Abstract
“How many? How tightly? Where? Why?” these were the questions posed by Scatchard (1949) in his elegant study of the adsorption of ions to proteins. These succinct questions also define what we wish to know about the adsorption of divalent cations to phospholipid bilayer membranes. The first two questions, which relate to the stoichiometry of the binding and the magnitude of the binding constants, will be addressed in this chapter. The third question, which relates to the exact location of the bound divalent cations in the phospholipid head group, requires a molecular approach such as nuclear magnetic resonance (NMR) and will be addressed in the following chapter. The fourth question, which relates to the physiological relevance of the adsorption of divalent cations to the bilayer component of biological membranes, cannot yet be completely answered. We shall, however, consider two phenomena: (1) the effect of divalent cations on the electrostatic potential at the surface of a nerve membrane and (2) the effect of the adsorption of calcium to intracellular membranes on the diffusion coefficient of this ion.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aveyard, R., and Haydon, D. A. (1973). An Introduction to the Principles of Surface Chemistry, Cambridge University Press, London.
Barlow, C. A., Jr. (1970). In Physical Chemistry, An Advanced Treatise, pp. 167–246, Academic Press, New York.
Brockris, J. O’M., and Reddy, A. K. N. (1970). Modern Electrochemistry, Plenum Press, New York. Castle, J. D., and Hubbell, W. L. (1976). Biochemistry 15, 4818–4831.
Chapman, D. L. (1913). Philos Mag. 25, 475–481.
Cohen, F. S., Zimmerberg, J., and Findelstein, A. (1980). J. Gen. Physiol. 75, 251–270.
Edsall, J. T., and Wyman, J. (1958). Biophysical Chemistry, Academic Press, New York.
Eisenberg, M., Gresalfi, T., Riccio, T., and McLaughlin, S. (1979). Biochemistry 18, 5213–5223.
Forsyth, P. A., Marcella, S., Mitchell, D. J., and Ninham, B. W. (1977). Biochim. Biophys. Acta 469, 335–344.
Gileadi, E. (1967). Electrosorption, Plenum Press, New York.
Gouy, M. (1910). J. Phys. (Paris) 19, 457–468.
Grahame, D. C. (1947). Chem. Rev. 41, 441–501.
Grasdalen, H., Eriksson, L. E. G., Westman, J., and Ehrenberg, A. (1977). Biochim. Biophys. Acta 469, 151–162.
Haydon, D. A. (1964). Recent Prog. Surf. Sci. 1, 94–158.
Hille, B., Woodhull, A. M., and Shapiro, B. I. (1975). Philos. Trans. R. Soc. London Ser. B 270, 301–318.
Jacobson, K., and Papahadjopoulos, D. (1975). Biochemistry 14, 152–161.
Lau, A., McLaughlin, A., and McLaughlin, S. (1981). Biochim. Biophys. Acta 645, 279–292.
McDonald, R. C., Simon, S. A., and Baer, E. (1976). Biochemistry 15, 885–891.
McLaughlin, A. C., Grathwohl, C., and McLaughlin, S. (1978). Biochim. Biophys. Acta 513, 338–357.
McLaughlin, S. (1977). Curr. Top. Membr. Transp. 9, 71–144.
McLaughlin, S., and Brown, J. (1981). J. Gen. Physiol. 77, 475–487.
McLaughlin, S., Mulrine, N., Gresalfi, T., Vaio, G., and McLaughlin, A. (1981). J. Gen. Physiol. 77, 445–473.
Mohilner, D. M. (1966). Electroanal. Chem. 1, 241–409.
Newton, C., Pangborn, W., Nir, S., and Papahadjopoulos, D. (1978). Biochim. Biophys. Acta 506, 281–287.
Ohki, S., and Duzgunes, N. (1979). Biochim. Biophys. Acta 552, 438–449.
Ohki, S., and Sauve, R. (1978). Biochim. Biophys. Acta 511, 377–387.
Papahadjopoulos, D., Vail, W. J., Newton, C., Nir, S., Jacobson, K., Poste, G., and Lazo, R. (1977). Biochim. Biophys. Acta 465, 579–598.
Portis, A., Newton, C., Pangborn, W., and Papahadjopoulos, D. (1979). Biochemistry 18, 780–790.
Puskin, J. S. (1977). J. Membr. Biol. 35, 39–55.
Puskin, J., and Coene, M. T. (1980). J. Membr. Biol. 52, 69–74.
Rice, S. A., and Nagasawa, M. (1961). Polyelectrolyte Solutions, Academic Press, New York.
Scatchard, G. (1949). Ann. N.Y. Acad. Sci. 51, 660–672.
Schoch, P., Sargent, D. F., and Schwyzer, R. (1979). J. Membr. Biol. 46, 71–89.
Sparnaay, M. J. (1972). The Electrical Double Layer, Pergamon Press, Oxford.
Stern, O. (1924). Z. Electrochem. Angew. Phys. Chem. 30, 508–516.
Träuble, H., and Eibl, H. (1974). Proc. Natl. Acad. Sci. USA 71, 214–219.
van Dijck, P. W. M., de Kruijff, B., Verkleij, A. J., van Deenen, L. L. M., and de Gier, J. (1978). Biochim. Biophys. Acta 512, 84–96.
Verwey, E. J. W., and Overbeek, J. Th. G. (1948). Theory of the Stability of Lyophobic Colloids, Elsevier, Amsterdam.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Plenum Press, New York
About this chapter
Cite this chapter
McLaughlin, S. (1982). Divalent Cations, Electrostatic Potentials, Bilayer Membranes. In: Martonosi, A.N. (eds) Membranes and Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4082-9_6
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4082-9_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4084-3
Online ISBN: 978-1-4684-4082-9
eBook Packages: Springer Book Archive