Abstract
The use of NMR for the study of membranes was introduced by Chapman and Salsbury (1966). Over the past decade several hundred reports of observations of 1H, 2H, 13C, 19F, and 31P spectra on phospholipid vesicles and several natural membranes have appeared. The majority of these have addressed various aspects of the problems of order, orientation, mobility, and lateral diffusion in phospholipid bilayers and multilayers. Others have dealt with the conformations of the polar head groups of phospholipids, transmembrane exchange (flip-flop) between the two layers, interactions of small molecules—notably cholesterol—and local anesthetics with both model and natural membranes, and function of ion channels in reconstituted membranes, the fusion of phospholipid bilayers catalyzed by peptides and proteins, and the nature of protein-lipid interactions.
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References
Assman, G., Highet, R. J., Sokoloski, E. A., and Brewer, H. B. (1974). Proc. Natl. Acad. Sci. USA 71, 3701–3705.
Batchelor, J. G., Prestegard, J. H., Cushley, R. J., and Lipsky, S. R. (1972). Biochem. Biophys. Res. Commun 48, 70–75.
Berden, J. A., Cullis, P. R., Hoult, D. I., McLaughlin, A. C., Radda, G. K., and Richards, R. E. (1974). FEBS Lett. 46, 55–58.
Bergelson, L. D., and Barsukov, L. I. (1977). Science 197, 224–230.
Brown, T. R., Ugurbil, K., and Shulman, R. G. (1977). Proc. Natl. Acad. Sci. USA 74, 551–553.
Brulet, P., and McConnell, H. M. (1976). J. Am. Chem. Soc 98, 1314–1318.
Chan, S. I., Feigenson, G. W., and Seiter, C. H. (1971). Nature 231, 110–112.
Chapman, D. (1968). In Biological Membranes(D. Chapman, ed.), pp. 189–202, Academic Press, New York.
Chapman, D., and Salsbury, N. J. (1966). Trans. Faraday Soc 62, 2607–2621.
Charvolin, J., Manneville, P., and Deloche, B. (1973). Chem. Phys. Lett 23, 345–348.
Chatterjee, N., and Brockerhoff, H. (1978). Biochim. Biophys. Acta 511, 116–119.
Copeland, B. R., and McConnell, H. M. (1980). Biochim. Biophys. Acta 599, 95–109.
Dahlquist, F. W., Muchmore, D. C., Davis, H. H., and Bloom, M. (1977). Proc. Natl. Acad. Sci. USA 74, 5435–5439.
Davis, D. G., and Inesi, G. (1972). Biochim. Biophys. Acta 282, 180–186.
Davis, J. H., Nichol, C. P., Weeks, G., and Bloom, M. (1979). Biochemistry 18, 2103–2112.
Dea, P., Chan, S. I., and Dea, F. J. (1972). Science 175, 206–209.
Finch, E. D., and Schneider, A. S. (1975). Biochim. Biophys. Acta 406, 146–154.
Finer, E. G., Henry, R., Leslie, R. B., and Robertson, R. S. (1975). Biochim. Biophys. Acta 380, 320–337.
Gent, M. P. N., and Ho, C. (1978). Biochemistry 17, 3023–3038.
Griffin, R. G., Powers, L., and Pershan, P. S. (1978). Biochemistry 17, 2718–2722.
Hagen, D. S., Weiner, J. H., and Sykes, B. D. (1979). Biochemistry 18, 2007–2012.
Hamilton, J. A., and Cordes, E. H. (1978). J. Biol. Chem 253, 5193–5198.
Hauser, H. (1975). FEBS Lett. 60, 71–75.
Hauser, H., Phillips, M. C., and Barratt, M. D. (1975). Biochim. Biophys. Acta 413, 341–353.
Hauser, H., Phillips, M. C., Levine, B. A., and Williams, R. J. P. (1976). Nature (London) 261, 390–394.
Horwitz, A. F., Michaelson, D., and Klein, M. P. (1973). Biochim. Biophys, Acta 298, 1–7.
Hubbell, W. L., and McConnell, H. M. (1971). J. Am. Chem. Soc 93, 314–326.
Jacobs, R., and Oldfield, E. (1979). Biochemistry 18, 3280–3285.
James, T. L., and Noggle, J. H. (1972). Anal. Biochem 49, 208–217.
Jardetzky, O. (1980). Biochim. Biophys. Acta 621, 227–232.
Jardetzky, O., and Roberts, G. C. K. (1981). NMR in Molecular Biology, Academic Press, New York.
Jost, P. C., Griffiths, O. H., Capaldi, R. A., and Vanderkooi, G. (1973). Biochim. Biophys. Acta 311, 141–152.
Kang, S. Y., Gutowsky, H. S., Hsung, J. C., Jacobs, R., King, T. E., Rice, D., and Oldfield, E. (1979). Biochemistry 18, 3257–3267.
Kornberg, R. D., and McConnell, H. M. (1971). Proc. Natl. Acad. Sci. USA 68, 2564–2568.
Kuo, A. L., and Wade, C. G. (1979). Biochemistry 18, 2300–2308.
Lee, A. G., Birdsall, N. J. M., Levine, Y. K., and Metcalfe, J. C. (1972). Biochim. Biophys. Acta 225, 43–56.
Lee, A. G., Birdsall, N. J. M., and Metcalfe, J. C. (1973). Biochemistry 12, 1650–1659.
Lee, A. G., Birdsall, N. J. M., Metcalfe, J. C., Warren, G. B., and Roberts, G. C. K. (1976). Proc. Roy. Soc. London Ser. B 193, 253–274.
Levine, Y. K., Birdsall, N. J. M., Lee, A. G., and Metcalfe, J. C. (1972). Biochemistry 11, 1416–142.
Luzzati, V. (1968). In Biological Membranes(D. Chapman, ed.), pp. 71–123, Academic Press, New York.
McFarland, B. G., and McConnell, H. M. (1971). Proc. Natl. Acad. Sci. USA 68, 1274–1278.
McLaughlin, A. C., Podo, F., and Blasie, J. K. (1973). Biochim. Biophys. Acta 330, 109–121.
McLaughlin, A. C., Cullis, P. R., Hemminga, M. A., Hoult, D. I., Radda, G. K., Ritchie, G. A., Seeley, P. J., and Richards, R. E. (1975). FEBS Lett. 57, 213–218.
Metcalfe, J. C., Birdsall, N. J. M., Feeney, J., Lee, A. G., Levine, Y. K., and Partington, P. (1971). Nature (London) 233, 199–201.
Nicolau, C., Dietrich, W., Steiner, M. R., Steiner, S., and Melnick, J. L. (1975). Biochim. Biophys. Acta 382, 311–321.
Oldfield, E., Meadows, M., Rice, D., and Jacobs, R. (1978). Biochemistry 17, 2727–2740.
Owicki, J. C., and McConnell, H. M. (1980). Biophys. J 30, 383–398.
Robinson, J. D., Birdsall, N. J. M., Lee, A. G., and Metcalfe, J. C. (1972). Biochemistry 11, 2903–2902.
Seelig, A., and Seelig, J. (1974). Biochemistry 13, 4839–4845.
Seelig, J. (1977). Q. Rev. Biophys 10, 353–418.
Seelig, J. (1978). Biochim. Biophys. Acta 515, 105–140.
Smith, I. C. P., Tullock, A. P., Stockton, G. W., Schreier, S., Joyce, A., Butler, K. W., Boulanger, Y., Blackwell, B., and Bennet, L. G. (1978). Ann. N.Y. Acad. Sci308, 8–31.
Stier, A., Finch, A. E., and Bosterling, B. (1978). FEBS Lett. 91, 109–112.
Stoffel, W., and Bister, K. (1975). Biochemistry 14, 2841–2847.
Taylor, R. P. (1976). Arch. Biochem. Biophys 173, 596–602.
Utsumi, H., Tunggal, B. D., and Stoffel, W. (1980). Biochemistry 19, 2385–2390.
Wennerstrom, H., and Lindblom, G. (1977). Q. Rev. Biophys 10, 67–96.
Yeagle, P. L., Hutton, W. C., Huang, C.-H., and Martin, R. B. (1975). Proc. Natl. Acad. Sci. USA 72, 3477–3481.
Yeagle, P. L., Martin, R. B., Pottenger, L., and Langdon, R. G. (1978). Biochemistry 17, 2727–2710.
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Jardetzky, O. (1982). NMR in the Study of Membranes. In: Martonosi, A.N. (eds) Membranes and Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4082-9_14
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DOI: https://doi.org/10.1007/978-1-4684-4082-9_14
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