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Should Hypophosphatemia be Treated?

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Regulation of Phosphate and Mineral Metabolism

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 151))

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Abstract

The answer to the question is yes. Phosphate treatment is necessary when hypophosphatemia is part of a true phosphate depletion syndrome (PDS). However, hypophosphatemia, even as low as 1.0–2.0 mg/dl in adults or 2.0–3.0 mg/dl in preadolescent children, does not necessarily mean or cause PDS. There are many examples in adult and child medicine of chronic hypophosphatemia caused by a high renal clearance of phosphorus (P) (low TmP/GFR) i.e. liberal amounts of P in the urine with low serum P. These do not develop a PDS unless there is superimposed a true lack of available P for the metabolic and growth needs of the patient. In the latter setting P excretion decreases markedly or disappears completely from the urine. This intense tubular reabsorption of P is an invariable feature of true phosphate depletion.

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Author information

Authors and Affiliations

  1. Division of Nephrology, School of Medicine, University of California, Los Angeles, Los Angeles, California, 90024, USA

    Charles R. Kleeman (Factor Family Foundation Professor of Nephrology, Medicine and Director, Center for Health Enhancement, Education and Research)

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  1. Charles R. Kleeman
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. State University of New York at Stony Brook, Stony Brook, New York, USA

    Joseph M. Letteri

  3. Nassau County Medical Center, East Meadow, New York, USA

    Joseph M. Letteri

  4. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1982 Plenum Press, New York

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Kleeman, C.R. (1982). Should Hypophosphatemia be Treated?. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_37

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  • DOI: https://doi.org/10.1007/978-1-4684-4259-5_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4261-8

  • Online ISBN: 978-1-4684-4259-5

  • eBook Packages: Springer Book Archive

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