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Regulation of eIF-2 Activity and Initiation of Protein Synthesis in Mammalian Cells

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Protein Biosynthesis in Eukaryotes

Part of the book series: NATO Advanced Study Institutes Series ((NSSA,volume 41))

Abstract

There is now convincing evidence that the eukaryotic peptide chain initiation factor 2 (eIF-2) plays a major role in regulation of protein syntehsis initiation in mammalian cells. Numerous reports indicate that eIF-2 activity changes under different physiological conditions with accompanying changes in protein synthesis activities in the cells. Austin and Clemens recently reviewed the literature concerning the role of eIF-2 in regulation of protein synthesis in different mammalian cells (1).

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  1. Department of Chemistry, The University of Nebraska, Lincoln, Nebraska, 68588, USA

    Naba K. Gupta

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  1. Naba K. Gupta
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Editors and Affiliations

  1. The Institute for Virology, University of Rome, Rome, Italy

    R. Pérez-Bercoff

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© 1982 Plenum Press, New York

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Gupta, N.K. (1982). Regulation of eIF-2 Activity and Initiation of Protein Synthesis in Mammalian Cells. In: Pérez-Bercoff, R. (eds) Protein Biosynthesis in Eukaryotes. NATO Advanced Study Institutes Series, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4124-6_16

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  • DOI: https://doi.org/10.1007/978-1-4684-4124-6_16

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