Abstract
Juvenile-type fatty streaks are the earliest lesions that can be recognized by macroscopic inspection of aortas of children. They characteristically appear as small yellow/white dots most frequently in longitudinal lines between the intercostal branches, they stain brilliantly red with macroscopic sudan staining, and Holman reported that they were already present in all children aged more than 3, increased in area rapidly between ages 8–15, and reached a maximum at about age 20 (1).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R.L. Holman, Atherosclerosis — a pediatric nutrition problem ? Amer.J.Clin.Nutr., 9: 565 (1961).
H.C. McGill, Fatty streaks in the coronary arteries and aorta, Lab.Invest., 18: 560 (1968).
E.B. Smith, The relationship between plasma and tissue lipids I nhuman atherosclerosis, Advan.Lipid Res., 12: 1 (1974).
D. Velican and C. Velican, Study of fibrous plaques occurring in the coronary arteries of children, Atherosclerosis, 33: 201 (1979).
D. Velican and C. Velican, Atherosclerotic involvement of the coronary arteries of adolescents and young adults, Atherosclerosis, 36: 449 (1980).
C. Velican and D. Velican, Incidence, topography and light-microscopic features of coronary atherosclerotic plaques in adults 26–35 years old, Atherosclerosis, 35: 111 (1980).
C. Velican and D. Velican, The precursors of coronary atherosclerotic plaques in subjects up to 40 years old, Atherosclerosis, 37: 33 (1980).
E.B. Smith, Metabolism of the arterial wall, this volume p
J.L. Goldstein and M.S. Brown, The low-density lipoprotein pathway and its relation to atherosclerosis, Ann.Rev.Biochem., 46: 897 (1977).
J.L. Goldstein, R.G.W. Anderson, L.M. Buja, S.K. Basu and M.S. Brown, Overloading human aortic smooth muscle cells with low density lipoprotein-cholesteryl esters reproduces features of atherosclerosis in vitro, J.Clin.Invest., 59: 1196 (1977).
R.W. Mahley, Cholesterol feeding: effects on lipoprotein structure and metabolism, in “Atherosclerosis V”., A.M. Gotto, L.C. Smith and B. Allen, Springer-Verlag, Berlin, 641 (1980).
M.D. Haust, The morphogenesis and fate of potential and early atherosclerotic lesions in man, Human Pathol., 2: 1 (1971).
E.B. Smith and R.S. Slater, Lipids and low density lipoproteins in intima in relation to its morphological characteristics, in, “Atherogenesis–Initiating Factors”, Ciba Foundation Symposium No. 12, New Series, Excerpta Medica, Amsterdam, 39 (1973).
E.B. Smith and R.H. Smith, Early changes in aortic intima, Atheroscler.Rev., 1: 119 (1976).
E.B. Smith, Acid glycosaminoglycan, collagen and elastin content of normal artery, fatty streaks and plaques, in, “Arterial Mesenchyme and Arteriosclerosis”, W.D. Wagner and T.B. Clarkson, Advan.Exp.Med.Biol., 43: 125 (1974).
E.B. Smith, Relation between arterial wall and risk factors for coronary heart disease: lipoproteins — steady state aspects, in, “Atherosclerosis IV”, G. Schettler, Y. Goto, Y. Hata and G. Klose, Springer-Verlag, Berlin, 24 (1977).
R. Ross, A. Vogel, E. Raines and B. Kariya, The platelet-derived growth factor, in, “Atherosclerosis V”, A.M. Gotto, L.C. Smith and B. Allen, eds., Springer-Verlag Berlin, 442 (1980).
E.P. Benditt, Implication of the monoclonal character of human atherosclerotic plaques, Amer.J.Pathol., 86: 693 (1977).
E.B. Smith, I.B. Massie and K.M. Alexander, The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin, Atherosclerosis, 25: 71 (1976).
E.B. Smith, H.S. Dietz and I.B. Craig, Characterization of free and tightly bound lipoprotein in intima by thin-layer iso-electric focusing, Atherosclerosis, 33: 329 (1979).
P. Bernfeld and T.F. Kelley, Proteolysis of human serum ß-lipoprotein, J.Biol.Chem., 239: 3341 (1964).
E.B. Smith and I.B. Massie, Destruction of endogenous low density lipoprotein in incubated intima, Atherosclerosis, 26: 427 (1977).
E.B. Smith, E.M. Staples, H.S. Dietz and R.H. Smith, Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudo-intimas, Lancet, ii: 812 (1979).
A. Sumiyoshi, R.H. More and B.I. Weigensberg, Aortic fibrofatty type atherosclerosis from thrombus in normolipidemic rabbits, Atherosclerosis, 18: 43 (1973).
T.W. Meade, R. Chakrabarti, A.P. Haines, W.R.S. North, Y. Stirling and S.G. Thompson, Haemostatic function and cardio-vascular death: early results of a prospective study, Lancet, i: 1050 (1980).
W.W. Meyer and J. Lind, Calcifications of the carotid siphon — a common finding in infancy and childhood, Arch.Pis.Childhood, 47: 364 (1972).
S.M. Partridge and F.W. Keeley, Age related and atherosclerotic changes in aortic elastin, in, “Arterial Mesenchyme and Arteriosclerosis”, W.D. Wagner and T.B. Clarkson, eds., Advan.Exp.Med.Biol., 43: 173 (1974).
S.Y. Yu, Calcification processes in atherosclerosis, in, “Arterial Mesenchyme and Arteriosclerosis”. W.D. Wagner and T.B. Clarkson, eds., Advan.Exp.Med.Biol., 43: 403 (1974).
K. Schmid, W.O. McSharry, C.H. Pameijer and J.P. Binette, Chemical and physicochemical studies on the mineral deposits of the human atherosclerotic aorta, Atherosclerosis, 37: 199 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this paper
Cite this paper
Smith, E.B. (1982). From the Fatty Streak to the Calcified Lesion. In: Born, G.R.V., Catapano, A.L., Paoletti, R. (eds) Factors in Formation and Regression of the Atherosclerotic Plaque. NATO Advanced Study Institutes Series, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4268-7_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4268-7_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4270-0
Online ISBN: 978-1-4684-4268-7
eBook Packages: Springer Book Archive