Abstract
Since the first suggestion, approximately ten years ago, that lipid vesicles might have practical uses in medicine, liposomes have been a treatment in search of a disease. The approach of my laboratory since 1976 has been to search for clinical applications among infectious diseases. Because parenterally injected liposomes natually travel in great amounts to the liver and spleen I felt, at least at the beginning of our research, that attempts to tailor liposomes to particular diseases by artificially targeting the vesicles to areas other than the liver and spleen, might be difficult. Therefore, my colleagues and I have concentrated only on diseases in which the liver and spleen play an important, or even a crucial, role.
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H. C. Goodman, Immunology and tropical diseases: Challenges and opportunities, Ann. Immunol. (Inst. Pasteur) 129C: 267 (1978)
C. R. Alving, E. A. Steck, W. L. Chapman, Jr., V. B. Waits, L. D. Hendricks, G. M. Swartz, Jr., and W. L. Hanson, Therapy of leishmaniasis: Superior efficacies of liposome-encapsulated drugs, Proc. Natl. Acad. Sci. U.S.A. 75: 2959 (1978).
C. R. Alving, E. A. Steck, W. L. Hanson, P. S. Loizeaux, W. L. Chapman, Jr., and V. B. Waits, Improved therapy of experimental leishmaniasis by use of a liposome-encapsulated antimonial drug, Life Sci. 22: 1021 (1978).
C. R. Alving, E. A. Steck, W. L. Chapman, Jr., V. B. Waits, L. D. Hendricks, G. M. Swartz, Jr., and W. L. Hanson, Liposomes in leishmaniasis: Therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline, Life Sci. 26: 2231 (1980).
C. R. Alving and E. A. Steck, The use of liposome-encapsulated drugs in leishmaniasis, Trends Biochem. Sci. 4 (8): N175 (1979).
C. R. Alving, I. Schneider, G. M. Swartz, Jr., and E. A. Steck, Sporozoite-induced malaria: Therapeutic effects of glycolipids in liposomes, Science 205: 1142 (1979).
C. R. Alving, Immune reactions of lipids and lipid model membranes, in:“The Antigens, vol. 4”, M. Sela, ed., Academic Press, NY, p.1 (1977).
B. G. Schuster, M. Neidig, B. M. Alving, and C. R. Alving, Production of antibodies against phosphocholine, phosphatidylcholine, sphingomyelin, and lipid A by injection of liposomes containing lipid A, J. Immunol. 122: 900 (1979).
C. R. Alving, Liposomes as vehicles for vaccines, in:“New Developments With Human and Veterinary Vaccines”, A. Mizrahi, M. A. Klingberg, I. Hertman, and A. Kohn, eds., Alan R. Liss, Inc., NY, (1980).
C. R. Alving, B. Banerji, J. Clements, and R. L. Richards, Adjuvanticity of lipid A and lipid A fractions in liposomes, in:“Liposomes and Immunobiology”, B. H. Tom and H. R. Six, eds., Elsevier/North-Holland, NY, (1980).
R. K. Sanyal and R. R. Arora, Assessment of drug therapy of kala-azar in current epidemic in Bihar, J. Com. Dis. 11: 198 (1979).
C. D. V. Black, G. J. Watson, and R. J. Ward, The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis, Trans. R. Soc. Trop. Med. Hyg. 71: 550 (1977).
R. R. C. New, M. L. Chance, S. C. Thomas, and W. Peters, Antileishmanial activity of antimonials entrapped in liposomes, Nature 272: 55 (1978).
W. H. Wernsdorfer, Long-term aims of malaria research, Trends Biochem. Res. 4 (3): N49 (1979)
P. Pirson, R. F. Steiger, A. Trouet, J. Gillet, and F. Herman, Primaquine liposomes in the chemotherapy of experimental murine malaria, Ann. Trop. Med. Parasit. 74: 383 (1980).
G. Ashwell and A. G. Morell, The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins, Adv. Enzymol. 41: 99 (1974).
A. Surolia and B. K. Bachhawat, Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells. Biochim. Biophys. Acta 497: 760 (1977).
M. M. Jonah, E. A. Cerny, and Y. E. Rahman, Tissue distribution of EDTA encapsulated within liposomes containing glycolipids or brain phospholipids, Biochim. Biophys. Acta 541: 321 (1978).
J. R. Riordan, L. Mitchell, and M. Slavik, The binding of asialo-glycoprotein to isolated Golgi apparatus, Biochem. Biophys. Res. Comm. 59: 1373 (1974).
W. E. Pricer, Jr. and G. Ashwell, Subcellular distribution of a mammalian hepatic binding protein specific for asialoglycoproteins, J. Biol. Chem. 251: 7539 (1976).
H. D. Danforth, M. Aikawa, A. H. Cochrane, and R. S. Nussenzweig, Sporozoites of mammalian malaria: Attachment to, interiorization and fate within macrophages, J. Protozool. 27: 193 (1980).
I. Schneider, and C.R. Alving, unpublished data.
R. F. Steiger, D. G. Layton, P. Pirson, J. Gillet, and F. Herman, Therapeutic activity of DAPI on experimental murine malaria, J. Parasitol. 66: 352 (1980).
B. H. Tom, An overview: Liposomes and immunobiology-macrophages, liposomes and tailored immunity, in:“Liposomes and Immunobiology”, B. H. Tom and H. R. Six, eds., Elsevier, North-Holland, NY, (1980).
C. R. Alving, J. J. Mooney, and G. E. Olson, Use of liposomes as a model for studying immune phagocytosis, Fed. Proc. 30: 693 (1971).
N. van Rooijen and R. van Nieuwmegen, Immunoadjuvant properties of liposomes, this volume.
B. Banerji and C. R. Alving, Anti-liposome antibodies induced by lipid A. I. Influence of ceramide, glycosphingolipids, and phosphocholine on complement damage, J. Immunol. 126: 1080 (1981).
J. M. Chiller, B. J. Skidmore, D. C. Morrison, and W. O. Weigle, Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity, Proc. Natl. Acad. Sci. U.S.A. 70: 2129 (1973).
Y. Cho, K. Tanamoto, Y. Oh, and J. Y. Homma, Differences of chemical structures of Pseudomonas aeruginosa lipopolysaccharide essential for adjuvanticity and antitumor and interferon-inducing activities, FEBS Lett. 105: 120 (1979).
B. Banerji and C. R. Alving, Lipid A from endotoxin: Antigenic activities of purified fractions in liposomes, J. Immunol. 123: 2558 (1979)
K. Uemura, R. A. Nicolotti, H. R. Six, and S. C. Kinsky, Antibody formation in response to liposomal model membranes sensitized with N-substituted phosphatidylethanolamine derivatives, Biochemistry 13: 1572 (1974).
F. Roerdink, B. J. Berson, R. L. Richards, G. M. Swartz, Jr., J. A. Lyon, and C. R. Alving, Specificity of a hybridoma monoclonal antibody against liposomes containing phosphatidylinositol monophosphate, Fed. Proc. 40: 996 (1981).
R. L. Friedman, F. Roerdink, B. H. Iglewski, and C. R. Alving, Suppression of cytotoxicity of diphtheria toxin by monoclonal antibodies against phosphatidylinositol phosphate, Biophys. J, in press
G. H. Strejan, P. M. Smith, C. W. Grant, and D. Surlan, Naturally occurring antibodies to liposomes. I. Rabbit antibodies to sphingomyelin-containing liposomes before and after immunization with unrelated antigens, J. Immunol. 123: 370 (1979).
R. L. Richards and C. R. Alving, Immune reactivities of antibodies against glycolipids. Natural Antibodies, in:“Cell Surface Glycolipids”, ACS Symposium Series No. 128, C. C. Sweeley, ed., American Chemical Society, Washington, (1980).
R. L. Richards and C. R. Alving, unpublished data.
C. R. Alving, J. Moss, R. L. Richards, and L. I. Alving, Liposomes as vehicles for vaccines. Increased antigenicity and lack of toxicity of a toxin bound to liposomes, Clin. Res. 29 (2): 531A (1981).
N. van Rooijen and R. van Nieuwmegen, Liposomes in immunology: evidence that their adjuvant effect results from surface exposition of the antigens, Cell. Immunol. 49: 402 (1980).
D. C. Morrison, R. J. Ulevitch, The effects of bacterial endotoxins on host mediation systems, Am. J. Pathol. 93: 525 (1978).
R. B. Ramsey, M. B. Hamner, B. M. Alving, J. S. Finlayson, C. R. Alving, Effects of lipid A and liposomes containing lipid A on platelet and fibrinogen production in rabbits, Blood 56: 307 (1980).
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Alving, C.R. (1982). Therapeutic Potential of Liposomes as Carriers in Leishmaniasis, Malaria, and Vaccines. In: Gregoriadis, G., Senior, J., Trouet, A. (eds) Targeting of Drugs. NATO Advanced Study Institutes Series, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4241-0_20
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