Abstract
Excess dietary phosphate produces progressive increase in calcium content of the kidney and also leads to progressive deterioration of renal function1–3. The important variables responsible for determination of both the rate of deposition of calcium and loss of renal function are the quantity of dietary phosphate, the amount of functioning renal tissue and the level of parathyroid activity3,4. Given sufficient reduction in the size of the functioning renal mass, progressive deposition of calcium can be demonstrated in the kidney of animals maintained on a diet of normal phosphate content5. The histologic changes associated with these progressive calcium deposits provide convincing evidence of the structural damage produced, apparently resulting from cellular damage associated with calcium phosphate deposition 3,6.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. M. MacKay, and J. Oliver, Renal damage following the ingestion of a diet containing an excess of inorganic phosphate, J. Exp. Med. 61:319 (1935).
A. M. Pappenheimer, The effect of experimental reduction of kidney substance upon the parathyroid glands and skeletal tissue, J. Exp. Med. 64:965 (1936).
J. Craig, Observations on the kidney after phosphate loading in the rat, Arch. Pathol. 68:306 (1959).
P. Haase, Parathyroid stimulation in phosphate-induced nephro-calcinosis, J. Ant. 125:299 (1978).
L. S. Ibels, A. C. Alfrey, L. L. Haut, and W. E. Huffer, Preservation of function in experimental renal disease by dietary restriction of phosphate, N. Engl. J. Med. 298:122 (1978).
L. L. Haut, A. C. Alfrey, S. Guggenheim, B. Buddington, and N. Schrier, Renal toxicity of phosphates in rats, Kidney Int. 17:722 (1980).
W. P. Tew, C. Mahle, J. Benavides, J. E. Howard, and A. L. Lehninger, Synthesis and characterization of phosphocitric acid, a potent inhibitor of hydroxyapatite crystal growth, Biochemistry 19:1983 (1980).
J. E. Howard, Studies on urinary stone formation: A saga of clinical investigation, Johns Hopkins Med. J. 139:239 (1976).
W. P. Tew, C. D. Malis, and W. G. Walker, The effects of phosphocitrate on experimentally induced nephrocalcinosis, Kidney Int. 19:117 (1981).
L. Gimenez, W. P. Tew, J. A. Hermann, and W. G. Walker, Prevention of phosphate-induced renal insufficiency by phosphocitrate, Kidney Int. 19:110 (1981).
J. M. Kaufman, H. J. DiMeola, N. J. Siegel, B. Lytton, M. Kashgarian, and J. P. Hayslett, Compensatory adaptation of structure and function following progressive renal ablation, Kidney Int. 6:10 (1974).
H. E. Harrison, and H. C. Harrison, Inhibition of urine citrate excretion and the production of renal calcinosis in the rat by acetazoleamide administration, J. Clin. Invest. 34:1662 (1955).
J. F. Van Pilsum, Determination of creatinine and related guanidinium compounds, in: “Methods of Biochemical Analysis,” D. Glick, ed., Interscience Publishers, New York 7:193 (1959).
C. H. Fiske, and Y. Subbarow, The colorimetric determination of phosphorus, J. Biol. Chem. 66:375 (1925).
D. McFarlane, Experimental phosphate nephritis in the rat, J. Pathol. 52:17 (1941).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
Walker, W.G., Gimenez, L., Tew, W.P., Hermann, J.A. (1982). Prevention of Phosphate Induced Progression of Experimental Uremia by 3-Phosphocitric Acid. In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4259-5_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4261-8
Online ISBN: 978-1-4684-4259-5
eBook Packages: Springer Book Archive