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The Molecular Biology of Marek’s Disease Herpesvirus

  • Chapter
The Herpesviruses

Part of the book series: The Viruses ((VIRS))

Abstract

Marek’s disease (MD) is a lymphoproliferative disease in chickens that was originally described by Marek (1907). A herpesvirus was isolated in cell cultures derived from tumors and from peripheral-blood lymphocytes (Churchill and Biggs, 1967; Solomon et al., 1968; Nazerian et al., 1968; Nazerian and Burmester, 1968), which implied that the virus is the causative agent of this disease (Churchill and Biggs, 1968; Witter et al., 1969). Although Marek’s disease virus (MDV) is generally found in the cell-associated form in tissue culture, cell-free virus is produced in the feather follicles of infected birds and released into the air (Calneck et al., 1970; Nazerian and Witter, 1970). Both cell-associated virus in infected cells and cell-free virus, extracted from the feather follicle, Can induce MD tumor in chickens by inoculation.

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Authors and Affiliations

  1. Department of Virology, Showa University Research Institute for Biomedicine in Florida, 5180 113th Avenue North, Clearwater, Florida, 33520, USA

    Meihan Nonoyama Ph.D.

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  1. Meihan Nonoyama Ph.D.
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Editors and Affiliations

  1. University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

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© 1982 Plenum Press, New York

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Nonoyama, M. (1982). The Molecular Biology of Marek’s Disease Herpesvirus. In: Roizman, B. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4163-5_7

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  • DOI: https://doi.org/10.1007/978-1-4684-4163-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4165-9

  • Online ISBN: 978-1-4684-4163-5

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