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Targeting of Drugs pp 261–284Cite as

Stimulation of Host Response Against Metastatic Tumors by Liposome-Encapsulated Immunomodulators

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Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 47))

Abstract

The metastatic spread of malignant tumors to form metastases at other sites in the body remains the principal cause of failure in the treatment of neoplastic disease1. Several factors are responsible for this unfortunate situation. First, metastases are frequently too small to be detected at the time the primary tumor is removed. Second, widespread dissemination of metastases often takes place before symptoms of metastatic disease occur. Third, the anatomic location of many metastatic lesions renders them inaccessible to surgical removal and/or limits the effective dose of therapeutic agents that reach metastases. The final, and most formidable, problem concerns emergence of metastatic lesions that are resistant to conventional therapy. Recent work suggests that metastases arise from non-random spread of specialized subpopulations of cells within the primary tumor and that the responsiveness of these metastatic subpopulations to therapy may not only differ from that of non-metastatic tumor cells in the primary tumor but may also vary significantly between the tumor cell subpopulations present in individual metastases within the same patient (review, 2). The depressing implication of this marked heterogeneity in the response of malignant cells to chemotherapy and other therapeutic modalities is that the only successful approach to the therapy of metastases will be one that circumvents the problem of cellular diversity between tumor cells in primary and metastatic lesions, and between different metastatic foci.

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Author information

Authors and Affiliations

  1. Smith Kline and French Laboratories, Philadelphia, PA, 19101, USA

    George Poste

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    George Poste

  3. Cancer Metastasis and Treatment Laboratory, NCI-Frederick Cancer Research Center, Frederick, MD, 21701, USA

    Corazon Bucana & Isaiah J. Fidler

Authors
  1. George Poste
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  2. Corazon Bucana
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  3. Isaiah J. Fidler
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Editor information

Editors and Affiliations

  1. Clinical Research Centre, Harrow, UK

    Gregory Gregoriadis  & Judith Senior  & 

  2. International Institute of Cellular and Molecular Pathology, Brussels, Belgium

    André Trouet

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© 1982 Plenum Press, New York

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Poste, G., Bucana, C., Fidler, I.J. (1982). Stimulation of Host Response Against Metastatic Tumors by Liposome-Encapsulated Immunomodulators. In: Gregoriadis, G., Senior, J., Trouet, A. (eds) Targeting of Drugs. NATO Advanced Study Institutes Series, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4241-0_16

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  • DOI: https://doi.org/10.1007/978-1-4684-4241-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4243-4

  • Online ISBN: 978-1-4684-4241-0

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