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Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 51))

Abstract

In this Advanced Study Institute other speakers will discuss endothelial prostaglandin metabolism, factors controlling smooth muscle and endothelial cell proliferation, and aspects of lipid metabolism. I will confine my discussion to three other areas of arterial wall metabolism — energy production and the consequences of hypoxia, the intimal and medial cellular environment, and collagen synthesis — and will try to show how these may be inter-related in terms of atherogenesis.

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References

  1. A.L. Lehninger, Biochemistry, Worth Publishers, New York (1970).

    Google Scholar 

  2. J.E. Kirk, P.G. Effersoe, and S.P. Chiang, The rate of respirat ion and glycolysis by human and dog aortic tissue, J.Gerontol., 9: 10 (1954).

    PubMed  CAS  Google Scholar 

  3. A.L. Lehninger, The metabolism of the arterial wall, in, “Then Arterial Wall”, Lansing, A.I., ed., Williams & Wilkins, Baltimore (1959).

    Google Scholar 

  4. A.F. Whereat, Atherosclerosis and metabolic disorder in the arterial wall, Exp.Mol.Pathol., 7: 233 (1967).

    Article  PubMed  CAS  Google Scholar 

  5. R.F. Scott, E.S. Morrison, and M. Kroms, Effect of cold shock on respiration and glycolysis in swine arterial tissue, Am.J, Physiol., 219: 1363 (1970).

    PubMed  CAS  Google Scholar 

  6. A.D. Morrison, L. Berwick, L. Orci, and A.I. Winegrad, Morphology and metabolism of an aortic intima-media preparation in which intact endothelium is preserved, J.Clin.Invest., 57: 650 (1976).

    Article  PubMed  CAS  Google Scholar 

  7. A.D. Morrison, L. Orci, L. Berwick, A. Perrelet and A.I. Winegrad, The status of the arterial endothelium in experimental studies, Atherosclerosis Revs., 3: 125 (1978).

    CAS  Google Scholar 

  8. E.S. Morrison, J. Frick and M. Kroms, The effects of O concen ration and albumin on respiration and aerobic glycolysis in rabbit aortic intima-media, Biochem.Med., 20: 279 (1978).

    Article  PubMed  CAS  Google Scholar 

  9. H.J. Arnqvist and L. Lundholm, Influence of oxygen tension on the metabolism of vascular smooth muscle: demonstration of a Pasteur effect, Atherosclerosis, 25: 245 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. V. Niinikoski, C. Heughan and T.K. Hunt, Oxygen tensions in the aortic wall of normal rabbits, Atherosclerosis, 17: 353 (1973).

    Article  PubMed  CAS  Google Scholar 

  11. E.R. Jurrus and H.S. Weiss, In vitro tissue oxygen tensions in the rabbit aortic arch, Atherosclerosis, 28: 223 (1977).

    Google Scholar 

  12. J.E. Kirk and T.J.S. Laursen, Diffusion coefficients of various solutes for human aortic tissue, with special reference to variation in tissue permeability with age, J.Gerontol., 10: 288 (1955).

    PubMed  CAS  Google Scholar 

  13. A.V. Hill, The diffusion of oxygen and lactic acid through tissues, Proc.Roy.Soc. (London) Series B, 104: 39 (1928–29).

    Google Scholar 

  14. L.H. Back, Analysis of oxygen transport in the avascular region of arteries, Math.Biosci., 31: 285 (1976).

    Article  CAS  Google Scholar 

  15. L.H. Back, D.W. Crawford, personal communication.

    Google Scholar 

  16. G. Sneiderman and T.K. Goldstick, Significance of luminal plasma layer resistance in arterial wall oxygen supply, Atherosclerosis, 31: 11 (1978).

    Article  Google Scholar 

  17. E.B. Smith, Metabolic activities in the arterial wall, in, “Dynamics of Arterial Flow”, S. Wolf and N.T. Werthessen, eds., Advan.Exp.Med.Biol., 115: 245 (1979).

    Google Scholar 

  18. E.B. Smith and E.M. Staples, Distribution of plasma proeins across the human aortic wall: barrier functions of endothelium and internal elastic lamina, Atherosclerosis, 37: 579 (1980).

    Article  PubMed  CAS  Google Scholar 

  19. M.A. Ricciutti, Myocardial lysosome stability in the early stages of acute ischaemic injury, Amer.J.Cardiol., 30: 492 (1972).

    Article  PubMed  CAS  Google Scholar 

  20. K. Wildenthal, R.S. Decker, R. Poole, E.E. Griffin and J.T. Dingle, Sequential lysosomal alterations during cardiac ischaemia: 1. Biochemical and immunohistochemical changes, Lab.Invest., 38: 656 (1978).

    PubMed  CAS  Google Scholar 

  21. K. Wildenthal, Lysosomal alterations in ischaemic myocardium: result or cause of myocardial damage?, J.Mol.Cell.Cardiol., 10: 595 (1978).

    Article  PubMed  CAS  Google Scholar 

  22. C. DeDuve and H. Beaufay, Tissue fractionation studies: 10. Influence of ischaemia on the state of some bound enzymes in rat liver, Biochem.J., 73: 610 (1959).

    Google Scholar 

  23. L. Gordis and H.M. Nitowsky, Lysosomes in human cell cultures: kinetics of enzyme release from injured particles, Exp.Cell Res., 38: 556 (1965).

    Article  PubMed  CAS  Google Scholar 

  24. E.B. Smith and R.H. Smith, Early changes in aortic intima, Atherosclerosis Rev., 1: 119 (1976).

    CAS  Google Scholar 

  25. E.B. Smith and I.B. Massie, Destruction of endogenous low density lipoprotein in incubated intima, Atherosclerosis, 26: 427 (1977).

    Article  PubMed  CAS  Google Scholar 

  26. M.C. Burleigh, A.J. Barrett and G.S. Lazarus, Cathepsin B: a lysosomal enzyme that degrades native collagen, Biochem.J. 137: 387 (1974).

    PubMed  CAS  Google Scholar 

  27. P.A. Poole-Wilson, Measurements of myocardial intracellular pH in pathological states, J.MoCell.Cardiol., 10: 511 (1978).

    Article  CAS  Google Scholar 

  28. J.J. Albers and E.L. Bierman, The effect of hypoxia on uptake and degradation of low density lipoproteins by cultured human arterial smooth muscle cells, Biochim.Biophys.Acta, 424: 422 (1976).

    PubMed  CAS  Google Scholar 

  29. E.B. Smith and R.S. Slater, Relationship between low density lipoprotein in aortic intima and serum lipid levels, Lancet i, 463 (1972).

    Google Scholar 

  30. E.B. Smith, The relationship between plasma and tissue lipids in human atherosclerosis, Advan.Lipid Res., 12: 1 (1974).

    CAS  Google Scholar 

  31. E.B. Smith, Biochemical studies on permeabiliy and the inter action between blood constituents and arterial components in atherosclerosis, in, Atherosclerosis VM, A.M. Gotto, L.C. Smith and B. Allen, Springer-Verlag, Berlin, 121 (1980).

    Google Scholar 

  32. R.L. Bratzler, G.M. Chisholm, C.K. Colton, K.A. Smith and R.S. Lees, The distribution of labelled low density lipoproteins across the rabbit thoracic aorta in vivo, Atherosclerosis, 28: 289 (1977).

    Article  PubMed  CAS  Google Scholar 

  33. G. Thorgeirsson and A.L. Robertson, The vascular endothelium — pathobiological significance, Amer.J.Path., 93: 803 (1978).

    PubMed  CAS  Google Scholar 

  34. A.L. Robertson, Arterial endothelium in the initial stages of atherogenesis, in, “Atherosclerosis V”, A.M. Gotto, L.C. Smith and B. Allen, Springer-Verlag, Berlin 103 (1980).

    Google Scholar 

  35. D.Y.M. Leung, S. Glagov, J.M. Clark and M.B. Mathews, Mechanical influences on the biosynthesis of extracellular macro-molecules by aortic cells, in, “Extracellular Matrix Influences on Gene Expression”, H.C. Slavkin and R.C. Greulich, eds., Academic Press, New York, 633 (1975).

    Google Scholar 

  36. D.Y.M. Leung, S. Glagov and M.B. Mathews, Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro, Science, 191: 475 (1976).

    Article  PubMed  CAS  Google Scholar 

  37. P.J. Reeds, R.M. Palmer and R.H. Smith, Protein and collagen synthesis in rat diaphragm muscle incubated in vitro: the effect of alterations in tension produced by electrical or mechanical means, Int.J.Biochem., 11: 7 (1980).

    Article  PubMed  CAS  Google Scholar 

  38. G.M. Fischer, M.L. Swain and K. Cherian, Increased vascular collagen and elastin synthesis in experimental atheroscler-osis in the rabbit, Atherosclerosis, 35: 11 (1980).

    Article  PubMed  CAS  Google Scholar 

  39. U. Langness and S. Udenfriend, Collagen proline hydroxylase activity and anaerobic metabolism, in, “Biology of the Fibroblast”, E. Kulonen and J. Pikkarainen, eds., Academic Press, New York, 373 (1973).

    Google Scholar 

  40. R. Schwarz, L. Colarusso and P. Doty, Maintenance of differ entiation in primary cultures of avian tendon cells, Exp. Cell Res., 102: 63 (1976).

    Article  PubMed  CAS  Google Scholar 

  41. K.G. McCullagh and L.A. Ehrhart, Increased arterial collagen synthesis in experimental canine atherosclerosis, Atherosclerosis, 19: 13 (1974).

    CAS  Google Scholar 

  42. K.G. McCullagh and L.A. Ehrhart, Enhanced synthesis and accumulation of collagen in cholesterol-aggravated pigeon atherosclerosis, Atherosclerosis, 26: 341 (1977).

    Article  PubMed  CAS  Google Scholar 

  43. G.C. Fuller, E. Miller, T. Farber and E. Vanloon, Aortic connective tissue changes in miniature pigs fed a lipid-rich diet, Connective Tiss.Res., 1: 217 (1972).

    Article  CAS  Google Scholar 

  44. R.W. St. Clair, J.J. Toma and H.B. Lofland, Proline hydroxylase activity and collagen content of pigeon aortas with natur-ally-occurring and cholesterol-aggravated atherosclerosis, Atherosclerosis, 21: 155 (1975).

    Article  Google Scholar 

  45. L.A. Ehrhart and D. Holderbaum, Stimulation of aortic protein synthesis in experimental rabbit atherosclerosis, Atherosclerosis, 27: 477 (1977).

    CAS  Google Scholar 

  46. D. Vesselinovitch, G.S. Getz, R.H. Hughes and R.W. Wissler, Atherosclerosis in the Rhesus monkey fed three food fats, Atherosclerosis, 20: 303 (1974).

    Article  PubMed  CAS  Google Scholar 

  47. L.A. Ehrhart and D. Holderbaum, Aortic collagen, elastin and non-fibrous protein synthesis in rabbits fed cholesterol and peanut oil, Atherosclerosis, 37: 423 (1980).

    Article  PubMed  CAS  Google Scholar 

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© 1982 Plenum Press, New York

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Smith, E.B. (1982). Metabolism of the Arterial Wall. In: Born, G.R.V., Catapano, A.L., Paoletti, R. (eds) Factors in Formation and Regression of the Atherosclerotic Plaque. NATO Advanced Study Institutes Series, vol 51. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4268-7_2

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  • DOI: https://doi.org/10.1007/978-1-4684-4268-7_2

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