Skip to main content

Part of the book series: Critical Issues in Psychiatry ((CIPS))

  • 63 Accesses

Abstract

The number of organisms that can affect the central nervous system to produce mental or behavioral changes is legion. Virtually any infection may alter brain functioning, either by direct invasion, secondary systemic effects, or postinfection allergic responses. The result may be vague neuropsychiatric disturbances, or the most commonly diagnosed psychiatric disorder associated with infection, delirium. In general, mental status changes produced by infection are nonspecific and have no direct relationship to the specific organism involved. Neuropsychiatric changes may be noted in response to a wide variety of bacterial, viral, mycotic, spirochetal, rickettsial, and protozoal infections. Although syphilis, malaria, and tuberculosis were once prominent offenders, viral infections are probably most common at the present time. Certain infectious diseases that merit special attention because psychiatric features may be marked are discussed below. (See Hepatic section for infectious hepatitis.)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Batchelor RB, Horne GO, Rodgerson HL: An unusual reaction to procaine penicillin in aqueous suspension. Lancet 2: 195–198, 1951.

    Article  PubMed  CAS  Google Scholar 

  • Bell RC: Sudden death following injection of procaine penicillin. Lancet 1: 13–17, 1954.

    Article  Google Scholar 

  • Bjornberg A, Selstam J: Acute psychotic reaction after injection of procaine penicillin—a report of 33 cases. Acta Psychiatr Scand 35 (suppl): 129–139, 1960.

    Article  PubMed  CAS  Google Scholar 

  • Borison RL : Amantadine-induced psychosis in a geriatric patient with renal disease. Am J Psychiatry 136: 111–112, 1979.

    PubMed  CAS  Google Scholar 

  • Bradberry JC, Owens J: Acute psychotic reactions to procaine penicillin. Am J Hosp Pharm 32: 411–413, 1975.

    PubMed  CAS  Google Scholar 

  • Brill H: Post-encephalitic psychiatric conditions, in Arieti S (ed): American Handbook of Psychiatry. New York, Basic Books, pp 1163–1174, 1959.

    Google Scholar 

  • Cadie M, Nye FJ, Storey T: Anxiety and depression after infectious mononucleosis. Br J Psychiatry 128: 559–561, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Cleobury JF, Skinner GRB, Thouless ME: Association between psychopathic disorder and serum antibody to herpes simplex virus (Type I). Br Med J 1: 438–439, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Davison K, Bagley CR: Schizophrenia-like psychoses associated with organic disorders of the central nervous system: A review of the literature, in Harrington RN (ed): Current Problems in Neuropsychiatry. Brit J Psychiat Special Publication No. 4, Ashford Kent, Headley Brothers, 1969.

    Google Scholar 

  • Downham TF II, Ramos DP: Non-allergic adverse reactions to aqueous procaine penicillin G. Mich Med 72: 223–227, 1973.

    Google Scholar 

  • Elliott FA: Propanolol for the control of belligerent behavior following acute brain damage. Ann Neurol 1: 489–491, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Fahn S, Craddock G, Kumin G: Acute toxic psychosis from suicidal overdosage of amantadine. Arch Neurol 25: 45–48, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Fairweather, DS: Psychiatric aspects of the post-encephalitic syndrome. J Med Sci 93: 201–254, 1947.

    CAS  Google Scholar 

  • Glaser GH, Pincus JH: Limbic encephalitis. J Nery Ment Dis 149: 59–67, 1969.

    Article  CAS  Google Scholar 

  • Greenfield NS, Roessler R, Crosley AP: Ego strength and length of recovery from infectious mononucleosis. J Nery Ment Dis 128: 125–128, 1959.

    Article  CAS  Google Scholar 

  • Hafstrom N: Neurologic complications of mononucleosis. Acta Neurol Scand 39: 69–81, 1963.

    Article  PubMed  CAS  Google Scholar 

  • Halonen PE, Arohonka K, Jantti V, et al: Antibody levels of herpes simplex type I, measles and rubella viruses in psychiatric patients. Br J Psychiatry 125: 461–463, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Hansten PD (ed): Drug Interactions, ed 3. Philadelphia, Lea & Febiger, 1976.

    Google Scholar 

  • Hendler N, Leahy W: Psychiatric and neurologic sequelae of infectious mononucleosis. Am J Psychiatry 135: 842–844, 1978.

    PubMed  CAS  Google Scholar 

  • Himmelhoch J, Pincus J, Tucker G, et al: Sub-acute encephalitis: Behavioral and neurologic aspects. Br J Psychiatry 116: 531–538, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Hollander MC, Duffy TE, Feldman HA, et al: Encephalitis or schizophrenia? Int Psychiatry Clin 2: 691–709, 1965.

    Google Scholar 

  • Imboden J: Psychosocial determinants of recovery. Adv Psychosom Med 8: 128–137, 1972.

    Google Scholar 

  • Johnson DW: The psychiatric side effects of drugs. Practitioner 209: 320–326, 1972.

    PubMed  CAS  Google Scholar 

  • Joyston-Bechal MP: The clinical features and outcome of stupor. Br J Psychiatry 112: 967–981, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Kakulas B, Adams RD: Viral Infections of the nervous system: Aseptic meningitis and encephalitis, in Thorn GW, Adams RD, Braunwald E (eds): Harrison’s Principles of Internal Medicine. New York, McGraw-Hill, 1977, pp 1895–1899.

    Google Scholar 

  • Kane, FJ Jr., Byrd G: Acute toxic psychosis associated with gentamicin therapy. South Med J 68: 1283–1285, 1975.

    Article  PubMed  Google Scholar 

  • Klein DB: Abnormal Psychology. New York, Holt, 1951.

    Google Scholar 

  • Landes R, Reich JP, Perlow S: Central nervous system manifestations of infectious mononucleosis. JAMA 116: 2482–2484, 1941.

    Article  Google Scholar 

  • Levine PH, Regelson W, Holland JS: Chloramphenicol-associated encephalopathy. Clin Pharm Ther 11: 194–199, 1970.

    CAS  Google Scholar 

  • Lipowski ZJ: Physical illness, the patient and its environment: Psychosocial foundations of medicine, in organic disorders and psychosomatic medicine, in Reiser MF, Arieti S (eds): American Handbook of Psychiatry, ed 2. New York, Basic Books, vol 4, 1975.

    Google Scholar 

  • Lycke E, Norrby R, Roos BE: A serological study on mentally-ill patients. Br J Psychiatry 124: 277, 1974.

    Article  Google Scholar 

  • Meninger KA: Influenza and schizophrenia. An analysis of post-influenzal “dementia praecox” as of 1918 and five years later. Am J Psychiatry 5: 469–474, 1926.

    Google Scholar 

  • Misra PC, Hay GG: Encephalitis presenting as acute schizophrenia. Br Med J 1: 532–533, 1971.

    Article  PubMed  CAS  Google Scholar 

  • Nikolovski OT, Fernandes JV: Capgras Syndrome as an aftermath of chicken pox encephalitis. Psych Opinion 15: 39–43, 1978.

    Google Scholar 

  • Penman HG: Fatal infectious mononucleosis: A critical review. J Clin Pathol 23: 765–769, 1970.

    Article  PubMed  CAS  Google Scholar 

  • Penn H, Racy J, Lapham L, et al: Catatonic behavior, viral encephalopathy, and death: The problem of fatal catatonia. Arch Gen Psychiatry 27: 758–761, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Peszke MA, Mason WM: Infectious mononucleosis and its relationship to psychological malaise. Conn Med 1: 260–262, 1969.

    Google Scholar 

  • Pokorny Ed, Rawls WE, Adam E, et al: Depression, psychopathology and herpes virus type I antibodies. Arch Gen Psychiatry 29:820–824, 1972.

    Google Scholar 

  • Postma JU, Van Tilburg W: Visual hallucinations and delirium during treatment with amantadine (Symmetrel). J Am Geriatr Soc 23: 212–215, 1975.

    PubMed  CAS  Google Scholar 

  • Pratt TH: Rifampin-induced organic brain syndrome. JAMA 241: 2421–2422, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Rasken DE: Herpes encephalitis with catatonic stupor. Arch Gen Psychiatry 31: 544–546, 1974.

    Article  Google Scholar 

  • Raymond RW, Williams RL: Infectious mononucleosis with psychosis: Report of a case. N Engl J Med 239: 542–544, 1948.

    Article  PubMed  CAS  Google Scholar 

  • Reilly DK: Isomiazid-related CNS toxicity. Drug Ther 9: 187–188, 1979.

    Google Scholar 

  • Rimon R, Halonen P: Herpes simplex virus infection and depressive illness. Dis. New Syst 30: 338–340, 1969.

    CAS  Google Scholar 

  • Rubin RL: Case reports: Adolescent infectious mononucleosis with psychosis. J Clin Psychiatry 39: 63–65, 1978.

    Google Scholar 

  • Sacks O: Awakenings. London, Duckworth, 1973.

    Google Scholar 

  • Saker BM, Musk AW, Hayward EF, et al: Reversible toxic psychosis after cephalexin. Med J Aust 1: 497–498, 1973.

    PubMed  CAS  Google Scholar 

  • Schnell RG, Dyck TJ, Bowie EW, et al: Infectious mononucleosis: Neurologic and EEG findings. Medicine 45: 51–63, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Schreier HR: Use of propranolol in the treatment of post-encephalitic psychoses. Am J Psychiatry 136: 840–841, 1979.

    PubMed  CAS  Google Scholar 

  • Schwab JJ: Psychiatric illnesses produced by infections. Hosp Med 5: 98–108, 1969.

    Google Scholar 

  • Schwab RS, England AC Jr., Poskanzer DC: Amantadine in the treatment of Parkinson’s disease. JAMA 208: 1168–1170, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Shearer ML, Finch SM: Periodic organic psychosis associated with recurrent herpes simplex. N Eng J Med 271: 494–497, 1964.

    Article  CAS  Google Scholar 

  • Silverstein A, Steinberg G, Nathanson M: Nervous system involvement in infectious mononucleosis. Arch Neural 26: 353–359, 1972.

    Article  CAS  Google Scholar 

  • Sorbin A, Ozer MN: Mental disorders in acute encephalitis. J Mt Sinai Hosp 33: 73–75, 1966.

    Google Scholar 

  • Spittle BJ, Fliegnar J, Faed JA, et al: Post-infectious encephalopathy simulating functional psychosis. New Eng Med J 85: 180–181, 1977.

    Google Scholar 

  • Steinberg D, Hirsch SR, Marston SD, et al: Influenza infection causing manic psychosis. Br J Psychiatry 120: 531–535, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Stewart RM, Baldessarini RJ: Viral encephalopathy and psychosis. Am J Psychiatry 133: 717, 1976.

    Google Scholar 

  • Still RML: Psychosis following Asian influenza in Barbados. Lancet 2: 20–21, 1958.

    Article  PubMed  CAS  Google Scholar 

  • Strauss H, Ostow M, Greenstein L: Diagnostic Electroencephalography. New York, Grune & Stratton, 1952.

    Google Scholar 

  • Thorn GW, Adams RD, Braunwald E, et al (eds): Harrison’s Principles of Internal Medicine, ed 8. New York, McGraw-Hill, 1977.

    Google Scholar 

  • Tompsett TR: Pseudoanaphylactic reactions to procaine penicillin G. Arch Intern Med 120: 565–567, 1967.

    Article  PubMed  CAS  Google Scholar 

  • Utley PM, Lucas JB, Billings GE: Acute psychotic reactions to aqueous procaine penicillin. South Med J 59: 1271–1274, 1966.

    Article  PubMed  CAS  Google Scholar 

  • Wadlington WB, Hatcher H, Turner DJ: Osteomyelitis of the patella—gentamicin therapy associated with encephalopathy. Clin Pediatr 10: 577–580, 1972.

    Article  Google Scholar 

  • Wallin JW: Children with Mental and Physical Handicaps. New York, Prentice–Hall, 1949.

    Book  Google Scholar 

  • Warm JS, Alluisi EA: Behavioral reactions to infection: Review of the psychological literature. Precept Skills 24: 755–761, 1967.

    Article  Google Scholar 

  • Weinstein EA, Linn L, Kahn RL: Encephalitis with a clinical picture of schizophrenia. J Mt Sinai Hosp 21: 341–354, 1955.

    CAS  Google Scholar 

  • Wilson LG: Viral encephalopathy mimicking functional psychosis. Am JPsychiatry 133: 165–170, 1976.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Publishing Corporation

About this chapter

Cite this chapter

Jefferson, J.W., Marshall, J.R. (1981). Infectious Disorders. In: Neuropsychiatric Features of Medical Disorders. Critical Issues in Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3920-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3920-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3922-9

  • Online ISBN: 978-1-4684-3920-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics