Abstract
The effects of calcium on ADH action have been the object of intense study for 20 years (1). Extreme elevations in serosal calcium (Ca++) concentration (10 mM) have been shown to block ADH-induced water flow in the toad urinary bladder (1,2). To test the effects of smaller elevations of calcium level on ADH action in a mammalian system, studies were performed in the ADH responsive cortical collecting tubule, “light” segment (3).
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References
M.J. Peterson and I.S. Edelman, Calcium inhibition of the action of vasopressin on the urinary bladder of the toad. J. Clin. Invest. 43: 583 (1964).
W.P. Argy Jr., J.S. Handler, and J. Orloff, Ca++ and Mg++ effects on toad bladder response to cyclic AMP, theophylline and ADH analogues. Am. J. Physiol. 213: 803 (1965).
M. Imbert, D. Chabardes, M. Montegut, A. Clique, and F. Morel, Vasopressin dependent adenylate cyclase in single segments of rabbit kidney tubule. Pflugers Arch. 357: 173 (1975).
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© 1982 Plenum Press, New York
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Goldfarb, S. (1982). The Effects of Calcium on ADH Action in Cortical Collecting Tubules Perfused In Vitro . In: Massry, S.G., Letteri, J.M., Ritz, E. (eds) Regulation of Phosphate and Mineral Metabolism. Advances in Experimental Medicine and Biology, vol 151. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4259-5_16
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DOI: https://doi.org/10.1007/978-1-4684-4259-5_16
Publisher Name: Springer, Boston, MA
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