Skip to main content

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

Saccharomyces cerewisiae is a lower eukaryote ideal for many current biological studies. It shares certain properties with higher eukaryotes: a nucleus containing multiple chromosomes packed in chromatin structures, and specialized organelles such as vacuoles and mitochondria. In addition, the organization of yeast structural genes is similar to that of higher eukaryotic cells: most functionally related genes are scattered on different chromosomes rather than linked together in operons (21). Yet, while yeast are more complex than bacteria, they still share many of the technical advantages which permitted rapid progress in the genetic and biochemical studies of prokaryotic organisms. Some of the properties which make yeast particularly amenable to study are their short generation time, the existence of both stable haploids and diploids, and the ease of replica plating and mutant isolation. Furthermore, the sophisticated classical genetics of yeast allows one to fully exploit recent technological advances in genetic engineering.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abelson, J. 1980. Science 209, 1319–1321.

    Article  PubMed  CAS  Google Scholar 

  2. Bach, M.L. and F. Lacroute. 1972. Mol. Gen. Genet. 115, 126–130.

    Article  PubMed  CAS  Google Scholar 

  3. Beggs, J.D. 1978. Nature 275, 104–109.

    Article  PubMed  CAS  Google Scholar 

  4. Borst, P. and L.A. Grivell. 1978. Cell 15, 705–723.

    Article  PubMed  CAS  Google Scholar 

  5. Bostian, K.A., J.E. Hopper, D.T. Roger, and D.J. Tipper. 1980. Cell 19, 403–414.

    Article  PubMed  CAS  Google Scholar 

  6. Botstein, D., S.C. Falco, S.E. Stewart, M. Brennan, S. Scherer, D.J. Stinchcomb, K. Struhl, and R. Davis. 1979. Gene 8, 17–24.

    Article  PubMed  CAS  Google Scholar 

  7. Broach, J.R., J.F. Atkins, C. McGill, and L. Chow. 1979. Cell 16, 827–839.

    Article  PubMed  CAS  Google Scholar 

  8. Broach, J.R., J.N. Strathern, and J.B. Hicks. 1979. Gene 8, 121–133.

    Article  PubMed  CAS  Google Scholar 

  9. Bussey, H. 1972. Nature New Biol. 235, 73–75.

    PubMed  CAS  Google Scholar 

  10. Bussey, H. and D. Sherman. 1973. Biochim. Biophys. Acta 298, 868–875.

    Article  PubMed  CAS  Google Scholar 

  11. Cameron, J.R., P. Philippsen, and R. W. Davis. 1977. Nucleic Acids Res. 4, 1429–1448.

    Article  PubMed  CAS  Google Scholar 

  12. Chatoo, B., F. Sherman, D. Azubalis, T. Fjellstedt, D. Mehnert, and M. Ogur. 1979. Genetics 93:51–65.

    Google Scholar 

  13. Church, G., P. Slonimski, W. Gilbert, 1979. Cell 18, 1209–1215.

    Article  PubMed  CAS  Google Scholar 

  14. Clarke, L. and J. Carbon. 1976. Cell 9, 91–99.

    Article  PubMed  CAS  Google Scholar 

  15. Clarke-Walker, G.D. and G. L. Miklos. 1974. Eur. J. Biochem. 41, 263–267.

    Article  Google Scholar 

  16. Douglas, H. and D. Hawthorne. 1964. Genetics 49, 837–844.

    PubMed  CAS  Google Scholar 

  17. Fink, G.R. 1966. Genetics 53, 445–459.

    PubMed  CAS  Google Scholar 

  18. Fisher, C. 1969. Biochem. Biophys. Res. Commun. 34, 306–310.

    Article  PubMed  CAS  Google Scholar 

  19. Fowell, R.R. 1969. In “The Yeasts”, Vol. 1 (A.H. Rose and J. S. Harrison, eds.), Academic Press, N.Y., 303–383.

    Google Scholar 

  20. Gerbaud, C., P. Fournier, H. Blanc, M. Aigle, H. Heslot, and M. Guerineau. 1979. Gene.5, 233–253.

    Article  PubMed  CAS  Google Scholar 

  21. Greer, H. and G.R. Fink. 1975. In “Methods in Cell Biology, Vol. XI, Yeast Cells.” (D. Prescott, ed.) Academic Press, N.Y. 247–272.

    Google Scholar 

  22. Grunstein, M. and D.S. Hogness. 1975. Proc. Natl. Acad. Sci. USA 72, 3961–3965.

    Google Scholar 

  23. Guerineau, M., C. Grandchamp, P.P. Slonimski. 1976. Proc. Natl. Acad. Sci. USA 73, 3030–3034.

    Google Scholar 

  24. Hartwell, L.H. 1974. Bacteriol. Rev. 38, 164–198.

    PubMed  CAS  Google Scholar 

  25. Hawthorne, D.C. and R.K. Mortimer. 1960. Genetics 45, 1085–1110.

    PubMed  CAS  Google Scholar 

  26. Henry, S., T. Donahue, and M. Culbertson. 1975. Molec. Gen. Genet. 143, 5–11.

    Article  PubMed  CAS  Google Scholar 

  27. Herring, A.J. and E.A. Bevan. 1974. J. Gen. Virol. 22, 387–394.

    Article  PubMed  CAS  Google Scholar 

  28. Hicks, J., J. Strathern, and I. Herskowitz. 1977. In “DNA Insertion Elements, Plasmids and Episomes” (A. Bukhari, J. Shapiro, and S. Adhya, eds.). Cold Spring Harbor Laboratory, N.Y., 457–462.

    Google Scholar 

  29. Hicks, J.B., A. Hinnen, and G.R. Fink. 1978. Cold Spring Harbor Symp. Quant. Biol. 43, 1305–1313.

    Article  Google Scholar 

  30. Hicks, J., J. Strathern, and A.J. Klar. 1979. Nature 282, 478–483.

    Article  PubMed  CAS  Google Scholar 

  31. Hilger, F. and R.K. Mortimer. 1980. J. Bact. 141, 270–274.

    PubMed  CAS  Google Scholar 

  32. Hinnen, A., J. Hicks, and G.R. Fink. 1978. Proc. Natl. Acad. Sci. USA 75, 1929–1933.

    Article  PubMed  CAS  Google Scholar 

  33. Hinnen, A., P. Farabaugh, C. Ilgen, and G.R. Fink. 1979. ICN-UCLA Symp. 14, 43–50.

    CAS  Google Scholar 

  34. Hitzeman, R.A., A.C. Chinault, A.J. Kingsman, and J. Carbon. 1979. INC-UCLA Symp. 14, 57–68.

    CAS  Google Scholar 

  35. Hollenberg, C.P., P. Borst, E.F. Van Bruggen. 1970. Biochim. Biophys. Acta 209, 1–15.

    PubMed  CAS  Google Scholar 

  36. Hollenberg, C.P., A. Degelmann, B. Kustermann-Kuhn, and H.D. Royer. 1976. Proc. Natl. Acad. Sci. USA 72, 2072–2076.

    Article  Google Scholar 

  37. Hsiao, C.H. and J. Carbon. 1979. Proc. Natl. Acad. Sci. USA 76, 3829–3833.

    Article  PubMed  CAS  Google Scholar 

  38. Johnston, J.R. and R.K. Mortimer. 1959. J. Bact. 78. 292.

    Article  PubMed  CAS  Google Scholar 

  39. Korch, C., F. Lacroute, and F. Exinger. 1974. Mol. Gen. Genet. 133, 63–75.

    Article  PubMed  CAS  Google Scholar 

  40. Lauer, G., T.M. Roberts, and L.C. Klotz. 1977. J. Mol. Biol. 114, 507–526.

    Article  PubMed  CAS  Google Scholar 

  41. Lazowka, J., C. Jacq, P. Slonimski. 1980. Cell 22, 333–348.

    Article  Google Scholar 

  42. Linnane, A.W., J.M. Haslam, H.B. Lukins, and P. Nagley. 1972. Ann. Rev. Microbiol. 25, 163–198.

    Google Scholar 

  43. Livingston, D.M. 1977. Genetics 86, 73–84.

    PubMed  CAS  Google Scholar 

  44. Mortimer, R.K. and D.C. Hawthorne. 1969. In “The Yeasts”, Vol. I, (A.H. Rose and J.S. Harrison, eds.). Academic Press, N.Y. 385–460.

    Google Scholar 

  45. Mortimer, R.K. and T.R. Manney. 1971. In “Chemical Mutagens” Vol. I. (A. Hollaender, ed.), Plenum Press, N.Y., p. 289–310.

    Chapter  Google Scholar 

  46. Mortimer, R.K. and D.C. Hawthorne 1973. Genetics 74., 33–54.

    PubMed  CAS  Google Scholar 

  47. Mortimer, R.K. and D.C. Hawthorne 1975. In “Methods in Cell Biology”, Vol. XI (D.M. Prescott, ed.). Academic Press, N.Y. 221–233.

    Google Scholar 

  48. Nagley, P. and A.W. Linnane. 1972. J. Mol. Biol. 66, 181–193.

    Article  PubMed  CAS  Google Scholar 

  49. Nasmyth, K.A. and K. Tatchell. 1980. Cell 19, 753–764.

    Article  PubMed  CAS  Google Scholar 

  50. Perkins, D.D. 1949. Genetics 34, 607–626.

    CAS  Google Scholar 

  51. Petes, T. 1980. Ann. Rev. Biochem. 49, 845–876.

    Article  PubMed  CAS  Google Scholar 

  52. Petes, T. and D.H. Williamson. 1975. Cell 4, 249–253.

    Article  PubMed  CAS  Google Scholar 

  53. Ratzkin, B. and J. Carbon. 1977. Proc. Natl. Acad. Sci. USA 24, 487–491.

    Article  Google Scholar 

  54. Seherer, S. and R.W. Davis. 1979. Proc. Natl. Acad. Sci. USA 76, 4951–4955.

    Article  Google Scholar 

  55. Sherman, F. 1975. In “Methods in Cell Biology, Vol. XI. Yeast Cells.” (D. Prescott, ed.). Academic Press, N.Y., 189–199.

    Google Scholar 

  56. Sherman, F. and H. Roman. 1963. Genetics 48, 255–261

    PubMed  CAS  Google Scholar 

  57. Sherman, F. and C. W. Lawrence. 1974. In “Handbook of Genetics” Vol. 1. (R.C. King, ed.). Plenum Publishing Corporation, N.Y. 359–393.

    Google Scholar 

  58. Sherman, F., J. Stewart, M. Jackson, R. Gilmore, and J. Parker. 1974. Genetics 77, 255–284.

    PubMed  CAS  Google Scholar 

  59. Silver, J. and N. Eaton. 1969. Biochem. Biophys. Res. Commun. 34, 301–305.

    Article  PubMed  CAS  Google Scholar 

  60. Sinclair, J.H., B.J. Stevens, P. Sanghavi, and M. Rabinowitz. 1967. Science 156, 1234–1237.

    Article  PubMed  CAS  Google Scholar 

  61. Snow, R. 1966. Nature 211, 206–207.

    Article  PubMed  CAS  Google Scholar 

  62. Somers, J.M. and E.A. Bavan. 1969. Genet. Res. 13, 71–83.

    Article  PubMed  CAS  Google Scholar 

  63. Stinchcomb, D.T., K. Struhl, and R.W. Davis. 1979. Nature 282, 39–43.

    Article  PubMed  CAS  Google Scholar 

  64. Storms, R.K., J.B. McNeil, P. S. Khandlkar, G. An, J. Parker, and J. D. Friesen. 1979. J. Bacteriol. 140, 73–82.

    PubMed  CAS  Google Scholar 

  65. Struhl, K., D.T. Stinchcomb, S. Scherer, and R.W. Davis. 1979. Proc. Natl. Acad. Sci. USA 76, 1035–1039.

    Article  PubMed  CAS  Google Scholar 

  66. Szostak, J. and R. Wu. 1979. Plasmid 2, 536–554.

    Article  PubMed  CAS  Google Scholar 

  67. Takano, I. and Y. Oshima. 1970. Genetics 65, 421–427.

    PubMed  CAS  Google Scholar 

  68. Thouvenot, D.R. and C.M. Bourgeois. 1971. Ann. Inst. Pasteur 120, 617–625.

    CAS  Google Scholar 

  69. Walton, E.F., B.L. Carter, and J.R. Pringle. 1979. Molec. Gen. Genet. 171, 111–114.

    Article  Google Scholar 

  70. Wickner, R. 1978. Genetics 88, 419–425.

    PubMed  CAS  Google Scholar 

  71. Wickner, R. 1979. Genetics 92, 803–821.

    PubMed  CAS  Google Scholar 

  72. Williamson, D.H. 1970. Symp. Soc. Exp. Biol. 24, 247–276.

    Google Scholar 

  73. Williamson, V.M., J. Bennetzen, E.T. Young, K. Nasmyth, and B.D. Hall. 1979. Nature 283, 214–216.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Greer, H. (1981). Mechanisms of Yeast Genetics. In: Hollaender, A., Rabson, R., Rogers, P., Pietro, A.S., Valentine, R., Wolfe, R. (eds) Trends in the Biology of Fermentations for Fuels and Chemicals. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3980-9_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3980-9_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3982-3

  • Online ISBN: 978-1-4684-3980-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics