Abstract
Today in the biological sciences there is a growing interest and use in technologies capable of remote in vivo quantization of cellular constituents. The biophysical application of two such technologies, as scanning (1) and flow (2) cytometry, to elucidate the in vivo mechanisms of proliferation, differentiation and expression of metastatic potential in mammalian cell systems, has been recently introduced (for an updated review see also the chapters by Nicolini, Mendelsohn and Casperson in the previous book of this NATO-ASI series (3)). These technologies have made possible the detailed and quantitatively accurate characterization of “native interphase chromatin” (1,4,5) and membrane (2,6). This characterization has in turn led to a new model for normal and abnormal cell growth, that is related to and dependent upon the quinternary nuclear organization of the chromatin (1,4).
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Nicolini, C., Lessin, S., Abraham, S., Chiabrera, A., Zietz, S. (1982). Growth Parameters in Normal and Tumor Cells: Non-Cycling Cells and Metastatic Variants as Monitored by Flow Cytometry. In: Nicolini, C. (eds) Cell Growth. NATO Advanced Study Institutes Series, vol 38. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4046-1_8
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DOI: https://doi.org/10.1007/978-1-4684-4046-1_8
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