Abstract
Acute intravenous infusions of phosphate have been used to study the relationship between plasma phosphate concentration and renal phosphate excretion (1 – 10). Animals maintained on a normal intake of phosphorus (0.8 – 1.2%) respond to acute phosphate infusions with phosphate excretions ranging from 60 – 90% of the filtered load (5, 7, 9). The high phosphate excretions are not only the result of increases in tubular load exceeding the reabsorptive capacity, but recent studies indicate that at high plasma phosphate concentrations (induced by prolonged intravenous phosphate infusions) the maximal transport rate actually declines (3, 4, 6, 9–11).
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References
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© 1982 Plenum Press, New York
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Haramati, A., Knox, F.G. (1982). Relationship between Plasma Phosphate and Renal Handling of Phosphate: Studies with Low Phosphate Diet and Nicotinamide. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_5
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DOI: https://doi.org/10.1007/978-1-4684-4259-5_5
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