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Epidemiology of Epstein—Barr Virus and Associated Diseases in Man

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Part of the book series: The Viruses ((VIRS))

Abstract

This definition includes two main areas: (1) descriptive epidemiology, covering the distribution of diseases in place and time; and (2) analytical epidemiology, aimed at characterizing possible causal factors.

To investigate the origins of diseases, one should first study the effects of the seasons, of the hot or cold winds, of the soil, naked or wooded, of the rains. Secondly, one will consider most attentively the way the inhabitants live, drink, eat, are indolent or active in exercise and labor.

Hippocrates (460–377 B.C.)

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References

  • Adatia, A.K., 1970, Dental aspects, in: Buikitt’s Lymphoma (D.P. Burkitt and D.H. Wright, eds.), pp. 34–42, Livingstone, Edinburgh and London.

    Google Scholar 

  • Addy, P.A., Ahiabor, T., Amane, C, and Pappoe, M.A., 1978, Jaundice and infectious mononucleosis in Ghana, Afr. J. Med. Sci. 7(2):85–92.

    CAS  Google Scholar 

  • Al-Attar, A., Al-Mondhiry, H., Al-Bahrani, Z., and Al-Saleem, T., 1979, Burkitt’s lymphoma in Iraq: Clinical and pathological study of 47 patients, Int. J. Cancel 23:14–17.

    Article  CAS  Google Scholar 

  • Allison, A.C., and Clyde, D.F., 1961, Malaria in African Children with deficient erythrocyte glucose-6-phosphate dehydrogenase, Br. Med. J. 1:1346–1349.

    Article  PubMed  CAS  Google Scholar 

  • American Joint Committee for Cancer Staging and End Results Reporting, 1976, Staging of Cancer at head and neck sites, in: Preliminary Handbook on Classification and Staging (Task Force on Head and Neck Sites, eds.), pp. 61–72, American Joint Committee, Chicago.

    Google Scholar 

  • Anderson, E.N., Jr., Anderson, M.L., and Ho, J.H.C., 1978, A study of the environmental backgrounds of young Chinese nasopharyngeal Carcinoma patients, 1978, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de-Thé and Y. Ito, eds.), pp. 231–239, IARC Scientific Publication No. 20, World Health Organization, Geneva.

    Google Scholar 

  • Andiman, W.A., 1979, The Epstein-Barr virus and EBV infection in Childhood, J. Pediatr. 95:171–182.

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, D., Henle, G., and Henle, W., 1966, Complement-fixation tests with Cell lines derived from Burkitt’s lymphoma and acute leukemias, J. Bacteiiol 91:1257–1262.

    CAS  Google Scholar 

  • Armstrong, R.W., Kannan-Kutty, M., and Armstrong, M.J., 1978, Self-specific environments associated with nasopharyngeal Carcinoma in Selangor, Malaysia, Soc. Sci. Med. 12:149–156.

    Article  PubMed  CAS  Google Scholar 

  • Arsenau, J.C., Canellos, G.P., Banks, P.M., Berard, CW., Granlick, H.R., and de-Vita, V.T., Jr., 1975, American Burkitt’s lymphoma: Clinicopathological study of thirty Cases. I. Clinical factors relating to prolonged survival, Am. J. Med. 58:314–321.

    Article  Google Scholar 

  • Bar, R.S., Delor, C.J., Clausen, K.P., Hurtubise, P., Henle, W., and Hewetson, J.F., 1974, Fatal infectious mononucleosis in a family, N. Engl. J. Med. 290:363–367.

    Article  PubMed  CAS  Google Scholar 

  • Baron, D., Benz, W.C., Carmichael, G., Yocum, R.R., and Strominger, J.L., 1975, Assay and partial purification of Epstein-Barr nuclear antigen, in: Proceedings of the International Workshop on the Production, Concentration and Purification of Epstein-Barr Virus, pp. 257–262, IARC Press, Lyon.

    Google Scholar 

  • Bender, C.E., 1962, Recurrent mononucleosis, J. Am. Med. Assoc. 182:954–956.

    Article  CAS  Google Scholar 

  • Berard, C., O’Conor, G.T., Thomas, L.B., and Torloni, H., 1969, Histopathological definition of Burkitt’s tumor, Bull. WHO 40:601–607.

    Google Scholar 

  • Beremblum, I., 1940, The mechanisms of Carcinogenesis: A study of the significance of Cocarcinogenic action and related phenomena, Cancer Res. 1:807.

    Google Scholar 

  • Beremblum, I., 1978, Historical perspectives, in: CarcinogenesisA Comprehensive Survey, Vol. 2 (T.J. Slaga, A. Sivak, and R.K. Boutwell, eds.), p. 1, Raven Press, New York.

    Google Scholar 

  • Berger, R., Bernheim, A., Fellous, M., and Brouet, J.C., 1979a, Cytogenetic study of a,European Burkitt’s lymphoma Cell line, J. Natl. Cancer Inst. 62:1187–1192.

    PubMed  CAS  Google Scholar 

  • Berger, R., Bernheim, A., Weh, H.J., Flandrin G., Daniel, M.T., Brouet, J.C., and Colbert, N., 1979b, A new translocation in Burkitt tumor cells, Hum. Genet. 53:111–112.

    Article  PubMed  CAS  Google Scholar 

  • Berger, T., Bernheim, A., Flandrin, G., Daniel, M.T., Schaison, G., Brouet, J.C., and Bernard, J., 1979c, Translocation t(8; 14) dans la leucémie lymphoblastique de type Burkitt, Nouv. Presse Med. 8(3):181–183.

    PubMed  CAS  Google Scholar 

  • Bernheim, A., Berger, R., and Lenoir, G., 1981, Cytogenetic studies on African Burkitt’s lymphoma Cell lines: t(8;14), t(2;8) and t(8;22) translocations, Cancer Genet. Cytogenet. 3:307–315.

    Article  PubMed  CAS  Google Scholar 

  • Betuel, H., Cammoun, M., Colombani, J., Day, N., Ellouz, R., and de Thé, G., 1975, The relationship between nasopharyngeal Carcinoma and the HL-A system among Tunisians, Int. J. Cancer 16:249–254.

    Article  PubMed  CAS  Google Scholar 

  • Biggar, R.J., and Nkrumah, F.K., 1979, Burkitt’s lymphoma in Ghana: Urban rural distribution, time-space Clustering and seasonality, Int. J. Cancer 23:330–336.

    Article  PubMed  CAS  Google Scholar 

  • Biggar, R.J., Henle, W., Fleisher, G., Bocker, J., Lennette, E.T., and Henle, G., 1978a, Primary Epstein-Barr virus infection in African infants. I. Decline of maternal antibodies and time of infection, Int. J. Cancer 22:239–243.

    Article  PubMed  CAS  Google Scholar 

  • Biggar, R.J., Henle, G., Bocker, S., Lennette, E.T., Fleisher, G., and Henle, W., 1978b, Primary Epstein-Barr virus infection in African infants. II. Clinical and serological observations during seroconversion, Int. J. Cancer 22:244–250.

    Article  PubMed  CAS  Google Scholar 

  • Black, F.L., Woodall, J.P., Evans, A.S., Liebhaber, H., and Henle, G., 1970, Prevalence of antibody against viruses in Tiriyo, an isolated Amazon tribe, Am. J. Epidemiol, 91:430–438.

    PubMed  CAS  Google Scholar 

  • Blot, W.J., Lanier, A., and Fraumeni, J.F., Jr., 1975, Cancer mortality among Alaskan natives, 1960–1969, J. Natl. Cancer Inst. 55:547–554.

    PubMed  CAS  Google Scholar 

  • Bornkamm, G.W., Stein, H., Lennert, K., Rüggeberg, F., Bartels, H., and Zur Hausen, H., 1976, Attempts to demonstrate virus-specific sequences in human tumors. IV. EB viral DNA in European Burkitt’s lymphoma and immunoblastic lymphadenopathy with excessive plasmocytosis, Int. J. Cancer 17:177–181.

    Article  PubMed  CAS  Google Scholar 

  • Britton, S., Andersson-Anvret, M, Gergely, P., Henle, W., Jonal, M., Klein, G., Sandstedt, B., and Svedmyr, E., 1978, Epstein-Barr virus immunity and tissue distribution in a fatal Case of infectious mononucleosis, N. Engl. J. Med. 298:89–92.

    Article  PubMed  CAS  Google Scholar 

  • Brown, T.D.K., Ernberg, I., Lamon, E.W., and Klein, G., 1974, Detection of Epstein-Barr virus (EBV)-associated nuclear antigen in human lymphoblastoid Cell lines by means of an I125-IgG-binding assay, Int. J. Cancer 13:784–794.

    Article  Google Scholar 

  • Brubaker, G., Geser, A., and Pike, M.C., 1973, Burkitt’s lymphoma in the North Mara district of Tanzania, 1964–1970: Failure to find evidence of space-time Clustering in a high risk isolated rural area, Br. J. Cancer 28:469–472.

    Article  PubMed  CAS  Google Scholar 

  • Burchenal, J.H., 1966, Geographical Chemotherapy, Burkitt’s tumor as stalking horse for leukemia: Presidential address, Cancer Res. 26:2393–2405.

    PubMed  CAS  Google Scholar 

  • Burkitt, D., 1958, A sarcoma involving the jaws in African Children, Br. J. Surg. 46:218.

    Article  PubMed  CAS  Google Scholar 

  • Burkitt, D.P., 1962a, A Children’s Cancer dependent on Climatic factors, Nature (London) 194:232–234.

    Article  CAS  Google Scholar 

  • Burkitt, D.P., 1962b, A “tumor safari” in East and Central Africa, Br. J. Cancer 16:379–386.

    Article  PubMed  CAS  Google Scholar 

  • Burkitt, D.P., 1967, Burkitt’s lymphoma outside the known endemic area of Africa and New Guinea, Int. J. Cancer 2:562–565.

    Article  PubMed  CAS  Google Scholar 

  • Burkitt, D.P., 1969, Etiology of Burkitt’s lymphoma: An alternative to a vectored virus, J. Natl. Cancer. Inst. 42:19–28.

    PubMed  CAS  Google Scholar 

  • Burkitt, D.P., 1970, Geographical distribution, in: Burkitt’s Lymphoma (D.P. Burkitt and D.H. Wright, eds.), pp. 186–197, Livingstone, Edinburgh and London.

    Google Scholar 

  • Burkitt, D.P., and Wright, D.H., 1966, Geographical and tribal distribution of the African lymphoma in Uganda, Br. Med.J. 5487:569–573.

    Article  Google Scholar 

  • Cammoun, M., Vogt-Hoerner, G., and Mourali, N., 1971, Les tumeurs du naso-pharynx en Tunisie: Etude anatomo-clinique de 143 observations, Tunis. Med. 49(3): 131–141.

    Google Scholar 

  • Carter, R.L., and Penman, H.G., 1969, Infectious Mononucleosis, Blackwell, Oxford.

    Google Scholar 

  • Carvalho, R.P.S., Evans, A.D., Forst, P., Dalldorf, G., Camargo, M.F., and Jamra, M., 1973, EBV infections in Brazil. I. Occurrence in normal persons, in lymphomas and in leukemias, Int. J. Cancer 11:191–201.

    CAS  Google Scholar 

  • Chan, S.H., Day, N.E., Khor, T.H., Kunaratnam, N., and Chia, K.B., HLA markers in the development and prognosis of NPC in Chinese, in: Cancer Campaign, Vol. 5, Nasopharyngeal Carcinoma (E. Grundmann, G.R.F. Krueger, and D.V. Ablashi, eds.) pp. 205–211, Gustav Fisher Verlag, Berlin.

    Google Scholar 

  • Chang, R.S., Lewis, J.S., Reynolds, R.D., Sullivan, M.J., and Neuman, J., 1978, Oropharyngeal excretion of Epstein-Barr virus by patients with lymphoproliferative disorders and by recipients of renal homografts, Ann. Intern. Med. 88:111–123.

    Google Scholar 

  • Chang, R.S., Char, D.F., Jones, J.H., and Halstead, S.B., 1979, Incidence of infectious mononucleosis at the Universities of California and Hawaii, J. Infect. Dis. 140(4):479–86.

    Article  PubMed  CAS  Google Scholar 

  • Cheeseman, S.H., Henle, W., Rubin, R.H., Tolkoff-Rubin, N.E., Cosimi, B., Cantell, K., Winkle, S., Herrin, J.T., Black, P.H., Russell, P.S., and Hirsch, M.S., 1980, Epstein-Barr virus infection in renal transplant recipients: Effects of antithymocyte globulin and interferon, Ann. Intern. Med. 93:39–42.

    PubMed  CAS  Google Scholar 

  • Clifford, P., 1970a, A review on the epidemiology of nasopharyngeal Carcinoma, Int. J. Cancer 5:287–309.

    Article  PubMed  CAS  Google Scholar 

  • Clifford, P., 1970b, Treatment, in: Burkitt’s lymphoma (D.P. Burkitt and D.H. Wright, eds.), pp. 52–63, Livingstone, Edinburg and London.

    Google Scholar 

  • Collected reports of Cases of Burkitt’s lymphoma from Countries outside the endemic areas, 1967, Int. J. Cancer 2:559–609.

    Article  Google Scholar 

  • Connelly, R.R., and Christine, B.W., 1974, A Cohort study of Cancer following infectious mononucleosis, Cancer Res. 34:1172–1178.

    PubMed  CAS  Google Scholar 

  • Crawford, D.H., Epstein, M.A., Achong, B.G., Finerty, S., Newman, J., Liversedge, S., Tedder, R.S., and Steward, J.W., 1979, Virological and immunological studies on a fatal Case of infectious mononucleosis, J. Infection 1:37–48.

    Article  Google Scholar 

  • Crawford, D.H., Thomas, J.A., Janossy, G., Sweny, P., Fernando, O.N., Moorhead, J.F., and Thompson, J.H., 1980, Epstein-Barr virus nuclear antigen positive lymphoma after cyclosporin-A treatment in patient with renal allograft, Lancet: 1355–1356.

    Google Scholar 

  • Dalldorf, G., Linsell, C.A., Barnhart, F.E., and Martyn, R., 1964, An epidemiological approach to the lymphomas of African Children and Burkitt’s sarcoma of the jaws, Verspect. Biol. Med. 7:435–449.

    CAS  Google Scholar 

  • Dambaugh, T., Nkrumah, F.K., Biggar, R.J., and Kieff, E., 1979, Epstein-Barr virus RNA in Burkitt’s tumor tissue, Cell 16:313–322.

    Article  PubMed  CAS  Google Scholar 

  • Dameshek, W., 1969, Speculations on the nature of infectious mononucleosis, in: Infectious Mononucleosis (R.L. Carter and H.G. Penman, eds.), pp. 225–240, Blackwell, London.

    Google Scholar 

  • Davidsohn, I., and Nelson, D.A., 1969, The blood, in: Todd-Sanfoid’s Clinical Diagnosis by Laboratory Methods, 14th ed. (I. Davidsohn and J.B. Henry, eds.), Chapt. 5, W.B. Saunders, Philadelphia.

    Google Scholar 

  • De Schryver, A., Friberg, S., Klein, G., Henle, W., Henle, G., de Thé, G., Clifford, P., and Ho, J.H.C., 1969, Epstein-Barr virus-associated antibody patterns in Carcinoma of the post-nasal space, Clin. Exp. Immunol. 5:443–459.

    PubMed  Google Scholar 

  • Desgranges, C., and de-Thé, G., 1977, Epstein-Barr virus induces viral nuclear antigen in nasopharyngeal epithelial cells, Lancet 2:1286–1287.

    Article  PubMed  CAS  Google Scholar 

  • Desgranges, C., and de-Thé, G., 1978a, Presence of EBV-specific IgA in saliva of nasopharyngeal Carcinoma (NPC) patients: Their activity, origin and possible Clinical value, in: Nasopharyngeal Carcinoma (G. de Thé and Y. Ito, eds.), pp. 459–469, IARC Scientific Publication No. 20, World Health Organization, Geneva.

    Google Scholar 

  • Desgranges, C., and de-Thé, G., 1978b, IgA and nasopharyngeal Carcinoma, in: Oncogenesis and Herpesviruses III (G. de Thé, Y. Ito, and F. Rapp, eds.), pp. 883–891, IARC Scientific Publication No. 25, Lyon.

    Google Scholar 

  • Desgranges, C., Wolf, H., de-Thé, G., Shanmugaratnam, K., Ellouz, R., Cammoun, N., Klein, G., and Zur Hausen, H., 1975a, Nasopharyngeal Carcinoma. X. Presence of Epstein-Barr genomes in epithelial cells of tumors from high and medium risk areas, Int. J. Cancer 16:7–15.

    Article  PubMed  CAS  Google Scholar 

  • Desgranges, C., Wolf, H., Zur Hausen, H., and de-Thé, G., 1975b, Further studies on the detection of the Epstein-Barr viral DNA on nasopharyngeal Carcinoma biopsies from different parts of the world, in: Oncogenesis and Herpesviruses II, Vol. 2 (G. de Thé, M.A. Epstein, and H. Zur Hausen, eds.), pp. 191–193, IARC Scientific Publication No 11, Lyon.

    Google Scholar 

  • Desgranges, C., de-Thé, G., Ho, J.H.C., and Ellouz, R., 1977a, Neutralizing EBV-specific IgA in throat washings of nasopharyngeal Carcinoma (NPC) patients, Int. J. Cancer 19:627–633.

    Article  PubMed  CAS  Google Scholar 

  • Desgranges, C., Li, J.Y., and de-Thé, G., 1977b, EBV specific secretory IgA in saliva of NPC patients: Presence of secretory piece in epithelial malignant cells, Int. J. Cancer 20:881–886.

    Article  PubMed  CAS  Google Scholar 

  • Desgranges, C., Bornhamm, G.W., Zeng, Y., Wang, P.C., Zhu, J.S., Shang, H., and de-Thé, G., 1982, Detection of Epstein-Barr viral DNA in the nasopharyngeal mucosa of Chinese with IgA/EBV-specific antibodies, Int. J. Cancer 29:187–191.

    Article  Google Scholar 

  • de-Thé, G., 1977, Is Burkitt’s lymphoma related to a perinatal infection by Epstein-Barr virus?, Lancet 1:335–338.

    Article  PubMed  Google Scholar 

  • de-Thé, G., 1978a, Epstein-Barr virus: Is it timely to discuss a vaccine?, Biomedicine 28:15–17.

    Google Scholar 

  • de-Thé, G., 1978b, Events early in life and risk to develop Burkitt’s lymphoma—Role of neonatal Epstein-Barr virus infection and heavy malaria burden, in: Tumors of Early Life in Man and Animals (L. Severi, ed.), pp. 225–231, Institute of Pathological Anatomy and Histology, Perugia.

    Google Scholar 

  • de-Thé, G., 1979, The epidemiology of Burkitt’s lymphoma: Evidence for a Causal relationship with Epstein-Barr virus, Am. J. Epidemiol. 1:32–54.

    Google Scholar 

  • de-Thé, G., 1980a, The role of the Epstein-Barr virus in human diseases: Infectious mononucleosis (IM), Burkitt’s lymphoma (BL) and nasopharyngeal Carcinoma (NPC), in: Viral Oncology (G. Klein, ed.), pp. 769–797, Raven Press, New York.

    Google Scholar 

  • de-Thé, G., 1980b, Multistep Carcinogenesis, Epstein-Barr virus and human malignancies: Viruses in naturally occurring Cancers, Cold Spring Harbor Conf. Cell Prolif. 7:11–21.

    Google Scholar 

  • de-Thé, G., 1981, The Chinese epidemiological approach of nasopharyngeal Carcinoma research and Control in China, Yale J. Biol. Med. 54:33–39.

    PubMed  Google Scholar 

  • de-Thé, G., and Lenoir, G., 1977, Comparative diagnosis of Epstein-Barr virus related diseases: Infectious mononucleosis, Burkitt’s lymphoma and nasopharyngeal Carcinoma, in: Comparative Diagnosis of Viral Diseases (E. Kurstak, ed.), pp. 196–241, Academic Press, New York.

    Google Scholar 

  • de-Thé, G., and Zeng, Y., 1982, Epidemiology of EBV: Recent results on endemic versus nonendemic BL and EBV related pre-NPC Conditions, in Advances in Comparative Leukemia Research (D. Yohn and J.R. Blakeslee, eds.), pp. 3–15, Elsevier/North Holland, New York.

    Google Scholar 

  • de-Thé, G., Ablashi, D.V., Liabeuf, A., and Mourali, N., 1973a, Nasopharyngeal Carcinoma (NPC). VI. Presence of an EBV nuclear antigen in fresh tumor biopsies: Preliminary results, Biomedicine 19:349–352.

    PubMed  Google Scholar 

  • de-Thé, G., Sohier, R., Ho, J.H.C., and Freund, R.J., 1973b, Nasopharyngeal Carcinoma. IV. Evolution of Complement-fixing antibodies during the Course of the disease, Int. J. Cancer 12:368–377.

    Article  PubMed  Google Scholar 

  • de-Thé, G., Ho, J.H.C., Ablashi, D.V., Day, N.E., Macario, A.J.L., Martin-Bertholon, M.C., Pearson, G., and Sohier, R., 1975a, Nasopharyngeal Carcinoma. IX. Antibodies to EBNA and Correlation with response to other EBV antigens in Chinese patients, Int. J. Cancer 16:713–721.

    Article  PubMed  Google Scholar 

  • de-Thé, G., Day, N.E., Geser, A., Lavoué, M.F., Ho, J.H.C., Simons, M.J., Sohier, R., Tukei, P., Vonka, V., and Zavadova, H., 1975b, Sero-epidemiology of the Epstein-Barr virus—Preliminary analysis of an international study, in: Oncogenesis and Herpesviruses II, Vol. 2 (G. de Thé, M.A. Epstein, and H. Zur Hausen, eds.), pp. 3–16, IARC Scientific Publication No. 11, Lyon.

    Google Scholar 

  • de-Thé, G., Vuillaume, M., Giovanella, B.C., and Klein, G., 1976, Epithelial Characteristics of tumor cells in nasopharyngeal Carcinoma (NPC) passaged in nude mice—an ultrastructural study, J. Natl. Cancer Inst. 57:1101–1105.

    PubMed  Google Scholar 

  • de-Thé, G., Geser, A., Day, N.E., Tukei, P.M., Williams, E.H., Beri, D.P., Smith, P.G., Dean, A.G., Bornkamm, G.W., Feorino, P., and Henle, W., 1978a, Epidemiological evidence for a Causal relationship between Epstein-Barr virus and Burkitt’s lymphoma: Results of the Ugandan prospective study, Nature (London) 274:756–761.

    Article  Google Scholar 

  • de-Thé, G., Lavoué, M.F., and Muenz, L., 1978b, Differences in EBV antibody titers of patients with nasopharyngeal Carcinoma originating from high, intermediate and low incidence areas, in: Nasopharyngeal Carcinoma: Etiology and Control (G. De Thé and Y. Ito, eds.), pp. 471–481, IARC Press, Lyon.

    Google Scholar 

  • de-Thé, G., Desgranges, C., Zeng, Y., Wang, P.C., Bornkamm, G.W., Zhu, J.S., and Shang, M., 1981, Search for pre-cancerous lesions and EBV markers in the nasopharynx of IgA positive individuals, in: Cancer Campaign, Vol. 5, Nasopharyngeal Carcinoma (E. Grundmann, G.R.F. Krueger and D.V. Ablashi eds.), pp. 111–117, Gustav Fischer, Stuttgart.

    Google Scholar 

  • Diehl, V., Henle, W., and Kohn, G., 1968, Demonstration of a herpes group virus in Cultures of peripheral leukocytes from patients with infectious mononucleosis, J. Virol. 2:663–669.

    PubMed  CAS  Google Scholar 

  • Durand-Fardel, 1837, Cancer du pharynx—ossification dans la substance musculaire du coeur, Bull. Soc. Anat. (Paris) 12:73–80.

    Google Scholar 

  • Ellouz, R., Cammoun, M., Ben-Altia, R., andBahi, J., 1978, NPC in Children and adolescents in Tunisia: Clinical aspects and paraneoplastic syndrome, in: Etiology and Control (G. de-Thé and Y. Ito, eds.), pp. 115–129, IARC Scientific Publication No. 20, Lyon.

    Google Scholar 

  • Epstein, M.A., 1976, Implications of a vaccine for the prevention of Epstein-Barr virus infection: Ethical and logistic Considerations, Cancer Res. 36:711–714.

    PubMed  CAS  Google Scholar 

  • Epstein, M.A., 1981, What we Could do with an EBV vaccine, Lancet 1:759–761.

    Google Scholar 

  • Epstein, M.A., Achong, B.G., and Barr, Y.M., 1964, Virus particles in Cultured lymphoblasts from Burkitt’s lymphoma, Lan Cet 1:702–703.

    CAS  Google Scholar 

  • Epstein, M.A., Hunt, R.D., and Rabin, H., 1973, Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). I. Reticuloproliferative disease in an inoculated animal, Int. J. Cancer 12:309–318.

    Article  PubMed  CAS  Google Scholar 

  • Evans, A.S., 1974, New discoveries in infectious mononucleosis, Mod. Med. 1:18–24.

    Google Scholar 

  • Evans, A.S., 1978, Infectious mononucleosis and related syndromes, IARC (Int. Agency Res. Cancer) Sci. Publ. 20:591–606.

    Google Scholar 

  • Evans, A.S., and Campos, L.E., 1971, Acute respiratory diseases in students at the University of the Philippines, Bull. WHO 45:103–112.

    PubMed  CAS  Google Scholar 

  • Evans, A.S., and Niederman, J.C., 1976, Epstein-Barr virus, in: Viral Infections of Humans: Epidemiology and Control (A.S. Evans, ed.), pp. 209–234, Plenum Press, New York.

    Chapter  Google Scholar 

  • Evans, A.S., Niederman, J.C., and McCollum, R.W., 1968, Seroepidemiological studies of infectious mononucleosis with EB virus, N. Engl. J. Med. 297:1121–1127.

    Article  Google Scholar 

  • Fialkow, P.J., Klein, G., Gartier, S.M., and Clifford, P., 1970, Clonal origin for individual Burkitt tumors, Lancet 1:384–386.

    Article  PubMed  CAS  Google Scholar 

  • Fong, Y.Y., and Chan, W.C., 1973, Bacterial production of di-methyl nitrosamine in salted fish, Nature (London) 243:421–423.

    Article  CAS  Google Scholar 

  • Fong, Y.Y., and Walsh, E.O., 1971, Carcinogenic nitrosamines in Cantonese salt-dried fish, Lancet 1:1032.

    Article  Google Scholar 

  • Fraumeni, J.F., Jr., and Mason, T.J., 1974, Cancer mortality among Chinese Americans, 1950–1969, J. Natl. Cancer Inst. 52:659–665.

    PubMed  Google Scholar 

  • Gazzolo, L., de-Thé, G., and Vuillaume, M., 1972, Nasopharyngeal Carcinoma. II. Ultra-structure of normal mucosa tumor biopsies and subsequent epithelial growth in vitro,J. Natl. Cancer Inst. 48:73–86.

    PubMed  CAS  Google Scholar 

  • Gerber, P., 1972, Activation of Epstein-Barr virus by 5-bromo-deoxyuridine in virus free human cells. Proc. Natl. Acad. Sci. U.S.A. 69:83–85.

    Article  PubMed  CAS  Google Scholar 

  • Gerber, P., and Deal, D.R., 1970, Epstein-Barr virus-induced viral and soluble Complement-fixing antigens in Burkitt’s lymphoma Cell Cultures, Proc. Soc. Exp. Biol. Med. 134:748–751.

    PubMed  CAS  Google Scholar 

  • Gerber, P., Purcell, R.H., Rosenblüm, E.N., and Walsh, J.H., 1969, Association of EB-virus infection with the post-perfusion syndrome, Lancet 1:593–596.

    Article  PubMed  CAS  Google Scholar 

  • Gerber, P., Goldstein, L.L., Lucas, S., Nonoyama, M., and Perlin, E., 1972, Oral excretion of Epstein-Barr viruses by healthy subjects and patients with infectious mononucleosis, Lancet 2:988–989.

    Article  PubMed  CAS  Google Scholar 

  • Geser, A., and de-Thé, G., 1972, Does the Epstein-Barr virus play an etiological role in Burkitt’s lymphoma?, in: Oncogenesis and Herpesviruses (V.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 372–375, IARC Scientific Publication No. 2, Lyon.

    Google Scholar 

  • Geser, A., Charnay, N., Day, N.E., de-Thé, G., and Ho, J.H.C., 1978, Environmental factors in the etiology of nasopharyngeal Carcinoma: Report on a Case-control study in Hongkong, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de Thé and Y. Ito, eds.), pp. 213–229, IARC Scientific Publication No. 20, Lyon.

    Google Scholar 

  • Geser, A., de-Thé, G., Lenoir, G., Day, N.E., and Williams, E.H., 1982, Final Case reporting from the Ugandan prospective study of the relationship between EBV and Burkitt’s lymphoma. Int. J. Cancer 29:397–400.

    Article  PubMed  CAS  Google Scholar 

  • Glaser, R., and Nonoyama, M., 1974, Host Cell regulation of induction of Epstein-Barr virus, J. Virol. 14:174–176.

    PubMed  CAS  Google Scholar 

  • Glaser, R., and Rapp, F., 1972, Rescue of Epstein-Barr virus from somatic Cell hybrids of Burkitt lymphoblastoid cells, J. Virol. 10:288–296.

    PubMed  CAS  Google Scholar 

  • Glaser, R., de-Thé, G., Lenoir, G., and Ho, J.H.C., 1976, Superinfection of nasopharyngeal Carcinoma epithelial tumor cells with Epstein-Barr virus, Proc. Natl. Acad. Sci. U.S.A. 73:960–963.

    Article  PubMed  CAS  Google Scholar 

  • Goldblum, N., Ben-Bassat, H., Mitrani, S., Andersson-Anvret, M., Goldblum, T., Aghai, E., Ramot, B., and Klein, G., 1977, A Case of an Epstein Barr virus genome-carrying lymphoma in an Israeli-Arab Child, Eur. J. Cancer 13:693–698.

    PubMed  CAS  Google Scholar 

  • Goldstein, G., Klein, G., Pearson, G., and Clifford, P., 1969, Direct membrane immunofluorescence reaction of Burkitt’s lymphoma cells in culture, Cancer Res. 29:749–752.

    PubMed  CAS  Google Scholar 

  • Granlund, D.J., and Andrese, A.P., 1977, Detection of Epstein-Barr virus antigen with enzyme-conjugated antibody, Int. J. Cancer 20:495–499.

    Article  PubMed  CAS  Google Scholar 

  • Gravell, M.; Levine, P.H., Mclntyre, R.F., Land, V.J., and Pagano, J.S., 1976, EBV in an American patient with Burkitt’s lymphoma: Detection of viral genome in tumor tissue and establishment of a tumor derived Cell line, J. Natl. Cancer Inst. 56:701.

    PubMed  CAS  Google Scholar 

  • Greene, M.H., Fraumeni, J.F., Jr., and Hoover, R., 1977, Nasopharyngeal Cancer among youths in United States: Racial variations by Cell type, J. Natl. Cancel Inst. 58:1267–1270.

    CAS  Google Scholar 

  • Greenwood, B.M., and Vick, R., 1975, Evidence for a malaria mitogen in human malaria, Nature (London) 257:592.

    Article  CAS  Google Scholar 

  • Greenwood, B.M., Oduloju, A.J., and Platts-Mill, T.A.E., 1979, Partial Characterization of a malaria mitogen, Trans. R. Soc. Trop. Med. Hyg. 73:178.

    Article  PubMed  CAS  Google Scholar 

  • Gresser, I., and Tovey, M., 1978, Anti-tumor effects of interferon, Biochim. Biophys. Acta 516:231–247.

    PubMed  CAS  Google Scholar 

  • Grose, C., and Feorino, P.M., 1972, Epstein-Barr virus and Guillain-Barré syndrome, Lancet 1:1285–1287.

    Article  Google Scholar 

  • Gross, L., 1970, Oncogenic Viruses, Pergamon Press, Oxford,

    Google Scholar 

  • Gu, S.Y., and Zeng, Y., 1978, Complement fixing antibody levels in sera from population groups in Kwangchow and in Peking, Chin. J. ENT, 1:23–25.

    Google Scholar 

  • Hallee, T.J., Evans, A.S., Niederman, J.C., Brooks, C.M., and Voegtly, J.H., 1974, Infectious mononucleosis as the U.S. Military Academy: A prospective study of a single Class over four years, Yale J. Biol. Med. 47:182–195.

    PubMed  CAS  Google Scholar 

  • Hampar, B., Derge, J.G., Martos, L.M., and Walker, J.L., 1972, Synthesis of Epstein-Barr virus after the activation of the viral genome in a virus negative human lymphoblastoid cell (Raji) made resistant to five bromodeoxyuridine, Troc. Natl. Acad. Sci. U.S.A. 69:78–82.

    Article  CAS  Google Scholar 

  • Harada, M., Pearson, G., Redmon, L., Winters, E., and Kasuga, S., 1975, Antibody production and interaction with lymphoid cells in relation to tumor immunity in the Moloney sarcoma virus system, J. Immunol. 114:1318–1322.

    PubMed  CAS  Google Scholar 

  • Hawkins, B.R., Simons, M.J., Goh, E.H., Chia, K.B., and Shanmugaratnam, K., 1974, Immunogenetic aspects of nasopharyngeal Carcinoma. II. Analysis of ABO, rhesus and MNS’s red Cell systems, Int. J. Cancer 13:116–121.

    Article  PubMed  CAS  Google Scholar 

  • Heath, C.W., Brodsky, A.L., and Potolsky, A.I., 1972, Infectious mononucleosis in general population, Am. J. Epidemiol. 95:46–52.

    PubMed  Google Scholar 

  • Hehlmann, R., Walther, B., Zöllner, N., Wolf, H., and Deinhardt, F., 1980, Infectious mononucleosis and acute monocytic leukaemia, Lancet:652–653.

    Google Scholar 

  • Henderson, B.E., Louie, E., Jing, J.S.H., Buell, P., and Gardner, M.B., 1976, Risk factors associated with nasopharyngeal Carcinoma, N. Engl. J. Med. 295:1101–1106.

    Article  PubMed  CAS  Google Scholar 

  • Henle, G., and Henle, W., 1976, Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal Carcinoma, Int. J. Cancer 17:1–7.

    Article  PubMed  CAS  Google Scholar 

  • Henle, G., Henle, W., and Diehl, V., 1968, Relation of Burkitt tumor associated herpes-type virus to infectious mononucleosis, Proc. Natl. Acad. Sci. U.S.A. 59:94–101.

    Article  PubMed  CAS  Google Scholar 

  • Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G.W., Kirya, B.G., Klein, G., Morrow, R.H., Munube, G.M.R., Pike, P., Tukei, P.M., and Ziegler, J.L. 1969, Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and Control groups, J. Natl. Cancer Inst. 43:1147–1157.

    PubMed  CAS  Google Scholar 

  • Henle, G., Henle, W., Klein, G., Gunren, P., Clifford, P., Morrow, R., and Ziegler, J., 1971, Antibodies to early Epstein-Barr virus induced antigens in Burktt’s lymphoma, J. Natl. Cancer Inst. 46:861–871.

    PubMed  CAS  Google Scholar 

  • Henle, G., Henle, W., and Horwitz, C.A., 1974, Antibodies to Epstein-Barr virus-associated nuclear antigen in infectious mononucleosis, J. Infect. Dis. 130:231–239.

    Article  PubMed  Google Scholar 

  • Henle, W., Henle, G., Harrison, F.S., Joyner, C.R., Klemola, E., Paloheimo, J., Scriba, M., and Von Essen, F., 1968, Antibody responses to the Epstein-Barr virus and Cytomegaloviruses after open-heart and other surgery, N. Engl. J. Med. 282:1068–1074.

    Article  Google Scholar 

  • Henle, W., Henle, G., Burtin, P., Cachin, Y., Clifford, P., de Schryver, A., de Thé, G., Diehl, V., Ho, J.H.C., and Klein, G., 1970a, Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms and Control groups, J. Natl. Cancer. Inst. 44:225–231.

    PubMed  CAS  Google Scholar 

  • Henle, W., Henle, G., Zajac, B.A., Pearson, G., Waubke, R., and Scriba, M., 1970b, Differential reactivity of human serums with early antigens induced by Epstein-Barr virus, Science 169:188–190.

    Article  PubMed  CAS  Google Scholar 

  • Henle, W., Ho, J.H.C., Henle, G., and Kwan, H.C., 1973, Antibodies to Epstein-Barr virus related antigens in nasopharyngeal Carcinoma: Comparison of active Cases and long term survivors, J. Natl. Cancer Inst. 51:361–369.

    PubMed  CAS  Google Scholar 

  • Henle, W., Ho, J.H.C., Henle, G., Chan, J.C.W., and Kwan, H.C., 1977, Nasopharyngeal carcinoma: Significance of Changes in Epstein-Barr virus related antibody patterns following therapy, Int. J. Cancer 20:663–672.

    Article  PubMed  CAS  Google Scholar 

  • Hewetson, J.F., Gothoskar, B., and Klein, G., 1972, Radioiodine-labelled antibody test for the detection of membrane antigens associated with Epstein-Barr virus, J. Natl. Cancer Inst. 48:87–94.

    PubMed  CAS  Google Scholar 

  • Hirayama, T., 1978, Descriptive and analytical epidemiology of nasopharyngeal Cancer, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de Thé and Y. Ito, eds.), pp. 167–190, IARC, Lyon.

    Google Scholar 

  • Hirshaut, Y., Cohen, M.H., and Stevens, D.A., 1973, Epstein-Barr virus antibodies in African and American Burkitt’s lymphomas, Lancet 1:114–116.

    Article  Google Scholar 

  • Ho, J.H.C., 1970, The natural history and treatment of nasopharyngeal Carcinoma (NPC), in: Oncology, Vol. 4 (R. Lee Clark, R. Cumley, f.E. McCay, and M. Copeland, eds.), pp. 1–14, Medical Publishers, Year Book, Chicago.

    Google Scholar 

  • Ho, J.H.C., 1971, Incidence of nasopharyngeal Cancer in Hongkong, UICC Bulletin, Cancer 9(2):5.

    Google Scholar 

  • Ho, J.H.C., 1972a, Current knowledge of the epidemiology of nasopharyngeal Carcinoma: A review, in: Oncogenesis and Herpesviruses (P. Biggs, de Thé, and L. Payne, eds.), pp. 357–366, IARC, Lyon.

    Google Scholar 

  • Ho, J.H.C., 1972b, Nasopharyngeal Carcinoma (NPC), in: Advances in Cancer Research (G. Klein, S. Weinhouse, and A. Haddow, eds.), pp. 59–92, Academic Press, New York.

    Google Scholar 

  • Ho, J.H.C., 1978, An epidemiologic and Clinical study of nasopharyngeal Carcinoma, Int. J. Radiol. Oncol. Biol. Phys. 4:181–198.

    Google Scholar 

  • Ho, J.H.C., Ng, M.H., Kwan, H.C., and Chan, J.C.W., 1976, Epstein-Barr virus specific IgA and IgG serum antibodies in nasopharyngeal Carcinoma, Br. J. Cancer 34:655–660.

    Article  PubMed  CAS  Google Scholar 

  • Ho, J.H.C., Kwan, H.C., Ng, M.H., and de-Thé, G., 1978, Serum IgA antibodies to EBV Capsid antigens preceeding symptoms of nasopharyngeal Carcinoma, Lancet 1:436–437.

    Article  PubMed  CAS  Google Scholar 

  • Ho, J.H.C., Lau, W.H., Kwan, H.C., Chan, C.L., Au, G.K.H., Saw, D., and De Thé, G., 1981, Diagnostic and prognostic serological markers in nasopharyngeal Carcinoma, in: Cancer Campaign, Vol. 5, Nasopharyngeal Carcinoma, (E. Grundmann, G.R.F. Krueger, and D.V. Ablashi, eds.), pp. 219–224, Gustav Fischer, Stuttgart.

    Google Scholar 

  • Hoogstraten, f., 1967, Observations on Burkitt’s tumor in Central and northern Canada, Int. J. Cancer 2:566–575.

    Article  PubMed  CAS  Google Scholar 

  • Huang, D.P., Ho, J.H.C., Henle, W., and Henle, G., 1974, Demonstration of Epstein-Barr virus associated nuclear antigen in nasopharyngeal Carcinoma cells from fresh biopsies, Int. J. Cancer 14:580–588.

    Article  PubMed  CAS  Google Scholar 

  • Huang, D.P., Ho, J.H.C., Saw, D., and Teoh, T.B., 1978, Carcinoma of the nasal and paranasal regions in rats fed Cantonese salted marine fish, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de Thé and Y. Ito, eds.), pp. 315–328, IARC, Lyon.

    Google Scholar 

  • Huebner, R.J., 1957, The virologist’s dilemma, Ann. N Y. Acad. Sci. 67:430.

    Article  PubMed  CAS  Google Scholar 

  • Huebner, R.J., and Todaro, G.J., 1969, Oncogenes of RNA tumor viruses as determinants of Cancer, Proc. Natl. Acad. Sci. U.S.A. 64:1087.

    Article  PubMed  CAS  Google Scholar 

  • International Agency for Research on Cancer (IARC), Annual Report, 1968, Internal Technical Report Series 68/004, Planning Conference for epidemiological studies on Burkitt’s lymphoma and infectious mononucleosis, Nairobi, Kenya, p. 35.

    Google Scholar 

  • International Agency for Research on Cancer, Annual Report, 1976, WHO Publications, Geneva.

    Google Scholar 

  • International Agency for Research on Cancer, Annual Report, 1978, WHO Publications, Geneva.

    Google Scholar 

  • International Agency for Research on Cancer, Annual Report, 1980, WHO Publications, Geneva.

    Google Scholar 

  • Ito, Y., Kawanishi, M., Hirayama, T., and Takabayashi, S., 1981, Combined effect of the extracts from Croton Tiglium, Euphorbia lathyhs or Euphorbia tizucalli and N-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells, Cancer Lett 12:175–180.

    Article  PubMed  CAS  Google Scholar 

  • Jarrett, W.F.H., McNeil, P.E., Laird, H.M., O’Neil, B.W., Murphy, J., Campo, M.S., and Moar, M.H., 1980, Papilloma viruses in benign and malignant tumors of Cattle, in: Viruses in Naturally Occurring Cancers (M. Essex, G. Todaro, H. Zur Hausen, eds.), Cold Spring Harbor Conf. Cell Prolif. 7:215–222.

    Google Scholar 

  • Jarvis, J.E., Ball, G., and Rickinson, A.B., 1974, Cytogenetic studies on human lymphoblastoid Cell lines from Burkitt’s lymphoma and other sources, Int. J. Cancer 14:716.

    Article  PubMed  CAS  Google Scholar 

  • Jennings, E., M.D. thesis, 1973, Yale School of Medicine.

    Google Scholar 

  • Jondal, M., 1976, Antibody-dependent Cellular Cytotoxicity (ADCC) against Epstein-Barr virus-determined membrane antigens. I. Reactivity in sera from normal persons and from patients with acute infectious mononucleosis, Clin. Exp. Immunol. 25:1–5.

    PubMed  CAS  Google Scholar 

  • Judson, S.C., Henle, W., and Henle, G., 1977, A Cluster of Epstein-Barr virus associated American Burkitt’s lymphoma, N. Engl. J. Med. 297:464–468.

    Article  PubMed  CAS  Google Scholar 

  • Kafuko, G.W., Henderson, B.E., Kirya, G.G., Manube, G.M., Tukei, P., Day, N.E., Henle, G., Henle, W., Morrow, R.H., Pike, M.C., Smith, P.G., and Williams, E. H., 1972, Epstein-Barr virus antibody levels in Children from the West Nile district of Uganda: Report of a field study, Lancet 1:706–709.

    Article  PubMed  CAS  Google Scholar 

  • King, H., and Haenszel, 1972, Cancer mortality among foreign and native-born Chinese in the United States, J. Chron. Dis. 26:623–646.

    Article  Google Scholar 

  • Kirk, R.L., Blake, N.M., Serjeantson, S., Simons, M.J., and Chan, S.H., 1978, Genetic Components in susceptibility to nasopharyngeal Carcinoma, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de Thé and Y. Ito, eds.), pp. 283–297, IARC Scientific Publication No. 20, Lyon.

    Google Scholar 

  • Klein, G., 1979, Lymphoma development in mice and humans: Diversity of initiation is followed by a Convergent Cytogenetic evolution, Proc. Natl. Acad. Sci. U.S.A. 76:2442.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G., Clifford, P., Klein, E., Smith, R.T., Minowada, J., Kourilski, F.M., and Burchenal, J.H., 1967, Membrane immunofluorescence reactions of Burkitt’s lymphoma cells from biopsy specimens and tissue Culture, J. Natl. Cancer Inst. 39:1027–1044..

    PubMed  CAS  Google Scholar 

  • Klein, G., Pearson, G., Nadkarni, J.S., Nadkarni, J.J., Klein, E., Henle, G., Henle, W., and Clifford, P., 1968, Relation between Epstein-Barr viral and Cell membrane immunofluorescence of Burkitt tumor Cells. I. Dependence of Cell membrane immunofluorescence on presence of EB virus, J. Exp. Med. 128:1011–1020.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G., Pearson, G., Henle, G., Henle, W., Goldstein, G., and Clifford, P., 1969, Relation between Epstein-Barr viral and Cell membrane immunofluorescence in Burkitt tumor Cells. III. Comparison of blocking of direct membrane immunoflurescence and anti-EBV reactivities of different sera, J. Exp. Med. 129:697–705.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G., Giovanella, B.C., Lindahl, T., Fialkow, P.J., Singh, S.; and Stehlin, J., 1974, Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with anaplastic Carcinoma of the nasopharynx, Proc. Natl. Acad. Sci. U.S.A. 71:4737–4741.

    Article  PubMed  CAS  Google Scholar 

  • Koch, R., 1980, Über bakteriologische Forschung, in: Verh. X. Int. Med. Congr. Berlin, 35.

    Google Scholar 

  • Kvale, G., Holby, E.A., and Pedersen, E., 1979, Hodgkin’s disease in patients with previous infectious mononucleosis, Int. J. Cancer 23(5):593–597.

    Article  PubMed  CAS  Google Scholar 

  • Lachet, B., Day, N.E., de-Thé, G., and Dufour, f., 1977, Temps de latence du lymphôme de Burkitt en Ouganda, Med. Biol. Environ. 5:60–67.

    Google Scholar 

  • Lang, D.J., Garruto, R.M., and Gajdusek, D.C., 1977, Early acquisition of Cytomegalovirus and Epstein-Barr virus antibody in several isolated Melanesian populations, Am. J. Epidemiol. 105:480–487.

    PubMed  CAS  Google Scholar 

  • Lange, B., Arbeter, A., Hewetson, J., and Henle, W., 1978, Longitudinal study of Epstein-Barr virus antibody titers and excretion in pediatric patients with Hodgkin’s disease, Int. J. Cancer 22(5):521–527.

    Article  PubMed  CAS  Google Scholar 

  • Lanier, A.P., Henle, W., Bender, T.R., Henle, G., and Talbot, M.L., 1980a, Epstein-Barr virus-specific antibody titers in seven Alaskan natives before and after diagnosis of nasopharyngeal Carcinoma, Int. J. Cancel 26:133–137.

    Article  CAS  Google Scholar 

  • Lanier, A.P., Bender, T., Talbot, M., Wilmeth, S., Tschopp, C., Henle, W., Henle, G., Ritter, D., and Terasaki, P., 1980b, Nasopharyngeal Carcinoma in Alaskan Eskimos, Indians and Aleuts: A review of Cases and study of Epstein-Barr virus, HLA and environmental risk factors, Cancer 46(9):2100–2006.

    Article  PubMed  CAS  Google Scholar 

  • Lenoir, G., Philip, T., Bornkamm, G.W., Gillet, P., Bryon, P.A., Bouvier, R., Dodat, H., Dore, J.F., Burnat-Mentigny, M., and Hermier, M., 1979, Lymphome de Burkitt associé au virus d’Epstein-Barr Chez un enfant français, Nouv. Presse Med. 49:4031–4034.

    Google Scholar 

  • Levine, P.H., O’Conor, G.T., and Berard, C.W., 1972, Antibodies to Epstein-Barr virus in American patients with Burkitt’s lymphoma, Cancer 30:610–615.

    Article  PubMed  CAS  Google Scholar 

  • Levine, P.H., Cho, B.R., Connelly, R.R., Berard, C.W., O’Conor, C.T., Dorfman, R.F., Easton, J.M., and de Vita, V.T., 1975, The American Burkitt’s Lymphoma Registry: A progress report, Ann. Intern. Med. 83:31–36.

    PubMed  CAS  Google Scholar 

  • Liang, P.C., 1964, Studies on nasopharyngeal Carcinoma in Chinese: Statistical and laboratory investigations, Chin. Med. J. 83:373–390.

    PubMed  CAS  Google Scholar 

  • Lin, T.M., Chen, K.P., Lin, C.C., Hsu, M.M., Tu, S.M., Chiang, T.C., Jung, P.F., and Hirayama, T., 1975, Retrospective study on nasopharyngeal Carcinoma, J. Natl. Cancer Inst. 51:1403–1408.

    Google Scholar 

  • Lindahl, T., Klein, G., Reedman, B.M., Johansson, B., and Singh, S., 1974, Relationship between Epstein-Barr virus DNA and the EBV-determined nuclear antigen (EBNA) in Burkitt’s lymphoma biopsies and other lympho-proliferative malignancies, Int. J. Cancer 13:764–772.

    Article  PubMed  CAS  Google Scholar 

  • Liu, Y.X., and Zeng, Y., 1979, Detection of EB-virus specific IgA antibody from patients with NPC by immunoenzymatic method, Chin. J. Oncol. 1:8.

    CAS  Google Scholar 

  • Lopez, C., Watanabe, K.A., and Fox, J.J., 1980, 2’-Fluoro-5-iodo-aracytosine, a potential and selective anti-herpesvirus agent, Antimicrob. Agents Chemother. 17:803–806.

    PubMed  CAS  Google Scholar 

  • Manolov, G., and Manolova, Y., 1972, Marker bank in one Chromosome 14 from Burkitt’s lymphomas, Nature (London) 237:33.

    Article  CAS  Google Scholar 

  • Marker, S.C., Ascher, N.L., Kalis, J.M., Simmons, R.L., Najarian, J.S., and Balfour, H.H., Jr., 1979, Epstein-Barr virus antibody responses and Clinical illness in renal transplant recipients, Surgery 85(4):433–440.

    PubMed  CAS  Google Scholar 

  • Mathew, G.D., Qualtière, L.F., Neel, H.B., III, and Pearson, G.R., 1981, IgA antibody, antibody-dependent-cellular-cytoxicity and prognosis in patients with nasopharyngeal carcinoma, Int. J. Cancer 27:175–180.

    Article  PubMed  CAS  Google Scholar 

  • Matsuo, T., Nishi, S., Hirasi, H., and Osato, T., 1976, Studies on Epstein-Barr virus-related antigens. I. Indirect single-radial immunodiffusion as a useful method for detection and assay of soluble antigen, Int. J. Cancer 18:453–457.

    Article  PubMed  CAS  Google Scholar 

  • McCaw, B.K., Epstein, A.L., Kaplan, H.S., and Hecht, F., 1977, Chromosome 14 translocation in African and North American Burkitt’s lymphoma, Int. J. Cancer 19:482–486.

    Article  Google Scholar 

  • Michaux, L., 1944, Carcinome de base du Crâne, Cited in Godtfredson (19). Ophthalmologic and neurologic symptoms at malignant nasopharyngeal tumors: Clinical study Comprising 454 Cases, with special reference to histopathology and possibility of earlier recognition, Acta Psychiatr. Scand. Suppl. 34:1–323.

    Google Scholar 

  • Micheau, C., de-Thé, G., Orofiamma, B., Schwaab, G., Brugère J., Tursz, T., Sancho-Garnier, H., and Cachin, Y., 1980, Carcinomas of the nasopharynx: Relationship between histological type and anti-Epstein-Barr virus serology, Nouv. Presse Med. 9(1):21–24.

    PubMed  CAS  Google Scholar 

  • Micheau, C., de-Thé, G., Orofiamma, B., Schwaab, G., Brugère, J., Tursz, T., Sancho-Garnier, H., and Cachin, Y., 1981, Practical value of Classifying nasopharyngeal Carcinoma in two major microscopical types, in: Cancer Campaign, Vol. 5, Nasopharyngeal Carcinoma (E. Grundmann, G.R.F. Krueger, and D.V. Ablashi, eds.), pp. 51–57, Gustav Fischer, Stuttgart.

    Google Scholar 

  • Miller, G., and Beebe, G.W., 1973, Infectious mononucleosis and the empirical risk of Cancer, J. Natl. Cancer Inst 50:315–321.

    PubMed  CAS  Google Scholar 

  • Miller, G., Niederman, J.C., and Stitt, D.A., 1972a, Infectious mononucleosis: Appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid Cell lines, J. Infect. Dis. 125:403–406.

    Article  PubMed  CAS  Google Scholar 

  • Miller, G., Shope, T., Lisco, H., Stitt, D., and Lipman, M., 1972b, Epstein-Barr virus: Transformation, Cytopathic Changes and viral antigens in squirrel monkey and marmoset leukocytes, Proc. Natl. Acad. Sci. U.S.A. 69:383–387.

    Article  PubMed  CAS  Google Scholar 

  • Miller, G., Niederman, J.C., and Andrews, L.L., 1973, Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis, N. Engl. J. Med. 188:229–232.

    Article  Google Scholar 

  • Miller, G., Shope, T., and Coope, D., 1974, Aspects of the pathogenesis of lymphoma in cotton-top marmosets following inoculation of EB virus, in: Mechanisms of Virus Diseases, Vol. 1 (W.S. Robinson and F.C. Fox, eds.), pp. 429–454, W.A. Benjamin, Menlo Park, California.

    Google Scholar 

  • Mitelman, F., Andersson-Anvret, M., Brandt, L., Catovsky, D., Klein, G., Manolov, G., Manolova, Y., Mark-Vendel, E., and Nilsson, P.G., 1979, Reciprocal 8; 14 translocation in EBV-negative B-cell acute lymphocytic leukemia with Burkitt type cells, Int. J. Cancer 24:27–33.

    Article  PubMed  CAS  Google Scholar 

  • Miyamoto, K., Miyano, K., Miyoshi, I., Hamasaki, K., Nishihara, R., Terao, S., Kimura, I, Maeda, K., Matsumara, K., Nishijima, K., and Tanaka, T., 1980, Chromosome 14q+ in a Japanese patient with Burkitt’s lymphoma, Acta Med. Okayama 34:61–65.

    PubMed  CAS  Google Scholar 

  • Miyoshi, I., Hiraki, S., Tsubota, T., Uno, J., Nakamura, K., Ota, T., Hikita, T., Hayashi, K., Kataoka, M., Tanaka, T., Kimura, I., and Sairenui Hinuma, Y., 1978, Epstein-Barr virus positive Japanese Burkitt lymphoma, Gann 69:449–450.

    PubMed  CAS  Google Scholar 

  • Miyoshi, I., Hiraki, S., Kimura, I., Miyamoto, K., and Sato, J., 1979, 2/8 translocation in a Japanese Burkitt’s lymphoma, Experientia 35:742–743.

    Article  PubMed  CAS  Google Scholar 

  • Moar, M.H., Siegert, W., and Klein, G., 1977, Detection and localization of Epstein-Barr virus associated early antigens in single cells by autoradiography using I125 labelled antibodies, Intervirology 8:226–239.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, D.G., Miller, G., Niederman, J.C., Smith, H.W., and Dowaliby, J.M., 1979, Site of Epstein-Barr virus replication in the oropharynx, Lancet:1154–1157.

    Google Scholar 

  • Morrow, R.H., Kisuule, A., Pike, M.C., and Smith, P., 1976, Burkitt’s lymphoma in the Mengo districts of Uganda: Epidemiologic features and their relationship to malaria, J. Natl. Cancer Inst. 56:479–483.

    PubMed  CAS  Google Scholar 

  • Morrow, R.H., Pike, M.C., and Smith, P.G., 1977, Further studies of space-time Clustering of Burkitt’s lymphoma in Uganda, Br. J. Cancer 35:668–673.

    Article  PubMed  CAS  Google Scholar 

  • Motulsky, A.G., 1964, Hereditary red Cell traits and malaria, Am. J. Trop. Med. Hyg. 13:147–158.

    PubMed  Google Scholar 

  • Muir, C.S., 1972, Nasopharyngeal Carcinoma in non-Chinese populations, in: Oncogenesis and Herpeviruses (P.M. Biggs, G. de Thé, and L.N. Payne, eds.), pp. 367–371, IARC, Lyon.

    Google Scholar 

  • Munoz, N., Davidson, R.J., Witthoff, B., Ericsson, J.E., and de-Thé, G., 1978, Infectious mononucleosis and Hodgkin’s disease, Int. J. Cancer 22:10–13.

    Article  PubMed  CAS  Google Scholar 

  • National Office for Cancer Control, China’s Ministry of Health, and the Nanjing Institute of Geography, Chinese Academy of Medical Sciences, 1981, Atlas of Cancer Mortality in the People’s Republic of China (Dr. LiPing) (in press).

    Google Scholar 

  • Niederman, J.C., McCollum, R.W., Henle, G., and Henle, W., 1968, Infectious mononucleosis: Clinical manifestations in relation to Epstein-Barr virus antibodies, J. Am. Med. Assoc. 203:205–209.

    Article  CAS  Google Scholar 

  • Nielsen, N.H., Mikkelsen, F., and Hansen, J.P., 1977, Nasopharyngeal Cancer in Greenland, Acta Pathol. Microbiol. Scand. 85(6):850–858.

    CAS  Google Scholar 

  • Nkrumah, F.K., and Perkins, I.V., 1976, Sickle Cell trait, hemoglobin C trait and Burkitt’s lymphoma, Am. J. Trop. Med. Hyg. 25:633–636.

    PubMed  CAS  Google Scholar 

  • Nkrumah, F.K., Perkins, I.V., and Biggar, R.J., 1977, Combination Chemotherapy in abdominal Burkitt’s lymphoma, Cancer 40:1410–1416.

    Article  PubMed  CAS  Google Scholar 

  • Nonoyama, M., and Pagano, J.S. 1973, Homology between Epstein-Barr viruses DNA and viral DNA from Burkitt’s lymphoma and nasopharyngeal Carcinoma determined by DNA-DNA reassociation kinetics, Nature (London) 242:44–47.

    Article  CAS  Google Scholar 

  • Nonoyama, M., Huang, D.P., Pagano, J.S., Klein, G., and Singh, S., 1973, DNA of Epstein-Barr virus detected in tissue of Burkitt’s lymphoma and nasopharyngeal Carcinoma, Proc. Natl Acad. Sci. U.S.A. 70:3265–3268.

    Article  PubMed  CAS  Google Scholar 

  • O’Conor, G.T., 1961, Malignant lymphoma in African Children. II. A pathological entity, Cancer 12:270–283.

    Article  Google Scholar 

  • O’Conor, G.T., 1970, Persistent immunologic stimulation as a factor in oncogenesis with special reference to Burkitt’s tumor, Am. J. Med. 48:279–285.

    Article  Google Scholar 

  • O’Conor, G.T., and Davies, J.N.P., 1960, Malignant tumors in African Children with special reference to malignant lymphoma, J. Pediatr. 56:526–535.

    Article  PubMed  Google Scholar 

  • Old, L.J., Clifford, P., Boyse, E.A., de Harven, E., Geering, G., Oettgen, H.F., and Williamson, B., 1966, Precipitating antibody in human serum to an antigen present in Cultured Burkitt lymphoma cells, Proc. Natl. Acad. Sci. U.S.A. 56:1699–1704.

    Article  PubMed  CAS  Google Scholar 

  • Olweny, CL.M., Atine, I., Kaddu-Mukasa, A., Owor, R., Anderson, M., Klein, G., Henle, W., and de Thé, G., 1977, Epstein-Barr virus genome studies in Burkitt and non-Burkitt lymphomas in Uganda, J. Natl. Cancer Inst. 58:1191–1196.

    PubMed  CAS  Google Scholar 

  • Olweny, CL.M., Katongole-Mbidde, E., Otim, D., Lwanga, S.K., Magrath, LT., and Ziegler, J.L., 1980, Long term experience with Burkitt’s lymphoma in Uganda, Int. J. Cancer 26:261–266.

    Article  PubMed  CAS  Google Scholar 

  • Orofiamma, B., Micheau, C., Schwaab, G., Sancho-Garnier, H., de-Thé, G., and Brugère, J., 1982, Carcinomes du rhinopharynx: Relations entre types histologiques et Caractéristiques étio-épidémiologiques, Nouv. Presse Med. (submitted).

    Google Scholar 

  • Pagano, J.S., Huang, D.H., and Levine, P., 1973, Absence of Epstein-Barr viral DNA in American Burkitt’s lymphoma, N. Engl. J. Med. 289:1395–1399.

    Article  PubMed  CAS  Google Scholar 

  • Paul, J.R., and Bunnell, W.W., 1932, The presence of heterophile antibodies in infectious mononucleosis, Am. J. Med. Sci. 183:91–104.

    Article  Google Scholar 

  • Pearson, G.R., and Orr, T.W., 1976, Antibody-dependent lymphocyte-cytotoxicity against cells expressing Epstein-Barr virus antigens, J. Natl. Cancer Inst. 56:485–488.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., and Qualtière, L.F., 1978, Papain solubilization of the Epstein-Barr virus-induced membrane antigen, J. Virol. 28:344–351.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., and Scott, R.E., 1978, Potential for immunization against herpesvirus infection with plasma membrane vesicles, in: Oncogenesis and Herpesviruses III (G. de Thé, W. Henle, and F. Rapp, eds.), pp. 1019–1025, IARC Scientific Publication No. 24, Lyon.

    Google Scholar 

  • Pearson, G.R., Dewey, F., Klein, G., Henle, G., and Henle, W., 1970, Relation between neutralization of Epstein-Barr virus and antibodies to Cell membrane antigens induced by the virus, J. Natl. Cancer Inst. 45:989–995.

    PubMed  CAS  Google Scholar 

  • Pearson, G.R., Prevost, J.M., and Orr, T.W., 1975, Detection of virus-associated antigens with the antibody-dependent lymphocyte Cytotoxicity test, in: Proceedings of the International Workshop on the Production, Concentration and Purification of Epstein-Barr Virus, pp. 263–275, IARC, Lyon.

    Google Scholar 

  • Pearson, G.R., Johansson, B., and Klein, G., 1978a, Antibody-dependent Cellular Cytotoxicity against Epstein-Barr virus associated antigens in African patients with nasopharyngeal Carcinoma, Int. J. Cancer 22:120–125.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, G.R., Coates, H.L., Needl, H.B., Levine, P., Ablashi, D., and Easton, J., 1978b, Clinical evaluation of EBV serology in American patients with nasopharyngeal Carcinoma, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de Thé and Y. Ito, eds.), pp. 439–448, IARC, Lyon.

    Google Scholar 

  • Pearson, G.R., Qualtière, L.F., Klein, G., Norin, T., and Bal, I.S., 1979, Epstein-Barr virus-specific antibody-dependent Cellular Cytotoxicity in patients with Burkitt’s lymphoma, Int. J. Cancer 24:402–406.

    Article  PubMed  CAS  Google Scholar 

  • Peto, R., 1977, Epidemiology, multistage models and short-term mutagenicity tests, Cold Spring Harbor Conf. Cell Prolif. 4:1403.

    Google Scholar 

  • Pfeiffer, E., 1889, Drüsenfieber, Jahrb. Kinderheilkd. 29:257–264.

    Google Scholar 

  • Pickens, S., and Murdoch, J.M., 1979, Infectious mononucleosis in the elderly, Age Ageing 8(2):93–95.

    Article  PubMed  CAS  Google Scholar 

  • Pike, M.C., Williams, E.H., and Wright, B., 1967, Burkitt’s tumor in the West Nile district of Uganda, 1961–1965, Br. Med. J. 2:395–399.

    Article  PubMed  CAS  Google Scholar 

  • Pike, M.C., Morrow, M.D., Kisuule, A., and Mafigiri, J., 1970, Burkitt’s lymphoma and sickle Cell trait in Uganda, Br. J. Prev. Soc. Med. 24:39–41.

    PubMed  CAS  Google Scholar 

  • Pope, J.H., Horne, M.K., and Scott, W., 1969a, Identification of the filtrable leucocyte transforming factor of QIMR-WILL cells as herpesvirus, Int. J. Cancer 4:255–260.

    Article  PubMed  CAS  Google Scholar 

  • Pope, J.H., Horne, M.K., and Wetters, E.J., 1969b, Significance of a Complement-fixing antigen associated with herpes-like virus and detected in the Raji Cell line, Nature (London) 222:166–167.

    Article  Google Scholar 

  • Prather, S.O., and Lausch, R.N., 1976, Kinetics of serum factors mediating blocking, unblocking and antibody-dependent Cellular Cytotoxicity in hamsters given isografts of Para-7 tumor cells, Int. J. Cancer 17:380–388.

    Article  PubMed  CAS  Google Scholar 

  • Purtilo, D.T., 1980, Registry of fatal infectious mononucleosis and Epstein-Barr virus infections, J. Am. Med. Assoc. 243(18):1806.

    Article  CAS  Google Scholar 

  • Purtilo, D.T., Cassel, C.K., Yang, J.P.S., Harper, R., Stephenson, S.R., Landing, B.H., and Vawter, G.F., 1975, X-linked recessive progressive Combined variable immunodeficiency (Duncan’s disease), Lancet 1:937–941.

    Google Scholar 

  • Purtilo, D.T., Paquin, L., DeFlorio, D., Virzi, F., and Sakhuia, R., 1979, Immunodiagnosis and immunopathogenesis of the X-linked recessive lymphoproliferative syndrome, Semin. Hematol. 16:309–343.

    PubMed  CAS  Google Scholar 

  • Reedman, B.M., and Klein, G., 1973, Cellular localization of an Epstein-Barr virus (EBV) associated Complement-fixing antigen in producer and non-producer lymphoblastoid Cell lines, Int. J. Cancer 2:499–520.

    Article  Google Scholar 

  • Reedman, B.M., Klein, G., Pope, J.H., Walters, M.K., Hilgers, J., Singh, S., and Johansson, B., 1974, Epstein-Barr virus associated Complement fixing and nuclear antigens in Burkitt’s lymphoma biopsies, Int. J. Cancer 13:755–763.

    Article  PubMed  CAS  Google Scholar 

  • Rickinson, A.B., Jarvis, J.E., Crawford, D.H., and Epstein, M.A., 1974, Observations on the type of infection by Epstein-Barr virus in peripheral lymphoid cells of patients with infectious mononucleosis, Int. J. Cancer 14:704–715.

    Article  PubMed  CAS  Google Scholar 

  • Rivers, T., 1937, Viruses and Koch’s postulates, J. Bacteriol. 33:1–12.

    PubMed  CAS  Google Scholar 

  • Robinson, J.E., Brown, N., Andiman, W., Halliday, K., Francke, U., Robert, M.F., Andersson-Anvret, M., Horstmann, D., and Miller, G., 1980, Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus, N. Engl. J. Med. 302:1293–1297.

    Article  PubMed  CAS  Google Scholar 

  • Rocchi, G., Hewetson, J., and Henle, W., 1973a, Specific neutralizing antibodies in Epstein-Barr virus-associated diseases, Int. J. Cancer 11:637–647.

    Article  PubMed  CAS  Google Scholar 

  • Rocchi, G., Hewetson, J., Henle, W., and Henle, G., 1973b, Antigen expression and Colony formation of lymphoblastoid Cell lines after superinfection with Epstein-Barr virus, J. Natl. Cancer Inst. 50:307–314.

    PubMed  CAS  Google Scholar 

  • Rosdahl, N., Larsen, S.O., and Clemmesen, J., 1974, Hodgkin’s disease in patients with previous infectious mononucleosis: 30 years’ experience, Br. Med. J. 2:253–256.

    Article  PubMed  CAS  Google Scholar 

  • Saad, A., 1968, Observations on nasopharyngeal Carcinoma in the Sudan, in: Cancer in Africa (C.A. Linsell and G.L. Limms, eds.), pp. 281–285, East African Publishing House, Nairobi.

    Google Scholar 

  • Saemundsen, E., Berkel, A.I., Henle, W., Henle, G., Anvret, M., Sanal, Ö., Ersoy, F., Caglar, M., Klein, G., 1981, Epstein-Barr virus Carrying lymphoma in a patient with ataxia-telangiectasia, Br. Med. J. 282:425–427.

    Article  CAS  Google Scholar 

  • Sakamoto, K., Aiba, M., Katayama, I., Sullivan, J., Humphreys, R., and Purtilo, D.T., 1981, Antibodies to Epstein-Barr virus specific antigens in patients with hairy-cell leukemia, Int. J. Cancer 27:453–458.

    Article  PubMed  CAS  Google Scholar 

  • Sawyer, R.N., Evans, A.S., Niederman, J.C., and McCollum, R.W., 1971, Prospective study of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis, J. Infect. Dis. 123:263–269.

    Article  PubMed  CAS  Google Scholar 

  • Shanmugaratnam, K., 1978, Variations in nasopharyngeal Carcinoma incidence among specific Chinese Communities (dialect groups) in Singapore, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de-Thé and Y. Ito, eds.), pp. 191–198, IARC, Lyon.

    Google Scholar 

  • Shanmugaratnam, K., and Higginson, J., 1967, Aetiology of nasopharyngeal Carcinoma: Report on a retrospective survey in Singapore, in: Cancer of the Nasopharynx (CS. Muir and K. Shanmugaratnam, eds.), UICC Monograph Series, Vol. 1, pp. 130–137, Munksgaard, Copenhagen.

    Google Scholar 

  • Shanmugaratnam, K., and Sobin, L.H., 1978b, Histological typing of upper respiratory tract tumors, in: International Histological Classification of Tumors, No. 19, World Health Organization, Geneva.

    Google Scholar 

  • Shanmugaratnam, K., Tan, K.K., and Lee, K.W., 1967, Lymphoma of the Burkitt type in Singapore, Int. J. Cancer 2:576–580.

    Article  PubMed  CAS  Google Scholar 

  • Shope, T., Dechairo, D., and Miller, G., 1973, Malignant lymphoma in Cotton-top marmosets following inoculation of Epstein-Barr virus, Proc. Natl. Acad. Sci. U.S.A. 70:2487–2491.

    Article  PubMed  CAS  Google Scholar 

  • Simons, M.J., Wee, G.B., Day, N.E., de-Thé, G., Morris, P.J., and Shanmugaratnam, K., 1974, Immuno-genetic aspects of nasopharyngeal Carcinoma. I. Difference in HL-A antigen profiles between patients and Comparison groups, Int. J. Cancer 13:122–134.

    Article  PubMed  CAS  Google Scholar 

  • Simons, M.J., Wee, G.B., Day, N.E., Chan, S.H., Shanmugaratnam, K., and de Thé, G., 1975, Immunogenetic aspects of nasopharyngeal Carcinoma (NPC). IV. Probable identification of an HL-A second antigen associated with a high risk for NPC, Lancet 1:142–143.

    Article  PubMed  CAS  Google Scholar 

  • Simons, M.J., Wee, G.B., Goh, E.H., Chan, S.H., Shanmugaratnam, K., Day, N.E., and de Thé, G., 1976, Immunogenetic aspects of nasopharyngeal Carcinoma. IV. Increased risk in Chinese of nasopharyngeal Carcinoma associated with a Chinese-related HLA profile (A2, Singapore 2), J. Natl. Cancer Inst. 57:977–980.

    PubMed  CAS  Google Scholar 

  • Simons, M.J., Wee, G.B., Singh, D., Dharmalingham, S., Yong, N.K., Chau, J.C.W., Ho, J.H.C., Day, N.E., and De Thé, G., 1977, Immunogenetic aspects of nasopharyngeal Carcinoma. V. Confirmation of a Chinese related HLA profile (A2, Singapore 2) associated with an increased risk for nasopharyngeal Carcinoma, in: Epidemiology and Cancer Registries in the Pacific, Natl. Cancer Inst. Monogr. 47:147–151.

    Google Scholar 

  • Simons, M.J., Chan, S.H., Wee, G.B., Shanmugaratnam, K., Goh, E.H., Ho, J.H.C., Chau, J.C.W., Darmalingham, S., Prasad, U., Betuel, H., Day, N.E., and de-Thé, G., 1978, Nasopharyngeal Carcinoma and histocompatibility antigens, in: Nasopharyngeal Carcinoma: Etiology and Control (G. de-Thé and Y. Ito, eds.), pp. 271–282, Scientific Publication No. 20, IARC, Lyon.

    Google Scholar 

  • Slater, R.M., Philip, P., Badsberg, E., Behrendt, H., Hansen, N.E., and Van Heerde, P., 1979, A 14q+ Chromosome in a B-cell acute lymphocytic leukemia and in a leukemic nonendemic Burkitt’s lymphoma, Int. J. Cancer 23:639–647.

    Article  PubMed  CAS  Google Scholar 

  • Sohier, R., 1971, Discordance au Cours de la mononucléose infectieuse entre l’élaboration des anticorps fixant le Complément avec un antigène soluble et des anticorps révélés par immunofluorescence, C. R. Acad. Sci. Ser. 272:3098–3101.

    CAS  Google Scholar 

  • Sohier, R., and de-Thé, G., 1978, EBNA antibodies are more useful than Complement-fixing antibody in monitoring infectious mononucleosis patients, Biomedicine 29:170–173.

    PubMed  CAS  Google Scholar 

  • Sohier, R., Lenoir, G.M., and Lamelin, J.P.L., 1981, Les formes mortelles de l’infection primaire à virus d’Epstein-Barr avec ou sans mononucléose infectieuse, Ann. Med. Intern. 132:48–57.

    CAS  Google Scholar 

  • Sprunt, T.P., and Evans, F.A., 1920, Mononuclear leucocytosis in reaction to acute infections (in infectious mononucleosis), Bull. Johns Hopkins Hosp. 31:410–417.

    Google Scholar 

  • Stancek, D., and Robensky, J., 1979, Enhancement of Epstein-Barr virus antibody production in systemic lupus erythematosus patients, Acta. Virol. (Prague) 23(2): 168–169.

    CAS  Google Scholar 

  • Stephens, R., Traul, K., Gaudreau, P., Teh, J., Fisher, L., and Mayyasi, S.A., 1977, Comparative studies on EBV antigens by immunofluorescence and immunoperixodase techniques, Int. J. Cancer 19:305–316.

    Article  PubMed  CAS  Google Scholar 

  • Sullivan, J.L., Wallen, W.C., and Johnson, F.L., 1978, Epstein-Barr virus infection following bone-marrow transplantation, Int. J. Cancer 22(2): 132–135.

    Article  PubMed  CAS  Google Scholar 

  • Sumaya, CV., 1977, Primary Epstein-Barr virus infections in Children, Pediatrics 59(1):16–21.

    PubMed  CAS  Google Scholar 

  • Svedmyr, E., and fondai, M., 1975, Cytotoxic effector cells specific for B Cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis, Proc.Natl. Acad. Sci. U.S.A. 7:1622.

    Article  Google Scholar 

  • Svedmyr, A., Demissie, A., Klein, G., and Clifford, P., 1970, Antibody patterns in different human sera against intracellular and membrane antigen Complexes associated with Epstein-Barr virus, J. Natl. Cancer Inst. 44:595–610.

    PubMed  CAS  Google Scholar 

  • Svoboda, D., Kirchner, K.R., and Shanmugaratnam, K., 1965, Ultrastructure of nasopharyngeal Carcinomas in American and Chinese patients: An application of electron microscopy to geographic pathology, Exp. Mol. Pathol. 4:189–204.

    Article  Google Scholar 

  • Thestrup-Pedersen, K., Esmann, V., Bisballe, S., Jensen, J.R., Pallesen, G., Hastrup, J., Madsen, M., Thorling, K., Masucci, M.G., Saedmundsen, A.K., and Ernberg, I., 1980, Epstein-Barr virus induced lymphoproliferative disorder Converting to fatal Burkitt-like lymphoma in a boy with interferon-inducible Chromosomal defect, Lancet:997–1002.

    Google Scholar 

  • Tischendorf, P., Shramek, G.J., Balagdas, R.C., Deinhardt, F., Knospe, W.H., Noble, G.R., and Maynard, J.E., 1970, Development and persistence of immunity to Epstein-Barr virus in man, J. Infect. Dis. 122:401–409.

    Article  PubMed  CAS  Google Scholar 

  • Tovey, M.G., Lenoir, G., and Begon-Lours, J., 1978, Activation of latent Epstein-Barr virus by antibody to human IgM, Nature (London) 276:270–272.

    Article  CAS  Google Scholar 

  • Trumper, P.A., Epstein, M.A., Giovanella, G.C., and Finerty, S., 1977, Isolation of infectious EB virus from epithelial tumor cells of nasopharyngeal Carcinoma, Int. J. Cancer 20:655–662.

    Article  PubMed  CAS  Google Scholar 

  • UICC, 1974, TNM Classification of Malignant Tumors, 2nd ed., Geneva.

    Google Scholar 

  • University Health Physicians and PHS Laboratories, 1971, A joint investigation: Infectious mononucleosis and its relationship to EB virus antibody, Br. Med. J. 4:643–646.

    Article  Google Scholar 

  • USPHS Advisory Committee on Smoking and Health, 1964, PHS Publ. No. 1103, USPHS, Washington, D.C.

    Google Scholar 

  • Van den Berghe, H., Parloir, C., Gosseye, S., Englebienne, V., Cornu, G., and Sokal, G., 1979, Variant traslocation in Burkitt’s lymphoma, Cancer Genet. Cytogenet. 1:9–14.

    Article  Google Scholar 

  • Virelizier, J.L., Lenoir, G., and Griscelli, C., 1978, Persistent Epstein-Barr virus infection in a Child with hypergammaglobulinaemia and immunoblastic proliferation associated with a selective defect in immune interferon secretion, Lancet 2:231–234.

    Article  PubMed  CAS  Google Scholar 

  • Vonka, V., and Kutinova, L., 1973, Increase of EB virus positive cells in Cultured Burkitt lymphoma cells after short-time exposure to heat, Neoplasma 30:349–352.

    Google Scholar 

  • Vonka, V., Benyesh-Melnick, M., and McCombs, R.J., 1970, Antibodies in human sera to soluble and viral antigens found in Burkitt’s lymphoma and other lymphoblastoid Cell lines, J. Natl. Cancer Inst. 44:865–872.

    PubMed  CAS  Google Scholar 

  • Vonka, V., Kutinova, L., Drobnik, J., and Bräuerova, J., 1972, Increase of Epstein-Barr virus positive cells in EB 3 Cultures after treatment with Cisdichloro-diammine-platinum (11), J. Natl. Cancer Inst. 48:1277–1281.

    PubMed  CAS  Google Scholar 

  • Wara, W.M., Wara, D.W., Phillips, T.L., and Ammahh, A., 1975, Elevated IgA in Carcinoma of the nasopharynx, Cancer 35:1313–1315.

    Article  PubMed  CAS  Google Scholar 

  • Williams, A.O., 1966, Hemoglobin genotypes ABO blood groups and Burkitt’s tumor, J. Med. Genet. 3:177–179.

    Article  PubMed  CAS  Google Scholar 

  • Williams, E.H., and de-Thé, G., 1974, Familial aggregation in nasopharyngeal Carcinoma, Lancet, 2:295.

    Article  PubMed  CAS  Google Scholar 

  • Williams, E.H., Spit, P., and Pike, M.C. 1969, Further evidence of space-time Clustering of Burkitt’s lymphoma patients in the West Nile district of Uganda, Br. J. Cancer, 23:235–246.

    Article  PubMed  CAS  Google Scholar 

  • Williams, E.H., Day, N.E., and Geser, A., 1974, Seasonal variation in onset of Burkitt’s lymphoma in the West Nile district of Uganda, Lancet 1:19–22.

    Article  CAS  Google Scholar 

  • Williams, E.H., Smith, P.G., Day, N.E., Geser, A., Ellice, J., and Tukei, P., 1978, Space-time Clustering of Burkitt’s lymphoma in the West Nile district of Uganda, 1961–1975, Br. J. Cancer 37:109–122.

    Article  PubMed  CAS  Google Scholar 

  • Wolf, H., Zur Hausen, H., and Becker, V., 1973, EB viral genomes in epithelial nasopharyngeal Carcinoma cells, Nature (London) New Biol. 244:245–257.

    CAS  Google Scholar 

  • World Health Organization, 1970, Mortality from malignant neoplasms, 1955–1965, Geneva.

    Google Scholar 

  • Wright, D.H., and Pike, P.A., 1969, Bone-marrow involvement in Burkitt’s tumor, Br. J. Haematol 15:409–416.

    Article  Google Scholar 

  • Wright, D.H., Schumacher, H.R., Thomas, W.J., Duval-Arnould, B.J., Creegan, W.J., Forman, D.S., Strong, D.M., Robinson, J.E., and Miller, G., 1980, Polyclonal B Cell lymphoma during infection with Epstein-Barr virus (letter to editor), N. Engl. J. Med. 303(18):1064–1065.

    Article  PubMed  CAS  Google Scholar 

  • Wu, C.H., 1921, in: The Encyclopaedia of Chinese Medical Terms, Vol. 1, p. 756, Commercial Press, Shanghai (in Chinese).

    Google Scholar 

  • Zech, L., Haglund, U., and Nilsson, K., 1976, Characteristic Chromosomal abnormalities in biopsies and lymphoid Cell lines from patients with Burkitt and non-Burkitt lymphomas, Int. J. Cancer 17:47.

    Article  PubMed  CAS  Google Scholar 

  • Zeng, Y., Shang, M., Liu, C.R., Cheng, Y.H., Ou, R.S., Li, X.H., Gan, B.W., Hu, M.G., Chen, M., He, S.Q., and Mu, G.P., 1979, Detection of IgA antibody to EB virus VCA from patients with nasopharyngeal Carcinoma by immunofluorescent test, Chin. J. Oncol. 1:81–83.

    CAS  Google Scholar 

  • Zeng, Y., Liu, Y.X., Liu, C.R., Chen, S.W., Wei, J.N., Zhu, J.S., and Zai, H.J., 1980a, Application of an immunoenzymatic method and an immunoautoradiographic method for a mass survey of nasopharyngeal Carcinoma, Intervirology 13:162–168.

    Article  Google Scholar 

  • Zeng, Y., Pi, G.H., and Zhao, W.P., 1980b, Detection of EBNA by anticomplement immunoenzymatic method, Acta Acad. Med. Sin. 2:134–135.

    CAS  Google Scholar 

  • Ziegler, J.L., 1972, Chemotherapy of Burkitt’s lymphoma, Cancer 30:1534–1540.

    Article  PubMed  CAS  Google Scholar 

  • Ziegler, J.L., 1977, Treatment results of 54 American patients with Burkitt’s lymphoma are similar to the African experience, N. Engl. J. Med. 297:75–80.

    Article  PubMed  CAS  Google Scholar 

  • Ziegler, J.L., Bluming, A.Z., Morrow, R.H., Fass, L., and Carbone, P.P., 1970, Central nervous system involvement in Burkitt’s lymphoma, Blood 36:718–728.

    PubMed  CAS  Google Scholar 

  • Ziegler, J.L., Andersson, M., Klein, G., and Henle, W., 1976, Detection of Epstein-Barr virus DNA in American Burkitt’s lymphoma, Int. J. Cancer 17:701–706.

    Article  PubMed  CAS  Google Scholar 

  • Zur Hausen, H., Schulte-Holthausen, H., Klein, G., Henle, W., Henle, G., Clifford, P., and Santesson, L., 1970, EBV DNA in biopsies of Burkitt’s tumors and anaplastic Carcinomas of the nasopharynx, Nature (London) 228:1056–1058.

    Article  Google Scholar 

  • Zur Hausen, H., O’Neill, F.J., Freese, U.K., and Hecher, E., 1978, Persisting oncogenic herpevirus induced by tumor promotor TPA, Nature (London) 272:373–375.

    Article  Google Scholar 

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De-Thé, G. (1982). Epidemiology of Epstein—Barr Virus and Associated Diseases in Man. In: Roizman, B. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4163-5_2

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