Abstract
The nitroimidazoles were launched on their pharmacological career in 1956 when azomycin or 2-nitroimidazole, a natural product obtained by fermentation, was found active against certain bacteria and Trichomonas, For a decade, nitroimidazole derivatives were used only to combat protozoa of the Trichomonadida order(1)(including Histomonas meleagridis in veterinary medicine), and for Vincent’s angina, a spirochaetal infection. Subsequently their use was extended to other parasitic infections (2), mainly amoebiasis and giardiasis, and only in the last five years have they been definitely employed in bacteriology (3) (Fig. 1) and as radiosensitizers.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. de Carneri, Antiprotozoan activity of nitroimidazoles, Arzneimittel-Forschung, 19:382.
I. de Carneri, A. Bianchi, S. Castellino, G. Meinardi, and F. Trane, New data on the mechanism and speed of action of nitroimidazoles on prokaryota and eukaryota with and without mitochondria, Arzneimillel-Forschung, 26: 765 (1976).
I. de Carneri, Taxonomy of amoebae and antiprotozoal activity of nitroimidazoles and dichloracetamide derivatives. Proceedings of the International Conference on Amebiasis, Centre de Estudios sobre Amibiasis, Mexico City, October 27–29, 1975. p. 174.
I. de Carneri, La trichomonase uro-génitale mérite-t-elle un traitement systémique ? Bulletins et mémoires de la société de médecine de Paris, 181: 189 (1978).
I. de Carneri, Variation of the sensitivity of a strain of Trichomonas vaginalis to metronidazole after culturing in the presence or absence of the drug, in: “Proceedings of the First International Congress of Parasitology”, A. Corradetti, ed,Pergamon Press-Tamburini Editore, Milan (1964) p. 366.
I. de Carneri and F. Trane, In vivo resistance to metronidazole induced on four recently isolated strains of Trichomonas vaginalis, Arzneimittel-Forschung, 21:377 (1971).
M. Muller, Nitroimidazole resistance in anaerobic bacteria and protozoa, Conference on nitroimidazoles, Cesenatico, 27-30 Augustf Program and Abstracts, 35 (1980).
F. Trane and I. de Carneri, Attività del nimorazolo in vitro su culture pure di Giardia intestinalis, 10th Congresso della Società Italiana di Parassitologia, Alghero 20–23 May 1980, Parassitologia, in press.
M. de Eguileor, F. Trane and I. de Carneri, Aspetti ultrastrut-turali dell’azione dei nitroimidazoli su culture pure di Giardia intestinalis, 10th Congresso della Societa Italiana di Parassitologia, Alghero 20–23 May 1980, Parassitologia, in press.
I. de Carneri, M. D. Candia Carnevali and F. Trane, Aspetti ultrastrutturali dell’azione del nimorazolo su Giardia muris, Giornale di Malattie Infettive e Parassitarie, 28: 503 (1976).
R. Delgado y Garnica and E. Martinez-Murray, Quimioprofilaxis de la amibiasis con metronidazol. Rev. Inst. Med. Trop. Sao Paulo, 13: 307 (1971).
W. Modell, “Drugs of choice 1980–1981”. Mosby Co., St. Louis (1980).
F. Biagi, Metronidazole in the treatment of balantidiasis, Trans. Roy. Soc. Trop. Med. Hyg., 67: 143 (1973).
D. R. Botero, Effectiveness of nitrimidazine in treatment of Balantidium coli infections, Trans. Roy. Soc. Trop. Med. Hyg., 67: 145 (1973).
R. Muller, Guinea worm disease: epidemiology, control and treatment, Bull. W.H.O., 57: 683 (1979).
L. Lasagna, The development and regulation of new medications. Science, 200: 871 (1978).
I. de Carneri, The place of chemotherapy in the control of parasitoses, Proceedings of the I Mediterranean Congress of Chemotherapy, Madrid, 18–20 September 1978. p. 1003.
F. W. Jennings, G. M. Urquhart, P. K. Murray and B. M. Miller, Berenil and nitroimidazole combinations in the treatment of Trypanosoma brucei infection with central nervous system involvement, Int. J. Parasitol., 10: 27 (1980).
A. C. Cuckler, C. M. Malanga and J. Conroy, Therapeutic efficacy of new nitroimidazoles for experimental trichomonia-sis, amebiasis and trypanosomiasis, Am. J. Trop. Med. Hyg., 19: 916 (1970).
E. Winkelmann and W. Raether, New chemotherapeutically active nitroimidazoles, 19th Interscience Conference on Anti-microbial agents and chemotherapy, Boston, Mass., 1–5 October 1979, Abstract 152.
E. W. J. de Maar, The future of tropical chemotherapy, Cronache Farmaceutische, 23: 84 (1980).
The Medical Letter, Drugs for parasitic infections, 21:105 (December 28, No. 26 ) (1979).
A. Polak and R. Riehle, Mode of action of the 2-nitroimidazole derivative benznidazole, Ann. Trop. Med. Parasitol., 72:45(1978)
B. P. Goldstein, R. R. Vidal-Plana, B. Cavalleri, L. Zerelli, G. Carniti and L. G. Silvestri, The mechanism of action of the nitro-heterocyclic antimicrobial drugs. Metabolic activation by micro-organisms, J. Gen. Microbiol., 100:283(1977).
C. M. Beard, K. L. Noller, W. M. O’Fallon, L. T. Kurland and M. B. Dockerty, Lack of evidence for cancer due to use of metronidazole, New Engl. J. Med., 10:519 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
de Carneri, I. (1982). Nitroimidazoles as Antiparasitic Agents. In: Breccia, A., Cavalleri, B., Adams, G.E. (eds) Nitroimidazoles. NATO Advanced Study Institutes Series, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4151-2_9
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4151-2_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4153-6
Online ISBN: 978-1-4684-4151-2
eBook Packages: Springer Book Archive