Abstract
In the last two decades, the development of saturation analysis methods has permitted specific and accurate measurement of circulating sex steroid hormones and documentation of their cyclic changes during the menstrual cycle. The large body of evidence accumulated over the past ten years indicates that hormones interact with a receptor system before triggering cellular responses. Hormone receptors were first identified and studied physiochemically for steroids, particularly estradiol, in the rat uterus. Once reliable measurements of hormone receptors became available in animal models, correlations between receptor concentrations and circulating levels of various hormones:were attempted. It was discovered that the concentration of receptor molecules is not fixed and varies with the physiological state of animals. Variations in the concentration and subcellular distribution of receptors were observed during the estrus cycle and could be mimicked in hormone-deprived animals by injecting estradiol and progesterone (Baulieu et al., 1975).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, J., Clark, J.H., and Peck, E.J., 1972, Oestrogen and nuclear binding sites. Determination of specific sites by [3H]oestradiol exchange, Biochem. J., 126: 561.
Batra, S., Grundsell, H., and Sjöberg, N.-O., 1977, Estradiol-173 and progesterone concentrations in human endometrium during the menstrual cycle, Contraception, 16:217.
Baulieu, E.E., Atger, M., Best-Belpomme, M., Corvol, P., Courvalin, J.C., Mester, J., Milgrom, E., Robel, P., Rochefort, H., and De Catalogne, D., 1975, Steroid hormone receptors, Vitam. Horm., 33:649.
Bayard, F., Louvet, J.P., Monrozies, M., Boulard, A., and Pontonnier, G., 1975, Endometrial progesterone concentrations during the menstrual cycle, J. Endocrinol. Metab., 41:412.
Bayard, F., Damilano, S., Robel, P., and Baulieu, E.E., 1978, Cytoplasmic and nuclear estradiol and progesterone receptors in human endometrium, J. Clin. Endocrinol. Metab., 46:635.
Brenner, R.M., Resko, J.A., and West, N.B., 1974, Cyclic changes in ovaductal morphology and residual cytoplasmic estradiol binding capacity induced by sequential estradiol-progesterone treatment of spayed rhesus monkeys, Endocrinology, 95:1094.
Brush, M.G., Taylor, R.W., and King, R.J.B., 1967, The uptake of [6,7- H]oestradiol by the normal human female reproductive tract, J. Endocrinol., 39:599.
Brush, M.G., King, R.J.B., and Taylor, R.W., 1978, “Endometrial Cancer,” Baillière Tindall, London.
Collins, J.A., and Jewkes, D.M., 1974, Progesterone metabolism by proliferative and secretory human endometrium, Am. J. Obstet. Gynecol., 118:179.
Crocker, S.G., Milton, P.J.D., and King, R.J.B., 1974, Uptake of [6,73-H]oestradiol-173 by normal and abnormal human endometrium, J. Endocrinol., 62:145.
Davis, M.E., Wiener, M., Jacobson, H.I., and Jensen, E.V., 1963, Estradiol metabolism in pregnant and nonpregnant women, Am. J. Obstet. Gynecol., 87:979.
Evans, L.H., and Hähnel, R., 1971, Oestrogen receptors in human uterine tissue, J . Endocrinol., 50:209.
Evans, L.H., Martin, J.D., and Hahnel, R., 1974, Estrogen receptor concentration in normal and pathological human uterine tissues, J. Clin. Endocrinol. Metab., 38:23.
Feil, P.D., Glasser, S.R., Toft, D.O., and O’Malley, B.W., 1972, Progesterone binding in the mouse and rat uterus, Endocrinology, 91:738.
Guerrero, R., Landgren, B.-M., Monteil, R., Cekan, Z., and Diczfalusy, E., 1975, Unconjugated steroids in the human endometrium, Contraception, 11:169.
Gurpide, E., Gusberg, S., and Tseng, L., 1976, Estradiol binding and metabolism in human endometrial hyperplasia and adenocarcinoma, J. Steroid Biochem., 7:891.
Gurpide, E., Tseng, L., and Gusberg, S.B., 1977, Estrogen metabolism in normal and neoplastic endometrium, Am. J. Obstest. Gynecol., 129:809.
Gusberg, S., 1976, The individual at high risk for endometrial carcinoma, Am. J. Obstet. Gynecol., 126:535.
Hahnel, R., 1971, Properties of the estrogen receptor in the soluble fraction of human uterus, Steroids, 17:105.
Haukkamaa, M., 1974, Binding of progesterone by rat myometrium during pregnancy and by human myometrium in late pregnancy, J. Steroid Biochem., 5:73.
Haukkamaa, M., and Luukkainen, T., 1974, The cytoplasmic progesterone receptor of human endometrium during the menstrual cycle, J. Steroid Biochem, 5:447.
Heyns, W., and De Moor, P., 1971, The binding of 17β-hydroxy-5α-androstan-3-one to the steroid-binding β-globulin in human plasma, as studied by means of ammonium sulfate precipitation, Steroids, 18:709.
Hsueh, A.J., Peck, E.J., and Clark, J.H., 1975, Progesterone antagonism of the oestrogen receptor and oestrogen-induced uterine growth, Nature, 254:337.
Illingworth, D.V., Wood, G.P., Flickinger, G.L., and Mikhail, G., 1975, Progesterone receptor of the human myometrium, J. Clin. Endocrinol. Metab., 40:1001.
Jänne, O., Kontula, K., Luukkainen, T., and Vihko, R., 1975, Oestrogen-induced progesterone receptor in human uterus, J. Steroid Biochem., 6:501.
Janne, O., Kontula, K., and Vihko, R., 1976, Progestin receptors in human tissues: concentrations and binding kinetics, J. Steroid Biochem., 7:1061.
Koenders, A.J., Geurts-Moespot, J., Kho, K.H., and Benraad, Th.J., 1978, Estradiol and progesterone receptor activities in stored lyophilised target tissue, J. Steroid Biochem., 9:947.
Kontula, K., 1975, Progesterone-binding protein in human myometrium. Binding site concentration in relation to endogenous proges-terine and estradiol-17β levels, J. Steroid Biochem., 7:1555.
Kreitmann, B., Derache, B., and Bayard, F., 1978, Measurement of the corticosteroid-binding globulin, progesterone, and progesterone “receptor” content in the human endometrium, J. Clin. Endocrinol. Metab., 47:350.
Krishnan, A.R., Hingorani, V., and Laumas, K.R., 1973, Binding of 3H-oestradiol with receptors in the human endometrium and myometrium, Acta Endocrinol., 74:756.
Levy, C., Robel, P., Gautray, J.P., de Brux, J., Verma, U., 1980a, Estradiol and progesterone receptors in human endometrium, normal and abnormal menstrual cycles and early pregnancy, Am. J. Obstet. Gynecol., 136:646.
Levy, C., Mortel, R., Eychenne, B., Robel, P., and Baulieu, E.E., 1980, Unoccupied nuclear oestradiol-receptor sites in normal human endometrium, Biochem. J., 185:733.
Lippman, M., Huff, K., Bolan, G., and Neifeld, J.P., 1977, Interactions of R5020 with progesterone and glucorticoid receptors in breast cancer and peripheral blood lymphocytes in vitro, in; “Progesterone Receptors in Normal and Neoplastic Tissues,” W.L. McGuire, J.P. Raynaud, and E.E. Baulieu, ed., Raven Press, New York, p. 193.
Lunan, C.B., and Green, B., 1975, Oestradiol-17β uptake in vitro into the nuclei of endometrium from different regions of the human uterus, Acta Endocrinol., 78:353.
McGuire, W.L., Raynaud, J.P., and Baulieu, E.E., 1977, Progesterone receptors: introduction and overview, in: “Progesterone Receptors in Normal and Neoplastic Tissues,” W.L. McGuire, J.P. Raynaud, and E.E. Baulieu, ed., Raven Press, New York, p. 1.
MacLaughlin, D.T., and Richardson, G.S., 1976, Progesterone binding by normal and abnormal human endometrium, J. Clin. Endocrinol. Metab., 42:667.
Makler, A., and Eisenfeld, A.J., 1974, In vitro binding of 3H-estradiol to macromolecules from the human endometrium, J. Clin. Endocrinol. Metab., 38:628.
Mercier-Bodard, C., Alfsen, A., and Baulieu, E.E., 1970, Sex steroid binding plasma protein (SBP), Acta Endocrinol., 147:204.
Mester, I., Martel, D., Psychoyos, A., and Baulieu, E.E., Hormonal control of oestrogen receptor in uterus and receptivity for ovoimplantation in the rat, Nature, 250:776.
Milgrom, E., and Baulieu, E.E., 1970, Progesterone in uterus and plasma. I. Binding in rat uterus 105,000g supernatant, Endocrinology, 87:276.
Milgrom, E., Atger, M., Perrot, M., and Baulieu, E.E., 1972, Progesterone in uterus plasma. VI. Uterine progesterone receptors during the estrus cycle and implantation in the guinea pig, Endocrinology, 90:1071.
Milgrom, E., Thi, M.L., Atger, M., and Baulieu, E.E., 1973, Mechanisms regulating the concentration and the conformation of progesterone receptor(s) in the uterus, J. Biol. Chem., 248:6366.
Philibert, D., and Raynaud, J.P., 1974, Binding of progesterone and R 5020, a highly potent progestin, to human endometrium and myometrium, Contraception, 10:457.
Pollow, K., Lübbert, H., Boquoi, E., Kreutzer, G., and Pollow, B., 1975a, Characterization and comparison of receptors of 17ß-estradiol and progesterone in human proliferative and endometrial carcinoma, Endocrinology, 96:319.
Pollow, K., Lübbert, H., Boquoi, E., Kreutzer, G., Jeske, R., and Pollow, B., 1975b, Studies on 17β-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma. I. Subcellular distribution and variations of specific enzyme activity, Acta Endocrinol., 79:134.
Pollow, K., Lübbert, H., Boquoi, E., and Pollow, B., 1975c, Progesterone metabolism in normal endometrium during the menstrual cycle in endometrial carcinoma, J. Clin. Endocrinol. Metab., 41:729.
Pollow, K., Boquoi, E., Schmidt-Gollwitzer, M., and Pollow, B., 1976, The nuclear estradiol and progesterone receptors of human endometrium and endometrial carcinoma, J. Mol. Med., 1:325.
Pollow, K., Schmidt-Gollwitzer, M., Boquoi, E., and Pollow, B., 1978, Influence of estrogens and gestagens on 17β-hydroxy-steroid dehydrogenase in human endometrium and endometrial carcinoma, J. Mol. Med., 3:81.
Powell, B., Garola, R.E., Chamness, G.C., and McGuire, W.L., 1979, Measurement of progesterone receptor in human breast cancer biopsies, Cancer Res., 39:1678.
Rao, B.R., Wiest, W.G., and Allen, W.M., 1974, Progesterone “receptor” in human endometrium, Endocrinology, 95:1275.
Raynaud, J.P., 1977, R 5020, a tag for the progestin receptor, in: “Progesterone Receptors in Normal and Neoplastic Tissues,” W.L. McGuire, J.P. Raynaud, and E.E. Baulieu, ed., Raven Press, New York, p. 9.
Raynaud, J.P., Martin, P.M., Bouton, M.M., and Ojasoo, T., 1978, llβ-methoxy-17-ethynyl-l,3,5(10)-estratriene-3,17ß-diol (Moxestrol), a tag for estrogen receptor binding sites in human tissues, Cancer Res., 38:3044.
Richardson, G.S., and MacLaughlin, E.T., 1978, “Hormonal Biology of Endometrial Cancer,” Vol. 42, UICC Technical Reports Series, Geneva.
Robel, P., Levy, C., Wolff, J.P., Nicolas, J.C., and Baulieu, E.E., 1978, Réponse à un anti-oestrogène comme critère d’hormono-sensibilité du cancer de l’endomètre, C.R. Acad. Sci. Paris, 287:1353.
Robertson, D.M., Mester, J., Beilby, J., Steele, S.J., and Kellie, A.E., 1971, The measurement of high-affinity oestradiol receptors in human uterine endometrium and myometrium, Acta Endocrinol., 68:534.
Sanborn, B.M., Kuo, H.S., and Held, B., 1978, Estrogen and progestogen binding site concentrations in human endometrium and cervix throughout the menstrual cycle and in tissue from women taking oral contraceptives, J. Steroid Biochem., 9:951.
Schmidt-Gollwitzer, M., Genz, T., Schmidt-Gollwitzer, K., Pollow, B., and Pollow, K., 1978, Correlation between oestradiol and progesterone receptor levels, 17β-hydroxysteroid dehydrogenase activity and endometrial tissue levels of oestradiol, pestrone and progesterone in women, in: “Endometrial Cancer,” M.G. Brush, R.J.B. King, and R.W. Taylor, ed., Baillière-Tindall, London, p. 227.
Scublinski, A., Marin, C., and Gurpide, E., 1976, Localization of estradiol 173 dehydrogenase in human endometrium, J. Steroid Biochem., 7:745.
Seematter, R.J., Hoffman, P.G., Kuhn, R.W., Lockwood, L.C., and Siiteri, P.K., 1978, Comparison of [3H] progesterone and [6,7–3H]-17, 21-dimethyl-19-norpregna-4,9-diene-3,20-dione for the measurement of progesterone receptors in human malignant tissue, Cancer Res., 38:2800.
Sutherland, R., Mester, J., and Baulieu, E.E., 1977, Tamoxifen is a potent ‘pure’ anti-oestrogen in the chick oviduct, Nature, 267:434.
Sweat, M.L., and Bryson, M.J., 1970, Comparative metabolism of progesterone in proliferative human endometrium and myometrium, Am. J. Obstet. Gynecol., 106:193.
Syrjälä, P., Kontula, K., Jämie, O., Kauppila, A., and Vihko, R., 1978, Steroid receptors in normal and neoplastic human uterine tissue, in: “Endometrial Cancer,” M.G. Brush, R.J.B. King, and R.W. Taylor, ed., Baillière-Tindall, London, p. 242.
Trams, G., Engel, B., Lehmann, F., and Maass, H., 1973, Specific binding of oestradiol in human uterine tissue, Acta Endocrinol., 72:351.
Tseng, L., and Gurpide, E., 1972a, Nuclear concentration of estradiol in superfused slices of human endometrium, Am. J. Obstet. Gynecol., 114:995.
Tseng, L., and Gurpide, E., 1972b, Changes in the in vitro metabolism of estradiol by human endometrium during the menstrual cycle, Am. J. Qbstet. Gynecol., 114:1002.
Tseng, L., and Gurpide, E., 1974, Estradiol and 20a-dihydroproges-terone dehydrogenase activities in human endometrium during the menstrual cycle, Endocrinology, 94:419.
Tseng, L., and Gurpide, E., 1975a, Induction of human endometrial estradiol dehydrogenase by progestins, Endocrinology, 97:825.
Tseng, L., and Gurpide, E., 1975b, Effects of progestins on estradiol receptor levels in human endometrium, J. Clin. Endocrinol. Metab., 41:402.
Tseng, L., Gusberg, S.B., and Gurpide, E., 1977, Estradiol receptor and 17β-dehydrogenase in normal and abnormal human endometrium, Ann. N.Y. Acad. Sci., 286:190.
Tsibris, J.C.M., Cazenave, C.R., Cantor, B., Notelovitz, M., Kalra, P.S., and Spellacy, W.N., 1978, Distribution of cytoplasmic estrogen and progesterone receptors in human endometrium, Am. J. Qbstet. Gynecol., 132:449.
Verma, U., and Laumas, K.R., 1973, In vitro binding of progesterone to receptors in the human endometrium and the myometrium, Biochem. Biophys. Acta, 317:403.
Wiest, W.G., and Rao, B.R., 1971, in: “Advances in the Biosciences,” G. Raspe, ed., Vol. VII, p. 251.
Young, P.C.M., and Cleary, R.E., 1974, Characterization and properties of progesterone-binding components in human endometrium, J. Clin. Endocrinol. Metab., 39:425.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Robel, P., Mortel, R., Baulieu, E.E. (1981). Estradiol and Progesterone Receptors in Human Endometrium. In: de Brux, J., Mortel, R., Gautray, J.P. (eds) The Endometrium. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3977-9_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3977-9_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3979-3
Online ISBN: 978-1-4684-3977-9
eBook Packages: Springer Book Archive