Skip to main content
SpringerLink
Log in

Herpesvirus saimiri and Herpesvirus ateles

  • Chapter
The Herpesviruses

Part of the book series: The Viruses ((VIRS))

Abstract

Herpesvirus saimiri (H. saimiri) is a ubiquitous agent of squirrel monkeys (Saimiri sciureus), a primate species native to the South American rain forests. The virus can easily be isolated from blood and tissue-culture cells of most healthy squirrel monkeys, and there is no evidence so far that H. saimiri is pathogenic in its natural host. After the first report on isolation of H. saimiri from primary kidney-cell cultures by Melendez et al. (1968) from the New England Primate Research Center, the virus was regarded as a harmless indigenous agent of squirrel monkeys. The interest in this virus arose from the observation that H. saimiri is extremely oncogenic in a number of other primate species that are presumably not infected under usual wildlife conditions (Melendez et al., 1969b). Marmoset monkeys of the genus Saguinus consistently develop malignant tumors of the lymphatic system, usually within 2 months of infection. The ability to induce neoplastic disease rapidly and reproducibly has made this system attractive for investigation of the biological, immunological, and molecular parameters of Cell transformation and tumor induction.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ablashi, D.V., Loeb, W.F., Valerio, M.G., Adamson, R.H., Armstrong, G.R., Bennett, D.G., and Heine, U., 1971a, Malignant lymphoma with lymphatic leukemia in owl monkeys induced by Herpesvirus saimiri, J. Natl. Cancer Inst. 47:837.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Armstrong, G.R., Heine, U., and Manaker, R.A., 1971b, Propagation of Herpesvirus saimiri in human cells, J. Natl. Cancer Inst. 47:241.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Loeb, W.F., Pearson, G., Valerio, M.G., Armstrong, G.R., Rabin, H., Kingsbury, E.W., and Heine, U., 1973, Induction of lymphoma in owl monkeys with heated, non- Cytopathogenetic Herpesvirus saimiri, Nature (London) New Biol. 242:28.

    CAS  Google Scholar 

  • Ablashi, D.V., Armstrong, G.R., Heine, U., and Manaker, R.A., 1974a, Propagation of Herpesvirus saimiri in human cells, in: Herpesvirus I: Recent Studies (J.A. Bellanti, H. Kabuta, and G. L. Rosenberg, eds.), pp. 219–225, MSS Information, New York.

    Google Scholar 

  • Ablashi, D.V., Armstrong, G.R., Easton, J.M., Chopra, H.C., and Adamson, R.H., 1974b, Evaluation of effects of Cystosine arabinoside on oncogenic Herpesvirus saimiri in owl monkey kidney cells, Biomedicine 21:57.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Armstrong, G.R., and Easton, J.M., 1976, Absence of horizontal transmission of Herpesvirus saimiri between experimentally infected and noninfected owl monkeys, Cancer Lett. 2:35.

    Article  Google Scholar 

  • Ablashi, D.V., Armstrong, G., Fellows, C., Easton, J., Pearson, G., and Twardzik, D., 1977a, Evaluation of the effects of phosphonoacetic acid and 2-deoxy-d-glucose on Herpesvirus saimiri and Epstein-Barr virus, in: Prevention and Detection of Cancer (H.E. Nieburgs, ed.), pp. 245–261, Marcel Dekker, New York.

    Google Scholar 

  • Ablashi, D.V., Twardzik, D., Easton, J.M., Armstrong, G.R., Luetzeler, F., Jasmin, C., and Chermann, J.-C., 1977b, Effects of 5-tungsto-2-antimoniate in oncogenic DNA and RNA virus-cell systems, Eur. J. Cancer 13:713.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Pearson, G., Rabin, H., Armstrong, G., Easton, J., Valerio, M., and Cicmanec, J., 1978, Experimental infection of Callithrix jacchus marmosets with Herpesvirus ateles, Herpesvirus saimiri and Epstein-Barr virus, Biomedicine 29:7.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Bengali, Z.H., Eichelberger, M.A., Sundar, K.S., Armstrong, G.R., Daniel, M., and Levine, P.H., 1980a, Increased infectivity of oncogenic herpes viruses of primates with tumor promoter 12–0-tetradecanoylphorbol-13-acetate (40901), Proc. Soc. Exp. Biol. Med. 164:485.

    PubMed  CAS  Google Scholar 

  • Ablashi, D.V., Sundar, K.S., Armstrong, G., Golway, P., Valerio, M., Bengali, Z., Lemp, J., and Fox, R.R., 1980b, Herpesvirus sazmiri-induced malignant lymphoma in inbred strain III/J rabbits (Oryctolagus Cuniculus), J. Cancer Res. Clin. Oncol. III:1.

    Google Scholar 

  • Acken, U.V., Simon, D., Grunert, F., Döring, H.-P., and Kroger, H., 1979, Methylation of viral DNA in vivo and in vitro, Virology 99:152.

    Article  Google Scholar 

  • Adams, A., 1979, The state of the virus genome in transformed cells and its relationship to host Cell DNA, in: The Epstein-Barr Virus (M.A. Epstein and B.G. Achong, eds.), pp. 156–183, Springer-Verlag, New York.

    Google Scholar 

  • Adamson, R.H., Ablashi, D.V., Armstrong, G.R., and Ellmore, N.W., 1972, Effect of Cytosine arabinoside, adenine arabinoside, tilorone, and rifamycin SV on multiplication of Herpesvirus saimiri in vitro, Antimicrob. Agents Chemother. 1:82.

    PubMed  CAS  Google Scholar 

  • Adamson, R.H., Ablashi, D.V., Rabin, H., Cicmanec, J., and Dalgard, D.W., 1974, Chemotherapy of Herpesvirus saimiri induced lymphoma and leukemia in owl monkey, J. Med. Primatol. 3:68.

    PubMed  CAS  Google Scholar 

  • Anderson, K.P., Costa, R.H., Holland, L.E., and Wagner, E.K. 1980, Characterization of herpes simplex virus type 1 RNA present in the absence of de novo protein synthesis, J. Virol. 34:9.

    PubMed  CAS  Google Scholar 

  • Anzil, A.P., Bowden, D.M., and Ploog, D., 1977, Malignant lymphoma in a squirrel monkey (Saimiri sciureus), J. Med. Primatol. 6:251.

    PubMed  CAS  Google Scholar 

  • Armstrong, G.R., Orr, T., Ablashi, D.V., Pearson, G.R., Rabin, H., Luetzeler, J., Loeb, W.F., and Valerio, M.G., 1976, Brief Communication: Chronic Herpesvirus saimiri infection in an owl monkey, J. Natl. Cancer Inst. 56:1069.

    PubMed  CAS  Google Scholar 

  • Banfield, W.G., Lee, C.W., Tralka, T.S., and Rabson, A.S., 1977, Lamella-particle Complexes in nuclei of owl monkey kidney cells infected with Herpesvirus saimiri, J. Natl. Cancer Inst. 58:1421.

    PubMed  CAS  Google Scholar 

  • Barahona, H.H., and Melendez, L.V., 1971, Herpesvirus saimiri: In vitro sensitivity to virus-induced interferon and to polyriboinosimic acid: polyribocytidylic acid, Proc. Soc. Exp. Biol. Med. 136(4):1163.

    PubMed  CAS  Google Scholar 

  • Barahona, H., Melendez, L.V., Hunt, R.D., Forbes, M., Fraser, C.E.O., and Daniel, M.D., 1975, Experimental horizontal transmission of Herpesvirus saimiri from squirrel monkeys to an owl monkey, J. Infect. Dis. 132:694.

    Article  PubMed  CAS  Google Scholar 

  • Barahona, H., Daniel, M.D., Bekesi, J.G., Fraser, C.E.O., King, N.W., Hunt, R.D., Ingalls, J.K., and Jones, T.C., 1977, In vitro suppression of Herpesvirus saimiri replication by phosphonoacetic acid (39687), Proc. Soc. Exp. Biol. Med. 154:431.

    PubMed  CAS  Google Scholar 

  • Barbacid, M., Daniel, M.D., and Aaronson, S.A., 1980, Immunological relationship of OMC-1, an endogenous virus of owl monkeys, with mammalian and avian type C viruses, J. Virol. 33:561.

    PubMed  CAS  Google Scholar 

  • Bird, A.P., 1980, DNA methylation and the frequency of CpG in animal DNA, Nucleic Acids Res. 8:1499.

    Article  PubMed  CAS  Google Scholar 

  • Bornkamm, G.W., Delius, H., Fleckenstein, B., Werner, F.-J., and Mulder, C., 1976, The structure of Herpesvirus saimiri genomes: Arrangement of heavy and light sequences within the M genome, J. Virol. 19:154.

    PubMed  CAS  Google Scholar 

  • Bornkamm, G.W., Delius, H., Zimber, U., Hudewentz, J., and Epstein, M.A., 1980, Comparison of Epstein-Barr virus strains of different origin by analysis of the viral DNAs, J.Virol. 35:603.

    PubMed  CAS  Google Scholar 

  • Buchman, T.G., Roizman, B., Adams, G., and Stover, B.H., 1978, Restriction endonuclease fingerprinting of herpes simplex virus DNA: A novel epidemiological tool applied to a nosocomial outbreak, J. Infect. Dis. 138:488.

    Article  PubMed  CAS  Google Scholar 

  • Cedar, R., Solage, A., Glaser, G., and Razin, A., 1979, Direct detection of methylated Cytosine in DNA by use of the restriction enzyme Msp I, Nucleic Acids Res. 6:2125.

    Article  PubMed  CAS  Google Scholar 

  • Chu, E.W., and Rabson, A.S., 1972, Chimerism in lymphoid Cell Culture line derived from lymph node of marmoset infected with Herpesvirus saimiri, J. Natl. Cancer Inst. 48:771.

    PubMed  CAS  Google Scholar 

  • Cicmanec, J.L., Loeb, W.F., and Valerio, M.G., 1974, Lymphoma in owl monkeys (Aotus trivirgatus) inoculated with Herpesvirus saimiri: Clinical, hematological and pathologic findings, J. Med. Primatol. 3:8.

    PubMed  CAS  Google Scholar 

  • Cohen, J.C., 1980, Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA, Cell 19:653.

    Article  PubMed  CAS  Google Scholar 

  • Daniel, M.D., Rabin, H., Barahona, H., and Melendez, L.V., 1971, Herpesvirus saimiri. III. Plaque formation under multi agar, methyl Cellulose, and starch overlays, Proc. Soc. Exp. Biol. Med. 136:1192.

    PubMed  CAS  Google Scholar 

  • Daniel, M.D., Meléndez, L.V., and Barahona, H.H., 1972, Plaque Characterization of viruses from South American nonhuman primates, J. Natl. Cancer Inst. 49:239.

    PubMed  CAS  Google Scholar 

  • Daniel, M.D., Melendez, L.V., Hunt, R.D., King, N.W., Anver, M., Fraser, C.E.O., Barahona, H., and Baggs, R.B., 1974a, Herpesvirus saimiri. VII. Induction of malignant lymphoma in New Zealand white rabbits, J. Natl. Cancer Inst. 53:1803.

    PubMed  CAS  Google Scholar 

  • Daniel, M.D., Melendez, L.V., and Silva, D., 1974b, Multiplication, Cytopathogenicity and latent infection of human Cell Cultures by Herpesvirus saimiri strains, In Vitro 9:354.

    Google Scholar 

  • Daniel, M.D., Hunt, R.D., DuBose, D., Silva, D., and Melendez, L.V., 1975, Induction of Herpesvirus saimiri lymphoma in New Zealand white rabbits inoculated intravenously, in: Oncogenesis and Herpesviruses II, Part 2 (G. de Thé, M.A. Epstein, H. zur Hausen, and W. Davis, eds.), pp. 205–208, IARC Press, Lyon.

    Google Scholar 

  • Daniel, M.D., Silva, D., and Ma, N., 1976, Establishment of owl monkey kidney 210 Cell line for virological studies, In Vitro 12:290.

    Google Scholar 

  • Daniel, M.D., Hunt, R.D., King, N.W., and Ingalls, J.K., 1977, The oncogenicity of Herpes virus ateles in rabbits, in: Abstracts of The Third International Symposium on Oncogenesis and Herpesviruses, Cambridge, Massachusetts, p. 213.

    Google Scholar 

  • Daniel, M.D., Silva, D., Koomey, J.M., Mulder, C., Fleckenstein, B., Tamulevich, R., King, N.W., Hunt, R.D., Seghal, P., and Falk, L.A., 1979a, Herpesvirus saimiri: Strain SMHI modification of oncogenicity, in: Advances in Comparative Leukemia Research (D.S. Yohn, B.A. Lapin, and J.R. Blakeslee, eds.), pp. 395–396, Elsevier/North-Holland, New York, Amsterdam, Oxford.

    Google Scholar 

  • Daniel, M.D., Tamulevich, R., Silva, D., Bekesi, G., Holland, J., King, N.W., and Falk, L.A., 1979b, Inhibitory effects of acycloguanosine and human lymphoblastoid interferon on Herpesvirus saimiri and Herpesvirus ateles, Proc. Am. Assoc. Cancer Res., p. 233.

    Google Scholar 

  • Daniel, M.D., Falk, L., Tamulevich, R., and King, N.W., 1979c, Interaction of Herpesvirus saimiri (HVS) and Herpesvirus ateles (HVA) with human and primate lymphoblastoid cells, Bacteriol. Proc, p. 289.

    Google Scholar 

  • Daniel, M.D., Falk, L.A., King, N.W., Tamulevich, R., Holland, J.S., and Bekesi, G., 1980, Comparative studies of interferon and three antiviral agents on neurotropic and oncogenic herpesviruses, Antimicrob. Agents Chemother. 18:622.

    PubMed  CAS  Google Scholar 

  • Daniel, M.D., Tamulevich, R., Bekesi, J.G., King, N.W., Falk, L.A., Silva, D., and Holland, J.F., 1981, Selective antiviral activity of human interferons on primate oncogenic and neurotropic herpesviruses: Selective viral inhibition by interferon, Int. J. Cancer, 27:113.

    Article  PubMed  CAS  Google Scholar 

  • Deinhardt, F., Wolfe, L., Northrop, R., Marczynska, B., Ogden, J., McDonald, R., Falk, L., Shramek, G., Smith, R., and Deinhardt, F., 1972, Induction of neoplasms by viruses in marmoset monkeys, J. Med. Primatol. 1:29–50.

    PubMed  CAS  Google Scholar 

  • Deinhardt, F., Falk, L., and Wolfe, L., 1973a, Simian herpesviruses, Cancer Res. 33:1424.

    PubMed  CAS  Google Scholar 

  • Deinhardt, F., Falk, L., Marczynska, B., Shramek, G., and Wolfe, L., 1973b, Herpesvirus saimiri: A simian Counterpart of Epstein-Barr virus of man?, in: Bibliotheca Hae- matologica (R.M. Dutcher and L. Chieco-Bianchi, eds.), pp. 416–427, S. Karger, Basel.

    Google Scholar 

  • Deinhardt, F.W., Falk, L.A., and Wolfe, L.G., 1974, Simian herpesviruses and neoplasia, in: Advances in Cancer Research (G. Klein and S. Weinhouse, eds.), pp. 167–205, Academic Press, New York.

    Google Scholar 

  • Desrosiers, R. C., 1981, Herpesvirus saimiri DNA in tumor cells — deleted sequences and sequence rearrangements, J. Virol. 39:497.

    PubMed  CAS  Google Scholar 

  • Desrosiers, R. C., 1982, Specifically unmethylated CG sites in Herpesvirus saimiri DNA in tumor Cells. J. Virol. 43: in press.

    Google Scholar 

  • Desrosiers, R. C., and Falk, L. A., 1981, Herpesvirus tamarinus and its relation to herpes simplex virus, J. Gen. Virol. 56:119.

    Article  PubMed  CAS  Google Scholar 

  • Desrosiers, R. C., and Falk, L. A., 1982, Herpesvirus saimiri strain variability, J. Virol. 43:000.

    Google Scholar 

  • Desrosiers, R.C., Mulder, C., and Fleckenstein, B., 1979, Methylation of Herpesvirus saimiri DNA in lymphoid tumor Cell lines, Proc. Natl. Acad. Sci. U.S.A. 76(8):3839.

    Article  PubMed  CAS  Google Scholar 

  • de Thé, G., Geser, A., and Day, N.E., 1978, Epidemiological evidence for Causal relationship between Epstein-Barr virus and Burkitt’s lymphoma from Ugandan prospective study, Nature (London) 274:756.

    Article  Google Scholar 

  • Didier, M.L., Ablashi, D.V., Oie, H.K., Armstrong, G.R., Easton, J.M., Chu, E.W., and Rabson, A.S., 1975, Some biological properties of Herpesvirus saimiri from Chronically infected monolayer and suspension Cultures, in: Oncogenesis and Herpesviruses II, Part I (G. de Thé, H. zur Hausen, and A.M. Epstein, eds.), p. 491, IARC Press, Lyon.

    Google Scholar 

  • Dolyniuk, M., Pritchett, R., and Kieff, E., 1976, Proteins of Epstein-Barr virus, J. Virol. 17:935.

    PubMed  CAS  Google Scholar 

  • Falk, L.A., Jr., 1980a, Biology of Herpesvirus saimiri and Herpesvirus ateles, in: Viral Oncology (G. Klein, ed.), pp. 813–832, Raven Press, New York.

    Google Scholar 

  • Falk, L.A., Jr., 1980b, Simian herpesviruses and their oncogenic properties, in: Oncogenic Herpesviruses (F. Rapp, ed.), pp. 145–173, CRC Press, Boca Raton, Florida.

    Google Scholar 

  • Falk, L.A., Wolfe, L.G., and Deinhardt, F., 1972a, Isolation of Herpesvirus saimiri from blood of squirrel monkeys (Saimiri sciureus), J. Natl. Cancer Inst. 48:1499.

    PubMed  CAS  Google Scholar 

  • Falk, L., Wolfe, L., and Deinhardt, F., 1972b, Epidemiology of Herpesvirus saimiri infection in squirrel monkeys, in: Medical Primatology III (E.I. Goldsmith and J. Moor-Jankowski, eds.), pp. 151–158, S. Karger, Basel.

    Google Scholar 

  • Falk, L., Wolfe, L.G., Hoekstra, J., and Deinhardt, F., 1972c, Demonstration of Herpesvirus saimiri-associated antigens in peripheral lymphocytes from infected marmosets during in vitro Cultivation, J. Natl. Cancer Inst. 48:523.

    PubMed  CAS  Google Scholar 

  • Falk, L.A., Wolfe, L.G., and Marczynska, F., 1972d, Characterization of lymphoid Cell lines established from Herpesvirus saimiri (HVS)-infected marmosets, Bacteriol. Proc. 38:191.

    Google Scholar 

  • Falk, L.A., Wolfe, L.G., and Deinhardt, F., 1973a, Herpesvirus saimiri: Experimental infection of squirrel monkeys (Saimiri sciureus), J. Natl. Cancer Inst. 51(1): 165.

    PubMed  CAS  Google Scholar 

  • Falk, L.A., Nigida, S., Deinhardt, F., Cooper, R.W., and Hernandez-Camacho, J.I., 1973b, Brief Communication: Oral excretion of Herpesvirus saimiri in Captive squirrel monkeys and incidence of infection in feral squirrel monkeys, J. Natl. Cancer Inst 51(6): 1987.

    PubMed  CAS  Google Scholar 

  • Falk, L.A., Nigida, S.M., Deinhardt, F., Wolfe, G., Cooper, R.W., and Hernandez-Camacho, J.I., 1974a, Herpesvirus ateles: Properties of an oncogenic herpesvirus isolated from circulating lymphocytes of spider monkeys (Ateles sp.), Int. J. Cancer 14:473.

    Article  PubMed  CAS  Google Scholar 

  • Falk, L., Wright, J., Wolfe, L., and Deinhardt, F., 1974b, Herpesvirus ateles: Transformation in vitro of marmoset splenic lymphocytes, Int. J. Cancer. 14:244.

    Article  PubMed  CAS  Google Scholar 

  • Falk, L.A., Wolfe, L., and Deinhardt, F., 1975, Transformation in vitro with Herpesvirus ateles, in: Oncogenesis and Herpesviruses II, Part I (G. de Thé, M.A. Epstein, and H. zur Hausen, eds.), pp. 379–384, IARC Press, Lyon.

    Google Scholar 

  • Falk, L., Wright, J., Deinhardt, F., Wolfe, L., Schaffer, P., and Benyesh-Melnick, M., 1976, Experimental infection of squirrel and marmoset monkeys with attenuated Herpesvirus saimiri, Cancer Res. 36:707.

    PubMed  CAS  Google Scholar 

  • Falk, L., Johnson, D., and Deinhardt, F., 1978, Transformation of marmoset lymphocytes in vitro with Herpesvirus ateles, Int. J. Cancer 21:652.

    Article  PubMed  CAS  Google Scholar 

  • Falk, L., Daniel, M.D., and King, N., 1979, Interaction of herpesviruses with lymphoblastoid cells, In Vitro, p. 170.

    Google Scholar 

  • Falk, L., Desrosiers, R., and Hunt, R.D., 1980, Herpesvirus saimiri infection in squirrel and marmoset monkeys, in: Viruses in Naturally Occurring Cancers (G. Todaro, M. Essex, and H. zur Hausen, eds.), pp. 137–143, Cold Spring Harbor Press, Cold Spring Harbor, New York.

    Google Scholar 

  • Fischer, R.G., Falk, L.A., Rytter, A., Burton, G.J., Luecke, D.H., and Deinhardt, F., 1974, Herpesvirus saimiri: Viability in four species of hematophagous insects and attempted insect transmission to marmosets, J. Natl. Cancer Inst. 52:1477.

    PubMed  CAS  Google Scholar 

  • Fleckenstein, B., 1979, Oncogenic herpesviruses of non-human primates, Biochim. Biophys. Acta 560:301.

    PubMed  CAS  Google Scholar 

  • Fleckenstein, B., and Bornkamm, G.W., 1975, Structure and function of H. saimiri DNA, in: Oncogenesis and Herpesviruses II, Part 1 (G. de Thé, H. zur Hausen, and M.A. Epstein, eds.), pp. 145–150, IARC Press, Lyon.

    Google Scholar 

  • Fleckenstein, B., and Mulder, C., 1980, Molecular biological aspects of Herpesvirus saimiri and Herpesvirus ateles, in: Viral Oncology (G. Klein, ed.), pp. 799–812, Raven Press, New York.

    Google Scholar 

  • Fleckenstein, B., and Wolf, H., 1974, Purification and properties of H. saimiri DNA, Virology 58:55.

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein, B., Bornkamm, G.W., and Ludwig, H., 1975a, Repetitive sequences in Complete and defective genomes of Herpesvirus saimiri, J. Virol. 15:398.

    PubMed  CAS  Google Scholar 

  • Fleckenstein, B., Werner, J., Bornkamm, G.W., and zur Hausen, H., 1975b, Induction of a malignant lymphoma by Herpesvirus saimiri DNA, in: Epstein-Barr Virus Production, Concentration, and Purification (G. de Thé and D.V. Ablashi, eds.), pp. 159–164, IARC Press, Lyon.

    Google Scholar 

  • Fleckenstein, B., Bornkamm, G.W., and Werner, F.-J. 1976, The role of Herpesvirus saimiri genomes in oncogenic transformation of primate cells, in: Bibliotheca Haematologica, No. 43 (J. Clemmesen and D.S. Yohn, eds.), pp. 308–312, S. Karger, Basel.

    Google Scholar 

  • Fleckenstein, B., Müller, I., and Werner, F.-J. 1977, The presence of Herpesvirus saimiri genomes in virus-transformed cells, Int. J. Cancer 19:546.

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein, B., Bornkamm, G.W., Mulder, C., Werner, F.-J., Daniel, M.D., Falk, L.A., and Delius, H., 1978a, Herpesvirus ateles DNA and its homology with Herpesvirus saimiri nucleic acid, J. Virol. 25:361.

    PubMed  CAS  Google Scholar 

  • Fleckenstein, B., Daniel, M.D., Hunt, R.D., Werner, F.-J., Falk, L.A., and Mulder, C., 1978b, Tumor induction with DNA of oncogenic primate herpesviruses, Nature (London) 274:57.

    Article  CAS  Google Scholar 

  • Frank-Kamenetskii, M.D., 1971, Simplification of the empirial relationship between melting temperature of DNA, its GC Content and Concentration of sodium ions in solution, Biopolymers 10:2623.

    Article  PubMed  CAS  Google Scholar 

  • Friedmann, A., Coward, J.E., and Morgan, C., 1976, Electron microscopic study of the development of Herpesvirus saimiri, Virology 69:810.

    Article  PubMed  CAS  Google Scholar 

  • Gautier, F., Büneman, H., and Grotjahn, F., 1977, Analysis of Calf-thymus satellite DNA: Evidence for specific methylation of Cytosine in C-G sequences, Eur. J. Biochem. 80:175.

    Article  PubMed  CAS  Google Scholar 

  • Gerber, P., Pritchett, R.F., and Kieff, E.D., 1976, Antigens and DNA of a Chimpanzee agent related to Epstein-Barr virus. J. Virol. 19:1090.

    PubMed  CAS  Google Scholar 

  • Giddens, W.E., 1975, Replication of Herpesvirus saimiri in Cultured lymphocytes of infected owl monkeys (Aotus trivirgatus): An electron microscopic and immunofluorescent study, Lab. Invest. 32(4):492.

    PubMed  Google Scholar 

  • Guntaka, R.V., Rao, P.Y., Mitsialis, A., and Katz, R., 1980, Modification of avian sarcoma proviral DNA sequences in non-permissive XC cells but not in permissive Chicken cells, J. Virol. 34:569.

    PubMed  CAS  Google Scholar 

  • Heine, U., and Ablashi, D.V., 1974, Morphological studies of Herpesvirus saimiri in primate cell Cultures, J. Med. Primatol. 3(1): 18.

    PubMed  CAS  Google Scholar 

  • Heine, U., Ablashi, D.V., and Armstrong, G.R., 1971, Morphological studies on Herpesvirus saimiri in subhuman and human Cell Cultures, Cancer Res. 31:1019.

    PubMed  CAS  Google Scholar 

  • Henle, W., Henle, G., Gunvén, P., Klein, G., Clifford, P., and Singh, S., 1973, Patterns of antibodies to Epstein-Barr virus-induced early antigens in Burkitt’s lymphoma: Comparison of dying patients with long term survivors, J. Natl. Cancer Inst. 50:1163.

    PubMed  CAS  Google Scholar 

  • Honess, R.W., O’Hare, P., and Young, D., 1982, Comparison of thymidine kinase activities induced in cells productively infected with Herpesvirus saimiri and Herpes simplex virus, J. Gen. Virol. 58:237.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, R.D., Melendez, L.V., King, N.W., Gilmore, C.E., Daniel, M.D., Williamson, M.E., and Jones, T.C., 1970, Morphology of a disease with features of malignant lymphoma in marmosets and owl monkeys inoculated with Herpesvirus saimiri, J. Natl. Cancer Inst. 44:447.

    PubMed  CAS  Google Scholar 

  • Hunt, R.D., Melendez, L.V., Garcia, F.G., and Trum, B.F., 1972a, Pathologic features of Herpesvirus ateles lymphoma in Cotton-topped marmosets (Saguinus oedipus), J. Natl. Cancer Inst. 49:1631.

    PubMed  CAS  Google Scholar 

  • Hunt, R.D., Melendez, L.V., King, N.W., and Garcia, F.G., 1972b, Herpesvirus saimiri: Malignant lymphoma in spider monkeys: A new susceptible host, J. Med. Primatol. 1:114.

    PubMed  CAS  Google Scholar 

  • Hunt, R.D., Garcia, F.G., Barahona, H.H., King, N.W., Fraser, C.E.O., and Melendez, L.V., 1973, Spontaneous Herpesvirus saimiri lymphoma in an owl monkey, J. Infect. Dis. 127:723.

    Article  PubMed  CAS  Google Scholar 

  • Hunt, R.D., Daniel, M.D., Baggs, R.B., Blake, B.J., Silva, D., DuBose, D., and Melendez L.V., 1975a, Clinico-pathologic Characterization of Herpesvirus saimiri malignant lymphoma in New Zealand White rabbits, J. Natl. Cancer Inst. 54:(6):1401.

    PubMed  CAS  Google Scholar 

  • Hunt, R.D., Barahona, H.H., King, N.W., Fraser, C.E.O., Garcia, F.G., and Melendez, L.V., 1975b, Spontaneous Herpesvirus saimiri lymphoma in owl monkeys, in: Comparative Leukemia Research 1973 (Y. Ito and R.M. Dutcher, eds.), Bibliotheca Haematologica, No. 40, pp. 351–355, S. Karger, Basel.

    Google Scholar 

  • Hunt, R.D., Blake, J.B., and Daniel, M.D., 1976, Herpesvirus saimiri lymphoma in owl monkeys (Aotus trivirgatus): Susceptibility, latent period, hematologic picture and course, Thehogenology, 6:139.

    Google Scholar 

  • Hunt, R.D., Barahona, H., and Daniel, M.D., 1978, Herpesvirus ateles malignant lymphoma in owl monkeys: A new susceptible primate, in: Advances in Comparative Leukemia Research (D.S. Yohn and P. Bentvelzen, eds.), pp. 198–200, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Johnson, D.R., Klein, G., and Falk, L., 1980, Interaction of Herpesvirus ateles and Herpesvirus saimiri with primate lymphocytes. I. Selective adsorption of virus by lymphoid cells, Intervirology 13:21.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, D.R., Ohno, S., Kaschka-Dierich, C., Fleckenstein, B., and Klein, G., 1981, Relationship between Herpesvirus ateles associated nuclear antigen (HATNA) and the number of viral genome equivalents in HVA-carrying lymphoid lines, J. Gen. Virol. 52:221.

    Article  PubMed  CAS  Google Scholar 

  • Judson, S.C., Henle, W., and Henle, G., 1977, A Cluster of Epstein-Barr virus-associated American Burkitt’s lymphoma, N. Engl. J. Med. 297:468.

    Article  Google Scholar 

  • Kaschka-Dierich, C., Bornkamm, G.W., and Thomssen, R., 1979, No homology detectable between Marek’s disease virus (MDV) and herpesvirus of the turkey (HVT) DNA, Med. Microbiol. Immunol. 165:223.

    Article  PubMed  CAS  Google Scholar 

  • Kaschka-Dierich, C., Bauer, I., Fleckenstein, B., and Desrosiers, R.C., 1981, Episomal and non-episomal herpesvirus DNA in lymphoid tumor Cell lines, in: Modern Trends in Human Leukemia (R. Neth, ed.), Springer-Verlag, Heidelberg, p. 197.

    Chapter  Google Scholar 

  • Kaschka-Dierich, C., Bauer, I., Schirm, S., and Fleckenstein, B., 1982, Structure of nonintegrated Covalently Closed Circular viral DNA in Herpesvirus saimiri and Herpesvirus ateles transformed cells (submitted).

    Google Scholar 

  • Keil, G., Müller, I., Fleckenstein, B., Koomey, J. M., and Mulder, C., 1980, Generation of recombinants between different strains of Herpesvirus saimiri, in: Viruses in Naturally Occurring Cancer (H. zur Hausen, G. Todaro, and M. Essex, eds.), pp. 145–161, Cold Spring Harbor Press, Cold Spring Harbor, New York.

    Google Scholar 

  • King, N.W., and Melendez, L.V., 1972, The ultrastructure of Herpesvirus saimiri-induced lymphoma in Cotton-top marmosets (Saguinus oedipus), Lab. Invest. 26:682.

    PubMed  CAS  Google Scholar 

  • King, N.W., Daniel, M.D., Barahona, H.H., and Melendez, L.V., 1972, Viruses from South American monkeys: Ultrastructural studies, J. Natl. Cancer Inst. 49:273.

    PubMed  CAS  Google Scholar 

  • Kirk, J.T.O., 1967, Effect of methylation of Cytosine residues on the buoyant density of DNA in Caesium Chloride solution, J. Mol. Biol. 28:171.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G., Pearson, G., Rabson, A., Ablashi, D.V., Falk, L., Wolfe, L., Deinhardt, F., and Rabin, H., 1973, Antibody reactions to Herpesvirus saimiri (HVS)-induced early and late antigens (EA and LA) in HVS-infected squirrel marmoset and owl monkeys, Int. J. Cancer 12:270.

    Article  PubMed  CAS  Google Scholar 

  • Laufs, R., 1974, Immunization of marmoset monkeys with a killed oncogenic herpesvirus, Nature(London) 249:571.

    Article  CAS  Google Scholar 

  • Laufs, R., and Fleckenstein, B., 1972, Malignant lymphoma induced by partially purified Herpesvirus saimiri and recovery of infectious virus from tumorous lymph nodes, Med. Microbiol. Immunol. 158:135.

    Article  PubMed  CAS  Google Scholar 

  • Aufs, R., and Fleckenstein, B., 1973, Susceptibility to Herpesvirus saimiri and antibody development in Old and New World monkeys, Med. Microbiol. Immunol. 158:227.

    Article  Google Scholar 

  • Laufs, R., and Melendez, L.V., 1973a, Latent infection of monkeys with oncogenic herpesvirus, Med. Microbiol. Immunol. 158:299.

    Article  PubMed  CAS  Google Scholar 

  • Laufs, R., and Melendez, L.V., 1973b, Oncogenicity of Herpesvirus ateles in monkeys, J. Natl. Cancer Inst. 51:599.

    PubMed  CAS  Google Scholar 

  • Laufs, R., and Steinke, H., 1975a, Vaccination of non-human primates against malignant lymphoma, Nature(London) 253:71.

    Article  CAS  Google Scholar 

  • Laufs, R., and Steinke, H., 1975b, No evidence for particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA in herpesvirus induced tumors of non-human primates, J. Gen. Virol. 27:239.

    Article  PubMed  CAS  Google Scholar 

  • Laufs, R., and Steinke, H., 1976, Vaccination of non-human primates with kiMed oncogenic herpesviruses, Cancer Res. 36:704.

    PubMed  CAS  Google Scholar 

  • Laufs, R., Steinke, H., Jacobs, C., Hilfenhaus, J., and Karges, H., 1974a, Influence of interferon on the replication of oncogenic herpesviruses in tissue Cultures and in non-human primates, Med. Microbiol. Immunol. 160:285.

    Article  PubMed  CAS  Google Scholar 

  • Laufs, R., Steinke, H., Steinke, G., and Petzold, D., 1974b, Latent infection and malignant lymphoma in marmosets (Callithrix jacchus) after infection with two oncogenic herpesviruses from primates, J. Natl. Cancer Inst. 53:195.

    PubMed  CAS  Google Scholar 

  • Lee, Y., Tanaka, A., Silver, S., Smith M., and Nonoyama, M., 1979, Minor DNA homology between herpesvirus of turkey and Marek’s disease virus?, Virology 93:277.

    Article  PubMed  CAS  Google Scholar 

  • Linnemann, C.C., Light, I.J., Buchman, T.G., and Ballard, J.L., 1978, Transmission of herpes-simplex virus type 1 in a nursery for the newborn: Identification of viral isolates by DNA “fingerprinting,” Lancet 1:964.

    Article  PubMed  Google Scholar 

  • Lvovsky, E., Levine, P.H., Fuccillo, D., Ablashi, D.V., Bengali, Z.H., Armstrong, G.R., and Levy, H.B., 1981, Epstein-Barr virus and Herpesvirus saimiri: Sensitivity to interferons and interferon inducers, J. Natl. Cancer Inst. 66:1013.

    PubMed  CAS  Google Scholar 

  • Ludwig, H., Biswal, N., and Benyesh-Melnick, M., 1972, Studies on the relatedness of herpesviruses through DNA-DNA hybridization, Virology 49:95.

    Article  PubMed  CAS  Google Scholar 

  • Luetzeler, J., Heine, U., Wendel, E., Prasad, U., and Ablashi, D.V., 1979, Ultrastructural studies on the replication of Herpesvirus ateles-73 in owl monkey kidney cells, Arch. Virol. 60:59.

    Article  PubMed  CAS  Google Scholar 

  • Ma, N.S.F., Jones, T.C., Miller, A.C., Morgan, L.M., and Adams, E.A., 1976, Chromosome polymorphism and banding patterns in the owl monkey (Aotus), Lab. Anim. Sci. 26(6):1022.

    PubMed  CAS  Google Scholar 

  • Mandel, J.L., and Chambon, P., 1979, DNA methylation: Organ specific variations in the methylation pattern within and around ovalbumin and other Chicken genes, Nucleic Acids Res. 7(8):2081.

    Article  PubMed  CAS  Google Scholar 

  • Marczynska, B., Falk, L., Wolfe, L., and Deinhardt, F., 1973, Transplantation and Cytogenetic studies of Herpesvirus saimiri-induced disease in marmoset monkeys, J. Natl. Cancer Inst. 50:331.

    PubMed  CAS  Google Scholar 

  • Martin, L.N., and Allen, W.P., 1975, Response to primary infection with Herpesvirus saimiri in immunosuppressed juvenile and newborn squirrel monkeys, Infect. Immun. 12:526.

    Google Scholar 

  • McGhee, J.D., and Ginder, G.D., 1979, Specific DNA methylation sites in the vicinity of the Chicken beta-globin genes, Nature (London) 280:419.

    Article  CAS  Google Scholar 

  • Medveczky, P., Desrosiers, R.C., Falk, L.A., Fleckenstein, B., and Mulder, C., 1980, Structural differences in the genomes of 14 strains of Herpesvirus saimiri, Abstracts of the Fifth Cold Spring Harbor Meeting on Herpesviruses, August 26–31, 1980.

    Google Scholar 

  • Melendez, L.V., Daniel, M.D., Hunt, R.D., and Garcia, F.G., 1968, An apparently new herpesvirus from primary kidney Cultures of the squirrel monkey (Saimiri sciureus), Lab. Anim. Care 18(3):374.

    PubMed  CAS  Google Scholar 

  • Melendez, L.V., Daniel, M.D., Garcia, F.G., Fraser, C.E.O., Hunt, R.D., and King, N.W., 1969a, Herpesvirus saimiri. I. Further Characterization studies of a new virus from the squirrel monkey, Lab. Anim. Care 19:372.

    PubMed  CAS  Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., Garcia, F.G., and Fraser, C.E.O., 1969b, Herpesvirus saimiri. II. An experimentally induced malignant lymphoma in primates, Lab. Anim. Care 19:378.

    PubMed  CAS  Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., Fraser, C.E.O., Garcia, F.G., and Williamson, M.E., 1970a, Lethal reticuloproliferative disease induced in Cebus albifrons monkeys by Herpesvirus saimiri, Int. J. Cancer 6:431.

    Article  PubMed  CAS  Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., and Trum, B.F., 1970b, New World monkeys, herpesviruses and Cancer, in: Infections and Immunosuppression in Sub-human Primates (H. Balner and W.J.B. Beveridge, eds.), pp. 111–117, Munksgaard, Copenhagen.

    Google Scholar 

  • Melendez, L.V., Daniel, M.D., Hunt, R.D., Fraser, C.E.O., Garcia, F.G., King, N.W., and Williamson, M.E., 1970c, Herpesvirus saimiri. V. Further evidence to Consider this virus as the etiological agent of a lethal disease in primates which resembles a malignant lymphoma, J. Natl. Cancer Inst. 44:1175.

    PubMed  CAS  Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., Blake, B.J., and Garcia, F.G., 1971, Acute lymphocytic leukemia in owl monkeys inoculated with Herpesvirus saimiri, Science 171:1161.

    Article  PubMed  CAS  Google Scholar 

  • Melendez, L.V., Hunt, R.D., King, N.W., Barahona, H.H., Daniel, M.D., Fraser, C.E.O., and Garcia, F.G., 1972a, Herpesvirus ateles, a new lymphoma virus of monkeys, Nature(London)New Biol. 235:182.

    CAS  Google Scholar 

  • Melendez, L.V., Castellano, H., Barahona, H.H., Daniel, M.D., Hunt, R.D., Fraser, C.E.O., Garcia, F.G., andKing, N.W., 1972b, Two new herpesviruses from spider monkeys (Ateles geoffroyi), J. Natl. Cancer Inst. 49:233.

    PubMed  CAS  Google Scholar 

  • Melendez, L.V., Barahona, H.H., Daniel, M.D., Hunt, R.D., Fraser, C.E.O., Garcia, F.G., King, N.W., and Castellanos, H., 1972c, Two new herpesviruses from spider monkeys (Ateles geoffroyi), Proceedings of the Second International Symposium on Health Aspects of the International Movement of Animals, (Pan American Health Organization Scientific Publication No. 235, p. 145.

    Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., Fraser, C.E.O., Barahona, H.H., Garcia, F.G., and King, N.W., 1972d, Lymphoma viruses of monkeys: Herpesvirus saimiri and Herpesvirus ateles, the first oncogenic herpesviruses of primates—a review, in: Oncogenesis and Herpesviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 451–461, IARC Press, Lyon.

    Google Scholar 

  • Melendez, L.V., Hunt, R.D., Daniel, M.D., Fraser, C.E.O., Barahona, H.H., King, N.W., and Garcia, F.G., 1972e, Herpesvirus saimiri and ateles—their role in malignant lymphomas of monkeys, Fed. Proc. Fed. Am. Soc. Exp. Biol. 31:1643.

    CAS  Google Scholar 

  • Morgan, D.G., and Epstein, M.A., 1977, Sequential immunofluorescence and infectivity studies on the replication of Herpesvirus saimiri on owl monkey kidney cells, J. Gen. Virol. 34:61.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, D.G., Epstein, M.A., Achong, B.G., and Melendez, L.V., 1970, Morphological Confirmation of the herpes nature of a Carcinogenetic virus of primates (Herpes saimiri), Nature (London) 228:170.

    Article  CAS  Google Scholar 

  • Morgan, D.G., Achong, B.G., and Epstein, M.A., 1973, Unusual intranuclear tubular structures associated with the maturation of Herpesvirus saimiri in monkey kidney Cell Cultures, Br. J. Cancer 27:434.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, D.G., Achong, B.G., and Epstein, M.A., 1976, Morphological observation on the replication of Herpesvirus saimiri in monkey kidney Cell Cultures, J. Gen. Virol. 32:461.

    Article  PubMed  CAS  Google Scholar 

  • Mulder, C., Koomey, J.M., Daniel, M.D., Desrosiers, R.C., Fleckenstein, B., and Falk, L., 1982, Structural alterations in the virion DNA of non-oncogenic variants of Herpesvirus saimiri, to be published.

    Google Scholar 

  • Neubauer, R.H., and Rabin, H., 1978, In vitro effect of levamisole on the mitogenic response of owl monkey peripheral blood lymphocytes with the development of Herpesvirus saimiri-induced lymphoma, in: Comparative Leukemia Research (D.S. Yohn and P. Bentvelzen, eds.), pp. 406–407, Elsevier, Amsterdam.

    Google Scholar 

  • Neubauer, R.H., and Rabin, H., 1979, Herpes-induced lymphomas: Immunodepression and disease, in: Naturally Occurring Biological Immunosuppressor Factors and the Relationship to Disease (R.H. Neubauer, ed.), pp. 203–231, CRC Press, West Palm Beach, Florida.

    Google Scholar 

  • Neubauer, R.H., Wallen, W.C., Parks, W.P., Rabin, H., and Cicmanec, J.L., 1974a, Attempts to demonstrate type-C virus in normal and neoplastic tissues of non-human primate origin, Lab. Anim. Sci. 24:235.

    PubMed  CAS  Google Scholar 

  • Neubauer, R.H., Wallen, W.C., and Rabin, H., 1974b, Stimulation of Herpesvirus saimiri expression in the absence of evidence for type C virus activation in a marmoset lymphoid Cell line, J. Virol. 14:745.

    PubMed  CAS  Google Scholar 

  • Neubauer, R.H., Wallen, W.C., Rabin, H., Pearson, G.R., and Ablashi, D.V., 1974c, Virol-ogical investigations of Herpesvirus saimiri-infected owl monkeys, J. Med. Primatol. 3:27.

    PubMed  CAS  Google Scholar 

  • Neubauer, R.H., Wallen, W.C., and Rabin, H., 1975, Inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a Herpesvirus saimiri lymphoid tumor Cell line, Infect. Immun. 12:1021.

    PubMed  CAS  Google Scholar 

  • Neubauer, R.H., Wallen, W.C., and Rabin, H., 1976, Antilymphocytic factor derived from a Herpesvirus saimiri lymphoid tumor Cell line, in: Comparative Leukemia Research (J. Clemmensen and D.S. Yohn, eds.), Bibliotheca Haematologica, pp. 388–395, S. Karger, Basel.

    Google Scholar 

  • Neubauer, R.H., Rabin, H., and Dunn, F.E., 1980, Antiviral Cell-mediated immune responses and effect of Chromosome polymorphism in Herpesvirus s aimiri -infected monkeys, Infect. Immun. 27:549.

    PubMed  CAS  Google Scholar 

  • Neubauer, R.H., Dunn, F.E., and Rabin, H., 1981, Infection of multiple T Cell subsets and Changes in lymphocyte functions associated with Herpesvirus saimiri infection of owl monkeys, Infect. Immun. 32:698.

    PubMed  CAS  Google Scholar 

  • Nussinov, R., 1980, Some rules in the ordering of nucleotides in the DNA, Nucleic Acids Res. 8(19):4545.

    Article  PubMed  CAS  Google Scholar 

  • Ohno, S., Luka, J., Klein, G., and Daniel, M.D., 1979, Detection of a nuclear antigen in Herpesvirus ateles-carrying marmoset lines by the acid-fixed nuclear binding technique, Proc. Natl. Acad. Sci. U.S.A. 76:2042.

    Article  PubMed  CAS  Google Scholar 

  • Oie, H.K., Ablashi, D.V., Armstrong, G.R., Pearson, G.R., Orr, T., and Heine, U., 1973, A Continuous in vitro source of Herpesvirus saimiri, J. Natl. Cancer Inst. 51:1077.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., and Beneke, J.S., 1977, Inhibition of Herpesvirus saimiri replication by phos-phonoacetic acid, benzo(a)pyrene, and methylcholanthrene, Cancer Res. 37:42.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., and Davis, S., 1976, Immune response of monkeys to lymphotropic herpesvirus antigens, Cancer Res. 36:688.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., and Scott, R.E., 1977, Isolation of virus-free Herpesvirus saimiri antigen-positive plasma membrane vesicles, Proc. Natl. Acad. Sci. U.S.A. 14:2546.

    Article  Google Scholar 

  • Pearson, G.R., and Scott, R.E., 1978, Potential for immunization against herpesvirus infection with plasma membrane vesicles, in: Oncogenesis and Herpesviruses III, Part 2 (G. de Thé, W. Henle, and F. Rapp, eds.), pp. 1019–1025, IARC Press, Lyon.

    Google Scholar 

  • Pearson, G., Ablashi, D., Orr, T., Rabin, H., and Armstrong, G., 1972, Intracellular and membrane immunofluorescence investigations on cells infected with Herpesvirus saimiri, J. Natl. Cancer Inst. 49:1417.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., Orr, T., Rabin, H., Cicmanec, J., Ablashi, D., and Armstrong, G., 1973, Antibody patterns to Herpesvirus saimiri-induced antigens in owl monkeys, J. Natl. Cancer Inst. 51:1939.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., Rabin, H., Wallen, W.C., Neubauer, R.H., Orr, T.W., and Gicmanec, J.L., 1974, Immunological and virological investigations on owl monkeys infected with Herpesvirus saimiri, J. Med. Primatol. 3:54.

    PubMed  CAS  Google Scholar 

  • Periman, P., Tyrrell, S., and Rabson, A.S., 1972, Herpesvirus saimiri in marmoset-mouse hybrid Cell lines, J. Natl. Cancer Inst, 49:387.

    PubMed  CAS  Google Scholar 

  • Prevost, J.M., Orr, T.W., and Pearson, G.R., 1975, Augmentation of lymphocyte Cytotoxicity by antibody to Herpesvirus saimiri associated antigens, Proc. Natl. Acad. Sci. U.S.A. 72:1671.

    Article  PubMed  CAS  Google Scholar 

  • Prevost, J.M., Pearson, G.R., Wallen, W.C., Rabin, H., and Qualtière, L., 1976, Antibody responses to membrane antigens in monkeys infected with Herpesvirus saimiri, Int. J. Cancer 18:679.

    Article  PubMed  CAS  Google Scholar 

  • Qualtiere, L.F., and Pearson, G.R., 1978, Solubilization and Characterization of Herpesvirus saimiri induced membrane antigens, J. Virol. 25:852.

    CAS  Google Scholar 

  • Rabin, H., 1971, Assay and pathogenesis of oncogenic viruses in non-human primates, Lab. Anim. Sci. 21:1032.

    PubMed  Google Scholar 

  • Rabin, H., Pearson, G., Klein, G., Ablashi, D., Wallen, W., and Cicmanec, J., 1973, Herpesvirus saimiri antigens and virus recovery from Cultured cells and antibody levels and virus isolations from squirrel monkeys, Am. J. Phys. Anthropol. 38:491.

    Article  PubMed  CAS  Google Scholar 

  • Rabin, H., Neubauer, R.H., Pearson, G.R., Cicmanec, J.L., Wallen, W.C., Loeb, W.F., and Valerio, M.G., 1975a, Brief Communication: Spontaneous lymphoma associated with Herpesvirus saimiri in owl monkeys, J. Natl. Cancer Inst. 54:499.

    PubMed  CAS  Google Scholar 

  • Rabin, H., Pearson, G.R., Wallen, W.C., Neubauer, R.H., Cicmanec, J.L., and Orr, T.W., 1975b, Infection of Capuchin monkeys (Cebus albifrons) with Herpesvirus saimiri, J. Natl. Cancer Inst. 54:673.

    PubMed  CAS  Google Scholar 

  • Rabin, H., Adamson, R.H., Neubauer, R.H., Cicmanec, J.L., and Wallen, W.C., 1976, Pilot studies with human interferon in Herpesvirus saimiri-induced lymphoma in owl monkeys, Cancer Res. 36:715.

    PubMed  CAS  Google Scholar 

  • Rabin, H., Neubauer, R.H., Hopkins, R.F., and Nonoyama, M., 1978, Further Characterization of a herpesvirus-positive orangutan Cell line and Comparative aspects of in vitro transformation with lymphotropic Old World primate herpesviruses, Int. J. Cancer 21:762.

    Article  PubMed  CAS  Google Scholar 

  • Rabson, A.S., O’Connor, G.T., Lorenz, D.E., Kirschstein, R.L., Legallais, F.Y., and Tralka, T.S., 1971, Lymphoid Cell-culture line derived from lymph node of marmoset infected with Herpesvirus saimiri -preliminary report, J. Natl. Cancer Inst. 46:1099.

    PubMed  CAS  Google Scholar 

  • Randall, R.E., and Honess, R.W., 1980, Proteins of Herpesvirus saimiri: Identification of two virus polypeptides released into the Culture medium of productively infected cells, J. Gen. Virol. 51:445.

    Article  PubMed  CAS  Google Scholar 

  • Rangan, S.R.S., 1976, Brief Communication: Oncornavirus particles in lymphoid Cultures from a howler monkey with Herpesvirus saimiri-induced disease, J. Natl. Cancer Inst. 57(4):951.

    PubMed  CAS  Google Scholar 

  • Rangan, S.R.S., Martin, L.N., Enright, F.M., and Allen, W.P. 1976, Herpesvirus saimiri-induced malignant lymphoma in rabbits, J. Natl. Cancer Inst. 57:151.

    PubMed  CAS  Google Scholar 

  • Rangan, R.S., Martin, L.N., Enright, F., and Abee, C., 1977, Herpesvirus saimiri induced lymphoproliferative disease in howler monkeys, J. Natl. Cancer Inst. 59:165.

    PubMed  CAS  Google Scholar 

  • Roberts, R., 1980, Restriction and modification enzymes and their recognition sequences, Gene 8:329.

    Article  PubMed  CAS  Google Scholar 

  • Robinson, J.E., Andiman, W.A., Henderson, E., and Miller, G., 1977, Host-determined differences in expression of surface marker Characteristics on human and simian lymphoblastoid Cell lines transformed by Epstein-Barr virus, Proc. Natl. Acad. Sci. U.S.A. 74:749.

    Article  PubMed  CAS  Google Scholar 

  • Roizman, B., 1979, The organization of the herpes simplex virus genomes, in: Annual Review of Genetics, Vol. 13 (H.L. Roman, A. Campbell, and L.M. Sandler, eds.), pp. 25–57, Annual Reviews, Palo Alto, California.

    Google Scholar 

  • Roizman, B., and Buchman, T., 1979, The molecular epidemiology of herpes simplex virus, Hosp. Pract., Jan. 1979, p. 95.

    Google Scholar 

  • Roizman, B., and Furlong, D., 1974, The replication of herpes-viruses, in: Comprehensive Virology, Vol. 3 (H. Fraenkel-Conrat and R.R. Wagner, eds.), pp. 229–403, Plenum Press, New York.

    Google Scholar 

  • Schaffer, P.A., 1975, Genetics of herpesviruses—A review, in: Oncogenesis and Herpesviruses II, Part I (G. de Thé, M.A. Epstein, and H. zur Hausen, eds.), pp. 195–217, IARC Press, Lyon.

    Google Scholar 

  • Schaffer, P.A., Falk, L.A., and Deinhardt, F., 1975, Brief Communication: Attenuation of Herpesvirus saimiri for marmosets after successive passage in Cell Culture at 39°C, J. Natl. Cancer Inst. 55:1243.

    PubMed  CAS  Google Scholar 

  • Schlom, J., and Spiegelman, S., 1971, Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses, Science 174:840.

    Article  PubMed  CAS  Google Scholar 

  • Schlom, J., and Spiegelman, S., 1974, Breast Cancer: Molecular basis for virus etiology, N. Y. State J. Med. 74:1373.

    PubMed  CAS  Google Scholar 

  • Simonds, J.A., Rabey, W.G., Graham, B.J., Oie, H., and Vande Woude, G.F., 1975, Purification of Herpesvirus saimiri and properties of the viral DNA, Arch. Virol. 49:249.

    Article  PubMed  CAS  Google Scholar 

  • Smith, C., Heberling, R.L., Barker, S.T., and Kalter, S.S., 1979, Squirrel monkey retrovirus and Herpesvirus saimiri: Observation in the same Cell following isolation, J. Natl. Cancer Inst. 63:983.

    PubMed  CAS  Google Scholar 

  • Southern, E.M., 1975, Detection of specific sequences among DNA fragments separated by gel electrophoresis, J. Mol. Biol. 98:503.

    Article  PubMed  CAS  Google Scholar 

  • Sterz, H., Ludwig, H., and Rott, R., 1973–1974, Immunologic and genetic relationship between herpes simplex virus and bovine herpes mammillitis virus, Intervirology 2:1.

    Article  CAS  Google Scholar 

  • Sutter, D., and Doerfler, W., 1980, Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely Correlated with viral gene expression, Proc. Natl. Acad. Sci. U.S.A. 77:253.

    Article  PubMed  CAS  Google Scholar 

  • Todaro, G.J., Scherr, C.J., Sen, A., King, N., Daniel, M.D., and Fleckenstein, B., 1978, Endogenous New World primate type C viruses isolated from owl monkey (Aotus trivirgatus) kidney Cell line, Proc. Natl. Acad. Sci. U.S.A. 75:1004.

    Article  PubMed  CAS  Google Scholar 

  • Tracy, S., and Desrosiers, R.C., 1980, RNA from unique and repetitive DNA sequences of Herpesvirus saimiri, Virology 100:204.

    Article  PubMed  CAS  Google Scholar 

  • Tralka, T.S., Costa, J., and Rabson, A., 1977, Electron microscopic study of Herpesvirus saimiri, Virology 80:158.

    Article  PubMed  CAS  Google Scholar 

  • Ullman, J.S., and McCarthy, B.J., 1973, The relationship between mismatched base pairs and the thermal stability of DNA duplexes. II. Effects of deamination of Cytosine, Biochim. Biophys. Acta 294:416.

    PubMed  CAS  Google Scholar 

  • Van der Ploeg, L.H.T., and Flavell, R.A., 1980, DNA methylation in the human 70ß-globin locus in erythroid and non-erythroid tissues, Cell 19:947.

    Article  PubMed  Google Scholar 

  • Waalwijk, C., and Flavell, R.A., 1978, Msp I, an isoschizomer of Hpa II which Cleaves both unmethylated and methylated Hpa II sites, Nucleic Acids Res. 5(9):323.

    Article  Google Scholar 

  • Wallen, W.C., Neubauer, R.H., Rabin, H., and Cicmanec, J.L., 1973, Nonimmune rosette formation by lymphoma and leukemia cells from Herpesvirus saimiri-infected owl monkeys, J. Natl. Cancer Inst. 51:967.

    PubMed  CAS  Google Scholar 

  • Wallen, W.C., Neubauer, R.H., and Rabin, H., 1974, In vitro immunological Characteristics of lymphoid cells derived from owl monkeys infected with Herpesvirus saimiri, J. Med. Primatol. 3:41.

    PubMed  CAS  Google Scholar 

  • Wallen, W.C., Rabin, H., Neubauer, R.H., and Cicmanec, J.L., 1975a, Depression in lymphocyte response to general mitogens by owl monkeys infected with Herpesvirus saimiri, J. Natl. Cancer Inst. 54:679.

    PubMed  CAS  Google Scholar 

  • Wallen, W.C., Neubauer, R.H., and Rabin, H., 1975b, Evidence for suppressor Cell activity associated with induction of Herpesvirus saimiri-induced lymphoma, Clin. Exp. Immunol. 22:468.

    PubMed  CAS  Google Scholar 

  • Wallen, W.C., Pearson, G.R., Prevost, J.M., Neubauer, R.H., and Rabin, H., 1976, Correspondence between T Cell suppression and ADLC titers during Herpesvirus saimiri (HVS) infection in owl monkeys, Bibl. Haematol. 43:339.

    Google Scholar 

  • Werner, F.-J., Bornkamm, G.W., and Fleckenstein, B., 1977, Episomal viral DNA in a Herpesvirus saimiri-transformed lymphoid Cell line, J. Virol. 22:794.

    PubMed  CAS  Google Scholar 

  • Werner, F.-J., Desrosiers, R.C., Mulder, C., Bornkamm, G.W., and Fleckenstein, B., 1978, Physical mapping of viral episomes in Herpesvirus saimiri transformed lymphoid cells, in: Persistent Viruses, Vol. XI (J.G. Stevens, G.J. Todaro, and CF. Fox, eds.), pp. 189–200, Academic Press, New York.

    Google Scholar 

  • Wetmur, J.G., and Davidson, N., 1968, Kinetics of renaturation of DNA, J. Mol. Biol. 31:349.

    Article  PubMed  CAS  Google Scholar 

  • Wittek, R., Cooper, J.A., Barbosa, E., and Moss, B., 1980, Expression of the vaccinia virus genome: Analysis and mapping of mRNAs encoded within the inverted terminal repetition, Cell 21:487.

    Article  PubMed  CAS  Google Scholar 

  • Wolfe, L.G., Falk, L.A., and Deinhardt, F., 1971a, Oncogenicity of Herpesvirus saimiri in marmoset monkeys, J. Natl. Cancer Inst. 47:1145.

    PubMed  CAS  Google Scholar 

  • Wolfe, L.G., Marczynska, B., Rabin, H., Smith, R., Tischendorf, T., Gavitt, F., and Deinhardt, F., 1971b, Viral oncogenesis in nonhuman primates, in: Medical Primatology (E.I. Goldsmith and J. Moor-Jankowski, eds.), pp. 671–682, S. Karger, Basel.

    Google Scholar 

  • Wright, J., Falk, L.A., Collins, D., and Deinhardt, F., 1976, Brief Communication: Mononuclear Cell fraction Carrying Herpesvirus saimiri in persistently infected squirrel monkeys, J. Natl. Cancer Inst. 57:959.

    PubMed  CAS  Google Scholar 

  • Wright, J., Falk, L.A., Wolfe, L.G., Ogden, J., and Deinhardt, F., 1977, Susceptibility of Common marmosets (Callithrix jacchus) to oncogenic and attenuated strains of Herpesvirus saimiri, J. Natl. Cancer Inst. 59:1475.

    PubMed  CAS  Google Scholar 

  • Wright, J., Falk, L.A., Wolfe, L.G., and Deinhardt, F., 1980, Herpesvirus saimiri: Protective effect of attenuated strain against lymphoma induction, Int. J. Cancer 26:477.

    Article  PubMed  CAS  Google Scholar 

  • Yang, R.C., and Wu, R., 1979, BK virus DNA sequence: Extent of homology with Sv40 DNA, Proc. Natl. Acad. Sci. U.S.A. 76:1179.

    Article  PubMed  CAS  Google Scholar 

  • Yefenof, E., Klein, G., Jondal, M., and Oldstone, M.B.A., 1976, Surface markers on human B- and T-lymphocytes in two-color immunofluorescence studies on the association between EBV receptors and Complement receptors on the surface of lymphoid Cell lines, Int. J. Cancer 17:693.

    Article  PubMed  CAS  Google Scholar 

  • Youssoufian, H., and Mulder, C., 1981, Detection of methylated sequences in eukaryotic DNA with the restriction endonucleases Smal and Xmal, J. Mol. Biol. 150:133.

    Article  PubMed  CAS  Google Scholar 

  • Yoshida, M., Kawai, S., and Toyoshima, K., 1980, Uninfected avian cells Contain structurally unrelated progenitors of viral sarcoma genes, Nature (London) 287:653.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Klinische Virologie, University of Erlangen-Nürnberg, Loschgestrasse 7, D-8520, Erlangen, West Germany

    Bernhard Fleckenstein M.D.

  2. New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, 01772, Southborough, Massachusetts, USA

    Ronald C. Desrosiers Ph.D.

Authors
  1. Bernhard Fleckenstein M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald C. Desrosiers Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Chicago, Chicago, Illinois, USA

    Bernard Roizman

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Fleckenstein, B., Desrosiers, R.C. (1982). Herpesvirus saimiri and Herpesvirus ateles. In: Roizman, B. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4163-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4163-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4165-9

  • Online ISBN: 978-1-4684-4163-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation