Abstract
Studies on the control of growth of mammalian cells have focused primarily on the role of diffusible factors, in the promotion of cell growth. However, a number of experimental results in the last several years suggest that there is another level at which cell growth may be controlled. These studies show that cell conformation plays a crucial role in growth control. The term “conformation” as used here refers both to cell shape and to the nature of the cell-substratum interaction. The experimental studies which will be described here show that cell conformation has a profound influence on (a) cell growth; (b) RNA and protein metabolism; and (c) gene expression. Furthermore, the acquisition of the fully transformed or neoplastic phenotype appears to involve the loss of the conformational-related control of these processes.
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© 1982 Plenum Press, New York
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Wittelsberger, S., Folkman, J. (1982). Cell Conformation and Growth Control. In: Nicolini, C. (eds) Cell Growth. NATO Advanced Study Institutes Series, vol 38. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4046-1_26
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DOI: https://doi.org/10.1007/978-1-4684-4046-1_26
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