limpet Hemocyanin Soluble Antigen Helper Activity Primed Lymph Node 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Neal Roehm
    • 1
  • John Kappler
    • 1
  • Philippa Marrack
    • 1
  1. 1.Department of MedicineNational Jewish Hospital and Research CenterDenverUSA

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