Abstract
Therapeutic trials are always expensive in terms of time of highly trained medical/scientific personnel and often in terms of money for extra staff and supporting service. They are also tedious to perform even where positive results may be expected. Therefore, it is important that they should be neither larger nor more prolonged than is necessary to obtain a definite result. This is easy to say but hard to do.
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Laurence, D.R. (1981). Sensitivity of Therapeutic Trials: Sequential Analysis: Peeking at Interim Results: Is it Scientific? Is it Ethical?. In: Wardell, W.M., Velo, G. (eds) Drug Development, Regulatory Assessment, and Postmarketing Surveillance. NATO Advanced Study Institutes Series, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4055-3_11
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DOI: https://doi.org/10.1007/978-1-4684-4055-3_11
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