Abstract
The number of organisms that can affect the central nervous system to produce mental or behavioral changes is legion. Virtually any infection may alter brain functioning, either by direct invasion, secondary systemic effects, or postinfection allergic responses. The result may be vague neuropsychiatric disturbances, or the most commonly diagnosed psychiatric disorder associated with infection, delirium. In general, mental status changes produced by infection are nonspecific and have no direct relationship to the specific organism involved. Neuropsychiatric changes may be noted in response to a wide variety of bacterial, viral, mycotic, spirochetal, rickettsial, and protozoal infections. Although syphilis, malaria, and tuberculosis were once prominent offenders, viral infections are probably most common at the present time. Certain infectious diseases that merit special attention because psychiatric features may be marked are discussed below. (See Hepatic section for infectious hepatitis.)
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Batchelor RB, Horne GO, Rodgerson HL: An unusual reaction to procaine penicillin in aqueous suspension. Lancet 2: 195–198, 1951.
Bell RC: Sudden death following injection of procaine penicillin. Lancet 1: 13–17, 1954.
Bjornberg A, Selstam J: Acute psychotic reaction after injection of procaine penicillin—a report of 33 cases. Acta Psychiatr Scand 35 (suppl): 129–139, 1960.
Borison RL : Amantadine-induced psychosis in a geriatric patient with renal disease. Am J Psychiatry 136: 111–112, 1979.
Bradberry JC, Owens J: Acute psychotic reactions to procaine penicillin. Am J Hosp Pharm 32: 411–413, 1975.
Brill H: Post-encephalitic psychiatric conditions, in Arieti S (ed): American Handbook of Psychiatry. New York, Basic Books, pp 1163–1174, 1959.
Cadie M, Nye FJ, Storey T: Anxiety and depression after infectious mononucleosis. Br J Psychiatry 128: 559–561, 1976.
Cleobury JF, Skinner GRB, Thouless ME: Association between psychopathic disorder and serum antibody to herpes simplex virus (Type I). Br Med J 1: 438–439, 1971.
Davison K, Bagley CR: Schizophrenia-like psychoses associated with organic disorders of the central nervous system: A review of the literature, in Harrington RN (ed): Current Problems in Neuropsychiatry. Brit J Psychiat Special Publication No. 4, Ashford Kent, Headley Brothers, 1969.
Downham TF II, Ramos DP: Non-allergic adverse reactions to aqueous procaine penicillin G. Mich Med 72: 223–227, 1973.
Elliott FA: Propanolol for the control of belligerent behavior following acute brain damage. Ann Neurol 1: 489–491, 1977.
Fahn S, Craddock G, Kumin G: Acute toxic psychosis from suicidal overdosage of amantadine. Arch Neurol 25: 45–48, 1971.
Fairweather, DS: Psychiatric aspects of the post-encephalitic syndrome. J Med Sci 93: 201–254, 1947.
Glaser GH, Pincus JH: Limbic encephalitis. J Nery Ment Dis 149: 59–67, 1969.
Greenfield NS, Roessler R, Crosley AP: Ego strength and length of recovery from infectious mononucleosis. J Nery Ment Dis 128: 125–128, 1959.
Hafstrom N: Neurologic complications of mononucleosis. Acta Neurol Scand 39: 69–81, 1963.
Halonen PE, Arohonka K, Jantti V, et al: Antibody levels of herpes simplex type I, measles and rubella viruses in psychiatric patients. Br J Psychiatry 125: 461–463, 1974.
Hansten PD (ed): Drug Interactions, ed 3. Philadelphia, Lea & Febiger, 1976.
Hendler N, Leahy W: Psychiatric and neurologic sequelae of infectious mononucleosis. Am J Psychiatry 135: 842–844, 1978.
Himmelhoch J, Pincus J, Tucker G, et al: Sub-acute encephalitis: Behavioral and neurologic aspects. Br J Psychiatry 116: 531–538, 1970.
Hollander MC, Duffy TE, Feldman HA, et al: Encephalitis or schizophrenia? Int Psychiatry Clin 2: 691–709, 1965.
Imboden J: Psychosocial determinants of recovery. Adv Psychosom Med 8: 128–137, 1972.
Johnson DW: The psychiatric side effects of drugs. Practitioner 209: 320–326, 1972.
Joyston-Bechal MP: The clinical features and outcome of stupor. Br J Psychiatry 112: 967–981, 1966.
Kakulas B, Adams RD: Viral Infections of the nervous system: Aseptic meningitis and encephalitis, in Thorn GW, Adams RD, Braunwald E (eds): Harrison’s Principles of Internal Medicine. New York, McGraw-Hill, 1977, pp 1895–1899.
Kane, FJ Jr., Byrd G: Acute toxic psychosis associated with gentamicin therapy. South Med J 68: 1283–1285, 1975.
Klein DB: Abnormal Psychology. New York, Holt, 1951.
Landes R, Reich JP, Perlow S: Central nervous system manifestations of infectious mononucleosis. JAMA 116: 2482–2484, 1941.
Levine PH, Regelson W, Holland JS: Chloramphenicol-associated encephalopathy. Clin Pharm Ther 11: 194–199, 1970.
Lipowski ZJ: Physical illness, the patient and its environment: Psychosocial foundations of medicine, in organic disorders and psychosomatic medicine, in Reiser MF, Arieti S (eds): American Handbook of Psychiatry, ed 2. New York, Basic Books, vol 4, 1975.
Lycke E, Norrby R, Roos BE: A serological study on mentally-ill patients. Br J Psychiatry 124: 277, 1974.
Meninger KA: Influenza and schizophrenia. An analysis of post-influenzal “dementia praecox” as of 1918 and five years later. Am J Psychiatry 5: 469–474, 1926.
Misra PC, Hay GG: Encephalitis presenting as acute schizophrenia. Br Med J 1: 532–533, 1971.
Nikolovski OT, Fernandes JV: Capgras Syndrome as an aftermath of chicken pox encephalitis. Psych Opinion 15: 39–43, 1978.
Penman HG: Fatal infectious mononucleosis: A critical review. J Clin Pathol 23: 765–769, 1970.
Penn H, Racy J, Lapham L, et al: Catatonic behavior, viral encephalopathy, and death: The problem of fatal catatonia. Arch Gen Psychiatry 27: 758–761, 1972.
Peszke MA, Mason WM: Infectious mononucleosis and its relationship to psychological malaise. Conn Med 1: 260–262, 1969.
Pokorny Ed, Rawls WE, Adam E, et al: Depression, psychopathology and herpes virus type I antibodies. Arch Gen Psychiatry 29:820–824, 1972.
Postma JU, Van Tilburg W: Visual hallucinations and delirium during treatment with amantadine (Symmetrel). J Am Geriatr Soc 23: 212–215, 1975.
Pratt TH: Rifampin-induced organic brain syndrome. JAMA 241: 2421–2422, 1979.
Rasken DE: Herpes encephalitis with catatonic stupor. Arch Gen Psychiatry 31: 544–546, 1974.
Raymond RW, Williams RL: Infectious mononucleosis with psychosis: Report of a case. N Engl J Med 239: 542–544, 1948.
Reilly DK: Isomiazid-related CNS toxicity. Drug Ther 9: 187–188, 1979.
Rimon R, Halonen P: Herpes simplex virus infection and depressive illness. Dis. New Syst 30: 338–340, 1969.
Rubin RL: Case reports: Adolescent infectious mononucleosis with psychosis. J Clin Psychiatry 39: 63–65, 1978.
Sacks O: Awakenings. London, Duckworth, 1973.
Saker BM, Musk AW, Hayward EF, et al: Reversible toxic psychosis after cephalexin. Med J Aust 1: 497–498, 1973.
Schnell RG, Dyck TJ, Bowie EW, et al: Infectious mononucleosis: Neurologic and EEG findings. Medicine 45: 51–63, 1966.
Schreier HR: Use of propranolol in the treatment of post-encephalitic psychoses. Am J Psychiatry 136: 840–841, 1979.
Schwab JJ: Psychiatric illnesses produced by infections. Hosp Med 5: 98–108, 1969.
Schwab RS, England AC Jr., Poskanzer DC: Amantadine in the treatment of Parkinson’s disease. JAMA 208: 1168–1170, 1969.
Shearer ML, Finch SM: Periodic organic psychosis associated with recurrent herpes simplex. N Eng J Med 271: 494–497, 1964.
Silverstein A, Steinberg G, Nathanson M: Nervous system involvement in infectious mononucleosis. Arch Neural 26: 353–359, 1972.
Sorbin A, Ozer MN: Mental disorders in acute encephalitis. J Mt Sinai Hosp 33: 73–75, 1966.
Spittle BJ, Fliegnar J, Faed JA, et al: Post-infectious encephalopathy simulating functional psychosis. New Eng Med J 85: 180–181, 1977.
Steinberg D, Hirsch SR, Marston SD, et al: Influenza infection causing manic psychosis. Br J Psychiatry 120: 531–535, 1972.
Stewart RM, Baldessarini RJ: Viral encephalopathy and psychosis. Am J Psychiatry 133: 717, 1976.
Still RML: Psychosis following Asian influenza in Barbados. Lancet 2: 20–21, 1958.
Strauss H, Ostow M, Greenstein L: Diagnostic Electroencephalography. New York, Grune & Stratton, 1952.
Thorn GW, Adams RD, Braunwald E, et al (eds): Harrison’s Principles of Internal Medicine, ed 8. New York, McGraw-Hill, 1977.
Tompsett TR: Pseudoanaphylactic reactions to procaine penicillin G. Arch Intern Med 120: 565–567, 1967.
Utley PM, Lucas JB, Billings GE: Acute psychotic reactions to aqueous procaine penicillin. South Med J 59: 1271–1274, 1966.
Wadlington WB, Hatcher H, Turner DJ: Osteomyelitis of the patella—gentamicin therapy associated with encephalopathy. Clin Pediatr 10: 577–580, 1972.
Wallin JW: Children with Mental and Physical Handicaps. New York, Prentice–Hall, 1949.
Warm JS, Alluisi EA: Behavioral reactions to infection: Review of the psychological literature. Precept Skills 24: 755–761, 1967.
Weinstein EA, Linn L, Kahn RL: Encephalitis with a clinical picture of schizophrenia. J Mt Sinai Hosp 21: 341–354, 1955.
Wilson LG: Viral encephalopathy mimicking functional psychosis. Am JPsychiatry 133: 165–170, 1976.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Publishing Corporation
About this chapter
Cite this chapter
Jefferson, J.W., Marshall, J.R. (1981). Infectious Disorders. In: Neuropsychiatric Features of Medical Disorders. Critical Issues in Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3920-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3920-5_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3922-9
Online ISBN: 978-1-4684-3920-5
eBook Packages: Springer Book Archive