Skip to main content
SpringerLink
Log in
Book cover

Membranes and Transport pp 213–218Cite as

Protein Translocation across the Membrane of the Endoplasmic Reticulum

  • Chapter

  • 123 Accesses

Abstract

The translocation of proteins across membranes is a feature common to all cells. In eukaryotes several distinct membranes are endowed with this capacity. Certain proteins (largely secretory) are translocated across the membrane of the endoplasmic reticulum (ER), while others are translocated across the membrane of mitochondria, chloroplasts, or peroxisomes. An understanding of the phenomenon of protein translocation depends upon answering three major questions: (1) What determines whether a protein will remain in the cytoplasm or will be translocated across a membrane? (2) How are the proteins selected to cross a specific membrane (endoplasmic reticulum, mitochondrial, chloroplast, or peroxisomal)? (3) What is the mechanism by which the actual physical translocation across the membrane occurs? This latter aspect requires the transfer of large hydrophilic moieties through a hydrophobic membrane and is certainly the most difficult to understand in molecular terms.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Austen, B. M. (1979). FEBS Lett. 103, 308–313.

    Article  CAS  Google Scholar 

  • Baty, D., and Lazdunski, C. (1979). Eur. J. Biochem. 102, 503–507.

    Article  CAS  Google Scholar 

  • Blobel, G. (1980). Proc. Natl. Acad. Sci. USA 77, 1496–1500.

    Article  CAS  Google Scholar 

  • Blobel, G., and Dobberstein, B. (1975). J. Cell. Biol. 67, 835–851, 852–862.

    Google Scholar 

  • Blobel, G., Walter, P., Chang, C. N., Goldman, B., Erickson, A. H., and Lingappa, V. R. (1979). In Symposia of the Society for Experimental Biology, Symposium XXXIII, pp. 9–36, Cambridge University Press, London.

    Google Scholar 

  • Bonatti, S., Canadda, R., and Blobel, G. (1979). J. Cell Biol. 80, 219–224.

    Article  CAS  Google Scholar 

  • Chua, N.-H., and Schmidt, G. W. (1979). J. Cell Biol. 81, 461–483.

    Article  CAS  Google Scholar 

  • Davis, B. D., and Tai, P.-C. (1980). Nature (London) 283, 433–438.

    Article  CAS  Google Scholar 

  • Dobberstein, B., Garoff, H., Warren, G., and Robinson, P. J. (1979). Cell 17, 759–769.

    Article  CAS  Google Scholar 

  • Emr, S. D., Hall, M. N., and Silhavy, T. J. (1980). J. Cell Biol. 86, 701–711.

    Article  CAS  Google Scholar 

  • Fraser, T., and Bruce, B. J. (1978). Proc. Natl. Acad. Sci. USA 75, 5936–5940.

    Article  CAS  Google Scholar 

  • Garoff, H., Simons, K., and Dobberstein, B. (1978). J. Mol. Biol. 124, 587–600.

    Article  CAS  Google Scholar 

  • Hortin, G., and Boime, I. (1980). J. Biol. Chem. 255, 8007–8010.

    CAS  Google Scholar 

  • Inouye, M., and Halegoua, S. (1980). CRC Crit. Rev. Biochem. 7, 339–371.

    Article  CAS  Google Scholar 

  • Jackson, R. C., and Blobel, G. (1977). Proc. Natl. Acad. Sci. USA 74, 5598–5602.

    Article  CAS  Google Scholar 

  • Jackson, R. C., and Blobel, G. (1980). Ann. N.Y. Acad. Sci. 343, 391–404.

    Article  CAS  Google Scholar 

  • Jackson, R. C., Walter, P., and Blobel, G. (1980). Nature (London) 286, 174–176.

    Article  CAS  Google Scholar 

  • Katz, F. N., Rothman, J. E., Lingappa, V. R., Blobel, G., and Lodish, H. F. (1977). Proc. Natl. Acad. Sci. USA 74, 3278–3282.

    Article  CAS  Google Scholar 

  • Koshland, D., and Botstein, D. (1980). Cell 20, 719–760.

    Article  Google Scholar 

  • Krangel, M. S., On, H. T., and Strominger, J. L. (1979). Cell 18, 979–991.

    Article  CAS  Google Scholar 

  • Kreibich, G., Czako-Graham, M., Grebenau, R., Mok, W., Rodriguez-Boulan, E., and Sabatini, D. (1978). J. Supramol. Structure 8, 279–302.

    Article  CAS  Google Scholar 

  • Lazarow, P. B. (1980). Ann. N.Y. Acad. Sci. 343, 293–301.

    Article  CAS  Google Scholar 

  • Lingappa, V. R., Katz, F. N., Lodish, H. F., and Blobel, G. (1978). J. Biol. Chem. 253, 8667–8670.

    CAS  Google Scholar 

  • Lingappa, V. R., Lingappa, J. R., and Blobel, G. (1979). Nature (London) 281, 117–121.

    Article  CAS  Google Scholar 

  • Majzoub, J. A., Rosenblatt, M., Fennick, B., Mannus, R., Kronenberg, H. M., Potts, J. T., Jr., and Habener, J. F. (1980). J. Biol. Chem. 255, 11478–11483.

    CAS  Google Scholar 

  • Meyer, D. I., and Dobberstein, B. (1980). J. Cell Biol. 87, 498–502, 503–508.

    Google Scholar 

  • Moreno, F., Fowler, A., Hall, M., Silhavy, T., Zabin, I., and Silhavy, M. (1980). Nature (London) 286, 356–360.

    Article  CAS  Google Scholar 

  • Patzelt, C., Labrecque, A. D., Duguid, J. R., Carroll, R. J., Keim, P. S., Heinrikson, R. L., and Steiner, D. F. (1978). Proc. Natl. Acad. Sci. USA 75, 1260–1264.

    Article  CAS  Google Scholar 

  • Schatz, G. (1979). FEBS Lett. 103, 203–211.

    Article  CAS  Google Scholar 

  • Szcesna, E., and Boime, I. (1976). Proc. Natl. Acad. Sci. USA 73, 1179–1183.

    Article  Google Scholar 

  • Talmadge, K., Stahl, S., and Gilbert, W. (1980a). Proc. Natl. Acad. Sci. USA 77, 3369–3373.

    Article  CAS  Google Scholar 

  • Talmadge, K., Kaufman, J., and Gilbert, W. (1980b). Proc. Natl. Acad. Sci. USA 77, 3988–3992.

    Article  CAS  Google Scholar 

  • Walter, P., Jackson, R. C., Marcus, M. M., Lingappa, V. R., and Blobel, G. (1979). Proc. Natl. Acad. Sci. USA 76, 1795–1799.

    Article  CAS  Google Scholar 

  • Warren, G., and Dobberstein, B. (1978). Nature (London) 273, 569–571.

    Article  CAS  Google Scholar 

  • Wickner, W. (1980). Science 210, 861–868.

    Article  CAS  Google Scholar 

  • Zwizinski, C., and Wickner, W. (1980). J. Biol. Chem. 255, 7973–7977.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. European Molecular Biology Laboratory, 6900, Heidelberg, West Germany

    Bernhard Dobberstein & David I. Meyer

Authors
  1. Bernhard Dobberstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David I. Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biochemistry, State University of New York, Upstate Medical Center, 13210, Syracuse, New York, USA

    Anthony N. Martonosi

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Dobberstein, B., Meyer, D.I. (1982). Protein Translocation across the Membrane of the Endoplasmic Reticulum. In: Martonosi, A.N. (eds) Membranes and Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4082-9_27

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4082-9_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4084-3

  • Online ISBN: 978-1-4684-4082-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation