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Immunomodulation by Bacteria and Their Products pp 165–179Cite as

Immunostimulation by LPS and Its Derivatives

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Abstract

Of the vast number of biological properties attributed to endotoxins, their unique capacity to stimulate the body’s natural defenses in an immunologically non-specific way is unquestionably their most important property. That the effect of endotoxin on the immune system is not a singular, well-defined interaction becomes obvious from studies in vivo and in vitro. The non-specific effects of endotoxin upon resistance to various pathogens have been reported by many investigators (7, 18, 26, 44) and are attributed to many different cellular and non-cellular mechanisms (3). Alterations of the hemopoietic system include an early appearance of leukopenia followed several hours later by marked leukocytosis (20, 25). The histological picture of the bone marrow, spleen, thymus, and lymph nodes also follows a bi-phasic response which is initially characterized by intensely degenerative-appearing tissue, hypocellularity and loss in size and weight. Within 24 to 48 hours, cell-rich foci appear, giving rise to hyperplasia several days thereafter (44, 20, 50). This is the result of increased production of granulocytes, lymphocytes, myelocytes, and macrophages. Functional changes are also evident during this time.

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Author information

Authors and Affiliations

  1. University of Pennsylvania, Philadelphia, PA, USA

    U. H. Behling & A. Nowotny

Authors
  1. U. H. Behling
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  2. A. Nowotny
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Herman Friedman , Thomas W. Klein  & Andor Szentivanyi ,  & 

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© 1981 Plenum Press, New York

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Behling, U.H., Nowotny, A. (1981). Immunostimulation by LPS and Its Derivatives. In: Friedman, H., Klein, T.W., Szentivanyi, A. (eds) Immunomodulation by Bacteria and Their Products. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4115-4_11

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  • DOI: https://doi.org/10.1007/978-1-4684-4115-4_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4117-8

  • Online ISBN: 978-1-4684-4115-4

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