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Principles and Application of Positron Emission Tomography in Neuroscience

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Experimental Neurochemistry

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Abstract

Positron Emission Tomography (PET) is a new nuclear medicine technique which evolved from the need to establish the relationship among the functional activity of the brain, its metabolic rate, and its anatomic structure. This technique allows the detection of the three-dimensional distribution within the brain of a previously administered positron-emitting radionuclide. Although similar in principle to quantitative autoradiography, it has the advantage of providing functional information of a structure in a living organism. Positron emission tomography incorporates principles from both transmission computed tomography and the uptake and flow techniques initially developed by Kety and Schmidt1 but has the advantage of being able to give information for localized regions of the brain. This information is based on the detection of the annihilation energy produced when a positron emitted from a radionuclide-labeled compound interacts with an electron in the tissue.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, New York University School of Medicine, New York, New York, 10016, USA

    Jonathan D. Brodie & Nora Volkow

  2. Psychiatry Service, Veterans Administration Medical Center, New York, New York, 10010, USA

    John Rotrosen

Authors
  1. Jonathan D. Brodie
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  2. Nora Volkow
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  3. John Rotrosen
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Editors and Affiliations

  1. Center for Neurochemistry, Ward’s Island, New York, USA

    Abel Lajtha

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© 1982 Plenum Press, New York

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Brodie, J.D., Volkow, N., Rotrosen, J. (1982). Principles and Application of Positron Emission Tomography in Neuroscience. In: Lajtha, A. (eds) Experimental Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4208-3_15

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  • DOI: https://doi.org/10.1007/978-1-4684-4208-3_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4210-6

  • Online ISBN: 978-1-4684-4208-3

  • eBook Packages: Springer Book Archive

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